Search Results - "Xiang, Jenny Zhaoying"

An Isogenic Human ESC Platform for Functional Evaluation of Genome-wide-Association-Study-Identified Diabetes Genes and Drug Discovery by Zeng, Hui, Guo, Min, Zhou, Ting, Tan, Lei, Chong, Chi Nok, Zhang, Tuo, Dong, Xue, Xiang, Jenny Zhaoying, Yu, Albert S., Yue, Lixia, Qi, Qibin, Evans, Todd, Graumann, Johannes, Chen, Shuibing

“…Genome-wide association studies (GWASs) have increased our knowledge of loci associated with a range of human diseases. However, applying such findings to…”
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Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing by Crespo, Miguel, Vilar, Eduardo, Tsai, Su-Yi, Chang, Kyle, Amin, Sadaf, Srinivasan, Tara, Zhang, Tuo, Pipalia, Nina H, Chen, Huanhuan Joyce, Witherspoon, Mavee, Gordillo, Miriam, Xiang, Jenny Zhaoying, Maxfield, Frederick R, Lipkin, Steven, Evans, Todd, Chen, Shuibing

“…A protocol based on chemical modulation of WNT activity is used to efficiently generate colonic organoids that recapitulate the molecular features of human…”
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Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction by Gómez-Salinero, Jesus Maria, Izzo, Franco, Lin, Yang, Houghton, Sean, Itkin, Tomer, Geng, Fuqiang, Bram, Yaron, Adelson, Robert P., Lu, Tyler M., Inghirami, Giorgio, Xiang, Jenny Zhaoying, Lis, Raphael, Redmond, David, Schreiner, Ryan, Rabbany, Sina Y., Landau, Dan A., Schwartz, Robert E., Rafii, Shahin

“…The liver vascular network is patterned by sinusoidal and hepatocyte co-zonation. How intra-liver vessels acquire their hierarchical specialized functions is…”
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Vaccinia E5 is a major inhibitor of the DNA sensor cGAS by Yang, Ning, Wang, Yi, Dai, Peihong, Li, Tuo, Zierhut, Christian, Tan, Adrian, Zhang, Tuo, Xiang, Jenny Zhaoying, Ordureau, Alban, Funabiki, Hironori, Chen, Zhijian, Deng, Liang

“…The DNA sensor cyclic GMP-AMP synthase (cGAS) is critical in host antiviral immunity. Vaccinia virus (VACV) is a large cytoplasmic DNA virus that belongs to…”
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Discovery of a drug candidate for GLIS3-associated diabetes by Amin, Sadaf, Cook, Brandoch, Zhou, Ting, Ghazizadeh, Zaniar, Lis, Raphael, Zhang, Tuo, Khalaj, Mona, Crespo, Miguel, Perera, Manuradhi, Xiang, Jenny Zhaoying, Zhu, Zengrong, Tomishima, Mark, Liu, Chengyang, Naji, Ali, Evans, Todd, Huangfu, Danwei, Chen, Shuibing

“…GLIS3 mutations are associated with type 1, type 2, and neonatal diabetes, reflecting a key function for this gene in pancreatic β-cell biology. Previous…”
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A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival by Zhou, Ting, Kim, Tae Wan, Chong, Chi Nok, Tan, Lei, Amin, Sadaf, Sadat Badieyan, Zohreh, Mukherjee, Suranjit, Ghazizadeh, Zaniar, Zeng, Hui, Guo, Min, Crespo, Miguel, Zhang, Tuo, Kenyon, Reyn, Robinson, Christopher L., Apostolou, Effie, Wang, Hui, Xiang, Jenny Zhaoying, Evans, Todd, Studer, Lorenz, Chen, Shuibing

“…Common disorders, including diabetes and Parkinson’s disease, are caused by a combination of environmental factors and genetic susceptibility. However,…”
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Using hESCs to Probe the Interaction of the Diabetes-Associated Genes CDKAL1 and MT1E by Guo, Min, Zhang, Tuo, Dong, Xue, Xiang, Jenny Zhaoying, Lei, Minxiang, Evans, Todd, Graumann, Johannes, Chen, Shuibing

