Search Results - "Xin, Minhang"

Small molecule selenium-containing compounds: Recent development and therapeutic applications by Chuai, Hongyan, Zhang, San-Qi, Bai, Huanrong, Li, Jiyu, Wang, Yang, Sun, Jiajia, Wen, Ergang, Zhang, Jiye, Xin, Minhang

“…Selenium (Se) is an essential micronutrient of organism and has important function. It participates in the functions of selenoprotein in several manners. In…”
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Review of the molecular mechanisms of Ganoderma lucidum triterpenoids: Ganoderic acids A, C2, D, F, DM, X and Y by Liang, Chengyuan, Tian, Danni, Liu, Yuzhi, Li, Han, Zhu, Jialiang, Li, Min, Xin, Minhang, Xia, Juan

“…Ganoderma lucidum is a multi-purpose plant medicine that is homologous to functional food. The most attractive properties of G. lucidum are its…”
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Strategies to target the Hedgehog signaling pathway for cancer therapy by Xin, Minhang, Ji, Xinyue, La Cruz, Ladie Kimberly, Thareja, Suresh, Wang, Binghe

“…Hedgehog (Hh) signaling is an essential pathway in the human body, and plays a major role in embryo development and tissue patterning. Constitutive activation…”
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Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC) by Zhang, Hao, Zhao, Hong-Yi, Xi, Xiao-Xiao, Liu, Yan-Jie, Xin, Minhang, Mao, Shuai, Zhang, Jun-Jie, Lu, A-Xin, Zhang, San-Qi

“…Epidermal growth factor receptor (EGFR), a member of the HER family, is closely related to the development of multiple cancers. Herein, we report the discovery…”
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Progress of small molecules for targeted protein degradation: PROTACs and other technologies by Zhao, Hong‐Yi, Xin, Minhang, Zhang, San‐Qi

“…Recent years have witnessed the rapid development of targeted protein degradation (TPD), especially proteolysis targeting chimeras. These degraders have…”
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Discovery of novel 9-heterocyclyl substituted 9H-purines as L858R/T790M/C797S mutant EGFR tyrosine kinase inhibitors by Lei, Hao, Fan, Shu, Zhang, Hao, Liu, Yan-Jie, Hei, Yuan-Yuan, Zhang, Jun-Jie, Zheng, A-Qun, Xin, Minhang, Zhang, San-Qi

“…Targeting L858R/T790M/C797S mutant EGFR is a major challenge in the new-generation EGFR tyrosine kinase inhibitors development for conquering drug resistant…”
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Design and synthesis of novel phthalazinone derivatives as potent poly(ADP-ribose)polymerase 1 inhibitors by Xin, Minhang, Sun, Jiajia, Huang, Wei, Tang, Feng, Liu, Zhaoyu, Jin, Qiu, Wang, Jia

“…The development of effective PARP-1 inhibitors has received great enthusiasm in medicinal chemistry communities. A new series of novel phthalazinone…”
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Design, synthesis, and evaluation of fluoroquinolone derivatives as microRNA-21 small-molecule inhibitors by Hei, Yuan-Yuan, Wang, Si, Xi, Xiao-Xiao, Wang, Hai-Peng, Guo, Yuanxu, Xin, Minhang, Jiang, Congshan, Lu, Shemin, Zhang, San-Qi

“…MicroRNA-21 (miRNA-21) is highly expressed in various tumors. Small-molecule inhibition of miRNA-21 is considered to be an attractive novel cancer therapeutic…”
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Cu-mediated selective bromination of aniline derivatives and preliminary mechanism study by Zhao, Hong-Yi, Yang, Xue-Yan, Lei, Hao, Xin, Minhang, Zhang, San-Qi

“…A simple and efficient bromination of aniline, aniline derivatives, and analogs have been developed. Forty three examples were given and the highest yield…”
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Introduction of pyrrolidineoxy or piperidineamino group at the 4-position of quinazoline leading to novel quinazoline-based phosphoinositide 3-kinase delta (PI3Kδ) inhibitors by Xin, Minhang, Duan, Weiming, Feng, Yifan, Hei, Yuan-Yuan, Zhang, Hao, Shen, Ying, Zhao, Hong-Yi, Mao, Shuai, Zhang, San-Qi

