Search Results - "Xie, Shaozhen"

PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer by Ding, Liya, Kim, Hye-Jung, Wang, Qiwei, Kearns, Michael, Jiang, Tao, Ohlson, Carolynn E., Li, Ben B., Xie, Shaozhen, Liu, Joyce F., Stover, Elizabeth H., Howitt, Brooke E., Bronson, Roderick T., Lazo, Suzan, Roberts, Thomas M., Freeman, Gordon J., Konstantinopoulos, Panagiotis A., Matulonis, Ursula A., Zhao, Jean J.

“…PARP inhibitors have shown promising clinical activities for patients with BRCA mutations and are changing the landscape of ovarian cancer treatment. However,…”
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Drug Resistance in HER2-Positive Breast Cancer Brain Metastases: Blame the Barrier or the Brain? by Kabraji, Sheheryar, Ni, Jing, Lin, Nancy U, Xie, Shaozhen, Winer, Eric P, Zhao, Jean J

“…The brain is the most common site of first metastasis for patients with HER2-positive breast cancer treated with HER2-targeting drugs. However, the development…”
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STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in BRCA1-deficient models of breast cancer by Wang, Qiwei, Bergholz, Johann S., Ding, Liya, Lin, Ziying, Kabraji, Sheheryar K., Hughes, Melissa E., He, Xiadi, Xie, Shaozhen, Jiang, Tao, Wang, Weihua, Zoeller, Jason J., Kim, Hye-Jung, Roberts, Thomas M., Konstantinopoulos, Panagiotis A., Matulonis, Ursula A., Dillon, Deborah A., Winer, Eric P., Lin, Nancy U., Zhao, Jean J.

“…PARP inhibitors (PARPi) have drastically changed the treatment landscape of advanced ovarian tumors with BRCA mutations. However, the impact of this class of…”
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p16INK4A-deficiency predicts response to combined HER2 and CDK4/6 inhibition in HER2+ breast cancer brain metastases by Ni, Jing, Kabraji, Sheheryar, Xie, Shaozhen, Wang, Yanzhi, Pan, Peichen, He, Xiaofang, Liu, Zongming, Leone, Jose Palbo, Long, Henry W., Brown, Myles A., Winer, Eric P., Dillon, Deborah A. R., Lin, Nancy U., Zhao, Jean J.

“…Approximately 50% of patients with metastatic HER2-positive (HER2+) breast cancer develop brain metastases (BCBMs). We report that the tumor suppressor p16…”
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Improving orthotopic mouse models of patient-derived breast cancer brain metastases by a modified intracarotid injection method by Liu, Zongming, Wang, Yanzhi, Kabraji, Sheheryar, Xie, Shaozhen, Pan, Peichen, Liu, Zhenning, Ni, Jing, Zhao, Jean J.

“…Breast cancer brain metastasis (BCBM) remains a major clinical problem. Approximately 10–16% of patients with breast cancer develop brain metastases (BCBM)…”
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The role of the PIK3CA gene in the development and aging of the brain by Xie, Shaozhen, Ni, Jing, Guo, Hanbing, Luu, Victor, Wang, Yanzhi, Zhao, Jean J., Roberts, Thomas M.

“…The CLOVES syndrome is an overgrowth disease arising from mosaic activating somatic mutations in the PIK3CA gene. These mutations occur during fetal…”
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Rac1-mediated membrane raft localization of PI3K/p110β is required for its activation by GPCRs or PTEN loss by Cizmecioglu, Onur, Ni, Jing, Xie, Shaozhen, Zhao, Jean J, Roberts, Thomas M

“…We aimed to understand how spatial compartmentalization in the plasma membrane might contribute to the functions of the ubiquitous class IA phosphoinositide…”
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Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases by Ni, Jing, Ramkissoon, Shakti H, Xie, Shaozhen, Goel, Shom, Stover, Daniel G, Guo, Hanbing, Luu, Victor, Marco, Eugenio, Ramkissoon, Lori A, Kang, Yun Jee, Hayashi, Marika, Nguyen, Quang-De, Ligon, Azra H, Du, Rose, Claus, Elizabeth B, Alexander, Brian M, Yuan, Guo-Cheng, Wang, Zhigang C, Iglehart, J Dirk, Krop, Ian E, Roberts, Thomas M, Winer, Eric P, Lin, Nancy U, Ligon, Keith L, Zhao, Jean J

