Search Results - "Xia, Yuntao"

Bringing precision oncology to cellular resolution with single-cell genomics by Xia, Yuntao, Gawad, Charles

“…Single-cell sequencing technologies have undergone rapid development and adoption by the scientific community in the past 5 years, fueling discoveries about…”
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Mechanosensing by the Lamina Protects against Nuclear Rupture, DNA Damage, and Cell-Cycle Arrest by Cho, Sangkyun, Vashisth, Manasvita, Abbas, Amal, Majkut, Stephanie, Vogel, Kenneth, Xia, Yuntao, Ivanovska, Irena L., Irianto, Jerome, Tewari, Manorama, Zhu, Kuangzheng, Tichy, Elisia D., Mourkioti, Foteini, Tang, Hsin-Yao, Greenberg, Roger A., Prosser, Benjamin L., Discher, Dennis E.

“…Whether cell forces or extracellular matrix (ECM) can impact genome integrity is largely unclear. Here, acute perturbations (∼1 h) to actomyosin stress or ECM…”
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DNA Damage Follows Repair Factor Depletion and Portends Genome Variation in Cancer Cells after Pore Migration by Irianto, Jerome, Xia, Yuntao, Pfeifer, Charlotte R., Athirasala, Avathamsa, Ji, Jiazheng, Alvey, Cory, Tewari, Manu, Bennett, Rachel R., Harding, Shane M., Liu, Andrea J., Greenberg, Roger A., Discher, Dennis E.

“…Migration through micron-size constrictions has been seen to rupture the nucleus, release nuclear-localized GFP, and cause localized accumulations of ectopic…”
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Nuclear rupture at sites of high curvature compromises retention of DNA repair factors by Xia, Yuntao, Ivanovska, Irena L, Zhu, Kuangzheng, Smith, Lucas, Irianto, Jerome, Pfeifer, Charlotte R, Alvey, Cory M, Ji, Jiazheng, Liu, Dazhen, Cho, Sangkyun, Bennett, Rachel R, Liu, Andrea J, Greenberg, Roger A, Discher, Dennis E

“…The nucleus is physically linked to the cytoskeleton, adhesions, and extracellular matrix-all of which sustain forces, but their relationships to DNA damage…”
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Nuclear constriction segregates mobile nuclear proteins away from chromatin by Irianto, Jerome, Pfeifer, Charlotte R, Bennett, Rachel R, Xia, Yuntao, Ivanovska, Irena L, Liu, Andrea J, Greenberg, Roger A, Discher, Dennis E

“…As a cell squeezes its nucleus through adjacent tissue, penetrates a basement membrane, or enters a small blood capillary, chromatin density and nuclear…”
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Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle by Xia, Yuntao, Pfeifer, Charlotte R, Zhu, Kuangzheng, Irianto, Jerome, Liu, Dazhen, Pannell, Kalia, Chen, Emily J, Dooling, Lawrence J, Tobin, Michael P, Wang, Mai, Ivanovska, Irena L, Smith, Lucas R, Greenberg, Roger A, Discher, Dennis E

“…Migration through 3D constrictions can cause nuclear rupture and mislocalization of nuclear proteins, but damage to DNA remains uncertain, as does any effect…”
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Constricted migration increases DNA damage and independently represses cell cycle by Pfeifer, Charlotte R, Xia, Yuntao, Zhu, Kuangzheng, Liu, Dazhen, Irianto, Jerome, García, Victor M Morales, Millán, Leeza M Santiago, Niese, Brandon, Harding, Shane, Deviri, Dan, Greenberg, Roger A, Discher, Dennis E

“…Cell migration through dense tissues or small capillaries can elongate the nucleus and even damage it, and any impact on cell cycle has the potential to affect…”
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Constricted migration modulates stem cell differentiation by Smith, Lucas R, Irianto, Jerome, Xia, Yuntao, Pfeifer, Charlotte R, Discher, Dennis E

“…Tissue regeneration at an injured site depends on proliferation, migration, and differentiation of resident stem or progenitor cells, but solid tissues are…”
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Elastic-Fluid Model for DNA Damage and Mutation from Nuclear Fluid Segregation Due to Cell Migration by Bennett, Rachel R., Pfeifer, Charlotte R., Irianto, Jerome, Xia, Yuntao, Discher, Dennis E., Liu, Andrea J.

