Search Results - "Xiao, Zhengtao"

Metabolic landscape of the tumor microenvironment at single cell resolution by Xiao, Zhengtao, Dai, Ziwei, Locasale, Jason W.

“…The tumor milieu consists of numerous cell types each existing in a different environment. However, a characterization of metabolic heterogeneity at…”
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Genome-wide assessment of differential translations with ribosome profiling data by Xiao, Zhengtao, Zou, Qin, Liu, Yu, Yang, Xuerui

“…The closely regulated process of mRNA translation is crucial for precise control of protein abundance and quality. Ribosome profiling, a combination of…”
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Function of HNRNPC in breast cancer cells by controlling the dsRNA‐induced interferon response by Wu, Yusheng, Zhao, Wenwei, Liu, Yang, Tan, Xiangtian, Li, Xin, Zou, Qin, Xiao, Zhengtao, Xu, Hui, Wang, Yuting, Yang, Xuerui

“…Elevated expression of RNA binding protein HNRNPC has been reported in cancer cells, while the essentialness and functions of HNRNPC in tumors were not clear…”
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Oncogenic Properties of NEAT1 in Prostate Cancer Cells Depend on the CDC5L-AGRN Transcriptional Regulation Circuit by Li, Xin, Wang, Xianteng, Song, Wanlu, Xu, Hui, Huang, Rongyao, Wang, Yuting, Zhao, Wenwei, Xiao, Zhengtao, Yang, Xuerui

“…The long noncoding RNA nuclear-enriched abundant transcript 1 (NEAT1) has been shown to regulate multiple cancer-related cellular activities including cell…”
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Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion by Yu, Yi-Ru, Imrichova, Hana, Wang, Haiping, Chao, Tung, Xiao, Zhengtao, Gao, Min, Rincon-Restrepo, Marcela, Franco, Fabien, Genolet, Raphael, Cheng, Wan-Chen, Jandus, Camilla, Coukos, George, Jiang, Yi-Fan, Locasale, Jason W., Zippelius, Alfred, Liu, Pu-Ste, Tang, Li, Bock, Christoph, Vannini, Nicola, Ho, Ping-Chih

“…The metabolic challenges present in tumors attenuate the metabolic fitness and antitumor activity of tumor-infiltrating T lymphocytes (TILs). However, it…”
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Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing by Davis, Ryan T., Blake, Kerrigan, Ma, Dennis, Gabra, Mari B. Ishak, Hernandez, Grace A., Phung, Anh T., Yang, Ying, Maurer, Dustin, Lefebvre, Austin E. Y. T., Alshetaiwi, Hamad, Xiao, Zhengtao, Liu, Juan, Locasale, Jason W., Digman, Michelle A., Mjolsness, Eric, Kong, Mei, Werb, Zena, Lawson, Devon A.

“…Although metastasis remains the cause of most cancer-related mortality, mechanisms governing seeding in distal tissues are poorly understood. Here, we…”
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Mutual dependency between lncRNA LETN and protein NPM1 in controlling the nucleolar structure and functions sustaining cell proliferation by Wang, Xianteng, Hu, Xiaolin, Song, Wanlu, Xu, Hui, Xiao, Zhengtao, Huang, Rongyao, Bai, Qingran, Zhang, Fan, Chen, Yongzhen, Liu, Yu, Fang, Jianhuo, Li, Xin, Shen, Qin, Zhao, Haitao, Yang, Xuerui

“…Fundamental processes such as ribosomal RNA synthesis and chromatin remodeling take place in the nucleolus, which is hyperactive in fast-proliferating cells…”
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Tumor-induced reshuffling of lipid composition on the endoplasmic reticulum membrane sustains macrophage survival and pro-tumorigenic activity by Di Conza, Giusy, Tsai, Chin-Hsien, Gallart-Ayala, Hector, Yu, Yi-Ru, Franco, Fabien, Zaffalon, Lea, Xie, Xin, Li, Xiaoyun, Xiao, Zhengtao, Raines, Lydia N., Falquet, Maryline, Jalil, Antoine, Locasale, Jason W., Percipalle, Piergiorgio, Masson, David, Huang, Stanley Ching-Cheng, Martinon, Fabio, Ivanisevic, Julijana, Ho, Ping-Chih

“…Tumor-associated macrophages (TAMs) display pro-tumorigenic phenotypes for supporting tumor progression in response to microenvironmental cues imposed by tumor…”
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RiboMiner: a toolset for mining multi-dimensional features of the translatome with ribosome profiling data by Li, Fajin, Xing, Xudong, Xiao, Zhengtao, Xu, Gang, Yang, Xuerui

“…Abstract Background Ribosome profiling has been widely used for studies of translation under a large variety of cellular and physiological contexts. Many of…”
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ZEB1 Represses Neural Differentiation and Cooperates with CTBP2 to Dynamically Regulate Cell Migration during Neocortex Development by Wang, Huanhuan, Xiao, Zhengtao, Zheng, Jiangli, Wu, Jun, Hu, Xiao-Ling, Yang, Xuerui, Shen, Qin

