Search Results - "Xiang, Qun"

Computational Fragment-Based Drug Design: Current Trends, Strategies, and Applications by Bian, Yuemin, Xie, Xiang-Qun (Sean)

“…Fragment-based drug design (FBDD) has become an effective methodology for drug development for decades. Successful applications of this strategy brought both…”
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Deep Learning for Drug Design: an Artificial Intelligence Paradigm for Drug Discovery in the Big Data Era by Jing, Yankang, Bian, Yuemin, Hu, Ziheng, Wang, Lirong, Xie, Xiang-Qun Sean

“…Over the last decade, deep learning (DL) methods have been extremely successful and widely used to develop artificial intelligence (AI) in almost every domain,…”
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Generative chemistry: drug discovery with deep learning generative models by Bian, Yuemin, Xie, Xiang-Qun

“…The de novo design of molecular structures using deep learning generative models introduces an encouraging solution to drug discovery in the face of the…”
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Gestational Hypoxia and Developmental Plasticity by Ducsay, Charles A, Goyal, Ravi, Pearce, William J, Wilson, Sean, Hu, Xiang-Qun, Zhang, Lubo

“…Hypoxia is one of the most common and severe challenges to the maintenance of homeostasis. Oxygen sensing is a property of all tissues, and the response to…”
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TET2 confers a mechanistic link of microRNA‐210 and mtROS in hypoxia‐suppressed spontaneous transient outward currents in uterine arteries of pregnant sheep by Hu, Xiang‐Qun, Song, Rui, Dasgupta, Chiranjib, Blood, Arlin B., Zhang, Lubo

“…Hypoxia during pregnancy impairs uterine vascular adaptation via microRNA‐210 (miR‐210)‐mediated mitochondrial dysfunction and mitochondrial reactive oxygen…”
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A low temperature formaldehyde gas sensor based on hierarchical SnO/SnO2 nano-flowers assembled from ultrathin nanosheets: Synthesis, sensing performance and mechanism by Li, Na, Fan, Yu, Shi, Ying, Xiang, Qun, Wang, Xiaohong, Xu, Jiaqiang

“…[Display omitted] •Hierarchical SnO/SnO2 nano-flowers were successfully synthesized through a nanosheets self-assembly route under a mild hydrothermal…”
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Hypoxia and the integrated stress response promote pulmonary hypertension and preeclampsia: Implications in drug development by Hu, Xiang-Qun, Zhang, Lubo

“…•Hypoxia is a common cause of pulmonary hypertension and preeclampsia.•Mitochondria and endoplasmic reticulum (ER) are the main targets of the hypoxic…”
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Effects of All-Atom Molecular Mechanics Force Fields on Amyloid Peptide Assembly: The Case of Aβ16–22 Dimer by Man, Viet Hoang, He, Xibing, Derreumaux, Philippe, Ji, Beihong, Xie, Xiang-Qun, Nguyen, Phuong H, Wang, Junmei

“…We investigated the effects of 17 widely used atomistic molecular mechanics force fields (MMFFs) on the structures and kinetics of amyloid peptide assembly. To…”
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Cryo-EM Structure of the Human Cannabinoid Receptor CB2-Gi Signaling Complex by Xing, Changrui, Zhuang, Youwen, Xu, Ting-Hai, Feng, Zhiwei, Zhou, X. Edward, Chen, Maozi, Wang, Lei, Meng, Xing, Xue, Ying, Wang, Junmei, Liu, Heng, McGuire, Terence Francis, Zhao, Gongpu, Melcher, Karsten, Zhang, Cheng, Xu, H. Eric, Xie, Xiang-Qun

“…Drugs selectively targeting CB2 hold promise for treating neurodegenerative disorders, inflammation, and pain while avoiding psychotropic side effects mediated…”
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Mitochondrial Dysfunction in the Pathogenesis of Preeclampsia by Hu, Xiang-Qun, Zhang, Lubo

