Search Results - "Xia, Xiaohuan"

COVID-19 and Alzheimer's disease: how one crisis worsens the other by Xia, Xiaohuan, Wang, Yi, Zheng, Jialin

“…Alzheimer's disease (AD) has emerged as a key comorbidity of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2…”
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Mitochondrial dysfunction in microglia: a novel perspective for pathogenesis of Alzheimer’s disease by Li, Yun, Xia, Xiaohuan, Wang, Yi, Zheng, Jialin C

“…Abstract Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly globally. Emerging evidence has demonstrated microglia-driven…”
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Editorial: The role of exosomes in neuroinflammation and neurodegeneration by Wang, Yi, Xia, Xiaohuan

“…Furthermore, they found that Rheb is a functional target of miR-155 and that microglial exosomal miR-155 accelerated heat stress-induced neuronal autophagy…”
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ROS-Targeted Depression Therapy via BSA-Incubated Ceria Nanoclusters by Fu, Shengyang, Chen, Huili, Yang, Weitao, Xia, Xiaohuan, Zhao, Shu, Xu, Xiaonan, Ai, Pu, Cai, Qingyuan, Li, Xiangyu, Wang, Yi, Zhu, Jie, Zhang, Bingbo, Zheng, Jialin C.

“…Depression is one of the most fatal mental diseases, and there is currently a lack of efficient drugs for the treatment of depression. Emerging evidence has…”
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Internal m7G methylation: A novel epitranscriptomic contributor in brain development and diseases by Xia, Xiaohuan, Wang, Yi, Zheng, Jialin C.

“…In recent years, N7-methylguanosine (m7G) methylation, originally considered as messenger RNA (mRNA) 5′ caps modifications, has been identified at defined…”
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Extracellular vesicles, from the pathogenesis to the therapy of neurodegenerative diseases by Xia, Xiaohuan, Wang, Yi, Zheng, Jialin C

“…Extracellular vesicles (EVs) are small bilipid layer-enclosed vesicles that can be secreted by all tested types of brain cells. Being a key intercellular…”
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Mechanisms of Ferroptosis and Emerging Links to the Pathology of Neurodegenerative Diseases by Sun, Yiyan, Xia, Xiaohuan, Basnet, Diksha, Zheng, Jialin C., Huang, Jian, Liu, Jianhui

“…Neurodegenerative diseases are a diverse class of diseases attributed to chronic progressive neuronal degeneration and synaptic loss in the brain and/or spinal…”
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Astrocytes: GABAceptive and GABAergic Cells in the Brain by Liu, Jianhui, Feng, Xuanran, Wang, Yi, Xia, Xiaohuan, Zheng, Jialin C.

“…Astrocytes, the most numerous glial cells in the brain, play an important role in preserving normal neural functions and mediating the pathogenesis of…”
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Exosomes released from neural progenitor cells and induced neural progenitor cells regulate neurogenesis through miR-21a by Ma, Yizhao, Li, Chunhong, Huang, Yunlong, Wang, Yi, Xia, Xiaohuan, Zheng, Jialin C

“…Neural stem/progenitor cells (NPCs) are known to have potent therapeutic effects in neurological disorders through secreting exosomes. The limited numbers of…”
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Induced neural progenitor cells abundantly secrete extracellular vesicles and promote the proliferation of neural progenitors via extracellular signal–regulated kinase pathways by Ma, Yizhao, Wang, Kaizhe, Pan, Jiabin, Fan, Zhaohuan, Tian, Changhai, Deng, Xiaobei, Ma, Kangmu, Xia, Xiaohuan, Huang, Yunlong, Zheng, Jialin C.