“…Phosphoinositide 3-kinase Delta (PI3Kδ) plays a key role in B-cell signal transduction and inhibition of PI3Kδ was confirmed to have clinical benefit in…”
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An efficient, practical synthesis of 2-methoxyestradiol by Xin, Minhang, You, Qidong, Xiang, Hua

“…An efficient and practical scheme to synthesize 2-methoxyestradiol has been developed. The key step was the copper-mediated methoxylation using ethyl acetate…”
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Hedgehog inhibitors: a patent review (2013 - present) by Xin, Minhang

“…The hedgehog (Hh) signaling pathway is an important signaling pathway, playing a critical role in regulation of cell growth, development, metastasis and…”
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The development of Bruton's tyrosine kinase (BTK) inhibitors from 2012 to 2017: A mini-review by Liang, Chengyuan, Tian, Danni, Ren, Xiaodong, Ding, Shunjun, Jia, Minyi, Xin, Minhang, Thareja, Suresh

“…Bruton's tyrosine kinase (BTK) has emerged as a promising drug target for multiple diseases, particularly haematopoietic malignancies and autoimmune diseases…”
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PI3Kδ inhibitors for the treatment of cancer: a patent review (2015-present) by Feng, Yifan, Cu, Xiaochuan, Xin, Minhang

“…: PI3Kδ is an important subtype of PI3K kinases, which is mainly expressed in leukocytes and plays an important role in the proliferation, differentiation,…”
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Modification of osimertinib to discover new potent EGFRC797S-TK inhibitors by Xi, Xiao-Xiao, Zhao, Hong-Yi, Mao, Yu-Ze, Xin, Minhang, Zhang, San-Qi

“…The EGFRC797S mutation is a dominant mechanism of acquired resistance after the treatment of non-small cell lung cancer (NSCLC) with osimertinib in clinic. To…”
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Discovery of potent small molecule PROTACs targeting mutant EGFR by Zhao, Hong-Yi, Yang, Xue-Yan, Lei, Hao, Xi, Xiao-Xiao, Lu, She-Min, Zhang, Jun-Jie, Xin, Minhang, Zhang, San-Qi

“…Epidermal growth factor receptor (EGFR) is an important therapeutic target for the treatment of non-small cell lung cancer. A number of efficacious EGFR…”
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Menin-MLL protein-protein interaction inhibitors: a patent review (2014-2021) by Bai, Huanrong, Zhang, San-Qi, Lei, Hao, Wang, Fang, Ma, Mengyan, Xin, Minhang

“…Chromosomal translocations involving the mixed-lineage leukemia (MLL, KMT2A, MLL1) genes result in the production of MLL fusion proteins, which cause abnormal…”
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Research advances on selective phosphatidylinositol 3 kinase δ (PI3Kδ) inhibitors by Sun, Jiajia, Feng, Yifan, Huang, Yuan, Zhang, San-Qi, Xin, Minhang

“…[Display omitted] PI3Kδ in B cells mediates antigen receptor signaling and promote neutrophil chemotaxis. The activation of PI3Kδ can cause mast cell…”
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Discovery of Potent PROTACs Targeting EGFR Mutants through the Optimization of Covalent EGFR Ligands by Zhao, Hong-Yi, Wang, Hai-Peng, Mao, Yu-Ze, Zhang, Hao, Xin, Minhang, Xi, Xiao-Xiao, Lei, Hao, Mao, Shuai, Li, Dong-Hui, Zhang, San-Qi

“…Drug resistance caused by epidermal growth factor receptor (EGFR) mutation has largely limited the clinical use of EGFR tyrosine kinase inhibitors (EGFR-TKIs)…”
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Recent Progress of Small Molecule Menin–MLL Interaction Inhibitors as Therapeutic Agents for Acute Leukemia by Lei, Hao, Zhang, San-Qi, Fan, Shu, Bai, Huan-Rong, Zhao, Hong-Yi, Mao, Shuai, Xin, Minhang

“…Mixed lineage leukemia (MLL) gene rearrangements are associated with acute leukemia. The protein menin is regarded as a critical oncogenic cofactor of the…”
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