“…In mouse models of patient-derived breast cancer brain metastases, combined inhibition of PI3K and mTOR resulted in regression, and therapeutic response was…”
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STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer by Ding, Liya, Wang, Qiwei, Martincuks, Antons, Kearns, Michael J, Jiang, Tao, Lin, Ziying, Cheng, Xin, Qian, Changli, Xie, Shaozhen, Kim, Hye-Jung, Launonen, Inga-Maria, Färkkilä, Anniina, Roberts, Thomas M, Freeman, Gordon J, Liu, Joyce F, Konstantinopoulos, Panagiotis A, Matulonis, Ursula, Yu, Hua, Zhao, Jean J

“…Poly (ADP-ribose) polymerase (PARP) inhibition (PARPi) has demonstrated potent therapeutic efficacy in patients with BRCA-mutant ovarian cancer. However,…”
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TR4 nuclear receptor functions as a fatty acid sensor to modulate CD36 expression and foam cell formation by Xie, Shaozhen, Lee, Yi-Fen, Kim, Eungseok, Chen, Lu-Min, Ni, Jing, Fang, Lei-Ya, Liu, Su, Lin, Shin-Jen, Abe, Jun-ichi, Berk, Bradford, Ho, Feng-Ming, Chang, Chawnshang

“…Testicular orphan nuclear receptor 4 (TR4) is an orphan member of the nuclear receptor superfamily with diverse physiological functions. Using TR4 knockout…”
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Induction of Androgen Receptor Expression by Phosphatidylinositol 3-Kinase/Akt Downstream Substrate, FOXO3a, and Their Roles in Apoptosis of LNCaP Prostate Cancer Cells by Yang, Lin, Xie, Shaozhen, Jamaluddin, Md. Saha, Altuwaijri, Saleh, Ni, Jing, Kim, Eungseok, Chen, Yei-Tsung, Hu, Yueh-Chiang, Wang, Liang, Chuang, Kuang-Hsiang, Wu, Chun-Te, Chang, Chawnshang

“…The phosphatidylinositol 3-kinase (PI3K)/Akt pathway plays important roles for prostate cancer cell survival, and the androgen receptor (AR) plays essential…”
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Tocopherol-associated protein suppresses prostate cancer cell growth by inhibition of the phosphoinositide 3-kinase pathway by JING NI, XINGQIAO WEN, DI SANT'AGNESE, Anthony, MESSING, Edward M, YEH, Shuyuan, YAO, Jorge, CHANG, Hong-Chiang, YI YIN, MIN ZHANG, SHAOZHEN XIE, MING CHEN, SIMONS, Brenna, CHANG, Philip

“…Epidemiologic studies suggested that vitamin E has a protective effect against prostate cancer. We showed here that tocopherol-associated protein (TAP), a…”
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APPL Suppresses Androgen Receptor Transactivation via Potentiating Akt Activity by Yang, Lin, Lin, Hui-Kuan, Altuwaijri, Saleh, Xie, Shaozhen, Wang, Liang, Chang, Chawnshang

“…APPL may function as an adapter protein to modulate the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. Although we have previously proven that the PI3K/Akt…”
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In vitro and In vivo Anticancer Effects of the Novel Vitamin E Ether Analogue RRR-α-Tocopheryloxybutyl Sulfonic Acid in Prostate Cancer by JING NI, TIEJUN MAI, YEH, Shuyuan, PANG, See-Tong, HAQUE, Imranul, HUANG, Kaohsing, DIMAGGIO, MatthewA, SHAOZHEN XIE, JAMES, Nadine S, KASI, Dhanalakshmi, CHEMLER, Sherry R

