Search Results - "Xiankun Zeng"

Enteroendocrine cells are generated from stem cells through a distinct progenitor in the adult Drosophila posterior midgut by Zeng, Xiankun, Hou, Steven X

“…Functional mature cells are continually replenished by stem cells to maintain tissue homoeostasis. In the adult Drosophila posterior midgut, both terminally…”
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Viral genomics in Ebola virus research by Di Paola, Nicholas, Sanchez-Lockhart, Mariano, Zeng, Xiankun, Kuhn, Jens H., Palacios, Gustavo

“…Filoviruses such as Ebola virus continue to pose a substantial health risk to humans. Advances in the sequencing and functional characterization of both…”
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The lipolysis pathway sustains normal and transformed stem cells in adult Drosophila by Singh, Shree Ram, Zeng, Xiankun, Zhao, Jiangsha, Liu, Ying, Hou, Gerald, Liu, Hanhan, Hou, Steven X.

“…Attenuating the lipolysis pathway in Drosophila melanogaster by modulation of the COP1–Arf1 signalling complex induced necrosis in stem cells and led to their…”
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Integration of UPRER and oxidative stress signaling in the control of intestinal stem cell proliferation by Wang, Lifen, Zeng, Xiankun, Ryoo, Hyung Don, Jasper, Heinrich

“…The Unfolded Protein Response of the endoplasmic reticulum (UPRER) controls proteostasis by adjusting the protein folding capacity of the ER to environmental…”
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SARS-CoV-2 leads to a small vessel endotheliitis in the heart by Maccio, Umberto, Zinkernagel, Annelies S., Shambat, Srikanth Mairpady, Zeng, Xiankun, Cathomas, Gieri, Ruschitzka, Frank, Schuepbach, Reto A., Moch, Holger, Varga, Zsuzsanna

“…SARS-CoV-2 infection (COVID-19 disease) can induce systemic vascular involvement contributing to morbidity and mortality. SARS-CoV-2 targets epithelial and…”
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Characterization of midgut stem cell- and enteroblast-specific Gal4 lines in drosophila by Zeng, Xiankun, Chauhan, Chhavi, Hou, Steven X.

“…The homeostasis of Drosophila midgut is maintained by multipotent intestinal stem cells (ISCs), each of which gives rise to a new ISC and an immature daughter…”
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Development of a coronavirus disease 2019 nonhuman primate model using airborne exposure by Johnston, Sara C, Ricks, Keersten M, Jay, Alexandra, Raymond, Jo Lynne, Rossi, Franco, Zeng, Xiankun, Scruggs, Jennifer, Dyer, David, Frick, Ondraya, Koehler, Jeffrey W, Kuehnert, Paul A, Clements, Tamara L, Shoemaker, Charles J, Coyne, Susan R, Delp, Korey L, Moore, Joshua, Berrier, Kerry, Esham, Heather, Shamblin, Joshua, Sifford, Willie, Fiallos, Jimmy, Klosterman, Leslie, Stevens, Stephen, White, Lauren, Bowling, Philip, Garcia, Terrence, Jensen, Christopher, Ghering, Jeanean, Nyakiti, David, Bellanca, Stephanie, Kearney, Brian, Giles, Wendy, Alli, Nazira, Paz, Fabian, Akers, Kristen, Danner, Denise, Barth, James, Johnson, Joshua A, Durant, Matthew, Kim, Ruth, Hooper, Jay W, Smith, Jeffrey M, Kugelman, Jeffrey R, Beitzel, Brett F, Gibson, Kathleen M, Pitt, Margaret L M, Minogue, Timothy D, Nalca, Aysegul

“…Airborne transmission is predicted to be a prevalent route of human exposure with SARS-CoV-2. Aside from African green monkeys, nonhuman primate models that…”
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Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease by Golden, Joseph W, Cline, Curtis R, Zeng, Xiankun, Garrison, Aura R, Carey, Brian D, Mucker, Eric M, White, Lauren E, Shamblin, Joshua D, Brocato, Rebecca L, Liu, Jun, Babka, April M, Rauch, Hypaitia B, Smith, Jeffrey M, Hollidge, Bradley S, Fitzpatrick, Collin, Badger, Catherine V, Hooper, Jay W

“…The emergence of SARS-CoV-2 has created an international health crisis, and small animal models mirroring SARS-CoV-2 human disease are essential for medical…”
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Protective efficacy of a SARS-CoV-2 DNA vaccine in wild-type and immunosuppressed Syrian hamsters by Brocato, Rebecca L., Kwilas, Steven A., Kim, Robert K., Zeng, Xiankun, Principe, Lucia M., Smith, Jeffrey M., Hooper, Jay W.

“…A worldwide effort to counter the COVID-19 pandemic has resulted in hundreds of candidate vaccines moving through various stages of research and development,…”
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Neuropathogenesis of Zika Virus in a Highly Susceptible Immunocompetent Mouse Model after Antibody Blockade of Type I Interferon by Smith, Darci R, Hollidge, Bradley, Daye, Sharon, Zeng, Xiankun, Blancett, Candace, Kuszpit, Kyle, Bocan, Thomas, Koehler, Jeff W, Coyne, Susan, Minogue, Tim, Kenny, Tara, Chi, Xiaoli, Yim, Soojin, Miller, Lynn, Schmaljohn, Connie, Bavari, Sina, Golden, Joseph W

