Search Results - "Xing, Junyue"

Hypoxia induces senescence of bone marrow mesenchymal stem cells via altered gut microbiota by Xing, Junyue, Ying, Yongquan, Mao, Chenxi, Liu, Yiwei, Wang, Tingting, Zhao, Qian, Zhang, Xiaoling, Yan, Fuxia, Zhang, Hao

“…Systemic chronic hypoxia is a feature of many diseases and may influence the communication between bone marrow (BM) and gut microbiota. Here we analyse…”
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HuR regulates telomerase activity through TERC methylation by Tang, Hao, Wang, Hu, Cheng, Xiaolei, Fan, Xiuqin, Yang, Fan, Zhang, Mengmeng, Chen, Yanlian, Tian, Yuyang, Liu, Cihang, Shao, Dongxing, Jiang, Bin, Dou, Yali, Cong, Yusheng, Xing, Junyue, Zhang, Xiaotian, Yi, Xia, Songyang, Zhou, Ma, Wenbin, Zhao, Yong, Wang, Xian, Ma, Jinbiao, Gorospe, Myriam, Ju, Zhenyu, Wang, Wengong

“…Telomerase consists of the catalytic protein TERT and the RNA TERC . Mutations in TERC are linked to human diseases, but the underlying mechanisms are poorly…”
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Baicalin-modified polyethylenimine for miR-34a efficient and safe delivery by Wang, Yingying, Wang, Baiyan, Xiao, Yangfan, Cai, Qingchun, Xing, Junyue, Tang, Hao, Li, Ruiqin, Zhang, Hongtao

“…The security and efficiency of gene delivery vectors are inseparable for the successful construction of a gene delivery vector. This work provides a practical…”
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Transcriptional Profile Alteration of Peripheral Blood in Chronic Hypoxia by Wang, Ting Ting, Xing, Jun Yue, Zhang, Li Jing, Zhang, Hao

“…Objective Many physiological and pathological conditions, including cyanotic congenital heart diseases (CCHD), are accompanied by chronic hypoxia, which might…”
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Novel rare genetic variants of familial and sporadic pulmonary atresia identified by whole-exome sequencing by Xing, Junyue, Wang, Hongdan, Xie, Yuanyuan, Fan, Taibing, Cui, Cunying, Li, Yanan, Wang, Shuai, Gu, Weiyue, Wang, Chengzeng, Tang, Hao, Liu, Lin

“…Pulmonary atresia (PA) is a severe cyanotic congenital heart disease. Although some genetic mutations have been described to be associated with PA, the…”
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An orally administered bacterial membrane protein nanodrug ameliorates doxorubicin cardiotoxicity through alleviating impaired intestinal barrier by Li, Zhen, Xing, Junyue, Ma, Xiaohan, Zhang, Wanjun, Wang, Chuan, Wang, Yingying, Qi, Xinkun, Liu, Yanhui, Jian, Dongdong, Cheng, Xiaolei, Zhu, Yanjie, Shi, Chao, Guo, Yongjun, Zhao, Huan, Jiang, Wei, Tang, Hao

“…The cardiotoxicity caused by Dox chemotherapy represents a significant limitation to its clinical application and is a major cause of late death in patients…”
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Circulating cardiac MicroRNAs safeguard against dilated cardiomyopathy by Cheng, Xiaolei, Jian, Dongdong, Xing, Junyue, Liu, Cihang, Liu, Yong, Cui, Cunying, Li, Zhen, Wang, Shixing, Li, Ran, Ma, Xiaohan, Wang, Yingying, Gu, Xiaoping, Ge, Zhenwei, Tang, Hao, Liu, Lin

“…Background Cardiac‐resident or ‐enriched microRNAs (miRNAs) could be released into the bloodstream becoming circulating cardiac miRNAs, which are increasingly…”
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Author Correction: HuR regulates telomerase activity through TERC methylation by Tang, Hao, Wang, Hu, Cheng, Xiaolei, Fan, Xiuqin, Yang, Fan, Zhang, Mengmeng, Chen, Yanlian, Tian, Yuyang, Liu, Cihang, Shao, Dongxing, Jiang, Bin, Dou, Yali, Cong, Yusheng, Xing, Junyue, Zhang, Xiaotian, Yi, Xia, Songyang, Zhou, Ma, Wenbin, Zhao, Yong, Wang, Xian, Ma, Jinbiao, Gorospe, Myriam, Ju, Zhenyu, Wang, Wengong

“…In the original version of this Article, the affiliation details for Fan Yang were incorrectly given as ‘Key Laboratory of Regenerative Medicine of Ministry of…”
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The tRNA methyltransferase NSun2 stabilizes p16INK4 mRNA by methylating the 3′-untranslated region of p16 by Zhang, Xiaotian, Liu, Zhenyun, Yi, Jie, Tang, Hao, Xing, Junyue, Yu, Minqwei, Tong, Tanjun, Shang, Yongfeng, Gorospe, Myriam, Wang, Wengong

“…The impact of methylation of the 3′-untranslated region (UTR) of a messenger RNA (mRNA) remains largely unknown. Here we show that NSun2, a transfer RNA…”
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Chronic hypoxia-induced Cirbp hypermethylation attenuates hypothermic cardioprotection via down-regulation of ubiquinone biosynthesis by Liu, Yiwei, Xing, Junyue, Li, Yongnan, Luo, Qipeng, Su, Zhanhao, Zhang, Xiaoling, Zhang, Hao

