Search Results - "Xie, Hong‐Guang"

LncRNA MALAT1 facilitates inflammasome activation via epigenetic suppression of Nrf2 in Parkinson’s disease by Cai, Li-Jun, Tu, Li, Huang, Xiao-Mo, Huang, Jia, Qiu, Nan, Xie, Guang-Hong, Liao, Jian-Xiong, Du, Wei, Zhang, Ying-Yue, Tian, Jin-Yong

“…Abstract The goal of the present study was to elucidate the mechanism by which long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1…”
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Extensive Intestinal First-Pass Elimination and Predominant Hepatic Distribution of Berberine Explain Its Low Plasma Levels in Rats by LIU, Yi-Tong, HAO, Hai-Ping, XIE, Hong-Guang, LI LAI, QIONG WANG, LIU, Chang-Xiao, WANG, Guang-Ji

“…Berberine, one of the most commonly used natural products, exhibits a poor plasma concentration-effect relationship whose underlying mechanisms remain largely…”
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Is platelet responsiveness to clopidogrel attenuated in overweight or obese patients and why? A reverse translational study in mice by Jiang, Li‐Ping, Ji, Jin‐Zi, Ge, Peng‐Xin, Zhu, Ting, Mi, Qiong‐Yu, Tai, Ting, Li, Yi‐Fei, Xie, Hong‐Guang

“…Background and Purpose Overweight or obese patients exhibit poorer platelet responses to clopidogrel. However, the mechanisms behind this phenotype remain to…”
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Polysaccharide from Angelica sinensis protects chondrocytes from H2O2-induced apoptosis through its antioxidant effects in vitro by Zhuang, Chao, Xu, Nan-Wei, Gao, Gong-Ming, Ni, Su, Miao, Kai-Song, Li, Chen-Kai, Wang, Li-Ming, Xie, Hong-Guang

“…This study aimed to explore the protective effects of Angelica sinensis polysaccharide (ASP) on rat chondrocyte injury induced by hydrogen peroxide (H2O2). Rat…”
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The Relationship of Tumor Microbiome and Oral Bacteria and Intestinal Dysbiosis in Canine Mammary Tumor by Zheng, Hui-Hua, Du, Chong-Tao, Yu, Chao, Tang, Xin-Yue, Huang, Rong-Lei, Zhang, Yu-Zhu, Gao, Wei, Xie, Guang-Hong

“…Canine mammary tumor (CMT) is the most common tumor in dogs, with 50% of malignant cases, and lacks an effective therapeutic schedule, hence its early…”
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Effects of CYP2C19 loss-of-function variants on the eradication of H. pylori infection in patients treated with proton pump inhibitor-based triple therapy regimens: a meta-analysis of randomized clinical trials by Tang, Hui-Lin, Li, Yan, Hu, Yong-Fang, Xie, Hong-Guang, Zhai, Suo-Di

“…There are inconsistent conclusions about whether CYP2C19 variants could affect H. pylori eradication rate in patients treated with the proton pump inhibitor…”
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Isolation, Identification and Antimicrobial Resistance Analysis of Canine Oral and Intestinal Escherichia coli Resistant to Colistin by Zheng, Hui-Hua, Yu, Chao, Tang, Xin-Yue, Du, Chong-Tao, Xie, Guang-Hong

“…In recent years, the antimicrobial resistance in Escherichia coli has gradually developed into a global problem. These resistant bacteria could be transmitted…”
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Vicagrel is hydrolyzed by Raf kinase inhibitor protein in human intestine by Zhu, Ting, Wu, Yu, Li, Xue‐Mei, Jia, Yu‐Meng, Zhou, Huan, Jiang, Li‐Ping, Tai, Ting, Mi, Qiong‐Yu, Ji, Jin‐Zi, Xie, Hong‐Guang

“…As an analog of clopidogrel and prasugrel, vicagrel is completely hydrolyzed to intermediate thiolactone metabolite 2‐oxo‐clopidogrel (also the precursor of…”
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Enhanced responsiveness of platelets to vicagrel in IL‐10‐deficient mice through STAT3‐dependent up‐regulation of the hydrolase arylacetamide deacetylase in the intestine by Jia, Yu‐Meng, Zhou, Huan, Tai, Ting, Gu, Tong‐Tong, Ji, Jin‐Zi, Mi, Qiong‐Yu, Huang, Bei‐Bei, Li, Yi‐Fei, Zhu, Ting, Xie, Hong‐Guang

“…Background and Purpose Vicagrel is a novel promising antiplatelet drug designed for overcoming clopidogrel resistance. There is limited evidence indicating…”
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Identification of Canine Pyometra-Associated Metabolites Using Untargeted Metabolomics by Zheng, Hui-Hua, Du, Chong-Tao, Zhang, Yu-Zhu, Yu, Chao, Huang, Rong-Lei, Tang, Xin-Yue, Xie, Guang-Hong