“…Animal models are needed to better understand the pathogenic mechanisms of Zika virus (ZIKV) and to evaluate candidate medical countermeasures. Adult mice…”
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Inhibitory effect of low-molecular-weight peptides (0–3 kDa) from Spirulina platensis on H2O2-induced oxidative damage in L02 human liver cells by Ma, Jun, Zeng, Xiankun, Zhou, Min, Cheng, Le, Ren, Difeng

“…Spirulina platensis protein hydrolysates were prepared by digesting protein extracts with papain, and the hydrolysates were separated into 30, 10, and 3 kDa…”
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Distinct signaling of Drosophila chemoreceptors in olfactory sensory neurons by Cao, Li-Hui, Jing, Bi-Yang, Yang, Dong, Zeng, Xiankun, Shen, Ying, Tu, Yuhai, Luo, Dong-Gen

“…In Drosophila, olfactory sensory neurons (OSNs) rely primarily on two types of chemoreceptors, odorant receptors (Ors) and ionotropic receptors (Irs), to…”
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Nucleocapsid protein-specific monoclonal antibodies protect mice against Crimean-Congo hemorrhagic fever virus by Garrison, Aura R., Moresco, Vanessa, Zeng, Xiankun, Cline, Curtis R., Ward, Michael D., Ricks, Keersten M., Olschner, Scott P., Cazares, Lisa H., Karaaslan, Elif, Fitzpatrick, Collin J., Bergeron, Éric, Pegan, Scott D., Golden, Joseph W.

“…Crimean-Congo hemorrhagic fever virus (CCHFV) is a WHO priority pathogen. Antibody-based medical countermeasures offer an important strategy to mitigate severe…”
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The novel tumour suppressor Madm regulates stem cell competition in the Drosophila testis by Singh, Shree Ram, Liu, Ying, Zhao, Jiangsha, Zeng, Xiankun, Hou, Steven X.

“…Stem cell competition has emerged as a mechanism for selecting fit stem cells/progenitors and controlling tumourigenesis. However, little is known about the…”
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Molecular detection of SARS-CoV-2 in formalin-fixed, paraffin-embedded specimens by Liu, Jun, Babka, April M, Kearney, Brian J, Radoshitzky, Sheli R, Kuhn, Jens H, Zeng, Xiankun

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of human coronavirus disease 2019 (COVID-19), emerged in Wuhan, China, in December…”
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Infection of the maternal-fetal interface and vertical transmission following low-dose inoculation of pregnant rhesus macaques (Macaca mulatta) with an African-lineage Zika virus by Koenig, Michelle R, Mitzey, Ann M, Morgan, Terry K, Zeng, Xiankun, Simmons, Heather A, Mejia, Andres, Leyva Jaimes, Fernanda, Keding, Logan T, Crooks, Chelsea M, Weiler, Andrea M, Bohm, Ellie K, Aliota, Matthew T, Friedrich, Thomas C, Mohr, Emma L, Golos, Thaddeus G

“…Congenital Zika virus (ZIKV) infection can result in birth defects, including malformations in the fetal brain and visual system. There are two distinct…”
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Temporal changes in pathology and viral RNA distribution in guinea pigs following separate infection with two New World Arenaviruses by Cline, Curtis, Zeng, Xiankun, Bell, Todd M., Shaia, Carl, Facemire, Paul, Williams, Janice, Davis, Neil, Babka, April, Picado, Edwin, Fitzpatrick, Colin, Golden, Joseph W.

“…Numerous arenaviruses have been identified throughout the Americas and a subset of these viruses cause viral hemorrhagic fever in humans. This study compared…”
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Smallpox lesion characterization in placebo-treated and tecovirimat-treated macaques using traditional and novel methods by Bell, Todd M, Facemire, Paul, Bearss, Jeremy J, Raymond, Jo Lynne, Chapman, Jennifer, Zeng, Xiankun, Shamblin, Joshua D, Williams, Janice A, Grosenbach, Douglas W, Hruby, Dennis E, Damon, Inger K, Goff, Arthur J, Mucker, Eric M

“…Smallpox was the most rampant infectious disease killer of the 20th century, yet much remains unknown about the pathogenesis of the variola virus. Using…”
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The host inflammatory response contributes to disease severity in Crimean-Congo hemorrhagic fever virus infected mice by Golden, Joseph W, Zeng, Xiankun, Cline, Curtis R, Smith, Jeffrey M, Daye, Sharon P, Carey, Brian D, Blancett, Candace D, Shoemaker, Charles J, Liu, Jun, Fitzpatrick, Collin J, Stefan, Christopher P, Garrison, Aura R

“…Crimean-Congo hemorrhagic fever virus (CCHFV) is an important human pathogen. In cell culture, CCHFV is sensed by the cytoplasmic RNA sensor retinoic…”
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Persistent Crimean-Congo hemorrhagic fever virus infection in the testes and within granulomas of non-human primates with latent tuberculosis by Smith, Darci R, Shoemaker, Charles J, Zeng, Xiankun, Garrison, Aura R, Golden, Joseph W, Schellhase, Christopher W, Pratt, William, Rossi, Franco, Fitzpatrick, Collin J, Shamblin, Joshua, Kimmel, Adrienne, Zelko, Justine, Flusin, Olivier, Koehler, Jeffrey W, Liu, Jun, Coffin, Kayla M, Ricks, Keersten M, Voorhees, Matt A, Schoepp, Randal J, Schmaljohn, Connie S

“…Crimean-Congo hemorrhagic fever (CCHF) is the most medically important tick-borne viral disease of humans and tuberculosis is the leading cause of death…”
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