Search Results - "Xie, Yihu"

Mechanisms of nuclear mRNA export: A structural perspective by Xie, Yihu, Ren, Yi

“…Export of mRNA from the nucleus to the cytoplasm is a critical process for all eukaryotic gene expression. As mRNA is synthesized, it is packaged with a myriad…”
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Cryo-EM structure of the CBC-ALYREF complex by Clarke, Bradley P, Angelos, Alexia E, Mei, Menghan, Hill, Pate S, Xie, Yihu, Ren, Yi

“…In eukaryotes, RNAs transcribed by RNA Pol II are modified at the 5' end with a 7-methylguanosine (m G) cap, which is recognized by the nuclear cap binding…”
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Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes by Takai, Hiroyuki, Xie, Yihu, de Lange, Titia, Pavletich, Nikola P

“…We reported previously that the stability of all mammalian phosphatidylinositol 3-kinase-related protein kinases (PIKKs) depends on their interaction with…”
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Cryo-EM structure of the yeast TREX complex and coordination with the SR-like protein Gbp2 by Xie, Yihu, Clarke, Bradley P, Kim, Yong Joon, Ivey, Austin L, Hill, Pate S, Shi, Yi, Ren, Yi

“…The evolutionarily conserved TRanscript-EXport (TREX) complex plays central roles during mRNP (messenger ribonucleoprotein) maturation and export from the…”
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Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression by Zhang, Ke, Miorin, Lisa, Makio, Tadashi, Dehghan, Ishmael, Gao, Shengyan, Xie, Yihu, Zhong, Hualin, Esparza, Matthew, Kehrer, Thomas, Kumar, Anil, Hobman, Tom C, Ptak, Christopher, Gao, Boning, Minna, John D, Chen, Zhijian, García-Sastre, Adolfo, Ren, Yi, Wozniak, Richard W, Fontoura, Beatriz M A

“…The ongoing unprecedented severe acute respiratory syndrome caused by the SARS-CoV-2 outbreak worldwide has highlighted the need for understanding viral-host…”
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Structural basis for high-order complex of SARNP and DDX39B to facilitate mRNP assembly by Xie, Yihu, Gao, Shengyan, Zhang, Ke, Bhat, Prasanna, Clarke, Bradley P., Batten, Kimberly, Mei, Menghan, Gazzara, Matthew, Shay, Jerry W., Lynch, Kristen W., Angelos, Alexia E., Hill, Pate S., Ivey, Austin L., Fontoura, Beatriz M.A., Ren, Yi

“…mRNA in eukaryotic cells is packaged into highly compacted ribonucleoprotein particles (mRNPs) in the nucleus and exported to the cytoplasm for translation…”
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Structural basis for influenza virus NS1 protein block of mRNA nuclear export by Zhang, Ke, Xie, Yihu, Muñoz-Moreno, Raquel, Wang, Juan, Zhang, Liang, Esparza, Matthew, García-Sastre, Adolfo, Fontoura, Beatriz M. A., Ren, Yi

“…Influenza viruses antagonize key immune defence mechanisms via the virulence factor non-structural protein 1 (NS1). A key mechanism of virulence by NS1 is…”
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Crystal structure of the Hendra virus attachment G glycoprotein bound to a potent cross-reactive neutralizing human monoclonal antibody by Xu, Kai, Rockx, Barry, Xie, Yihu, DeBuysscher, Blair L, Fusco, Deborah L, Zhu, Zhongyu, Chan, Yee-Peng, Xu, Yan, Luu, Truong, Cer, Regina Z, Feldmann, Heinz, Mokashi, Vishwesh, Dimitrov, Dimiter S, Bishop-Lilly, Kimberly A, Broder, Christopher C, Nikolov, Dimitar B

“…The henipaviruses, represented by Hendra (HeV) and Nipah (NiV) viruses are highly pathogenic zoonotic paramyxoviruses with uniquely broad host tropisms…”
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Mouse phosphoglycerate mutase M and B isozymes: cDNA cloning, enzyme activity assay and mapping by Zhang, J, Yu, L, Fu, Q, Gao, J, Xie, Y, Chen, J, Zhang, P, Liu, Q, Zhao, S

“…Two mouse cDNAs encoding the non-muscle-specific or brain isoform (type B, Pgam1) and the muscle-specific isoform (type M, Pgam2) of phosphoglycerate mutase…”
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Cellular mRNA export factor UAP56 recognizes nucleic acid binding site of influenza virus NP protein by Morris, Andrew K., Wang, Zhen, Ivey, Austin L., Xie, Yihu, Hill, Pate S., Schey, Kevin L., Ren, Yi

“…Influenza A virus nucleoprotein (NP) is a structural component that encapsulates the viral genome into the form of ribonucleoprotein complexes (vRNPs)…”
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Molecular basis for the exploitation of nuclear mRNA export by influenza A virus by Ren, Yi, Zhang, Ke, Xie, Yihu, Morris, Andrew, Wang, Zhen, Muñoz-Moreno, Raquel, Wang, Juan, Zhang, Liang, Esparza, Matthew, García-Sastre, Adolfo, Schey, Kevin, Fontoura, Beatriz

“…Abstract only…”
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Structure and activation mechanism of the yeast RNA Pol II CTD kinase CTDK-1 complex by Xie, Yihu, Lord, Christopher L., Clarke, Bradley P., Ivey, Austin L., Hill, Pate S., McDonald, W. Hayes, Wente, Susan R., Ren, Yi

“…The C-terminal domain (CTD) kinase I (CTDK-1) complex is the primary RNA Polymerase II (Pol II) CTD Ser2 kinase in budding yeast. CTDK-1 consists of a…”
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Crystal Structure of the Hendra Virus Attachment G Glycoprotein Bound to a Potent Cross-Reactive Neutralizing Human Monoclonal Antibody: e1003684 by Xu, Kai, Rockx, Barry, Xie, Yihu, DeBuysscher, Blair L, Fusco, Deborah L, Zhu, Zhongyu, Chan, Yee-Peng, Xu, Yan, Luu, Truong, Cer, Regina Z, Feldmann, Heinz, Mokashi, Vishwesh, Dimitrov, Dimiter S, Bishop-Lilly, Kimberly A, Broder, Christopher C, Nikolov, Dimitar B

“…The henipaviruses, represented by Hendra (HeV) and Nipah (NiV) viruses are highly pathogenic zoonotic paramyxoviruses with uniquely broad host tropisms…”
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Structural and functional studies of PIKK regulation by Xie, Yihu

“…The six members of the phosphatidylinositol 3-kinase related kinases (PIKKs) regulate a diverse set of responses in cells. The mammalian target of rapamycin…”
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Molecular cloning and characterization of CT120, a novel membrane-associated gene involved in amino acid transport and glutathione metabolism by He, Xianghuo, Di, Yujun, Li, Jinjun, Xie, Yihu, Tang, Yuntian, Zhang, Fengrui, Wei, Lin, Zhang, Yu, Qin, Wenxin, Huo, Keke, Li, Yuyang, Wan, Dafang, Gu, Jianren

“…Within the minimum LOH region on chromosome 17p13.3 deleted in hepatocellular carcinoma, a novel human plasma membrane-associated gene, named CT120, was…”
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