“…Canine pyometra frequently occurs in middle-aged to older intact bitches, which seriously affects the life of dogs and brings an economic loss to their owners…”
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Diagnosis of Canine Tumours and the Value of Combined Detection of VEGF, P53, SF and NLRP3 for the Early Diagnosis of Canine Mammary Carcinoma by Yang, Ning-Yu, Zheng, Hui-Hua, Yu, Chao, Ye, Yan, Xie, Guang-Hong

“…The average life of a dog is generally maintained at ten to fifteen years, and tumours are the predominant reason that leads to the death of dogs, especially…”
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Lower tacrolimus daily dose requirements and acute rejection rates in the CYP3A5 nonexpressers than expressers by Tang, Hui-Lin, Xie, Hong-Guang, Yao, Yao, Hu, Yong-Fang

“…BACKGROUNDCYP3A5 genetic polymorphisms contribute to marked interindividual differences in the metabolism of and response to tacrolimus in humans…”
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Antiepileptics Topiramate and Levetiracetam Alleviate Behavioral Deficits and Reduce Neuropathology in APPswe/PS1dE9 Transgenic Mice by Shi, Jian‐Quan, Wang, Bian‐Rong, Tian, You‐Yong, Xu, Jun, Gao, Li, Zhao, Shu‐Li, Jiang, Teng, Xie, Hong‐Guang, Zhang, Ying‐Dong

“…Summary Background The close relationship between epileptic seizure and Alzheimer's disease (AD) has been demonstrated in the past decade. Valproic acid, a…”
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Epidemiological Investigation of Canine Mammary Tumors in Mainland China Between 2017 and 2021 by Zheng, Hui-Hua, Du, Chong-Tao, Yu, Chao, Zhang, Yu-Zhu, Huang, Rong-Lei, Tang, Xin-Yue, Xie, Guang-Hong

“…Epidemiological studies enable us to analyze disease behavior, define risk factors, and establish fundamental prognostic criteria. This study aimed to…”
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Berberine ameliorates chronic kidney injury caused by atherosclerotic renovascular disease through the suppression of NFκB signaling pathway in rats by Wan, Xin, Chen, Xin, Liu, Lin, Zhao, Ye, Huang, Wen-Juan, Zhang, Qian, Miao, Gang-Gang, Chen, Wen, Xie, Hong-Guang, Cao, Chang-Chun

“…Impaired renal function in atherosclerotic renovascular disease (ARD) may be the result of crosstalk between atherosclerotic renovascular stenosis and…”
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Vicagrel enhances aspirin-induced inhibition of both platelet aggregation and thrombus formation in rodents due to its decreased metabolic inactivation by Jia, Yu-Meng, Ge, Peng-Xin, Zhou, Huan, Ji, Jin-Zi, Tai, Ting, Gu, Tong-Tong, Zhu, Ting, Li, Yi-Fei, Mi, Qiong-Yu, Huang, Bei-Bei, Xie, Hong-Guang

“…[Display omitted] Both aspirin and vicagrel are effective antiplatelet drugs, with the potential for concomitant use as another dual-antiplatelet therapy for…”
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Identification of functionally variant MDR1 alleles among European Americans and African Americans by Kim, Richard B., Leake, Brenda F., Choo, Edna F., Dresser, George K., Kubba, Samir V., Schwarz, Ute I., Taylor, Amanda, Xie, Hong‐Guang, McKinsey, Joel, Zhou, Sheng, Lan, Lu‐Bin, Schuetz, John D., Schuetz, Erin G., Wilkinson, Grant R.

“…MDR1 (P‐glycoprotein) is an important factor in the disposition of many drugs, and the involved processes often exhibit considerable interindividual…”
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CYP2C9 allelic variants: ethnic distribution and functional significance by Xie, Hong-Guang, Prasad, Harish C, Kim, Richard B, Stein, C.Michael

“…Cytochrome P-450 (CYP) 2C9 CYP2C9 is a polymorphically expressed enzyme responsible for the metabolism of several clinically important drugs, some with a low…”
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A tectonic model for Cenozoic igneous activities in the eastern Indo–Asian collision zone by Wang, Jiang-Hai, Yin, An, Harrison, T.Mark, Grove, Marty, Zhang, Yu-Quan, Xie, Guang-Hong

“…Geochronologic dating and compilation of existing age data suggest that Cenozoic activities in the eastern Indo–Asian collision zone of southeast China and…”
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Clonidine Clearance Matures Rapidly During the Early Postnatal Period: A Population Pharmacokinetic Analysis in Newborns With Neonatal Abstinence Syndrome by Xie, Hong-Guang, Cao, Ying Jun, Gauda, Estelle B., Agthe, Alexander G., Hendrix, Craig W., Lee, Howard

“…The population pharmacokinetic (PK) profile of oral clonidine was characterized in newborns with neonatal abstinence syndrome, and significant covariates…”
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