“…Therapeutic hypothermia is commonly used during cardiopulmonary bypass (CPB) to protect the heart against myocardial injury in cardiac surgery. Patients who…”
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Suppression of Myocardial Hypoxia-Inducible Factor-1α Compromises Metabolic Adaptation and Impairs Cardiac Function in Patients With Cyanotic Congenital Heart Disease During Puberty by Liu, Yiwei, Luo, Qipeng, Su, Zhanhao, Xing, Junyue, Wu, Jinlin, Xiang, Li, Huang, Yuan, Pan, Haizhou, Wu, Xie, Zhang, Xiaoling, Li, Jun, Yan, Fuxia, Zhang, Hao

“…Cyanotic congenital heart disease (CCHD) is a complex pathophysiological condition involving systemic chronic hypoxia (CH). Some patients with CCHD are…”
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NSun2 delays replicative senescence by repressing p27 (KIP1) translation and elevating CDK1 translation by Tang, Hao, Fan, Xiuqin, Xing, Junyue, Liu, Zhenyun, Jiang, Bin, Dou, Yali, Gorospe, Myriam, Wang, Wengong

“…A rise in the levels of the cyclin-dependent kinase (CDK) inhibitor p27KIP1 is important for the growth arrest of senescent cells, but the mechanisms…”
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NSun2 Promotes Cell Growth via Elevating Cyclin-Dependent Kinase 1 Translation by Xing, Junyue, Yi, Jie, Cai, Xiaoyu, Tang, Hao, Liu, Zhenyun, Zhang, Xiaotian, Martindale, Jennifer L., Yang, Xiaoling, Jiang, Bin, Gorospe, Myriam, Wang, Wengong

“…The tRNA methytransferase NSun2 promotes cell proliferation, but the molecular mechanism has not been elucidated. Here, we report that NSun2 regulates…”
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Targeting OGF/OGFR signal to mitigate doxorubicin-induced cardiotoxicity by Chen, Xiru, Jian, Dongdong, Xing, Junyue, Cheng, Xiaolei, Wang, Chuan, Wang, Chenqiu, Pan, Jiangpeng, Qi, Xinkun, Wang, Shixing, Li, Zhen, Liu, Ying, Jian, Liguo, Tang, Hao

“…Enkephalins are reportedly correlated with heart function. However, their regulation in the heart remains unexplored. This study revealed a substantial…”
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Notch1 signaling mediated dysfunction of bone marrow mesenchymal stem cells derived from cyanotic congenital heart disease by Wang, Tingting, Xing, Junyue, Ying, Yongquan, Tang, Hao, Li, Jun, Wei, Yingjie, Zhang, Hao

“…Bone marrow mesenchymal stem cells (BMSCs) derived from cyanotic congenital heart disease (CCHD) exhibit deficient multi-lineage differentiation potential due…”
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Methylation by NSun2 Represses the Levels and Function of MicroRNA 125b by Yuan, Shuai, Tang, Hao, Xing, Junyue, Fan, Xiuqin, Cai, Xiaoyu, Li, Qiu, Han, Pei, Luo, Yuhong, Zhang, Zhuojun, Jiang, Bin, Dou, Yali, Gorospe, Myriam, Wang, Wengong

“…Methylation is a prevalent posttranscriptional modification of RNAs. However, whether mammalian microRNAs are methylated is unknown. Here, we show that the…”
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DNMT1 determines osteosarcoma cell resistance to apoptosis by associatively modulating DNA and mRNA cytosine‐5 methylation by Shao, Dongxing, Liu, Cihang, Wang, Yingying, Lin, Jing, Cheng, Xiaolei, Han, Pei, Li, Zhen, Jian, Dongdong, Nie, Junwei, Jiang, Mingyang, Wei, Yuanzhi, Xing, Junyue, Guo, Zhiping, Wang, Wengong, Yi, Xia, Tang, Hao

“…Cellular apoptosis is a central mechanism leveraged by chemotherapy to treat human cancers. 5‐Methylcytosine (m5C) modifications installed on both DNA and mRNA…”
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Suppression of Myocardial HIF-1α Compromises Metabolic Adaptation and Impairs Cardiac Function in Patients with Cyanotic Congenital Heart Disease During Puberty by Liu, Yiwei, Luo, Qipeng, Su, Zhanhao, Xing, Junyue, Wu, Jinlin, Xiang, Li, Huang, Yuan, Pan, Haizhou, Wu, Xie, Zhang, Xiaoling, Li, Jun, Yan, Fuxia, Zhang, Hao

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A Cardiac-Targeting and Anchoring Bimetallic Cluster Nanozyme Alleviates Chemotherapy-Induced Cardiac Ferroptosis and PANoptosis by Xing, Junyue, Ma, Xiaohan, Yu, Yanan, Xiao, Yangfan, Chen, Lu, Yuan, Weining, Wang, Yingying, Liu, Keyu, Guo, Zhiping, Tang, Hao, Fan, Kelong, Jiang, Wei

“…Doxorubicin (DOX), a potent antineoplastic agent, is commonly associated with cardiotoxicity, necessitating the development of strategies to reduce its adverse…”
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RNA methyltransferase NSUN2 promotes stress-induced HUVEC senescence by Cai, Xiaoyu, Hu, Yuanyuan, Tang, Hao, Hu, Han, Pang, Lijun, Xing, Junyue, Liu, Zhenyun, Luo, Yuhong, Jiang, Bin, Liu, Te, Gorospe, Myriam, Chen, Chuan, Wang, Wengong

“…The tRNA methyltransferase NSUN2 delays replicative senescence by regulating the translation of CDK1 and CDKN1B mRNAs. However, whether NSUN2 influences…”
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