Search Results - "Xiang, Zhijun"

Identification of key genes affecting ventilator-induced diaphragmatic dysfunction in diabetic mice by Xing, Rongchun, Yu, Haibo, Yu, Jiangtao, Zeng, Rong, Xiang, Zhijun, Ma, Haoli, Li, Gang, Zhao, Yan

“…Mechanical ventilation (MV) is often required in critically ill patients. However, prolonged mechanical ventilation can lead to Ventilator-induced…”
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Anisotropic and Non-Gaussian Diffusion of Thin Nanorods in Polymer Networks by Chen, Yulong, Xiang, Zhijun, Ren, Haozhe, Guo, Fengqin, Ganesan, Venkat, Liu, Jun

“…Understanding the confined diffusion dynamics of anisotropic-shaped nanoparticles in polymer networks is of great importance for many applications. By…”
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A 28GHz CMOS FREQUENCY DOUBLER WITH TFMS by Yang, Tao, Yang, Ziqiang, Chen, Jia, Xiang Zhijun

“…In this paper, a 28GHz CMOS frequency doubler with TFMS (thin film microstrip line) has been introduced in order to experimentally study the possibility of…”
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A big data framework for short-term power load forecasting using heterogenous data by Zhao, Haibo, Xiang, Zhijun, Xiao, Linsong

“…The power system is in a transition towards a more intelligent, flexible and interactive system with higher penetration of renewable energy generation, load…”
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Small-Molecule RORγt Antagonists Inhibit T Helper 17 Cell Transcriptional Network by Divergent Mechanisms by Xiao, Sheng, Yosef, Nir, Yang, Jianfei, Wang, Yonghui, Zhou, Ling, Zhu, Chen, Wu, Chuan, Baloglu, Erkan, Schmidt, Darby, Ramesh, Radha, Lobera, Mercedes, Sundrud, Mark S., Tsai, Pei-Yun, Xiang, Zhijun, Wang, Jinsong, Xu, Yan, Lin, Xichen, Kretschmer, Karsten, Rahl, Peter B., Young, Richard A., Zhong, Zhong, Hafler, David A., Regev, Aviv, Ghosh, Shomir, Marson, Alexander, Kuchroo, Vijay K.

“…We identified three retinoid-related orphan receptor gamma t (RORγt)-specific inhibitors that suppress T helper 17 (Th17) cell responses, including…”
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SPH7854, a gut-limited RORγt antagonist, ameliorates TNBS-induced experimental colitis in rat by Xiang, Zhijun, Zhang, Bingbin, Cao, Shuangyi, Cao, Long, Li, Lingwen, huang, Dehua, Li, Qian, Chen, Yuxiang, Gong, Xuelian, Zhang, Xiaohong, Li, Ruizhi, Wu, Jinmiao, Peng, Yayuan, Huo, Guoyong, Xu, Lixia, Zhang, Zhihui, Li, Di, Xia, Guangxin

“…[Display omitted] •The imbalance of Th17 cells/Treg cells in mucosa of gastrointestinal tract often results in the recruitment and activation of neutrophil and…”
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Increasing human Th17 differentiation through activation of orphan nuclear receptor retinoid acid-related orphan receptor γ (RORγ) by a class of aryl amide compounds by Zhang, Wei, Zhang, Jing, Fang, Leiping, Zhou, Ling, Wang, Shuai, Xiang, Zhijun, Li, Yuan, Wisely, Bruce, Zhang, Guifeng, An, Gang, Wang, Yonghui, Leung, Stewart, Zhong, Zhong

“…In a screen for small-molecule inhibitors of retinoid acid-related orphan receptor γ (RORγ), we fortuitously discovered that a class of aryl amide compounds…”
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Discovery of novel N-(5-(arylcarbonyl)thiazol-2-yl)amides and N-(5-(arylcarbonyl)thiophen-2-yl)amides as potent RORγt inhibitors by Wang, Yonghui, Cai, Wei, Zhang, Guifeng, Yang, Ting, Liu, Qian, Cheng, Yaobang, Zhou, Ling, Ma, Yingli, Cheng, Ziqiang, Lu, Sijie, Zhao, Yong-Gang, Zhang, Wei, Xiang, Zhijun, Wang, Shuai, Yang, Liuqing, Wu, Qianqian, Orband-Miller, Lisa A., Xu, Yan, Zhang, Jing, Gao, Ruina, Huxdorf, Melanie, Xiang, Jia-Ning, Zhong, Zhong, Elliott, John D., Leung, Stewart, Lin, Xichen