“…Purpose: Among derivatives of α-vitamin E, α-vitamin E succinate (VES), has attracted much attention due to its potent anti–prostate cancer activity in vitro…”
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Disruption of TR4 Orphan Nuclear Receptor Reduces the Expression of Liver Apolipoprotein E/C-I/C-II Gene Cluster by Kim, Eungseok, Xie, Shaozhen, Yeh, Shauh-Der, Lee, Yi-Fen, Collins, Loretta L., Hu, Yueh-Chiang, Shyr, Chih-Rong, Mu, Xiao-Min, Liu, Ning-Chun, Chen, Yen-Ta, Wang, Peng-Hui, Chang, Chawnshang

“…Apolipoprotein E (apoE) is synthesized in many tissues, and the liver is the primary site from which apoE redistributes cholesterol and other lipids to…”
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CDK4/6 inhibition triggers anti-tumour immunity by Goel, Shom, DeCristo, Molly J., Watt, April C., BrinJones, Haley, Sceneay, Jaclyn, Li, Ben B., Khan, Naveed, Ubellacker, Jessalyn M., Xie, Shaozhen, Metzger-Filho, Otto, Hoog, Jeremy, Ellis, Matthew J., Ma, Cynthia X., Ramm, Susanne, Krop, Ian E., Winer, Eric P., Roberts, Thomas M., Kim, Hye-Jung, McAllister, Sandra S., Zhao, Jean J.

“…Mouse models of breast carcinoma and other solid tumours show that selective cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors not only induce tumour cell…”
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CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer by Wang, Yubao, Zhang, Tinghu, Kwiatkowski, Nicholas, Abraham, Brian J., Lee, Tong Ihn, Xie, Shaozhen, Yuzugullu, Haluk, Von, Thanh, Li, Heyuan, Lin, Ziao, Stover, Daniel G., Lim, Elgene, Wang, Zhigang C., Iglehart, J. Dirk, Young, Richard A., Gray, Nathanael S., Zhao, Jean J.

“…Triple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer that exhibits extremely high levels of genetic complexity and yet a…”
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PI3Kβ controls immune evasion in PTEN-deficient breast tumours by Bergholz, Johann S., Wang, Qiwei, Wang, Qi, Ramseier, Michelle, Prakadan, Sanjay, Wang, Weihua, Fang, Rong, Kabraji, Sheheryar, Zhou, Qian, Gray, G. Kenneth, Abell-Hart, Kayley, Xie, Shaozhen, Guo, Xiaocan, Gu, Hao, Von, Thanh, Jiang, Tao, Tang, Shuang, Freeman, Gordon J., Kim, Hye-Jung, Shalek, Alex K., Roberts, Thomas M., Zhao, Jean J.

“…Loss of the PTEN tumour suppressor is one of the most common oncogenic drivers across all cancer types 1 . PTEN is the major negative regulator of PI3K…”
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Functional characterization of an isoform-selective inhibitor of PI3K-p110β as a potential anticancer agent by Ni, Jing, Liu, Qingsong, Xie, Shaozhen, Carlson, Coby, Von, Thanh, Vogel, Kurt, Riddle, Steve, Benes, Cyril, Eck, Michael, Roberts, Thomas, Gray, Nathanael, Zhao, Jean

“…Genetic approaches have shown that the p110β isoform of class Ia phosphatidylinositol-3-kinase (PI3K) is essential for the growth of PTEN-null tumors. Thus, it…”
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Abstract 337: p16INK4A-deficiency predicts for response to combined HER2 and CDK4/6 inhibition in HER2+ breast cancer brain metastases by Ni, Jing, Kabraji, Sheheryar, Xie, Shaozhen, Wang, Yanzhi, Pan, Peichen, He, Xiaofang, Liu, Zongming, Long, Henry, Brown, Myles, Winer, Eric P., Dillon, Deborah, Lin, Nancy, Zhao, Jean

“…Abstract Approximately 50% of patients with metastatic HER2-positive (HER2+) breast cancer develop brain metastases (BCBMs). To identify predictors of response…”
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