“…Purpose of Review Preeclampsia complicates 5–10% of all pregnancies and is a leading cause of maternal and perinatal mortality and morbidity. The placenta…”
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SQSTM1/p62: A Potential Target for Neurodegenerative Disease by Ma, Shifan, Attarwala, Insiya Y, Xie, Xiang-Qun

“…Neurodegenerative diseases, characterized by a progressive loss of brain function, affect the lives of millions of individuals worldwide. The complexity of the…”
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Roles and mechanisms of exosomal non-coding RNAs in human health and diseases by Li, Chen, Ni, Yu-Qing, Xu, Hui, Xiang, Qun-Yan, Zhao, Yan, Zhan, Jun-Kun, He, Jie-Yu, Li, Shuang, Liu, You-Shuo

“…Exosomes play a role as mediators of cell-to-cell communication, thus exhibiting pleiotropic activities to homeostasis regulation. Exosomal non-coding RNAs…”
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AlzPlatform: An Alzheimer’s Disease Domain-Specific Chemogenomics Knowledgebase for Polypharmacology and Target Identification Research by Liu, Haibin, Wang, Lirong, Lv, Mingliang, Pei, Rongrong, Li, Peibo, Pei, Zhong, Wang, Yonggang, Su, Weiwei, Xie, Xiang-Qun

“…Alzheimer’s disease (AD) is one of the most complicated progressive neurodegeneration diseases that involve many genes, proteins, and their complex…”
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Development and Testing of Druglike Screening Libraries by Wang, Junmei, Ge, Yubin, Xie, Xiang-Qun

“…Although significant advances in experimental high throughput screening (HTS) have been made for drug lead identification, in silico virtual screening (VS) is…”
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MicroRNA‐210‐mediated mtROS confer hypoxia‐induced suppression of STOCs in ovine uterine arteries by Hu, Xiang‐Qun, Song, Rui, Dasgupta, Chiranjib, Romero, Monica, Juarez, Rucha, Hanson, Jenna, Blood, Arlin B., Wilson, Sean M., Zhang, Lubo

“…Background and Purpose Hypoxia during pregnancy is associated with increased uterine vascular resistance and elevated blood pressure both in women and female…”
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Ca2+-Activated K+ Channels and the Regulation of the Uteroplacental Circulation by Hu, Xiang-Qun, Zhang, Lubo

“…Adequate uteroplacental blood supply is essential for the development and growth of the placenta and fetus during pregnancy. Aberrant uteroplacental perfusion…”
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Long‐term high altitude hypoxia during gestation suppresses large conductance Ca2+‐activated K+ channel function in uterine arteries: a causal role for microRNA‐210 by Hu, Xiang‐Qun, Dasgupta, Chiranjib, Xiao, Jeffery, Yang, Shumei, Zhang, Lubo

“…Key points Gestational hypoxia represses ten–eleven translocation methylcytosine dioxygenase 1 (TET1) expression in uterine arteries, which is recovered by…”
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Hypoxia and Mitochondrial Dysfunction in Pregnancy Complications by Hu, Xiang-Qun, Zhang, Lubo

“…Hypoxia is a common and severe stress to an organism's homeostatic mechanisms, and hypoxia during gestation is associated with significantly increased…”
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Decreased Risk of Radiation Pneumonitis With Incidental Concurrent Use of Angiotensin-Converting Enzyme Inhibitors and Thoracic Radiation Therapy by Kharofa, Jordan, M.D, Cohen, Eric P., M.D, Tomic, Rade, M.D, Xiang, Qun, M.S, Gore, Elizabeth, M.D

“…Purpose Angiotensin-converting enzyme (ACE) inhibitors have been shown to mitigate radiation-induced lung injury in preclinical models. The aim of this study…”
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Function and regulation of large conductance Ca(2+)-activated K+ channel in vascular smooth muscle cells by Hu, Xiang-Qun, Zhang, Lubo

“…Large conductance Ca(2+)-activated K(+) (BK(Ca)) channels are abundantly expressed in vascular smooth muscle cells. Activation of BK(Ca) channels leads to…”
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