“…Novel series of N-(5-(arylcarbonyl)thiazol-2-yl)amides and N-(5-(arylcarbonyl)thiophen-2-yl)amides were discovered as potent retinoic acid receptor-related…”
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Discovery of Biaryl Amides as Potent, Orally Bioavailable, and CNS Penetrant RORγt Inhibitors by Wang, Yonghui, Cai, Wei, Cheng, Yaobang, Yang, Ting, Liu, Qian, Zhang, Guifeng, Meng, Qinghua, Han, Fangbin, Huang, Yafei, Zhou, Ling, Xiang, Zhijun, Zhao, Yong-Gang, Xu, Yan, Cheng, Ziqiang, Lu, Sijie, Wu, Qianqian, Xiang, Jia-Ning, Elliott, John D, Leung, Stewart, Ren, Feng, Lin, Xichen

“…A novel series of biaryl amides was identified as RORγt inhibitors through core replacement of a starting hit 1. Structure–activity relationship exploration on…”
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Discovery of N-(4-aryl-5-aryloxy-thiazol-2-yl)-amides as potent RORγt inverse agonists by Wang, Yonghui, Yang, Ting, Liu, Qian, Ma, Yingli, Yang, Liuqing, Zhou, Ling, Xiang, Zhijun, Cheng, Ziqiang, Lu, Sijie, Orband-Miller, Lisa A., Zhang, Wei, Wu, Qianqian, Zhang, Kathleen, Li, Yi, Xiang, Jia-Ning, Elliott, John D., Leung, Stewart, Ren, Feng, Lin, Xichen

“…[Display omitted] A novel series of N-(4-aryl-5-aryloxy-thiazol-2-yl)-amides as RORγt inverse agonists was discovered. Binding mode analysis of a RORγt partial…”
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From RORγt Agonist to Two Types of RORγt Inverse Agonists by Wang, Yonghui, Cai, Wei, Tang, Ting, Liu, Qian, Yang, Ting, Yang, Liuqing, Ma, Yingli, Zhang, Guifeng, Huang, Yafei, Song, Xiaoxia, Orband-Miller, Lisa A, Wu, Qianqian, Zhou, Ling, Xiang, Zhijun, Xiang, Jia-Ning, Leung, Stewart, Shao, Liming, Lin, Xichen, Lobera, Mercedes, Ren, Feng

“…Biaryl amides as new RORγt modulators were discovered. The crystal structure of biaryl amide agonist 6 in complex with RORγt ligand binding domain (LBD) was…”
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Discovery of Tertiary Amine and Indole Derivatives as Potent RORγt Inverse Agonists by Yang, Ting, Liu, Qian, Cheng, Yaobang, Cai, Wei, Ma, Yingli, Yang, Liuqing, Wu, Qianqian, Orband-Miller, Lisa A, Zhou, Ling, Xiang, Zhijun, Huxdorf, Melanie, Zhang, Wei, Zhang, Jing, Xiang, Jia-Ning, Leung, Stewart, Qiu, Yang, Zhong, Zhong, Elliott, John D, Lin, Xichen, Wang, Yonghui

“…A novel series of tertiary amines as retinoid-related orphan receptor gamma-t (RORγt) inverse agonists was discovered through agonist/inverse agonist…”
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An improved TR method for the measurement of permittivity of powder and liquid samples with slabline by Licun Han, Zhijun Xiang, Bingjie Tao, Minhui Zeng, Yu Zhang, En Li

“…An improved TR (transmission/reflection) method for measuring the complex permittivity of powder and liquid samples with slabline is provided in this paper…”
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Small-Molecule ROR[gamma]t Antagonists Inhibit T Helper 17 Cell Transcriptional Network by Divergent Mechanisms by Xiao, Sheng, Yosef, Nir, Yang, Jianfei, Wang, Yonghui, Zhou, Ling, Zhu, Chen, Wu, Chuan, Baloglu, Erkan, Schmidt, Darby, Ramesh, Radha, Lobera, Mercedes, Sundrud, Mark S, Tsai, Pei-Yun, Xiang, Zhijun, Wang, Jinsong, Xu, Yan, Lin, Xichen, Kretschmer, Karsten, Rahl, Peter B, Young, Richard A, Zhong, Zhong, Hafler, David A, Regev, Aviv, Ghosh, Shomir, Marson, Alexander, Kuchroo, Vijay K

“…We identified three retinoid-related orphan receptor gamma t (RORγt)-specific inhibitors that suppress T helper 17 (Th17) cell responses, including…”
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