Search Results - "Xie, Yingtian"

Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer by Cejas, Paloma, Xie, Yingtian, Font-Tello, Alba, Lim, Klothilda, Syamala, Sudeepa, Qiu, Xintao, Tewari, Alok K., Shah, Neel, Nguyen, Holly M., Patel, Radhika A., Brown, Lisha, Coleman, Ilsa, Hackeng, Wenzel M., Brosens, Lodewijk, Dreijerink, Koen M. A., Ellis, Leigh, Alaiwi, Sarah Abou, Seo, Ji-Heui, Baca, Sylvan, Beltran, Himisha, Khani, Francesca, Pomerantz, Mark, Dall’Agnese, Alessandra, Crowdis, Jett, Van Allen, Eliezer M., Bellmunt, Joaquim, Morrisey, Colm, Nelson, Peter S., DeCaprio, James, Farago, Anna, Dyson, Nicholas, Drapkin, Benjamin, Liu, X. Shirley, Freedman, Matthew, Haffner, Michael C., Corey, Eva, Brown, Myles, Long, Henry W.

“…Neuroendocrine carcinomas (NEC) are tumors expressing markers of neuronal differentiation that can arise at different anatomic sites but have strong…”
Get full text

Juvenile Hormone Activates the Transcription of Cell-division-cycle 6 (Cdc6) for Polyploidy-dependent Insect Vitellogenesis and Oogenesis by Wu, Zhongxia, Guo, Wei, Xie, Yingtian, Zhou, Shutang

“…Although juvenile hormone (JH) is known to prevent insect larval metamorphosis and stimulate adult reproduction, the molecular mechanisms of JH action in…”
Get full text

MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets by Qiu, Xintao, Boufaied, Nadia, Hallal, Tarek, Feit, Avery, de Polo, Anna, Luoma, Adrienne M., Alahmadi, Walaa, Larocque, Janie, Zadra, Giorgia, Xie, Yingtian, Gu, Shengqing, Tang, Qin, Zhang, Yi, Syamala, Sudeepa, Seo, Ji-Heui, Bell, Connor, O’Connor, Edward, Liu, Yang, Schaeffer, Edward M., Jeffrey Karnes, R., Weinmann, Sheila, Davicioni, Elai, Morrissey, Colm, Cejas, Paloma, Ellis, Leigh, Loda, Massimo, Wucherpfennig, Kai W., Pomerantz, Mark M., Spratt, Daniel E., Corey, Eva, Freedman, Matthew L., Shirley Liu, X., Brown, Myles, Long, Henry W., Labbé, David P.

“…c-MYC (MYC) is a major driver of prostate cancer tumorigenesis and progression. Although MYC is overexpressed in both early and metastatic disease and…”
Get full text

Responses of wheat and rice to factorial combinations of ambient and elevated CO2 and temperature in FACE experiments by Cai, Chuang, Yin, Xinyou, He, Shuaiqi, Jiang, Wenyu, Si, Chuanfei, Struik, Paul C., Luo, Weihong, Li, Gang, Xie, Yingtian, Xiong, Yan, Pan, Genxing

“…Elevated CO₂ and temperature strongly affect crop production, but understanding of the crop response to combined CO₂ and temperature increases under field…”
Get full text

Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway by Kurppa, Kari J., Liu, Yao, To, Ciric, Zhang, Tinghu, Fan, Mengyang, Vajdi, Amir, Knelson, Erik H., Xie, Yingtian, Lim, Klothilda, Cejas, Paloma, Portell, Andrew, Lizotte, Patrick H., Ficarro, Scott B., Li, Shuai, Chen, Ting, Haikala, Heidi M., Wang, Haiyun, Bahcall, Magda, Gao, Yang, Shalhout, Sophia, Boettcher, Steffen, Shin, Bo Hee, Thai, Tran, Wilkens, Margaret K., Tillgren, Michelle L., Mushajiang, Mierzhati, Xu, Man, Choi, Jihyun, Bertram, Arrien A., Ebert, Benjamin L., Beroukhim, Rameen, Bandopadhayay, Pratiti, Awad, Mark M., Gokhale, Prafulla C., Kirschmeier, Paul T., Marto, Jarrod A., Camargo, Fernando D., Haq, Rizwan, Paweletz, Cloud P., Wong, Kwok-Kin, Barbie, David A., Long, Henry W., Gray, Nathanael S., Jänne, Pasi A.

