Search Results - "Xie, Shanglun"
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Deletion of the transmembrane protein Prom1b in zebrafish disrupts outer-segment morphogenesis and causes photoreceptor degeneration
Published in The Journal of biological chemistry (20-09-2019)“…Mutations in human prominin 1 (PROM1), encoding a transmembrane glycoprotein localized mainly to plasma membrane protrusions, have been reported to cause…”
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Knockout of ush2a gene in zebrafish causes hearing impairment and late onset rod-cone dystrophy
Published in Human genetics (01-10-2018)“…Most cases of Usher syndrome type II (USH2) are due to mutations in the USH2A gene. There are no effective treatments or ideal animal models for this disease,…”
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Regulation of the Inflammatory Response, Proliferation, Migration, and Epithelial-Mesenchymal Transition of Human Lens Epithelial Cells by the lncRNA-MALAT1/miR-26a-5p/TET1 Signaling Axis
Published in Journal of ophthalmology (16-01-2023)“…Background. The ocular inflammatory microenvironment has been reported to be closely associated with the occurrence and progression of highly myopic cataract…”
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Regulation of the stem‑like properties of estrogen receptor‑positive breast cancer cells through NR2E3/NR2C2 signaling
Published in Experimental and therapeutic medicine (01-10-2023)“…Cancer stem cells (CSCs) are major drivers of metastasis, drug resistance and recurrence in numerous cancers. However, critical factors that can modulate CSC…”
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Knocking out lca5 in zebrafish causes cone-rod dystrophy due to impaired outer segment protein trafficking
Published in Biochimica et biophysica acta. Molecular basis of disease (01-10-2019)“…Leber congenital amaurosis (LCA) is the most serious form of inherited retinal dystrophy that leads to blindness or severe visual impairment within a few…”
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Knockout of tnni1b in zebrafish causes defects in atrioventricular valve development via the inhibition of the myocardial wnt signaling pathway
Published in The FASEB journal (01-01-2019)“…ABSTRACT The proper development of atrioventricular (AV) valves is critical for heart morphogenesis and for the formation of the cardiac conduction system…”
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BCAS2 is essential for hematopoietic stem and progenitor cell maintenance during zebrafish embryogenesis
Published in Blood (21-02-2019)“…Hematopoietic stem and progenitor cells (HSPCs) originate from the hemogenic endothelium via the endothelial-to-hematopoietic transition, are self-renewing,…”
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Knockout of Nr2e3 prevents rod photoreceptor differentiation and leads to selective L-/M-cone photoreceptor degeneration in zebrafish
Published in Biochimica et biophysica acta. Molecular basis of disease (01-06-2019)“…Mutations in the photoreceptor cell-specific nuclear receptor gene Nr2e3 increased the number of S-cone photoreceptors in human and murine retinas and led to…”
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