Search Results - "Xiao, Haihua"

RNAi therapeutic and its innovative biotechnological evolution by Weng, Yuhua, Xiao, Haihua, Zhang, Jinchao, Liang, Xing-Jie, Huang, Yuanyu

“…Recently, United States Food and Drug Administration (FDA) and European Commission (EC) approved Alnylam Pharmaceuticals' RNA interference (RNAi) therapeutic,…”
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The challenge and prospect of mRNA therapeutics landscape by Weng, Yuhua, Li, Chunhui, Yang, Tongren, Hu, Bo, Zhang, Mengjie, Guo, Shuai, Xiao, Haihua, Liang, Xing-Jie, Huang, Yuanyu

“…Messenger RNA (mRNA)-based therapeutics hold the potential to cause a major revolution in the pharmaceutical industry because they can be used for precise and…”
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Enhanced Cisplatin Chemotherapy by Iron Oxide Nanocarrier-Mediated Generation of Highly Toxic Reactive Oxygen Species by Ma, Ping’an, Xiao, Haihua, Yu, Chang, Liu, Jianhua, Cheng, Ziyong, Song, Haiqin, Zhang, Xinyang, Li, Chunxia, Wang, Jinqiang, Gu, Zhen, Lin, Jun

“…Reactive oxygen species (ROS) plays a key role in therapeutic effects as well as side effects of platinum drugs. Cisplatin mediates activation of nicotinamide…”
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Theranostic imaging and multimodal photodynamic therapy and immunotherapy using the mTOR signaling pathway by Zhou, Huiling, Tang, Dongsheng, Yu, Yingjie, Zhang, Lingpu, Wang, Bin, Karges, Johannes, Xiao, Haihua

“…Tumor metastases are considered the leading cause of cancer-associated deaths. While clinically applied drugs have demonstrated to efficiently remove the…”
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Sandwich‐Like Fibers/Sponge Composite Combining Chemotherapy and Hemostasis for Efficient Postoperative Prevention of Tumor Recurrence and Metastasis by Zhang, Zhiyun, Kuang, Gaizhen, Zong, Shan, Liu, Shi, Xiao, Haihua, Chen, Xuesi, Zhou, Dongfang, Huang, Yubin

“…Intraoperative bleeding is an essential factor leading to the earliest recurrence and tumor metastasis frequently seen after resection of solid tumors. Local…”
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Light-activatable liposomes for repetitive on-demand drug release and immunopotentiation in hypoxic tumor therapy by Yang, Yuanyuan, Liu, Xin, Ma, Wen, Xu, Qing, Chen, Gui, Wang, Yufei, Xiao, Haihua, Li, Nan, Liang, Xing-Jie, Yu, Meng, Yu, Zhiqiang

“…External stimuli-responsive nanomedicine with desirable repetitive on-demand drug release character is postulated to greatly accommodate patients' flexible…”
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Secreted Protein Acidic and Rich in Cysteine Mediated Biomimetic Delivery of Methotrexate by Albumin-Based Nanomedicines for Rheumatoid Arthritis Therapy by Liu, Lu, Hu, Fanlei, Wang, Hui, Wu, Xiaoli, Eltahan, Ahmed Shaker, Stanford, Stephanie, Bottini, Nunzio, Xiao, Haihua, Bottini, Massimo, Guo, Weisheng, Liang, Xing-Jie

“…Rheumatoid arthritis (RA) is one of the most common chronic autoimmune diseases. Despite considerable advances in clinical treatment of RA, suboptimal response…”
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In Vivo Multimodality Imaging and Cancer Therapy by Near-Infrared Light-Triggered trans-Platinum Pro-Drug-Conjugated Upconverison Nanoparticles by Dai, Yunlu, Xiao, Haihua, Liu, Jianhua, Yuan, Qinghai, Ma, Ping’an, Yang, Dongmei, Li, Chunxia, Cheng, Ziyong, Hou, Zhiyao, Yang, Piaoping, Lin, Jun

“…Controlling anticancer drug activity and release on demand is very significant in cancer therapy. The photoactivated platinum(IV) pro-drug is stable in the…”
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A Targeted and Stable Polymeric Nanoformulation Enhances Systemic Delivery of mRNA to Tumors by Chen, Qixian, Qi, Ruogu, Chen, Xiyi, Yang, Xi, Wu, Sudong, Xiao, Haihua, Dong, Wenfei

“…The high vulnerability of mRNA necessitates the manufacture of delivery vehicles to afford adequate protection in the biological milieu. Here, mRNA was…”
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Advanced biosafety materials for prevention and theranostics of biosafety issues by Ding, Jianxun, Xiao, Haihua, Chen, Xuesi

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Nanoparticle conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer by Qi, Ruogu, Wang, Yongheng, Bruno, Peter M., Xiao, Haihua, Yu, Yingjie, Li, Ting, Lauffer, Sam, Wei, Wei, Chen, Qixian, Kang, Xiang, Song, Haiqin, Yang, Xi, Huang, Xing, Detappe, Alexandre, Matulonis, Ursula, Pepin, David, Hemann, Michael T., Birrer, Michael J., Ghoroghchian, P. Peter

