Search Results - "Xiao, Xiangshu"

Toward Developing Chemical Modulators of Hsp60 as Potential Therapeutics by Meng, Qianli, Li, Bingbing X, Xiao, Xiangshu

“…The 60 kDa heat shock protein (Hsp60) is classically known as a mitochondrial chaperonin protein working together with co-chaperonin 10 kDa heat shock protein…”
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Systemic Inhibition of CREB is Well-tolerated in vivo by Li, Bingbing X., Gardner, Ryan, Xue, Changhui, Qian, David Z., Xie, Fuchun, Thomas, George, Kazmierczak, Steven C., Habecker, Beth A., Xiao, Xiangshu

“…cAMP-response element binding protein (CREB) is a nuclear transcription factor activated by multiple extracellular signals including growth factors and…”
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Design, synthesis and biological evaluation of regioisomers of 666-15 as inhibitors of CREB-mediated gene transcription by Xie, Fuchun, Li, Bingbing X., Xiao, Xiangshu

“…[Display omitted] cAMP-response element binding protein (CREB) is a nuclear transcription factor that has been implicated in the pathogenesis and maintenance…”
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Discovery of a Small-Molecule Inhibitor of the KIX-KID Interaction by Li, Bingbing X, Xiao, Xiangshu

“…Are you too small? The small molecule (MW=297) shown here was discovered to be an inhibitor of the KIX–KID interaction by using a novel Renilla luciferase…”
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Design, synthesis and evaluation of antitumor acylated monoaminopyrroloquinazolines by Chao, Bo, Li, Bingbing X., Xiao, Xiangshu

“…[Display omitted] Pyrroloquinazoline is a privileged chemical scaffold with diverse biological activities. We recently described a series of N-3 acylated…”
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CG-SLENP: A Chemical Genetics Strategy To Selectively Label Existing Proteins and Newly Synthesized Proteins by Wang, Jian, Chao, Bo, Piesner, Jake, Kelly, Felice, Petrie, Stefanie Kaech, Xiao, Xiangshu, Li, Bingbing X.

“…Protein synthesis and subsequent delivery to the target locations in cells are essential for their proper functions. Methods to label and distinguish newly…”
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Phosphorylation of Lamin A/C at serine 22 modulates Nav1.5 function by Olaopa, Michael A., Ai, Tomohiko, Chao, Bo, Xiao, Xiangshu, Vatta, Matteo, Habecker, Beth A.

“…Variants in the LMNA gene, which encodes for Lamin A/C, are associated with cardiac conduction disease (CCD). We previously reported that Lamin A/C variants…”
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A clickable photoaffinity probe of betulinic acid identifies tropomyosin as a target by Martín-Acosta, Pedro, Meng, Qianli, Klimek, John, Reddy, Ashok P., David, Larry, Petrie, Stefanie Kaech, Li, Bingbing X., Xiao, Xiangshu

“…Target identification of bioactive compounds is important for understanding their mechanisms of action and provides critical insights into their therapeutic…”
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Identification, synthesis and evaluation of substituted benzofurazans as inhibitors of CREB-mediated gene transcription by Xie, Fuchun, Li, Bingbing X., Broussard, Candice, Xiao, Xiangshu

“…2-[(7-Nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio]pyridine 1-oxide was identified as a potent inhibitor of KIX–KID interaction from screening the NCI diversity…”
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An Ab Initio Quantum Mechanics Calculation that Correlates with Ligand Orientation and DNA Cleavage Site Selectivity in Camptothecin−DNA−Topoisomerase I Ternary Cleavage Complexes by Xiao, Xiangshu, Cushman, Mark

“…Camptothecin (CPT), a cytotoxic natural alkaloid isolated from Camptotheca acuminata, and its derivatives represent an important class of cancer…”
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Design, Synthesis, and Biological Evaluation of Indenoisoquinoline Topoisomerase I Inhibitors Featuring Polyamine Side Chains on the Lactam Nitrogen by Nagarajan, Muthukaman, Xiao, Xiangshu, Antony, Smitha, Kohlhagen, Glenda, Pommier, Yves, Cushman, Mark

