Search Results - "Xie, Junkai"

Review: In vitro Cell Platform for Understanding Developmental Toxicity by Xie, Junkai, Wettschurack, Kyle, Yuan, Chongli

“…Developmental toxicity and its affiliation to long-term health, particularly neurodegenerative disease (ND) has attracted significant attentions in recent…”
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Developmental neurotoxicity of PFOA exposure on hiPSC-derived cortical neurons by Wu, Shichen, Xie, Junkai, Zhao, Han, Zhao, Xihui, Sánchez, Oscar F., Rochet, Jean-Christophe, Freeman, Jennifer L., Yuan, Chongli

“…[Display omitted] •Pre-differentiation PFOA exposure altered neuronal network complexity and activity.•Developmental PFOA exposure resulted in significant…”
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Hyperexcitability and Pharmacological Responsiveness of Cortical Neurons Derived from Human iPSCs Carrying Epilepsy-Associated Sodium Channel Nav1.2-L1342P Genetic Variant by Que, Zhefu, Olivero-Acosta, Maria I, Zhang, Jingliang, Eaton, Muriel, Tukker, Anke M, Chen, Xiaoling, Wu, Jiaxiang, Xie, Junkai, Xiao, Tiange, Wettschurack, Kyle, Yunis, Layan, Shafer, J Marshall, Schaber, James A, Rochet, Jean-Christophe, Bowman, Aaron B, Yuan, Chongli, Huang, Zhuo, Hu, Chang-Deng, Trader, Darci J, Skarnes, William C, Yang, Yang

“…With the wide adoption of genomic sequencing in children having seizures, an increasing number of genetic variants have been revealed as genetic causes of…”
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Electroacupuncture Induces Bilateral S1 and ACC Epigenetic Regulation of Genes in a Mouse Model of Neuropathic Pain by Ping, Xingjie, Xie, Junkai, Yuan, Chongli, Jin, Xiaoming

“…Clinical and animal studies have shown that acupuncture may benefit controlling neuropathic pain. However, the underlying molecular mechanisms are poorly…”
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Research and Development of Civil Engineering Intelligent Structure System by Xie, Junkai, Gao, Bo, Cheng, Huamin

“…With the rapid development of global civil engineering construction, the intelligent structural system of civil engineering has evolved into one of the current…”
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Single-Cell Image-Based Analysis Reveals Chromatin Changes during the Acquisition of Tamoxifen Drug Resistance by Zhao, Han, Lin, Li F, Hahn, Joshua, Xie, Junkai, Holman, Harvey F, Yuan, Chongli

“…Cancer drug resistance is the leading cause of cancer related deaths. The development of drug resistance can be partially contributed to tumor heterogeneity…”
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Lead exposure induces dysregulation of constitutive heterochromatin hallmarks in live cells by Sánchez, Oscar F., Lin, Li F., Xie, Junkai, Freeman, Jennifer L., Yuan, Chongli

“…[Display omitted] •Exposure to Pb significantly lowered meCpG and H3K9me3 levels in HEK293T cells.•The observed epigenetic changes can be partially attributed…”
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A Quantum Dynamical Treatment of Symmetry-Induced Kinetic Isotope Effects in the Formation of He2 by Xie, Junkai, Poirier, Bill, Gellene, Gregory I

“…Kinetic isotope effects for He2 + formation are calculated quantum dynamically using high-quality Born−Oppenheimer (BO) potentials for two electronic states of…”
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Research on Expert System Technology of Biomass Detection in Fermentation Process by Junkai, Xie, Wanpeng, Li, Qiyu, Wu, Chaosong, Zheng, Liaoyuan, Zhang

“…The fermentation process refers to the reaction process in which specialized metabolites are produced and accumulated in large quantities through the growth,…”
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Pre-differentiation GenX exposure induced neurotoxicity in human dopaminergic-like neurons by Wu, Shichen, Xie, Junkai, Zhao, Han, Sanchez, Oscar, Zhao, Xihui, Freeman, Jennifer L., Yuan, Chongli