“…Advanced-stage epithelial ovarian cancers are amongst the most difficult to treat tumors and have proven to be refractory to most cytotoxic, molecularly…”
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Nanoparticles destabilizing the cell membranes triggered by NIR light for cancer imaging and photo-immunotherapy by Tang, Dongsheng, Cui, Minhui, Wang, Bin, Liang, Ganghao, Zhang, Hanchen, Xiao, Haihua

“…Cationic polymers have great potential for cancer therapy due to their unique interactions with cancer cells. However, their clinical application remains…”
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Identification of SARS-CoV-2-against aptamer with high neutralization activity by blocking the RBD domain of spike protein 1 by Yang, Ge, Li, Ziyue, Mohammed, Irfan, Zhao, Liping, Wei, Wei, Xiao, Haihua, Guo, Weisheng, Zhao, Yongxiang, Qu, Feng, Huang, Yuanyu

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Near-Infrared Light Irradiation Induced Mild Hyperthermia Enhances Glutathione Depletion and DNA Interstrand Cross-Link Formation for Efficient Chemotherapy by Zhang, Jimei, Zhao, Baochang, Chen, Shizhu, Wang, Yongchao, Zhang, Yuxuan, Wang, Yufei, Wei, Dengshuai, Zhang, Lingpu, Rong, Guanghua, Weng, Yuhua, Hao, Jifu, Li, Binglong, Hou, Xue-Qin, Kang, Xiaoxu, Zhao, Yao, Wang, Fuyi, Zhao, Yongxiang, Yu, Yingjie, Wu, Qin-Pei, Liang, Xing-Jie, Xiao, Haihua

“…DNA alkylating agents generally kill tumor cells by covalently binding with DNA to form interstrand or intrastrand cross-links. However, in the case of…”
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Light triggered release of a triple action porphyrin-cisplatin conjugate evokes stronger immunogenic cell death for chemotherapy, photodynamic therapy and cancer immunotherapy by Song, Haiqin, Cai, Zhenghao, Li, Juyi, Xiao, Haihua, Qi, Ruogu, Zheng, Minhua

“…Abstract Photodynamic therapy (PDT) has emerged as an attractive therapeutic approach which can elicit immunogenic cell death (ICD). However, current ICD…”
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Encapsulation of Platinum Prodrugs into PC7A Polymeric Nanoparticles Combined with Immune Checkpoint Inhibitors for Therapeutically Enhanced Multimodal Chemotherapy and Immunotherapy by Activation of the STING Pathway by Gao, Xiangjie, Lei, Guanxiong, Wang, Bin, Deng, Zhong, Karges, Johannes, Xiao, Haihua, Tan, Donghui

“…Tumor immunotherapy has emerged as one of the most promising therapeutic methods to treat cancer. Despite its clinical application, the immunosuppressive tumor…”
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A prodrug strategy to deliver cisplatin(IV) and paclitaxel in nanomicelles to improve efficacy and tolerance by Xiao, Haihua, Song, Haiqin, Yang, Qiang, Cai, Haidong, Qi, Ruogu, Yan, Lesan, Liu, Shi, Zheng, Yonghui, Huang, Yubin, Liu, Tongjun, Jing, Xiabin

“…Abstract A strategy of preparing composite micelles containing both cisplatin(IV) prodrug and paclitaxel was developed, i.e., synthesizing a cisplatin(IV)…”
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Nanoparticle-mediated convection-enhanced delivery of a DNA intercalator to gliomas circumvents temozolomide resistance by Wang, Yongheng, Jiang, Yuhang, Wei, Dengshuai, Singh, Priya, Yu, Yingjie, Lee, Teresa, Zhang, Lingpu, Mandl, Hanna K., Piotrowski-Daspit, Alexandra S., Chen, Xinyuan, Li, Fan, Li, Xing, Cheng, Yiyu, Josowitz, Alexander, Yang, Fan, Zhao, Yao, Wang, Fuyi, Zhao, Zhenwen, Huttner, Anita, Bindra, Ranjit S., Xiao, Haihua, Mark Saltzman, W.

“…In patients with glioblastoma, resistance to the chemotherapeutic temozolomide (TMZ) limits any survival benefits conferred by the drug. Here we show that the…”
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Degradable Pseudo Conjugated Polymer Nanoparticles with NIR‐II Photothermal Effect and Cationic Quaternary Phosphonium Structural Bacteriostasis for Anti‐Infection Therapy by Zhou, Huiling, Tang, Dongsheng, Kang, Xiaoxu, Yuan, Haitao, Yu, Yingjie, Xiong, Xiaolu, Wu, Nier, Chen, Fangzhou, Wang, Xing, Xiao, Haihua, Zhou, Dongsheng

“…Photothermal therapy based on conjugated polymers represents a promising antibacterial strategy but still possesses notable limitations. Herein, degradable…”
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Co-delivery of daunomycin and oxaliplatin by biodegradable polymers for safer and more efficacious combination therapy by Xiao, Haihua, Li, Wenliang, Qi, Ruogu, Yan, Lesan, Wang, Rui, Liu, Shi, Zheng, Yonghui, Xie, Zhigang, Huang, Yubin, Jing, Xiabin

“…An oxaliplatin pro-drug (Oxa(IV)–COOH) with an axial carboxyl group was synthesized and conjugated to biodegradable polymers with pendant hydroxyl groups to…”
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