Search Results - "Xie, Huanli"

Plasma membrane flipping of Syntaxin-2 regulates its inhibitory action on insulin granule exocytosis by Kang, Fei, Xie, Li, Qin, Tairan, Miao, Yifan, Kang, Youhou, Takahashi, Toshimasa, Liang, Tao, Xie, Huanli, Gaisano, Herbert Y.

“…Enhancing pancreatic β-cell secretion is a primary therapeutic target for type-2 diabetes (T2D). Syntaxin-2 (Stx2) has just been identified to be an inhibitory…”
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Pancreatitis-Induced Depletion of Syntaxin 2 Promotes Autophagy and Increases Basolateral Exocytosis by Dolai, Subhankar, Liang, Tao, Orabi, Abrahim I., Holmyard, Douglas, Xie, Li, Greitzer-Antes, Dafna, Kang, Youhou, Xie, Huanli, Javed, Tanveer A., Lam, Patrick P., Rubin, Deborah C., Thorn, Peter, Gaisano, Herbert Y.

“…Pancreatic acinar cells are polarized epithelial cells that store enzymes required for digestion as inactive zymogens, tightly packed at the cell apex…”
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Syntaxin-4 mediates exocytosis of pre-docked and newcomer insulin granules underlying biphasic glucose-stimulated insulin secretion in human pancreatic beta cells by Xie, Li, Zhu, Dan, Dolai, Subhankar, Liang, Tao, Qin, Tairan, Kang, Youhou, Xie, Huanli, Huang, Ya-Chi, Gaisano, Herbert Y.

“…Aims/hypothesis Of the four exocytotic syntaxins (Syns), much is now known about the role of Syn-1A (pre-docked secretory granules [SGs]) and Syn-3 (newcomer…”
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Syntaxin-3 Binds and Regulates Both R- and L-Type Calcium Channels in Insulin-Secreting INS-1 832/13 Cells by Xie, Li, Dolai, Subhankar, Kang, Youhou, Liang, Tao, Xie, Huanli, Qin, Tairan, Yang, Lu, Chen, Liangyi, Gaisano, Herbert Y

“…Syntaxin (Syn)-1A mediates exocytosis of predocked insulin-containing secretory granules (SGs) during first-phase glucose-stimulated insulin secretion (GSIS)…”
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RalA GTPase Tethers Insulin Granules to L‐ and R‐Type Calcium Channels Through Binding α2δ‐1 Subunit by Xie, Li, Kang, Youhou, Liang, Tao, Dolai, Subhankar, Xie, Huanli, Parsaud, Leon, Lopez, Jamie A., He, Yu, Chidambaram, Subbulakshmi, Lam, Patrick P., James, David E., Sugita, Shuzo, Gaisano, Herbert Y.

“…RalA GTPase has been implicated in the regulated delivery of exocytotic vesicles to the plasma membrane (PM) in mammalian cells. We had reported that RalA…”
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Syntaxin-1A inhibition of P-1075, cromakalim, and diazoxide actions on mouse cardiac ATP-sensitive potassium channel by Ng, Betty, Kang, Youhou, Xie, Huanli, Sun, Hui, Gaisano, Herbert Y.

“…Aims Syntaxin (Syn)-1A binds sulfonylurea receptor (SUR) nucleotide binding folds of cardiac myocyte (SUR2A) and islet β-cells (SUR1) to inhibit ATP-sensitive…”
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Syntaxin 1A Binds to the Cytoplasmic C Terminus of Kv2.1 to Regulate Channel Gating and Trafficking by Leung, Yuk M., Kang, Youhou, Gao, Xiaodong, Xia, Fuzhen, Xie, Huanli, Sheu, Laura, Tsuk, Sharon, Lotan, Ilana, Tsushima, Robert G., Gaisano, Herbert Y.

“…Voltage-gated K+(Kv) 2.1 is the dominant Kv channel that controls membrane repolarization in rat islet औ-cells and downstream insulin exocytosis. We recently…”
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Syntaxin-1A Inhibits Cardiac KATP Channels by Its Actions on Nucleotide Binding Folds 1 and 2 of Sulfonylurea Receptor 2A by Kang, Youhou, Leung, Yuk-Man, Manning-Fox, Jocelyn E, Xia, Fuzhen, Xie, Huanli, Sheu, Laura, Tsushima, Robert G, Light, Peter E, Gaisano, Herbert Y

“…ATP-sensitive potassium (K ATP ) channels couple the metabolic status of the cell to its membrane potential to regulate a number of cell actions, including…”
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H3 Domain of Syntaxin 1A Inhibits KATP Channels by Its Actions on the Sulfonylurea Receptor 1 Nucleotide-Binding Folds-1 and -2 by Cui, Ningren, Kang, Youhou, He, Yan, Leung, Yuk-Man, Xie, Huanli, Pasyk, Ewa A., Gao, Xiaodong, Sheu, Laura, Hansen, John B., Wahl, Philip, Tsushima, Robert G., Gaisano, Herbert Y.