“…GenX, also known as hexafluoropropylene oxide dimer acid (HFPO-DA) was introduced as a safer alternative to perfluorooctanoic acid (PFOA) in 2009. After nearly…”
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Profiling epigenetic changes in human cell line induced by atrazine exposure by Sánchez, Oscar F., Lin, Li, Bryan, Chris J., Xie, Junkai, Freeman, Jennifer L., Yuan, Chongli

“…How environmental chemicals can affect and exert their toxic effect at a molecular level has gained significant interest in recent years, not only for…”
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Pre-differentiation exposure to low-dose of atrazine results in persistent phenotypic changes in human neuronal cell lines by Xie, Junkai, Lin, Li, Sánchez, Oscar F., Bryan, Chris, Freeman, Jennifer L., Yuan, Chongli

“…Exposures to organic pesticides, particularly during a developmental window, have been associated with various neurodegenerative diseases later in life…”
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Developmental Pb exposure increases AD risk via altered intracellular Ca2+ homeostasis in hiPSC-derived cortical neurons by Xie, Junkai, Wu, Shichen, Szadowski, Hailey, Min, Sehong, Yang, Yang, Bowman, Aaron B., Rochet, Jean-Christophe, Freeman, Jennifer L., Yuan, Chongli

“…Exposure to environmental chemicals such as lead (Pb) during vulnerable developmental periods can result in adverse health outcomes later in life. Human cohort…”
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Low dose lead exposure induces alterations on heterochromatin hallmarks persisting through SH-SY5Y cell differentiation by Lin, Li F., Xie, Junkai, Sánchez, Oscar F., Bryan, Chris, Freeman, Jennifer L., Yuan, Chongli

“…Lead (Pb) is a commonly found heavy metal due to its historical applications. Recent studies have associated early-life Pb exposure with the onset of various…”
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Pre-differentiation exposure of PFOA induced persistent changes in DNA methylation and mitochondrial morphology in human dopaminergic-like neurons by Zhao, Han, Xie, Junkai, Wu, Shichen, Sánchez, Oscar F, Zhang, Xinle, Freeman, Jennifer L., Yuan, Chongli

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Identifying distinct heterochromatin regions using combinatorial epigenetic probes in live cells by Mendonca, Agnes, Sánchez, Oscar F., Xie, Junkai, Carneiro, Ana, Lin, Li, Yuan, Chongli

“…The 3D spatial organization of the genome controls gene expression and cell functionality. Heterochromatin (HC), which is the densely compacted and largely…”
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Impacts of Nucleosome Positioning Elements and Pre-Assembled Chromatin States on Expression and Retention of Transgenes by Kwizera, Ronard, Xie, Junkai, Nurse, Nathan, Yuan, Chongli, Kirchmaier, Ann L

“…Transgene applications, ranging from gene therapy to the development of stable cell lines and organisms, rely on maintaining the expression of transgenes. To…”
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Elevated parkinsonism pathological markers in dopaminergic neurons with developmental exposure to atrazine by Zhao, Han, Xie, Junkai, Wu, Shichen, Zhao, Xihui, Sánchez, Oscar F, Min, Sehong, Rochet, Jean-Christophe, Freeman, Jennifer L, Yuan, Chongli

“…Atrazine (ATZ) is one of the most used herbicides in the US and a known endocrine disruptor. ATZ is frequently detected in drinking water, especially in…”
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Corrigendum to “Elevated parkinsonism pathological markers in dopaminergic neurons with developmental exposure to atrazine” [Sci. Total Environ. 908 2024: Article 168307] by Zhao, Han, Xie, Junkai, Wu, Shichen, Zhao, Xihui, Sánchez, Oscar F., Min, Sehong, Dutta, Sayan, Rochet, Jean-Christophe, Freeman, Jennifer L., Yuan, Chongli

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Atrazine exposure in zebrafish induces aberrant genome-wide methylation by Wang, Shiyan, Bryan, Chris, Xie, Junkai, Zhao, Han, Lin, Li F., Tai, Janiel Ahkin Chin, Horzmann, Katharine A., Sanchez, Oscar F., Zhang, Min, Freeman, Jennifer L., Yuan, Chongli

“…Atrazine (ATZ) is the second most common agricultural herbicide used in the United States and is an endocrine disrupting chemical (EDC). Developmental exposure…”
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