“…The indenoisoquinolines are a class of noncamptothecin topoisomerase I inhibitors that display significant cytotoxicity in human cancer cell cultures. They…”
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A Lamin-Binding Ligand Inhibits Homologous Recombination Repair of DNA Double-Strand Breaks by Li, Bingbing X, Chen, Jingjin, Chao, Bo, Zheng, Yixian, Xiao, Xiangshu

“…Nuclear lamins are type V intermediate filament proteins. Lamins, including LA, LB1, LB2, and LC, are the major protein components forming the nuclear lamina…”
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Total Synthesis and Biological Evaluation of 22-Hydroxyacuminatine by Xiao, Xiangshu, Antony, Smitha, Pommier, Yves, Cushman, Mark

“…A total synthesis of 22-hydroxyacuminatine, a cytotoxic alkaloid isolated from Camptotheca acuminata, is reported. The key step in the synthesis involves the…”
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On the Binding of Indeno[1,2-c]isoquinolines in the DNA−Topoisomerase I Cleavage Complex by Xiao, Xiangshu, Antony, Smitha, Pommier, Yves, Cushman, Mark

“…An ab initio quantum mechanics calculation is reported which predicts the orientation of indenoisoquinoline 4 in the ternary cleavage complex formed from DNA…”
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Design, Synthesis, and Biological Evaluation of Cytotoxic 11-Alkenylindenoisoquinoline Topoisomerase I Inhibitors and Indenoisoquinoline−Camptothecin Hybrids by Fox, Brian M, Xiao, Xiangshu, Antony, Smitha, Kohlhagen, Glenda, Pommier, Yves, Staker, Bart L, Stewart, Lance, Cushman, Mark

“…The indenoisoquinolines are a novel class of topoisomerase I (top1) inhibitors that are cytotoxic in cancer cell cultures and are therefore under development…”
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Novel Type of Prodrug Activation through a Long-Range O,N‑Acyl Transfer: A Case of Water-Soluble CREB Inhibitor by Li, Bingbing X, Xie, Fuchun, Fan, Qiuhua, Barnhart, Kerry M, Moore, Curtis E, Rheingold, Arnold L, Xiao, Xiangshu

“…CREB (cAMP response element binding protein) has been shown to play an important role in tumor initiation, progression, and metastasis. We discovered that…”
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Effect of E-Ring Modifications in Camptothecin on Topoisomerase I Inhibition:  A Quantum Mechanics Treatment by Xiao, Xiangshu, Cushman, Mark

“…Camptothecins (CPTs) are the prototypical class of topoisomerase I (Top1) inhibitors with significant anticancer activities. Structure−activity relationship…”
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Rapid identification of improved protein ligands using peptoid microarrays by Lim, Hyun-Suk, Muralidhar Reddy, M., Xiao, Xiangshu, Wilson, Johnnie, Wilson, Rosemary, Connell, Steven, Kodadek, Thomas

“…A rapid array-based protocol is presented by which a modest affinity protein-binding small molecule can be appended to a library of peptoids via click…”
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A general system for evaluating the efficiency of chromophore-assisted light inactivation (CALI) of proteins reveals Ru(II) tris-bipyridyl as an unusually efficient "warhead" by Lee, Jiyong, Yu, Peng, Xiao, Xiangshu, Kodadek, Thomas

“…Chromophore-assisted light inactivation (CALI) of proteins is a potentially powerful tool in biological research for the triggered disruption of protein…”
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Design, synthesis, and biological evaluation of cytotoxic 11-aminoalkenylindenoisoquinoline and 11-diaminoalkenylindenoisoquinoline topoisomerase I inhibitors by Xiao, Xiangshu, Antony, Smitha, Kohlhagen, Glenda, Pommier, Yves, Cushman, Mark

“…[Display omitted] The cytotoxic indenoisoquinolines are a novel class of noncamptothecin topoisomerase I inhibitors having certain features that compare…”
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