“…Eradicating tumor dormancy that develops following epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) treatment of EGFR-mutant non-small…”
Get full text

Integrative analyses of single-cell transcriptome and regulome using MAESTRO by Wang, Chenfei, Sun, Dongqing, Huang, Xin, Wan, Changxin, Li, Ziyi, Han, Ya, Qin, Qian, Fan, Jingyu, Qiu, Xintao, Xie, Yingtian, Meyer, Clifford A, Brown, Myles, Tang, Ming, Long, Henry, Liu, Tao, Liu, X Shirley

“…We present Model-based AnalysEs of Transcriptome and RegulOme (MAESTRO), a comprehensive open-source computational workflow (…”
Get full text

Chromatin accessibility promotes hematopoietic and leukemia stem cell activity by Cabal-Hierro, Lucia, van Galen, Peter, Prado, Miguel A., Higby, Kelly J., Togami, Katsuhiro, Mowery, Cody T., Paulo, Joao A., Xie, Yingtian, Cejas, Paloma, Furusawa, Takashi, Bustin, Michael, Long, Henry W., Sykes, David B., Gygi, Steven P., Finley, Daniel, Bernstein, Bradley E., Lane, Andrew A.

“…Chromatin organization is a highly orchestrated process that influences gene expression, in part by modulating access of regulatory factors to DNA and…”
Get full text

Therapeutically Increasing MHC-I Expression Potentiates Immune Checkpoint Blockade by Gu, Shengqing Stan, Zhang, Wubing, Wang, Xiaoqing, Jiang, Peng, Traugh, Nicole, Li, Ziyi, Meyer, Clifford, Stewig, Blair, Xie, Yingtian, Bu, Xia, Manos, Michael P, Font-Tello, Alba, Gjini, Evisa, Lako, Ana, Lim, Klothilda, Conway, Jake, Tewari, Alok K, Zeng, Zexian, Sahu, Avinash Das, Tokheim, Collin, Weirather, Jason L, Fu, Jingxin, Zhang, Yi, Kroger, Benjamin, Liang, Jin Hua, Cejas, Paloma, Freeman, Gordon J, Rodig, Scott, Long, Henry W, Gewurz, Benjamin E, Hodi, F Stephen, Brown, Myles, Liu, X Shirley

“…Immune checkpoint blockade (ICB) therapy revolutionized cancer treatment, but many patients with impaired MHC-I expression remain refractory. Here, we combined…”
Get more information

FiTAc-seq: fixed-tissue ChIP-seq for H3K27ac profiling and super-enhancer analysis of FFPE tissues by Font-Tello, Alba, Kesten, Nikolas, Xie, Yingtian, Taing, Len, Varešlija, Damir, Young, Leonie S., Hamid, Anis A., Van Allen, Eliezer M., Sweeney, Christopher J., Gjini, Evisa, Lako, Ana, Hodi, F. Steven, Bellmunt, Joaquim, Brown, Myles, Cejas, Paloma, Long, Henry W.

“…Fixed-tissue ChIP-seq for H3K27 acetylation (H3K27ac) profiling (FiTAc-seq) is an epigenetic method for profiling active enhancers and promoters in…”
Get full text

Reprogramming of the esophageal squamous carcinoma epigenome by SOX2 promotes ADAR1 dependence by Wu, Zhong, Zhou, Jin, Zhang, Xiaoyang, Zhang, Zhouwei, Xie, Yingtian, Liu, Jie bin, Ho, Zandra V., Panda, Arpit, Qiu, Xintao, Cejas, Paloma, Cañadas, Israel, Akarca, Fahire Goknur, McFarland, James M., Nagaraja, Ankur K., Goss, Louisa B., Kesten, Nikolas, Si, Longlong, Lim, Klothilda, Liu, Yanli, Zhang, Yanxi, Baek, Ji Yeon, Liu, Yang, Patil, Deepa T., Katz, Jonathan P., Hai, Josephine, Bao, Chunyang, Stachler, Matthew, Qi, Jun, Ishizuka, Jeffrey J., Nakagawa, Hiroshi, Rustgi, Anil K., Wong, Kwok-Kin, Meyerson, Matthew, Barbie, David A., Brown, Myles, Long, Henry, Bass, Adam J.

