Search Results - "Xia, Zuping"

Impact of nonsynonymous single nucleotide polymorphisms on in-vitro metabolism of exemestane by hepatic cytosolic reductases by Platt, Amity, Xia, Zuping, Liu, Ying, Chen, Gang, Lazarus, Philip

“…OBJECTIVEExemestane (EXE) is a potent third-generation aromatase inhibitor used as endocrine therapy in breast cancer treatment and prevention…”
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Synthesis and Evaluation of Novel Inhibitors of Pim-1 and Pim-2 Protein Kinases by Xia, Zuping, Knaak, Christian, Ma, Jian, Beharry, Zanna M, McInnes, Campbell, Wang, Wenxue, Kraft, Andrew S, Smith, Charles D

“…The Pim protein kinases are frequently overexpressed in prostate cancer and certain forms of leukemia and lymphoma…”
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Pim protein kinases regulate energy metabolism and cell growth by Beharry, Zanna, Mahajan, Sandeep, Zemskova, Marina, Lin, Ying-Wei, Tholanikunnel, Baby G, Xia, Zuping, Smith, Charles D, Kraft, Andrew S

“…The serine/threonine Pim kinases are overexpressed in solid cancers and hematologic malignancies and promote cell growth and survival. Here, we find that a…”
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A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma by Lin, Ying-Wei, Beharry, Zanna M., Hill, Elizabeth G., Song, Jin H., Wang, Wenxue, Xia, Zuping, Zhang, Zhenhua, Aplan, Peter D., Aster, Jon C., Smith, Charles D., Kraft, Andrew S.

“…The serine/threonine Pim kinases are up-regulated in specific hematologic neoplasms, and play an important role in key signal transduction pathways, including…”
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Discovery and evaluation of inhibitors of human ceramidase by Draper, Jeremiah M, Xia, Zuping, Smith, Ryan A, Zhuang, Yan, Wang, Wenxue, Smith, Charles D

“…The ceramide/sphingosine-1-phosphate (S1P) rheostat has been hypothesized to play a critical role in regulating tumor cell fate, with elevated levels of…”
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Identification of the 4‑Position of 3‑Alkynyl and 3‑Heteroaromatic Substituted Pyridine Methanamines as a Key Modification Site Eliciting Increased Potency and Enhanced Selectivity for Cytochrome P‑450 2A6 Inhibition by Denton, Travis T., Srivastava, Pramod, Xia, Zuping, Chen, Gang, Watson, Christy J. W., Wynd, Alec, Lazarus, Philip

“…Cigarette smoking causes nearly one in every five deaths in the United States. The development of a specific inhibitor of cytochrome P450 2A6 (CYP2A6), the…”
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Suppression of Ulcerative Colitis in Mice by Orally Available Inhibitors of Sphingosine Kinase by Maines, Lynn W., Fitzpatrick, Leo R., French, Kevin J., Zhuang, Yan, Xia, Zuping, Keller, Staci N., Upson, John J., Smith, Charles D.

“…A critical step in the mechanism of action of inflammatory cytokines is the stimulation of sphingolipid metabolism, including activation of sphingosine kinase…”
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Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells by Beharry, Zanna, Zemskova, Marina, Mahajan, Sandeep, Zhang, Fengxue, Ma, Jian, Xia, Zuping, Lilly, Michael, Smith, Charles D, Kraft, Andrew S

“…The Pim protein kinases play important roles in cancer development and progression, including prostate tumors and hematologic malignancies. To investigate the…”
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Discovery and characterization of inhibitors of human palmitoyl acyltransferases by Ducker, Charles E, Griffel, Lindsay K, Smith, Ryan A, Keller, Staci N, Zhuang, Yan, Xia, Zuping, Diller, John D, Smith, Charles D

“…The covalent attachment of palmitate to specific proteins by the action of palmitoyl acyltransferases (PAT) plays critical roles in the biological activities…”
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Cellular palmitoylation and trafficking of lipidated peptides by Draper, Jeremiah M., Xia, Zuping, Smith, Charles D.

