Search Results - "Xin Fu"

Stairway Plot 2: demographic history inference with folded SNP frequency spectra by Liu, Xiaoming, Fu, Yun-Xin

“…Inferring the demographic histories of populations has wide applications in population, ecological, and conservation genomics. We present Stairway Plot 2, a…”
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Uniqueness of tangent cone of Kähler-Einstein metrics on singular varieties with crepant singularities by Fu, Xin

“…Let ( X ,  L ) be a polarized Calabi-Yau variety (or canonical polarized variety) with crepant singularities. Suppose ω KE ∈ c 1 ( L ) (or ω KE ∈ c 1 ( K X ) )…”
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Phagocytosis checkpoints as new targets for cancer immunotherapy by Feng, Mingye, Jiang, Wen, Kim, Betty Y. S., Zhang, Cheng Cheng, Fu, Yang-Xin, Weissman, Irving L.

“…Cancer immunotherapies targeting adaptive immune checkpoints have substantially improved patient outcomes across multiple metastatic and treatment-refractory…”
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Exploring population size changes using SNP frequency spectra by Liu, Xiaoming, Fu, Yun-Xin

“…Xiaoming Liu and Yun-Xin Fu present a model-flexible method for inferring changes in population size over time on the basis of the composite likelihood of SNP…”
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Host STING-dependent MDSC mobilization drives extrinsic radiation resistance by Liang, Hua, Deng, Liufu, Hou, Yuzhu, Meng, Xiangjiao, Huang, Xiaona, Rao, Enyu, Zheng, Wenxin, Mauceri, Helena, Mack, Matthias, Xu, Meng, Fu, Yang-Xin, Weichselbaum, Ralph R.

“…Radiotherapy induces and promotes innate and adaptive immunity in which host STING plays an important role. However, radioresistance in irradiated tumors can…”
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Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis by Rao, Lang, Wu, Lei, Liu, Zhida, Tian, Rui, Yu, Guocan, Zhou, Zijian, Yang, Kuikun, Xiong, Hong-Gang, Zhang, Anli, Yu, Guang-Tao, Sun, Wenjing, Xu, Han, Guo, Jingya, Li, Andrew, Chen, Hongmin, Sun, Zhi-Jun, Fu, Yang-Xin, Chen, Xiaoyuan

“…Effectively activating macrophages against cancer is promising but challenging. In particular, cancer cells express CD47, a ‘don’t eat me’ signal that…”
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Dual-targeting nanoparticle vaccine elicits a therapeutic antibody response against chronic hepatitis B by Wang, Wenjun, Zhou, Xiaoxiao, Bian, Yingjie, Wang, Shan, Chai, Qian, Guo, Zhenqian, Wang, Zhenni, Zhu, Ping, Peng, Hua, Yan, Xiyun, Li, Wenhui, Fu, Yang-Xin, Zhu, Mingzhao

“…Chronic hepatitis B is caused by prolonged infection with the hepatitis B virus (HBV), which can substantially increase the risk of developing liver disease…”
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Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice by Deng, Liufu, Liang, Hua, Burnette, Byron, Beckett, Michael, Darga, Thomas, Weichselbaum, Ralph R, Fu, Yang-Xin

“…High-dose ionizing irradiation (IR) results in direct tumor cell death and augments tumor-specific immunity, which enhances tumor control both locally and…”
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Tumor-reprogrammed resident T cells resist radiation to control tumors by Arina, Ainhoa, Beckett, Michael, Fernandez, Christian, Zheng, Wenxin, Pitroda, Sean, Chmura, Steven J., Luke, Jason J., Forde, Martin, Hou, Yuzhu, Burnette, Byron, Mauceri, Helena, Lowy, Israel, Sims, Tasha, Khodarev, Nikolai, Fu, Yang-Xin, Weichselbaum, Ralph R.

“…Successful combinations of radiotherapy and immunotherapy depend on the presence of live T cells within the tumor; however, radiotherapy is believed to damage…”
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PD-L1 on dendritic cells attenuates T cell activation and regulates response to immune checkpoint blockade by Peng, Qi, Qiu, Xiangyan, Zhang, Zihan, Zhang, Silin, Zhang, Yuanyuan, Liang, Yong, Guo, Jingya, Peng, Hua, Chen, Mingyi, Fu, Yang-Xin, Tang, Haidong

“…Immune checkpoint blockade therapies have shown clinical promise in a variety of cancers, but how tumor-infiltrating T cells are activated remains unclear. In…”
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Deriving suitability factors for CA-Markov land use simulation model based on local historical data by Fu, Xin, Wang, Xinhao, Yang, Y. Jeffrey

