Search Results - "Xie, Yongmei"

Paeoniflorin is a promising natural monomer for neurodegenerative diseases via modulation of Ca2+ and ROS homeostasis by Peng, Wei, Chen, Yunhui, Tumilty, Steve, Liu, Lizhou, Luo, Ling, Yin, Haiyan, Xie, Yongmei

“…Neurodegenerative diseases (NDDs) are a range of neurological disorders featured by neuronal degeneration and apoptosis. Cellular Calcium (Ca2+) and reactive…”
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Synthesis and In Vitro Anti-tumor Evaluation of Novel Glycoconjugated SN38 Derivatives by Wang, Xin, Yang, Chao, Liao, Mengya, Xie, Yongmei, Yang, Jinliang

“…Five types of novel glycoconjugated 7-ethyl-10-hydroxycamptothecin (SN38) derivatives were synthesized to evaluate their anti-tumor activity against HCT116…”
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A Novel NIR Fluorescent Probe for Highly Selective Detection of Nitroreductase and Hypoxic-Tumor-Cell Imaging by Liu, Feng, Zhang, Hong, Li, Kun, Xie, Yongmei, Li, Zhihui

“…Nitroreductase as a potential biomarker for aggressive tumors has received extensive attention. In this work, a novel NIR fluorescent probe for nitroreductase…”
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Editorial: Herbal medicines and their metabolites: effects on lipid metabolic disorders via modulating oxidative stress by Chen, Yunhui, Xie, Yongmei, Lin, Cailu, Peng, Wei

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MicroRNA-21 promotes osteogenesis of bone marrow mesenchymal stem cells via the Smad7-Smad1/5/8-Runx2 pathway by Li, Xiaoyan, Guo, Lijia, Liu, Yitong, Su, Yingying, Xie, Yongmei, Du, Juan, Zhou, Jian, Ding, Gang, Wang, Hao, Bai, Yuxing, Liu, Yi

“…Bone marrow mesenchymal stem cells (BMMSCs) are pluripotent stem cells, and the osteogenic differentiation of BMMSCs has been drawing attention for a long…”
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An overview of PROTACs: a promising drug discovery paradigm by Liu, Zi, Hu, Mingxing, Yang, Yu, Du, Chenghao, Zhou, Haoxuan, Liu, Chengyali, Chen, Yuanwei, Fan, Lei, Ma, Hongqun, Gong, Youling, Xie, Yongmei

“…Proteolysis targeting chimeras (PROTACs) technology has emerged as a novel therapeutic paradigm in recent years. PROTACs are heterobifunctional molecules that…”
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Efficacy and Safety of Evolocumab and Alirocumab as PCSK9 Inhibitors in Pediatric Patients with Familial Hypercholesterolemia: A Systematic Review and Meta-Analysis by Xiao, Guoguang, Gao, Shan, Xie, Yongmei, Wang, Zhiling, Shu, Min

“…: The proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors evolocumab and alirocumab are recently developed promising drugs used for treatment of…”
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Synthesis and biological evaluation of novel SN38-glucose conjugate for colorectal cancer treatment by Zhang, Ruiming, Luo, Yi, Du, Chenghao, Wu, Ling, Wang, Yankang, Chen, Yuanduan, Li, Shouqian, Jiang, Xin, Xie, Yongmei

“…[Display omitted] 7-Ethyl-10-hydroxycamptothecin (SN38), the bioactive metabolite of irinotecan (CPT-11), has been shown to be 100–1000 times more effective…”
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Nifuroxazide ameliorates pulmonary fibrosis by blocking myofibroblast genesis: a drug repurposing study by Gan, Cailing, Zhang, Qianyu, Liu, Hongyao, Wang, Guan, Wang, Liqun, Li, Yali, Tan, Zui, Yin, Wenya, Yao, Yuqin, Xie, Yongmei, Ouyang, Liang, Yu, Luoting, Ye, Tinghong

“…Idiopathic pulmonary fibrosis (IPF) is a serious interstitial lung disease with a complex pathogenesis and high mortality. The development of new drugs is…”
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Dietary Immunoglobulin Y by Targeting Both GbpB and GtfB Enhances the Anticaries Effect in Rats by Du, Yunxiao, Li, Guobin, Li, Xinglin, Jian, Xiaohong, Wang, Xiaoling, Xie, Yongmei, Li, Zaixin, Zhang, Zhi

“…The purpose of this work was to develop an anti-CAT-SYI immunoglobulin Y (IgY) antibody that targeted both GtfB (glucosyltransferase B) and GbpB…”
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Mitochondriomics reveals the underlying neuroprotective mechanism of TrkB receptor agonist R13 in the 5×FAD mice by Li, Ting, Li, Xiao, Huang, Xi, Yu, Hao, Li, Shupeng, Zhang, Zaijun, Xie, Yongmei, Song, Xiangrong, Liu, Jianjun, Yang, Xifei, Liu, Gongping