“…Many important signaling proteins require the posttranslational addition of fatty acid chains for their proper subcellular localization and function. One such…”
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Improved synthesis of a fluorogenic ceramidase substrate by Xia, Zuping, Draper, Jeremiah M., Smith, Charles D.

“…Substantial interest has focused on the roles of sphingolipid metabolizing enzymes in a variety of hyperproliferative and inflammatory diseases. A key family…”
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Pharmacokinetics of 3'-O-retinoyl-5-fluoro-2'-deoxyuridine (RFUdR), a dual acting mutually masking prodrug, and its metabolites in tumor bearing mice by Xia, Zuping, Knaus, Edward E, Wiebe, Leonard I

“…3'-O-Retinoyl-5-fluoro-2'-deoxyuridine (RFUdR) is a putative dual-acting, mutually-masking (DAMM) prodrug for the treatment of cancer. As part of the proof of…”
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Synthesis and Evaluation of Dihydropyrroloquinolines That Selectively Antagonize P-Glycoprotein by Lee, Brian D, Li, Zhanjiang, French, Kevin J, Zhuang, Yan, Xia, Zuping, Smith, Charles D

“…In a search for improved multiple drug resistance (MDR) modulators, we identified a novel series of substituted pyrroloquinolines that selectively inhibits the…”
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Cyclohexyl-octahydro-pyrrolo[1,2-a]pyrazine-based inhibitors of human N-myristoyltransferase-1 by French, Kevin J, Zhuang, Yan, Schrecengost, Randy S, Copper, Jean E, Xia, Zuping, Smith, Charles D

“…N-myristoyltransferase (NMT) is an emerging therapeutic target that catalyzes the attachment of myristate to the N terminus of an acceptor protein. We have…”
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Characterization of Cytosolic Glutathione S -Transferases Involved in the Metabolism of the Aromatase Inhibitor, Exemestane by Teslenko, Irina, Watson, Christy J W, Xia, Zuping, Chen, Gang, Lazarus, Philip

“…Exemestane (EXE) is a hormonal therapy used to treat estrogen receptor-positive breast cancer by inhibiting the final step of estrogen biosynthesis catalyzed…”
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Role of glutathione‐S‐transferases in the metabolism of the anti‐cancer agent and aromatase inhibitor, exemestane by Teslenko, Irina L., Chen, Gang, Xia, Zuping, Lazarus, Philip

“…Breast cancer is the most commonly diagnosed cancer in women, with approximately 1 in 8 women in the U.S. developing breast cancer over their lifetime. The…”
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Glutathione‐S‐Transferases Represent a Novel Pathway Contributing to the Metabolic Clearance of the Anti‐Cancer Agent and Aromatase Inhibitor, Exemestane by Teslenko, Irina L, Chen, Gang, Watson, Christy, Xia, Zuping, Lazarus, Philip

“…Breast Cancer is the second leading cause of cancer death among women in the USA, with estrogen‐receptor positive (ER+) tumors accounting for 75% of breast…”
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Cytochrome P450 Enzyme Contributions to the N‐oxide Detoxification Pathway of Tobacco‐Specific Nitrosamines; a Possible Role in Tobacco‐Related Cancer Risk by Perez‐Paramo, Yadira X, Watson, Christy J.W., Xia, Zuping, Chen, Gang, Lazarus, Philip

“…Tobacco‐specific nitrosamines (TSNAs) including 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK) are among the most potent carcinogens found in tobacco…”
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Identification and Quantification of Novel Major Metabolites of the Steroidal Aromatase Inhibitor, Exemestane by Luo, Shaman, Chen, Gang, Truica, Cristina I, Baird, Cynthia C, Xia, Zuping, Lazarus, Philip

“…Exemestane (EXE) is an aromatase inhibitor used for the prevention and treatment of estrogen receptor-positive breast cancer. Although the known major…”
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In vitro metabolism of exemestane by hepatic cytochrome P450s: impact of nonsynonymous polymorphisms on formation of the active metabolite 17β‐dihydroexemestane by Peterson, Amity, Xia, Zuping, Chen, Gang, Lazarus, Philip

“…Exemestane (EXE) is an endocrine therapy commonly used by postmenopausal women with hormone‐responsive breast cancer due to its potency in inhibiting…”
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