“…Genome-wide association studies (GWASs) have identified many disease-associated variant alleles, but understanding whether and how different genes/loci…”
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Derivation and characterization of a UCP1 reporter human ES cell line by Mukherjee, Suranjit, Zhang, Tuo, Lacko, Lauretta A., Tan, Lei, Xiang, Jenny Zhaoying, Butler, Jason M., Chen, Shuibing

“…Interest in human brown fat as a novel therapeutic target to tackle the growing obesity and diabetes epidemic has increased dramatically in recent years. While…”
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Integration of whole-exome and anchored PCR-based next generation sequencing significantly increases detection of actionable alterations in precision oncology by Beg, Shaham, Bareja, Rohan, Ohara, Kentaro, Eng, Kenneth Wha, Wilkes, David C., Pisapia, David J., Zoughbi, Wael Al, Kudman, Sarah, Zhang, Wei, Rao, Rema, Manohar, Jyothi, Kane, Troy, Sigouros, Michael, Xiang, Jenny Zhaoying, Khani, Francesca, Robinson, Brian D., Faltas, Bishoy M., Sternberg, Cora N., Sboner, Andrea, Beltran, Himisha, Elemento, Olivier, Mosquera, Juan Miguel

“…•NGS-based clinical studies have reported detection of clinically relevant alterations in ∼30% of patients.•To increase the detection of potential targets, we…”
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696 Single-cell RNA-seq reveals the critical roles of the STING- and MDA5-mediated cytosolic nucleic acid-sensing pathways as well as IFNAR/STAT2 signaling in recombinant MVA-induced antitumor immunity by Liu, Shuaitong, Mazo, Gregory, Zhang, Tuo, Yang, Ning, Wang, Yi, Tan, Adrian, Wang, Jiahu, Choi, John, Xiang, Jenny Zhaoying, Merghoub, Taha, Wolchok, Jedd, Deng, Liang

“…BackgroundOncolytic viruses are promising therapeutic agents for advanced cancers because of their ability to induce antitumor innate and adaptive immunity…”
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A dual SHOX2:GFP; MYH6:mCherry knockin hESC reporter line for derivation of human SAN-like cells by Ghazizadeh, Zaniar, Zhu, Jiajun, Fattahi, Faranak, Tang, Alice, Sun, Xiaolu, Amin, Sadaf, Tsai, Su-Yi, Khalaj, Mona, Zhou, Ting, Samuel, Ryan M., Zhang, Tuo, Ortega, Francis A., Gordillo, Miriam, Moroziewicz, Dorota, Paull, Daniel, Noggle, Scott A., Xiang, Jenny Zhaoying, Studer, Lorenz, Christini, David J., Pitt, Geoffrey S., Evans, Todd, Chen, Shuibing

“…The sinoatrial node (SAN) is the primary pacemaker of the heart. The human SAN is poorly understood due to limited primary tissue access and limitations in…”
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Detection of rare and novel gene fusions in patients with diffuse glioma: An institutional retrospective study by Ohara, Kentaro, Al Assaad, Majd, McNulty, Samantha N, Alnajar, Hussein, Sboner, Andrea, Wilkes, David C, He, Feng, Xiang, Jenny Zhaoying, Mathew, Susan, Elemento, Olivier, Pisapia, David J, Mosquera, Juan Miguel

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GLI1 -Rearranged Enteric Tumor : Expanding the Spectrum of Gastrointestinal Neoplasms With GLI1 Gene Fusions by Jessurun, José, Orr, Christine, McNulty, Samantha N., Hagen, Catherine E., Alnajar, Hussein, Wilkes, David, Kudman, Sarah, Al Assaad, Majd, Dorsaint, Princesca, Ohara, Kentaro, He, Feng, Chu, Kenrry, Yin, Yong Mei, Xiang, Jenny Zhaoying, Qin, Lihui, Sboner, Andrea, Elemento, Olivier, Yantiss, Rhonda K., Graham, Rondell P., Poizat, Flora, Mosquera, Juan Miguel