“…The ATP-sensitive potassium (KATP) channel in pancreatic islet beta cells consists of four pore-forming (Kir6.2) subunits and four regulatory sulfonylurea…”
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Modulation of Kv2.1 channel gating and TEA sensitivity by distinct domains of SNAP-25 by He, Yan, Kang, Youhou, Leung, Yuk-Man, Xia, Fuzhen, Gao, Xiaodong, Xie, Huanli, Gaisano, Herbert Y, Tsushima, Robert G

“…Distinct domains within the SNARE (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor) proteins, STX1A (syntaxin 1A) and SNAP-25…”
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The Actions of a Novel Potent Islet β-Cell–Specific ATP-Sensitive K+ Channel Opener Can Be Modulated by Syntaxin-1A Acting on Sulfonylurea Receptor 1 by Ng, Betty, Kang, Youhou, Elias, Chadwick L, He, Yan, Xie, Huanli, Hansen, John B, Wahl, Philip, Gaisano, Herbert Y

“…The Actions of a Novel Potent Islet β-Cell–Specific ATP-Sensitive K + Channel Opener Can Be Modulated by Syntaxin-1A Acting on Sulfonylurea Receptor 1 Betty Ng…”
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Syntaxin-1A Actions on Sulfonylurea Receptor 2A Can Block Acidic pH-induced Cardiac KATP Channel Activation by Kang, Youhou, Ng, Betty, Leung, Yuk-Man, He, Yan, Xie, Huanli, Lodwick, David, Norman, Robert I., Tinker, Andrew, Tsushima, Robert G., Gaisano, Herbert Y.

“…During cardiac ischemia, ATP stores are depleted, and cardiomyocyte intracellular pH lowers to <7.0. The acidic pH acts on the Kir6.2 subunit of KATP channels…”
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Synaptotagmin-7 Functions to Replenish Insulin Granules for Exocytosis in Human Islet β-Cells by Dolai, Subhankar, Xie, Li, Zhu, Dan, Liang, Tao, Qin, Tairan, Xie, Huanli, Kang, Youhou, Chapman, Edwin R, Gaisano, Herbert Y

“…Synaptotagmin (Syt)-7, a major component of the exocytotic machinery in neurons, is also the major Syt in rodent pancreatic β-cells shown to mediate…”
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Pancreas-specific SNAP23 depletion prevents pancreatitis by attenuating pathological basolateral exocytosis and formation of trypsin-activating autolysosomes by Dolai, Subhankar, Takahashi, Toshimasa, Qin, Tairan, Liang, Tao, Xie, Li, Kang, Fei, Miao, Yi-Fan, Xie, Huanli, Kang, Youhou, Manuel, Justin, Winter, Erin, Roche, Paul A., Cattral, Mark S., Gaisano, Herbert Y.

“…Intrapancreatic trypsin activation by dysregulated macroautophagy/autophagy and pathological exocytosis of zymogen granules (ZGs), along with activation of…”
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Syntaxin 2 Acts as Inhibitory SNARE for Insulin Granule Exocytosis by Zhu, Dan, Xie, Li, Kang, Youhou, Dolai, Subhankar, Bondo Hansen, Jakob, Qin, Tairan, Xie, Huanli, Liang, Tao, Rubin, Deborah C, Osborne, Lucy, Gaisano, Herbert Y

“…Of the four syntaxins specialized for exocytosis, syntaxin (Syn)-2 is the least understood. In this study, we used Syn-2/epimorphin knockout mice to examine…”
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Synaptotagmin-7 Functions to Replenish Insulin Granules for Exocytosis in Human Islet[Beta]-Cells by Dolai, Subhankar, Xie, Li, Zhu, Dan, Liang, Tao, Qin, Tairan, Xie, Huanli, Kang, Youhou, Chapman, Edwin R, Gaisano, Herbert Y

“…Synaptotagmin (Syt)-7, a major component of the exocytotic machinery in neurons, is also the major Syt in rodent pancreatic β-cells shown to mediate…”
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Depletion of the membrane-fusion regulator Munc18c attenuates caerulein hyperstimulation–induced pancreatitis by Dolai, Subhankar, Liang, Tao, Orabi, Abrahim I., Xie, Li, Holmyard, Douglas, Javed, Tanveer A., Fernandez, Nestor A., Xie, Huanli, Cattral, Mark S., Thurmond, Debbie C., Thorn, Peter, Gaisano, Herbert Y.

“…Epithelial pancreatic acinar cells perform crucial functions in food digestion, and acinar cell homeostasis required for secretion of digestive enzymes relies…”
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Kv2.1 clusters on β-cell plasma membrane act as reservoirs that replenish pools of newcomer insulin granule through their interaction with syntaxin-3 by Greitzer-Antes, Dafna, Xie, Li, Qin, Tairan, Xie, Huanli, Zhu, Dan, Dolai, Subhankar, Liang, Tao, Kang, Fei, Hardy, Alexandre B., He, Yan, Kang, Youhou, Gaisano, Herbert Y.

“…The voltage-dependent K+ (Kv) channel Kv2.1 is a major delayed rectifier in many secretory cells, including pancreatic β cells. In addition, Kv2.1 has a direct…”
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Phosphatidylinositol 4,5-Biphosphate (PIP2) Modulates Interaction of Syntaxin-1A with Sulfonylurea Receptor 1 to Regulate Pancreatic β-Cell ATP-sensitive Potassium Channels by Liang, Tao, Xie, Li, Chao, Christin, Kang, Youhou, Lin, Xianguang, Qin, Tairan, Xie, Huanli, Feng, Zhong-Ping, Gaisano, Herbert Y.

“…In β-cells, syntaxin (Syn)-1A interacts with SUR1 to inhibit ATP-sensitive potassium channels (KATP channels). PIP2 binds the Kir6.2 subunit to open KATP…”
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Syntaxin-1A inhibits K ATP channels by interacting with specific conserved motifs within sulfonylurea receptor 2A by Chao, Christin, Liang, Tao, Kang, Youhou, Lin, Xianguang, Xie, Huanli, Feng, Zhong-Ping, Gaisano, Herbert Y.

“…We previously demonstrated that syntaxin (Syn)-1A is present in the sarcolemma of rat cardiomyocytes and binds sulfonylurea receptor (SUR) 2A nucleotide…”
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