“…Multiple Criteria Evaluation (MCE) is a multi-attributes decision making tool often used in land suitability analysis and land use simulation using Cellular…”
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A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development by Shi, Yuanyuan, Hu, Xiaoqing, Cheng, Jin, Zhang, Xin, Zhao, Fengyuan, Shi, Weili, Ren, Bo, Yu, Huilei, Yang, Peng, Li, Zong, Liu, Qiang, Liu, Zhenlong, Duan, Xiaoning, Fu, Xin, Zhang, Jiying, Wang, Jianquan, Ao, Yingfang

“…Degradation of extracellular matrix (ECM) underlies loss of cartilage tissue in osteoarthritis, a common disease for which no effective disease-modifying…”
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Non-canonical NF-κB Antagonizes STING Sensor-Mediated DNA Sensing in Radiotherapy by Hou, Yuzhu, Liang, Hua, Rao, Enyu, Zheng, Wenxin, Huang, Xiaona, Deng, Liufu, Zhang, Yuan, Yu, Xinshuang, Xu, Meng, Mauceri, Helena, Arina, Ainhoa, Weichselbaum, Ralph R., Fu, Yang-Xin

“…The NF-κB pathway plays a crucial role in supporting tumor initiation, progression, and radioresistance of tumor cells. However, the role of the NF-κB pathway…”
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A cytokine receptor-masked IL2 prodrug selectively activates tumor-infiltrating lymphocytes for potent antitumor therapy by Hsu, Eric J., Cao, Xuezhi, Moon, Benjamin, Bae, Joonbeom, Sun, Zhichen, Liu, Zhida, Fu, Yang-Xin

“…As a potent lymphocyte activator, interleukin-2 (IL-2) is an FDA-approved treatment for multiple metastatic cancers. However, its clinical use is limited by…”
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Highly atroposelective synthesis of nonbiaryl naphthalene-1,2-diamine N-C atropisomers through direct enantioselective C-H amination by Bai, He-Yuan, Tan, Fu-Xin, Liu, Tuan-Qing, Zhu, Guo-Dong, Tian, Jin-Miao, Ding, Tong-Mei, Chen, Zhi-Min, Zhang, Shu-Yu

“…Nonbiaryl N-C atropisomer is an important structural scaffold, which is present in natural products, medicines and chiral ligands. However the direct…”
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Mutual Incoherence and Relative Total Variation Regularizations for Blind Hyperspectral Unmixing by Song, Fu-Xin, Kan, Chao, Deng, Shi-Wen

“…The unsupervised hyperspectral unmixing (HU) technique, also known as blind HU, directly decomposes the mixed pixels of a hyperspectral image (HSI) into a…”
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Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling by Shi, Yaoyao, Zheng, Wenxin, Yang, Kaiting, Harris, Katharine G, Ni, Kaiyuan, Xue, Lai, Lin, Wenbin, Chang, Eugene B, Weichselbaum, Ralph R, Fu, Yang-Xin

“…Most studies focus on how intestinal microbiota influence cancer immunotherapy through activating gut immunity. However, immunotherapies related to innate…”
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A next-generation tumor-targeting IL-2 preferentially promotes tumor-infiltrating CD8+ T-cell response and effective tumor control by Sun, Zhichen, Ren, Zhenhua, Yang, Kaiting, Liu, Zhida, Cao, Shuaishuai, Deng, Sisi, Xu, Lily, Liang, Yong, Guo, Jingya, Bian, Yingjie, Xu, Hairong, Shi, Jiyun, Wang, Fan, Fu, Yang-Xin, Peng, Hua

“…While IL-2 can potently activate both NK and T cells, its short in vivo half-life, severe toxicity, and propensity to amplify Treg cells are major barriers…”
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P75 neurotrophin receptor as a therapeutic target for drug development to treat neurological diseases by Xiong, Liu‐Lin, Chen, Li, Deng, Isaac Bul, Zhou, Xin‐Fu, Wang, Ting‐Hua

“…The interaction of neurotrophins with their receptors is involved in the pathogenesis and progression of various neurological diseases, including Alzheimer's…”
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Notch1/TAZ axis promotes aerobic glycolysis and immune escape in lung cancer by Xie, Mian, Fu, Xin-ge, Jiang, Ke

“…Oncogenic signaling pathway reprograms cancer cell metabolism to promote aerobic glycolysis in favor of tumor growth. The ability of cancer cells to evade…”
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