“…Esophageal squamous cell carcinomas (ESCCs) harbor recurrent chromosome 3q amplifications that target the transcription factor SOX2. Beyond its role as an…”
Get full text

FGFR-inhibitor-mediated dismissal of SWI/SNF complexes from YAP-dependent enhancers induces adaptive therapeutic resistance by Li, Yihao, Qiu, Xintao, Wang, Xiaoqing, Liu, Hui, Geck, Renee C., Tewari, Alok K., Xiao, Tengfei, Font-Tello, Alba, Lim, Klothilda, Jones, Kristen L., Morrow, Murry, Vadhi, Raga, Kao, Pei-Lun, Jaber, Aliya, Yerrum, Smitha, Xie, Yingtian, Chow, Kin-Hoe, Cejas, Paloma, Nguyen, Quang-Dé, Long, Henry W., Liu, X. Shirley, Toker, Alex, Brown, Myles

“…How cancer cells adapt to evade the therapeutic effects of drugs targeting oncogenic drivers is poorly understood. Here we report an epigenetic mechanism…”
Get full text

Hsa_circ_0001859 Regulates ATF2 Expression by Functioning as an MiR-204/211 Sponge in Human Rheumatoid Arthritis by Zheng, Zheng, Xie, Yingtian, Li, Kai, Zhang, Le, Li, Nianyu, Li, Bingrui, Xue, Meilan

“…Background. circRNAs are part of the competitive endogenous RNA network, which putatively function as miRNA sponges and play a crucial role in the development…”
Get full text

Androgen receptor monomers and dimers regulate opposing biological processes in prostate cancer cells by Safi, Rachid, Wardell, Suzanne E., Watkinson, Paige, Qin, Xiaodi, Lee, Marissa, Park, Sunghee, Krebs, Taylor, Dolan, Emma L., Blattler, Adam, Tsuji, Toshiya, Nayak, Surendra, Khater, Marwa, Fontanillo, Celia, Newlin, Madeline A., Kirkland, Megan L., Xie, Yingtian, Long, Henry, Fink, Emma C., Fanning, Sean W., Runyon, Scott, Brown, Myles, Xu, Shuichan, Owzar, Kouros, Norris, John D., McDonnell, Donald P.

“…Most prostate cancers express the androgen receptor (AR), and tumor growth and progression are facilitated by exceptionally low levels of systemic or…”
Get full text

CoBRA: Containerized Bioinformatics Workflow for Reproducible ChIP/ATAC-seq Analysis by Qiu, Xintao, Feit, Avery S., Feiglin, Ariel, Xie, Yingtian, Kesten, Nikolas, Taing, Len, Perkins, Joseph, Gu, Shengqing, Li, Yihao, Cejas, Paloma, Zhou, Ningxuan, Jeselsohn, Rinath, Brown, Myles, Shirley Liu, X., Long, Henry W.

“…Chromatin immunoprecipitation sequencing (ChIP-seq) and the Assay for Transposase-Accessible Chromatin with high-throughput sequencing (ATAC-seq) have become…”
Get full text

Androgen Receptor Is a Non-canonical Inhibitor of Wild-Type and Mutant Estrogen Receptors in Hormone Receptor-Positive Breast Cancers by Ponnusamy, Suriyan, Asemota, Sarah, Schwartzberg, Lee S., Guestini, Fouzia, McNamara, Keely M., Pierobon, Mariaelena, Font-Tello, Alba, Qiu, Xintao, Xie, Yingtian, Rao, Prakash K., Thiyagarajan, Thirumagal, Grimes, Brandy, Johnson, Daniel L., Fleming, Martin D., Pritchard, Frances E., Berry, Michael P., Oswaks, Roy, Fine, Richard E., Brown, Myles, Sasano, Hironobu, Petricoin, Emanuel F., Long, Henry W., Narayanan, Ramesh

