Search Results - "Xiao, Weibin"

Role of CYP3A in regulating hepatic clearance and hepatotoxicity of triptolide in rat liver microsomes and sandwich-cultured hepatocytes by Shen, Guolin, Zhuang, Xiaomei, Xiao, Weibin, Kong, Linglei, Tan, Yan, Li, Hua

“…•This study reveals that triptolide is a weak and time-dependent CYP3A inhibitor.•CYP3A mediated metabolism is a detoxification pathway of TP in…”
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Potent synergy and sustained bactericidal activity of polymyxins combined with Gram-positive only class of antibiotics versus four Gram-negative bacteria by Wang, Yan, Feng, Jianwen, Yu, Jiameng, Wen, Lirong, Chen, Lidan, An, Huijie, Xiao, Weibin, Zhang, Bing, Feng, Huanhuan, Zhou, Mou, Jiang, Zhihui

“…Gram-negative bacteria (GNB) are becoming increasingly resistant to a wide variety of antibiotics. There are currently limited treatments for GNB, and the…”
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Effectiveness and safety of pembrolizumab for patients with advanced non-small cell lung cancer in real-world studies and randomized controlled trials: A systematic review and meta-analysis by Yang, Beibei, Wang, Bing, Chen, Yongbang, Wan, Ning, Xie, Fei, Yang, Ning, Lu, Liqing, Xiao, Weibin, Yuan, Jin, Li, Jian, Xie, Bo, Ji, Bo

“…Several randomized controlled trials (RCTs) have confirmed the favorable clinical benefit of pembrolizumab in advanced non-small cell lung cancer (NSCLC)…”
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Simultaneous quantification of l‐tetrahydropalmatine and its urine metabolites by ultra high performance liquid chromatography with tandem mass spectrometry by Xiao, Weibin, Zhuang, Xiaomei, Shen, Guolin, Zhong, Yuhuan, Yuan, Mei, Li, Hua

“…l‐tetrahydropalmatine (l‐THP) is a tetrahydroprotoberberine isoquinoline alkaloid that has been used as an analgesic agent in China for more than 40 years…”
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BBB: Permeable Conjugate of Exogenic GABA by Li, Qian, Wang, Shuhao, Xiao, Weibin, Huang, Chunqian, Li, Hua, Sun, Manji

“…Neurotransmitters are the key factors in ameliorating the symptoms of nervous system diseases. Stroke/cerebral ischemia has been proven to be caused by the…”
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Inhibitory effect of ketoconazole, quinidine and 1-aminobenzotriazole on pharmacokinetics of l-tetrahydropalmatine and its metabolite in rats by Xiao, Weibin, Deng, Zhirong, Lai, Chongfa, Lu, Haoyang, Huang, Mutu, Wen, Yuguan, Shi, Lei

“…l-tetrahydropalmatine (l-THP) is mainly metabolised by CYP450 enzymes. This study was to investigate the possible effect of co-administered CYP inhibitors on…”
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Characterization of human metabolism and disposition of levo-tetrahydropalmatine: Qualitative and quantitative determination of oxidative and conjugated metabolites by Xiao, Weibin, Shen, Guolin, Zhuang, Xiaomei, Ran, Xiaorong, Zhu, Mingshe, Li, Hua

“…[Display omitted] •An effective analytical strategy was developed to investigate the metabolism and disposition of l-THP in human.•Twenty metabolites were…”
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Cirrhotic myocardiopathy by Xiao, Weibin, Liu, Yulan

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Rhizosphere and bulk soil enzyme activities in a Nothotsuga longibracteata forest in the Tianbaoyan National Nature Reserve, Fujian Province, China by Xiao, Shihong, You, Huiming, You, Weibin, Liu, Jinshan, Cai, Changtang, Wu, Jianqin, Ji, Zhirong, Zhan, Shihua, Hu, Zhesen, Zhang, Zhongrui, He, Dongjin

“…The rhizosphere, distinct from bulk soil, is defined as the volume of soil around living roots and influenced by root activities. We investigated protease,…”
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