Search Results - "Xie, Edward"

Mitoautophagy: A Unique Self-Destructive Path Mitochondria of Upper Motor Neurons With TDP-43 Pathology Take, Very Early in ALS by Gautam, Mukesh, Xie, Edward F, Kocak, Nuran, Ozdinler, P Hande

“…Mitochondrial dysfunction is one of the converging paths for many neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), and TDP-43…”
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MCP1-CCR2 and neuroinflammation in the ALS motor cortex with TDP-43 pathology by Jara, Javier H, Gautam, Mukesh, Kocak, Nuran, Xie, Edward F, Mao, Qinwen, Bigio, Eileen H, Özdinler, P Hande

“…The involvement of non-neuronal cells and the cells of innate immunity has been attributed to the initiation and progression of ALS. TDP-43 pathology is…”
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Using Computational Drug-Gene Analysis to Identify Novel Therapeutic Candidates for Retinal Neuroprotection by Xie, Edward, Nadeem, Urooba, Xie, Bingqing, D’Souza, Mark, Sulakhe, Dinanath, Skondra, Dimitra

“…Retinal cell death is responsible for irreversible vision loss in many retinal disorders. No commercially approved treatments are currently available to…”
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Exploring miRNA-mRNA regulatory network in cardiac pathology in Na + /H + exchanger isoform 1 transgenic mice by Xue, Jin, Zhou, Dan, Poulsen, Orit, Hartley, Iain, Imamura, Toshihiro, Xie, Edward X, Haddad, Gabriel G

“…Numerous studies have demonstrated that Na /H exchanger isoform 1 (NHE1) is elevated in myocardial diseases and its effect is detrimental. To better understand…”
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Identifying novel candidate compounds for therapeutic strategies in retinopathy of prematurity via computational drug-gene association analysis by Xie, Edward F, Hilkert Rodriguez, Sarah, Xie, Bingqing, D'Souza, Mark, Reem, Gonnah, Sulakhe, Dinanath, Skondra, Dimitra

“…Retinopathy of prematurity (ROP) is the leading cause of preventable childhood blindness worldwide. Although interventions such as anti-VEGF and laser have…”
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Using Advanced Bioinformatics Tools to Identify Novel Therapeutic Candidates for Age-Related Macular Degeneration by Nadeem, Urooba, Xie, Bingqing, Xie, Edward F., D'Souza, Mark, Dao, David, Sulakhe, Dinanath, Skondra, Dimitra

“…PurposeAge-related macular degeneration (AMD) is the most common cause of aging-related blindness in the developing world. Although medications can slow…”
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Students help shape medical education to keep up with the times by Xie, Edward, MD MSc, Hulme, Jennifer, MD CM MPH, Howard, Courtney, MD

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Using Advanced Bioinformatics Tools to Identify Novel Therapeutic Candidates for Proliferative Vitreoretinopathy by Xie, Edward F, Xie, Bingqing, Nadeem, Urooba, D'Souza, Mark, Reem, Gonnah, Sulakhe, Dinanath, Skondra, Dimitra

“…Proliferative vitreoretinopathy (PVR) is the dreaded cause of failure following retinal detachment repair; however, no cures or preventative therapies exist to…”
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Climate change and health in medical school curricula: A national survey of medical students’ experiences, attitudes and interests by Létourneau, Sasha, Roshan, Aishwarya, Kitching, George T., Robson, Julia, Walker, Celia, Xu, Chenchen, Jubas-Malz, Daniel, Xie, Edward

“…Physicians play a critical role in addressing the health-related impacts of climate change. However, integration of education on the health effects of climate…”
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Improving mitochondria and ER stability helps eliminate upper motor neuron degeneration that occurs due to mSOD1 toxicity and TDP‐43 pathology by Genç, Barış, Gautam, Mukesh, Gözütok, Öge, Dervishi, Ina, Sanchez, Santana, Goshu, Gashaw M., Koçak, Nuran, Xie, Edward, Silverman, Richard B., Özdinler, P. Hande

“…Background Upper motor neurons (UMNs) are a key component of motor neuron circuitry. Their degeneration is a hallmark for diseases, such as hereditary spastic…”
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CAEP position statement on improving emergency care for persons experiencing homelessness: executive summary by Xie, Edward C, Chan, Kathryn, Khangura, Jaspreet K, Koh, Justin Jek-Kahn, Orkin, Aaron M, Sheikh, Hasan, Hayman, Kate, Gupta, Sahil, Kumar, Thara, Hulme, Jennifer, Mrochuk, May, Dong, Kathryn

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Leadership on prescription drugs needed by Xie, Edward

“…As the authors allude to, public policy is of critical importance and can and should have a role in reigning in nonadherence and expenditure on prescription…”
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Mortality among patients with frequent emergency department use for alcohol-related reasons in Ontario: a population-based cohort study by Hulme, Jennifer, Sheikh, Hasan, Xie, Edward, Gatov, Evgenia, Nagamuthu, Chenthila, Kurdyak, Paul

“…Little is known about the risk of death among people who visit emergency departments frequently for alcohol-related reasons, including whether mortality risk…”
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Agir contre le changement climatique pour un avenir plus sain: Le rôle essentiel des soins primaires au Canada by Xie, Edward, Howard, Courtney, Buchman, Sandy, Miller, Fiona A.

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Acting on climate change for a healthier future: Critical role for primary care in Canada by Xie, Edward, Howard, Courtney, Buchman, Sandy, Miller, Fiona A.

“…In 2018, the Declaration of Astana on primary health care renewed the principles established more than 40 years earlier in another Kazakh city, once known as…”
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Effectiveness of permanent supportive housing and income assistance interventions for homeless individuals in high-income countries: a systematic review by Aubry, Tim, Bloch, Gary, Brcic, Vanessa, Saad, Ammar, Magwood, Olivia, Abdalla, Tasnim, Alkhateeb, Qasem, Xie, Edward, Mathew, Christine, Hannigan, Terry, Costello, Chris, Thavorn, Kednapa, Stergiopoulos, Vicky, Tugwell, Peter, Pottie, Kevin

“…BACKGROUNDPermanent supportive housing and income assistance are valuable interventions for homeless individuals. Homelessness can reduce physical and social…”
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Updating our language around substance use disorders by Xie, Edward, Green, Samantha, Puri, Nitasha, Sheikh, Hasan

“…We thank Drs. Kumar and Rosenberg for enhancing care providers' knowledge of treatments for opioid abuse and its consequences. However, we need to be more…”
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The counterintuitive role of efficiency: implications for the ecological impact of health care by Sue-Chue-Lam, Colin, Shove, Elizabeth, Xie, Edward

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Treating homelessness as an emergency: learning from the COVID-19 response by Gupta, Sahil, Xie, Edward, Dong, Kathryn

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Glyburide confers neuroprotection against age-related macular degeneration (AMD) by Picard, Emilie, Youale, Jenny, Hyman, Max J., Xie, Edward, Achiedo, Seiki, Kaufmann, Gabriel T., Moir, John, Daruich, Alejandra, Crisanti, Patricia, Torriglia, Alicia, Polak, Michel, Behar-Cohen, Francine, Skondra, Dimitra, Berdugo, Marianne

“…Glyburide, a sulfonylurea drug used to treat type 2 diabetes, boasts neuroprotective effects by targeting the sulfonylurea receptor 1 (SUR1) and associated ion…”
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