“…Decreased energy metabolism and mitochondrial biogenesis defects are implicated in the pathogenesis of Alzheimer's disease (AD). In present study,…”
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Direct construction of novel exo′-selective spiropyrrolidine bisoxindoles via a three-component 1,3-dipolar cycloaddition reaction by Liu, Jie, Sun, Hongbao, Liu, Xiangjun, Ouyang, Liang, Kang, Tairan, Xie, Yongmei, Wang, Xiaoyan

“…An efficient synthesis of novel exo′-selective spiropyrrolidine bisoxindoles has been achieved via a three-component 1,3-dipolar cycloaddition reaction. The…”
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Identification of Hub lncRNAs Along With lncRNA-miRNA-mRNA Network for Effective Diagnosis and Prognosis of Papillary Thyroid Cancer by Li, Haiyan, Liu, Feng, Wang, Xiaoyang, Li, Menglong, Li, Zhihui, Xie, Yongmei, Guo, Yanzhi

“…Long noncoding RNAs (lncRNAs) play important roles in tumorigenesis and progression of different cancers and they have been potential biomarkers for cancer…”
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Discovery of the first potent proteolysis targeting chimera (PROTAC) degrader of indoleamine 2,3-dioxygenase 1 by Hu, Mingxing, Zhou, Weilin, Wang, Yijie, Yao, Dongping, Ye, Tinghong, Yao, Yuqin, Chen, Bin, Liu, Gongping, Yang, Xifei, Wang, Wei, Xie, Yongmei

“…Cancer immunotherapy is revolutionizing oncology and has emerged as a promising strategy for the treatment of multiple cancers. Indoleamine 2,3-dioxygenase 1…”
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A novel benzothiazole derivative induces apoptosis via the mitochondrial intrinsic pathway producing antitumor activity in colorectal cancer by Zhou, Jing, Zhao, Rongce, Zhou, Haoxuan, Yang, Shuping, Tao, Feiyan, Xie, Yongmei, Wang, Hongli, Yun, Jingping

“…Colorectal cancer (CRC) is one of the most common malignancies causing the third highest mortality rate in the world. It is particularly urgent to explore…”
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Synthesis and biological evaluation of the novel chrysin prodrug for non-alcoholic fatty liver disease treatment by Zhang, Ruiming, Gao, Chuanyue, Hu, Mingxing, Wang, Xingxing, Li, Shuoyuan, An, Zhenmei, Yang, Xifei, Xie, Yongmei

“…Chrysin (5,7-dihydroxyflavone) is a natural flavonoid that has been reported as a potential treatment for non-alcoholic fatty liver disease (NAFLD). However,…”
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Nifuroxazide exerts potent anti-tumor and anti-metastasis activity in melanoma by Zhu, Yongxia, Ye, Tinghong, Yu, Xi, Lei, Qian, Yang, Fangfang, Xia, Yong, Song, Xuejiao, Liu, Li, Deng, Hongxia, Gao, Tiantao, Peng, Cuiting, Zuo, Weiqiong, Xiong, Ying, Zhang, Lidan, Wang, Ningyu, Zhao, Lifeng, Xie, Yongmei, Yu, Luoting, Wei, Yuquan

“…Melanoma is a highly malignant neoplasm of melanocytes with considerable metastatic potential and drug resistance, explaining the need for new candidates that…”
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Applying an innovative biodegradable self-assembly nanomicelles to deliver α-mangostin for improving anti-melanoma activity by Yang, Shuping, Gao, Xiang, He, Yihong, Hu, Yuzhu, Xu, Bocheng, Cheng, Zhiqiang, Xiang, Mingli, Xie, Yongmei

“…α-Mangostin (αM), a traditional natural product with promising application of treating a series of diseases, was limited use in clinical due to its…”
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Novel lysosome-targeted anticancer fluorescent agents used in zebrafish and nude mouse tumour imaging by Chen, Xiuli, Liu, Feng, Chen, Bin, Wu, Haiying, Li, Kun, Xie, Yongmei, Kuang, Weihong, Li, Zhihui

“…The design of three novel fatty nitrogen mustard-based anticancer agents with fluorophores incorporated into the alkene structure ( CXL 118 , CXL121 , and…”
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Inhibition of Stat3 Signaling Pathway by Natural Product Pectolinarigenin Attenuates Breast Cancer Metastasis by Li, Yali, Gan, Cailing, Zhang, Yange, Yu, Yan, Fan, Chen, Deng, Yuanle, Zhang, Qianyu, Yu, Xi, Zhang, Yiwen, Wang, Liqun, He, Fang, Xie, Yongmei, Ye, Tinghong, Yin, Wenya

“…Background: Breast cancer is the most common female cancer with considerable metastatic potential, which urges the need for developing novel potential drug…”
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