Search Results - "Xie, Irene Y."

Microbiome Composition and Function Drives Wound-Healing Impairment in the Female Genital Tract by Zevin, Alexander S, Xie, Irene Y, Birse, Kenzie, Arnold, Kelly, Romas, Laura, Westmacott, Garrett, Novak, Richard M, McCorrister, Stuart, McKinnon, Lyle R, Cohen, Craig R, Mackelprang, Romel, Lingappa, Jairam, Lauffenburger, Doug A, Klatt, Nichole R, Burgener, Adam D

“…The mechanism(s) by which bacterial communities impact susceptibility to infectious diseases, such as HIV, and maintain female genital tract (FGT) health are…”
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The genomic landscape of recurrent pancreatic cancer is modified by treatment by Xie, Irene Y., Gallinger, Steven

“…Most patients who undergo curative intent surgery for pancreatic cancer will still die of recurrent disease. A new study shows that pancreatic tumours that…”
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Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women by Klatt, Nichole R., Cheu, Ryan, Birse, Kenzie, Zevin, Alexander S., Perner, Michelle, Noël-Romas, Laura, Grobler, Anneke, Westmacott, Garrett, Xie, Irene Y., Butler, Jennifer, Mansoor, Leila, McKinnon, Lyle R., Passmore, Jo-Ann S., Karim, Quarraisha Abdool, Karim, Salim S. Abdool, Burgener, Adam D.

“…Antiretroviral-based strategies for HIV prevention have shown inconsistent results in women. We investigated whether vaginal microbiota modulated tenofovir gel…”
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Soluble T cell immunoglobulin mucin domain 3 is shed from CD8+ T cells by the sheddase ADAM10, is increased in plasma during untreated HIV infection, and correlates with HIV disease progression by Clayton, Kiera L, Douglas-Vail, Matthew B, Nur-ur Rahman, A K M, Medcalf, Karyn E, Xie, Irene Y, Chew, Glen M, Tandon, Ravi, Lanteri, Marion C, Norris, Philip J, Deeks, Steven G, Ndhlovu, Lishomwa C, Ostrowski, Mario A

“…Chronic HIV infection results in a loss of HIV-specific CD8(+) T cell effector function, termed "exhaustion," which is mediated, in part, by the membrane…”
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BRAF Δβ3-αC in-frame deletion mutants differ in their dimerization propensity, HSP90 dependence, and druggability by Lauinger, Manuel, Christen, Daniel, Klar, Rhena F. U., Roubaty, Carole, Heilig, Christoph E., Stumpe, Michael, Knox, Jennifer J., Radulovich, Nikolina, Tamblyn, Laura, Xie, Irene Y., Horak, Peter, Forschner, Andrea, Bitzer, Michael, Wittel, Uwe A., Boerries, Melanie, Ball, Claudia R., Heining, Christoph, Glimm, Hanno, Fröhlich, Martina, Hübschmann, Daniel, Gallinger, Steven, Fritsch, Ralph, Fröhling, Stefan, O’Kane, Grainne M., Dengjel, Jörn, Brummer, Tilman

“…In-frame BRAF exon 12 deletions are increasingly identified in various tumor types. The resultant BRAF Δβ3-αC oncoproteins usually lack five amino acids in the…”
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HIVR4P 2016, Partnering for Prevention: Conference Summary and Highlights by Shacklett, Barbara L, Derdeyn, Cynthia A, Folayan, Morenike Oluwatoyin, Landovitz, Raphael J, Anthony, Colin, Behrens, Anna-Janina, Hope, Thomas J, Landais, Elise, Leal, Lorna, Marrazzo, Jeanne M, Morris, Lynn, Mugo, Nelly, Ngure, Kenneth, Noseda, Veronica, Ranasinghe, Srinika, Tully, Damien C, Voronin, Yegor, Warren, Mitchell, Wibmer, Constantinos Kurt, Xie, Irene Y, Scarlatti, Gabriella, Thyagarajan, Bargavi

“…HIV Research for Prevention: AIDS Vaccine, Microbicide, and ARV-based Prevention Science (HIVR4P) was built on a growing consensus that effective HIV…”
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Abstract PO-077: Establishment of a novel living biobank of patient-derived pancreatic cancer organoids with genomic and drug response characterization by Xie, Irene Y., Tamblyn, Laura, Ng, Karen, Flores-Figueroa, Eugenia, Wilson, Julie M., Jang, Gun Ho, Zhang, Amy X., Ramotar, Stephanie, Dodd, Anna, Radulovich, Nikolina, Knox, Jennifer J., O'Kane, Grainne M., Gallinger, Steven, Notta, Faiyaz

“…Abstract Advanced pancreatic cancer has a dismal prognosis and current treatment options (FOLFIRINOX, Gemcitabine/nab-paclitaxel [GnP]) are associated with…”
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Abstract 173: Genomic characterization of patient-derived pancreatic cancer organoids by Xie, Irene Y., Fang, Yuanchang, Zhang, Amy X., Ng, Karen, Liu, Zhen-Mei, Flores-Figueroa, Eugenia, Jang, Gun Ho, Ramotar, Stephanie, Dodd, Anna, Wilson, Julie, Knox, Jennifer J., Gallinger, Steven, Notta, Faiyaz

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer death with few effective therapies. Patient-derived organoids (PDOs) are a 3-D…”
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Abstract A064: High-throughput organoid drug screening to identify molecular vulnerabilities in pancreatic cancer by Xie, Irene Y, Liu, Zhen-Mei, Ng, Karen, Flores-Figueroa, Eugenia, Jang, Gun Ho, Zhang, Amy X., Ramotar, Stephanie, Dodd, Anna, Wilson, Julie, O'Kane, Grainne M., Knox, Jennifer J., Gallinger, Steven, Notta, Faiyaz

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer that typically presents at the advanced or metastatic stage. Although some patients achieve…”
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Viral RNA binding by the human IFIT1-IFIT3 protein complex in the innate immune response by Górna, Maria W., Vladimer, Gregory I., Abbas, Yazan M., Gebhardt, Anna, Habjan, Matthias, Laudenbach, Beatrice T., Dimech, Christina, Xie, Irene Y., Bennett, Keiryn L., Nagar, Bhushan, Pichlmair, Andreas, Superti-Furga, Giulio

“…Abstract only…”
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