“…Zinc-finger E-box binding homeobox 1 (Zeb1) is a key regulator of epithelial-mesenchymal transition and cancer metastasis. Mutation of ZEB1 is associated with…”
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Metabolism in the tumor microenvironment: insights from single-cell analysis by Xiao, Zhengtao, Locasale, Jason W., Dai, Ziwei

“…The metabolism of both cancer and immune cells in the tumor microenvironment (TME) is poorly understood since most studies have focused on analysis in bulk…”
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Dependency of the Cancer-Specific Transcriptional Regulation Circuitry on the Promoter DNA Methylome by Liu, Yu, Liu, Yang, Huang, Rongyao, Song, Wanlu, Wang, Jiawei, Xiao, Zhengtao, Dong, Shengcheng, Yang, Yang, Yang, Xuerui

“…Dynamic dysregulation of the promoter DNA methylome is a signature of cancer. However, comprehensive understandings about how the DNA methylome is incorporated…”
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Tumor suppressor BAP1 suppresses disulfidptosis through the regulation of SLC7A11 and NADPH levels by Wang, Jin, Wang, Minglin, Wu, Shaobo, Zhu, Yanan, Fan, Kexin, Chen, Yuhan, Xiao, Zhengtao, Chen, Jing, Tu, Kangsheng, Huang, Dongsheng, Zhang, Yilei, Xu, Qiuran

“…BAP1, BRCA1-Associated Protein 1, serves as a novel tumor suppressor through the deubiquitination of monoubiquitination of H2A and subsequent gene…”
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Clinical characteristics and variant analyses of transient infantile hypertriglyceridemia related to GPD1 gene by Wang, Jun, Sun, Xinrong, Jiao, Lianying, Xiao, Zhengtao, Riaz, Farooq, Zhang, Yufeng, Xu, Pengfei, Liu, Ruiqing, Tang, Tiantian, Liu, Meiqi, Li, Dongmin

“…Objective : Our study aims to summarize and analyze the clinical characteristics of transient infantile hypertriglyceridemia (HTGTI) and variants in the…”
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Ribosome Profiling Reveals Genome-wide Cellular Translational Regulation upon Heat Stress in Escherichia coli by Zhang, Yanqing, Xiao, Zhengtao, Zou, Qin, Fang, Jianhuo, Wang, Qifan, Yang, Xuerui, Gao, Ning

“…Heat shock response is a classical stress-induced regulatory system in bacteria, character- ized by extensive transcriptional reprogramming. To compare the…”
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933 Heme-mediated reprogramming guides CD8+ T cell exhaustion in response to mitochondrial dysfunction by Xu, Yingxi, Peng, Jhan-Jie, Chuang, Yu-Ming, Akrami, Maryam, Roychoudhuri, Rahul, Zippelius, Alfred, Xiao, Zhengtao, Ho, Ping-Chih

“…BackgroundThe accumulation of depolarized mitochondria in tumor-infiltrating T lymphocytes (TILs) has been shown to orchestrate transcriptomic and epigenetic…”
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Single-cell transcriptomic analysis of normal and pathological tissues from the same patient uncovers colon cancer progression by Sun, Ruifang, Yang, Yang, Lü, Weidong, Yang, Yanqi, Li, Yulong, Liu, Zhigang, Diao, Dongmei, Wang, Yang, Chang, Su'e, Lu, Mengnan, Jiang, Qiuyu, Dai, Bingling, Ma, Xiaobin, Zhao, Chang'an, Lü, Moqi, Zhang, Juan, Ding, Caixia, Li, Na, Zhang, Jian, Xiao, Zhengtao, Zhou, Dangxia, Huang, Chen

“…The aim of the present study was to elucidate the evolutionary trajectory of colon cells from normal colon mucosa, to adenoma, then to carcinoma in the same…”
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Single-cell sequencing reveals antitumor characteristics of intratumoral immune cells in old mice by Zhang, Cangang, Lei, Lei, Yang, Xiaofeng, Ma, Kaili, Zheng, Huiqiang, Su, Yanhong, Jiao, Anjun, Wang, Xin, Liu, Haiyan, Zou, Yujing, Shi, Lin, Zhou, Xiaobo, Sun, Chenming, Hou, Yuzhu, Xiao, Zhengtao, Zhang, Lianjun, Zhang, Baojun

“…BackgroundAging has long been thought to be a major risk factor for various types of cancers. However, accumulating evidence indicates increased resistance of…”
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Combined 3D-QSAR, molecular docking and molecular dynamics study on derivatives of peptide epoxyketone and tyropeptin-boronic acid as inhibitors against the β5 subunit of human 20S proteasome by Liu, Jianling, Zhang, Hong, Xiao, Zhengtao, Wang, Fangfang, Wang, Xia, Wang, Yonghua

“…An abnormal ubiquitin-proteasome is found in many human diseases, especially in cancer, and has received extensive attention as a promising therapeutic target…”
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Two TPX2-dependent switches control the activity of Aurora A by Xu, Xue, Wang, Xia, Xiao, Zhengtao, Li, Yan, Wang, Yonghua

“…Aurora A is an important oncogenic kinase for mitotic spindle assembly and a potentially attractive target for human cancers. Its activation could be regulated…”
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