“…When cells migrate through constricting pores, they incur DNA damage and develop genomic variation. Experiments show that this damage is not due to DNA…”
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Pyroelectrically Induced Pyro-Electro-Chemical Catalytic Activity of BaTiO3 Nanofibers under Room-Temperature Cold–Hot Cycle Excitations by Xia, Yuntao, Jia, Yanmin, Qian, Weiqi, Xu, Xiaoli, Wu, Zheng, Han, Zichen, Hong, Yuanting, You, Huilin, Ismail, Muhammad, Bai, Ge, Wang, Liwei

“…A pyro-electro-chemical catalytic dye decomposition using lead-free BaTiO3 nanofibers was realized under room-temperature cold-hot cycle excitation (30-47 °C)…”
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Nuclear mechanics during and after constricted migration by Xia, Yuntao, Pfeifer, Charlotte R., Discher, Dennis E.

“…Cell migration through very narrow spaces in tissues has been seen in both physiological and pathological contexts. For example, immune cells squeeze through…”
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Progerin phosphorylation in interphase is lower and less mechanosensitive than lamin-A,C in iPS-derived mesenchymal stem cells by Cho, Sangkyun, Abbas, Amal, Irianto, Jerome, Ivanovska, Irena L., Xia, Yuntao, Tewari, Manu, Discher, Dennis E.

“…Interphase phosphorylation of lamin-A,C depends dynamically on a cell's microenvironment, including the stiffness of extracellular matrix. However,…”
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Strong piezo-electrochemical effect of multiferroic BiFeO3 square micro-sheets for mechanocatalysis by You, Huilin, Jia, Yanmin, Wu, Zheng, Xu, Xiaoli, Qian, Weiqi, Xia, Yuntao, Ismail, Muhammad

“…A strong piezo-electrochemical effect is realized in hydrothermally synthesized multiferroic BiFeO3 micro-sheets via the product of the piezoelectric effect…”
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High-efficiency and mechano-/photo- bi-catalysis of piezoelectric-ZnO@ photoelectric-TiO2 core-shell nanofibers for dye decomposition by You, Huilin, Wu, Zheng, Jia, Yanmin, Xu, Xiaoli, Xia, Yuntao, Han, Zichen, Wang, Yu

“…A mechano-/photo- bi-catalyst of piezoelectric-ZnO@photoelectric-TiO2 core-shell nanofibers was hydrothermally synthesized for Methyl Orange (10 mg L−1)…”
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Thermo-electrochemical coupling for room temperature thermocatalysis in pyroelectric ZnO nanorods by Qian, Weiqi, Wu, Zheng, Jia, Yanmin, Hong, Yuanting, Xu, Xiaoli, You, Huilin, Zheng, Yangqiong, Xia, Yuntao

“…A strong thermo-electrochemical coupling in solvothermally-synthesized ZnO nanorods is achieved by combining pyroelectric effects and electrochemical…”
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Ultrasensitive ECL immunoassay for CA15-3 via self-enhanced L012-loaded ZnNi-MOF as an emitter and CeO2–Pt as a co-reaction accelerator by Cui, Chen, Liu, Naxin, Nian, Qiurui, Xia, Yuntao, Zhao, Liuchuang, Hu, Leqian, Bai, Hongjuan, Jiang, Dechen

“…Improvement in the sensitivity and accuracy of ECL-based biosensors, to a great extent, depends on the fabrication of high-performance electrochemiluminescence…”
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CHALLENGING PGT-M CASES RESOLVED WITH WHOLE GENOME SEQUENCING (WGS) OF EMBRYOS by Katz, Maria H.J., Girod, Rebecca, Chandramohan, Dhruva, Li, Shenglai, Podgursky, Benjamin, Siddiqui, Noor, Xia, Yuntao

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Loss of Chromosomes Monitored in Live Cells by Zhu, Kuangzheng, Xia, Yuntao, Discher, Dennis

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Accurate genomic variant detection in single cells with primary template-directed amplification by Gonzalez-Pena, Veronica, Natarajan, Sivaraman, Xia, Yuntao, Klein, David, Carter, Robert, Pang, Yakun, Shaner, Bridget, Annu, Kavya, Putnam, Daniel, Chen, Wenan, Connelly, Jon, Pruett-Miller, Shondra, Chen, Xiang, Easton, John, Gawad, Charles

“…Improvements in whole genome amplification (WGA) would enable new types of basic and applied biomedical research, including studies of intratissue genetic…”
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VALIDATION STUDY OF ORCHID'S WHOLE GENOME SCREENING PREIMPLANTATION GENETIC TESTING by Katz, Maria H.J., Xia, Yuntao, Chandramohan, Dhruva, Bechor, Elan, Slotnick, Robert Nathan

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