“…GLI1 encodes a transcription factor that targets cell cycle regulators affecting stem cell proliferation. GLI1 gene fusions were initially described in…”
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OX40L-expressing recombinant modified vaccinia virus Ankara induces potent antitumor immunity via reprogramming Tregs by Yang, Ning, Wang, Yi, Liu, Shuaitong, Tariq, Shanza Baseer, Luna, Joseph M, Mazo, Gregory, Tan, Adrian, Zhang, Tuo, Wang, Jiahu, Yan, Wei, Choi, John, Rossi, Anthony, Xiang, Jenny Zhaoying, Rice, Charles M, Merghoub, Taha, Wolchok, Jedd D, Deng, Liang

“…Effective depletion of immune suppressive regulatory T cells (Tregs) in the tumor microenvironment without triggering systemic autoimmunity is an important…”
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GLI1-Rearranged Enteric Tumor: Expanding the Spectrum of Gastrointestinal Neoplasms with GLI1 gene fusions by Jessurun, José, Orr, Christine, McNulty, Samantha N., Hagen, Catherine E., Alnajar, Hussein, Wilkes, David, Kudman, Sarah, Al Assaad, Majd, Dorsaint, Princesca, Ohara, Kentaro, He, Feng, Chu, Kenrry, Yin, Yong Mei, Xiang, Jenny Zhaoying, Qin, Lihui, Sboner, Andrea, Elemento, Olivier, Yantiss, Rhonda K., Graham, Rondell P., Poizat, Flora, Mosquera, Juan Miguel

“…GLI1 encodes a transcription factor that targets cell cycle regulators affecting stem cell proliferation. GLI1 gene fusions were initially described in…”
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Abstract 4132: Low-dose carbon monoxide therapies suppress cancer metastasis by Zhang, Tiantian, Zhang, Cheryl, Chen, Xiang, Yang, Xiaoxiao, Mao, Qiyue, Zhang, George, Chen, Zhengming, Tan, Adrian, Xiang, Jenny Zhaoying, Hissong, Erika, Chen, Yao-Tseng, Wang, Binghe, Du, Nancy

“…Abstract Metastasis is the primary cause of cancer-related deaths. Novel systemic therapies for metastatic cancer are urgently needed. Carbon monoxide (CO) is…”
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Corrigendum: Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing by Crespo, Miguel, Vilar, Eduardo, Tsai, Su-Yi, Chang, Kyle, Amin, Sadaf, Srinivasan, Tara, Zhang, Tuo, Pipalia, Nina H, Chen, Huanhuan Joyce, Witherspoon, Mavee, Gordillo, Miriam, Xiang, Jenny Zhaoying, Maxfield, Frederick R, Lipkin, Steven, Evans, Todd, Chen, Shuibing

“…This corrects the article DOI: 10.1038/nm.4355…”
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Erratum: Corrigendum: Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing by Crespo, Miguel, Vilar, Eduardo, Tsai, Su-Yi, Chang, Kyle, Amin, Sadaf, Srinivasan, Tara, Zhang, Tuo, Pipalia, Nina H, Chen, Huanhuan Joyce, Witherspoon, Mavee, Gordillo, Miriam, Xiang, Jenny Zhaoying, Maxfield, Frederick R, Lipkin, Steven, Evans, Todd, Chen, Shuibing

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Correction: Corrigendum: Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing by Crespo, Miguel, Vilar, Eduardo, Tsai, Su-Yi, Chang, Kyle, Amin, Sadaf, Srinivasan, Tara, Zhang, Tuo, Pipalia, Nina H, Chen, Huanhuan Joyce, Witherspoon, Mavee, Gordillo, Miriam, Xiang, Jenny Zhaoying, Maxfield, Frederick R, Lipkin, Steven, Evans, Todd, Chen, Shuibing

“…Nat. Med. 23, 878–884 (2017); published online 19 June 2017; corrected after print 13 March 2018 In the version of this article initially published, there were…”
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Colonic Organoids Derived from Human Pluripotent Stem Cells for Modeling Colorectal Cancer and Drug Testing by Crespo, Miguel, Vilar, Eduardo, Tsai, Su-Yi, Chang, Kyle, Amin, Sadaf, Srinivasan, Tara, Zhang, Tuo, Pipalia, Nina H, Chen, Huanhuan Joyce, Witherspoon, Mavee, Gordillo, Miriam, Xiang, Jenny Zhaoying, Maxfield, Frederick R., Lipkin, Steven, Evans, Todd, Chen, Shuibing

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