“…Sustained treatment of estrogen receptor (ER)-positive breast cancer with ER-targeting drugs results in ER mutations and refractory unresponsive cancers…”
Get full text

700 Increasing MHC-I expression to potentiate immune checkpoint blockade therapy by Gu, Shengqing, Zhang, Wubing, Wang, Xiaoqing, Jiang, Peng, Traugh, Nicole, Li, Ziyi, Meyer, Clifford, Stewig, Blair, Xie, Yingtian, Bu, Xia, Manos, Michael, Font-Tello, Alba, Gjini, Evisa, Lako, Ana, Lim, Klothilda, Conway, Jake, Tewari, Alok, Zeng, Zexian, Sahu, Avinash Das, Tokheim, Collin, Weirather, Jason, Fu, Jingxin, Zhang, Yi, Kroger, Benjamin, Liang, Jin Hua, Cejas, Paloma, Freeman, Gordon, Rodig, Scott, Long, Henry, Gewurz, Benjamin, Stephen Hodi, F., Brown, Myles, Shirley Liu, X

“…BackgroundCancer immunotherapy, especially immune checkpoint blockade (ICB) therapy, is leading to a paradigm shift in cancer treatment, as a small percentage…”
Get full text

Combined high-resolution H3K27ac epigenomic and single-cell transcriptional profiling as a signature predictive of response to neoadjuvant immune checkpoint inhibitors (ICI) in urothelial cancer (UC) by Bellmunt, Joaquim, Hully, Margot, Epstein, Ilana B., Liria, Sonsoles, Xie, Yingtian, Muñoz, Miguel, Garoz, Paula, Fernandez, Nuria, Buisán, Oscar, CHOUEIRI, Toni K., Cabrera, Cecilia, Long, Henry, Cejas, Paloma

“…4595 Background: Multiple molecular predictors have been associated with response to ICI in metastatic UC (mUC), including clonal TMB, APOBEC mutagenesis and…”
Get full text

An Enhancer-Driven Stem Cell–Like Program Mediated by SOX9 Blocks Intestinal Differentiation in Colorectal Cancer by Liang, Xiaoyan, Duronio, Gina N., Yang, Yaying, Bala, Pratyusha, Hebbar, Prajna, Spisak, Sandor, Sahgal, Pranshu, Singh, Harshabad, Zhang, Yanxi, Xie, Yingtian, Cejas, Paloma, Long, Henry W., Bass, Adam J., Sethi, Nilay S.

“…Genomic alterations that encourage stem cell activity and hinder proper maturation are central to the development of colorectal cancer (CRC). Key molecular…”
Get full text

Hdac3 is an epigenetic inhibitor of the cytotoxicity program in CD8 T cells by Tay, Rong En, Olawoyin, Olamide, Cejas, Paloma, Xie, Yingtian, Meyer, Clifford A, Ito, Yoshinaga, Weng, Qing Yu, Fisher, David E, Long, Henry W, Brown, Myles, Kim, Hye-Jung, Wucherpfennig, Kai W

“…Cytotoxic T cells play a key role in adaptive immunity by killing infected or cancerous cells. While the transcriptional control of CD8 T cell differentiation…”
Get full text

Pan-ERBB kinase inhibition augments CDK4/6 inhibitor efficacy in oesophageal squamous cell carcinoma by Zhou, Jin, Wu, Zhong, Zhang, Zhouwei, Goss, Louisa, McFarland, James, Nagaraja, Ankur, Xie, Yingtian, Gu, Shengqing, Peng, Ke, Zeng, Yong, Zhang, Xiaoyang, Long, Henry, Nakagawa, Hiroshi, Rustgi, Anil, Diehl, J Alan, Meyerson, Matthew, Wong, Kwok-Kin, Bass, Adam

“…Oesophageal squamous cell carcinoma (OSCC), like other squamous carcinomas, harbour highly recurrent cell cycle pathway alterations, especially hyperactivation…”
Get more information