“…Neural stem/progenitor cells (NPCs) are known to have potent therapeutic effects in neurological disorders through the secretion of extracellular vesicles…”
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Glutaminase 1 Regulates Neuroinflammation After Cerebral Ischemia Through Enhancing Microglial Activation and Pro-Inflammatory Exosome Release by Gao, Ge, Li, Congcong, Zhu, Jie, Wang, Yi, Huang, Yunlong, Zhao, Shu, Sheng, Shiyang, Song, Yu, Ji, Chenhui, Li, Chunhong, Yang, Xiaoyu, Ye, Ling, Qi, Xinrui, Zhang, Yanyan, Xia, Xiaohuan, Zheng, Jialin C

“…Cerebral ischemia induces a robust neuroinflammatory response that is largely mediated by the activation of CNS resident microglia. Activated microglia produce…”
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The microRNA-17 ~ 92 Family as a Key Regulator of Neurogenesis and Potential Regenerative Therapeutics of Neurological Disorders by Xia, Xiaohuan, Wang, Yi, Zheng, Jialin C

“…miR-17 ~ 92, an miRNA family containing three paralogous polycistronic clusters, was initially considered as an oncogene and was later demonstrated to trigger…”
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Glutaminase C Regulates Microglial Activation and Pro-inflammatory Exosome Release: Relevance to the Pathogenesis of Alzheimer's Disease by Gao, Ge, Zhao, Shu, Xia, Xiaohuan, Li, Chunhong, Li, Congcong, Ji, Chenhui, Sheng, Shiyang, Tang, Yalin, Zhu, Jie, Wang, Yi, Huang, Yunlong, Zheng, Jialin C

“…Microglial activation is a key pathogenic process at the onset of Alzheimer's disease (AD). Identifying regulators of microglial activation bears great…”
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Glutaminase 1 deficiency confined in forebrain neurons causes autism spectrum disorder-like behaviors by Ji, Chenhui, Tang, Yalin, Zhang, Yanyan, Huang, Xiaoyan, Li, Congcong, Yang, Yuhong, Wu, Qihui, Xia, Xiaohuan, Cai, Qingyuan, Qi, Xin-Rui, Zheng, Jialin C.

“…An abnormal glutamate signaling pathway has been proposed in the mechanisms of autism spectrum disorder (ASD). However, less is known about the involvement of…”
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Extracellular vesicles derived from glioblastoma promote proliferation and migration of neural progenitor cells via PI3K-Akt pathway by Pan, Jiabin, Sheng, Shiyang, Ye, Ling, Xu, Xiaonan, Ma, Yizhao, Feng, Xuanran, Qiu, Lisha, Fan, Zhaohuan, Wang, Yi, Xia, Xiaohuan, Zheng, Jialin C

“…Glioblastomas are lethal brain tumors under the current combinatorial therapeutic strategy that includes surgery, chemo- and radio-therapies. Extensive changes…”
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Unlocking the Neurogenic Potential of Mammalian Müller Glia by Xia, Xiaohuan, Ahmad, Iqbal

“…Müller glia (MG) are the primary support cells in the vertebrate retina, regulating homeostasis in one of the most metabolically active tissues. In lower…”
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Responsibility and Sustainability in Brain Science, Technology, and Neuroethics in China—a Culture-Oriented Perspective by Wang, Yi, Yin, Jie, Wang, Guoyu, Li, Pingping, Bi, Guoqiang, Li, Suning, Xia, Xiaohuan, Song, Jianren, Pei, Gang, Zheng, Jialin C.

“…The China Brain Project is in development. Integrating an ethical framework to identify and assess ethical challenges and plan for solutions is a priority…”
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m6A Reader Igf2bp1 Regulates the Inflammatory Responses of Microglia by Stabilizing Gbp11 and Cp mRNAs by Ding, Lu, Wu, Huiran, Wang, Yi, Li, Yun, Liang, Zhanping, Xia, Xiaohuan, Zheng, Jialin C

“…Microglia are brain resident cells that function as brain phagocytic macrophages. The inflammatory responses of microglia induced by pathologic insults are key…”
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Neural Stem Cell-Derived Exosomes Regulate Neural Stem Cell Differentiation Through miR-9-Hes1 Axis by Yuan, Ping, Ding, Lu, Chen, Huili, Wang, Yi, Li, Chunhong, Zhao, Shu, Yang, Xiaoyu, Ma, Yizhao, Zhu, Jie, Qi, Xinrui, Zhang, Yanyan, Xia, Xiaohuan, Zheng, Jialin C.

“…Exosomes, a key element of the central nervous system microenvironment, mediate intercellular communication via horizontally transferring bioactive molecules…”
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miR-106b regulates the proliferation and differentiation of neural stem/progenitor cells through Tp53inp1-Tp53-Cdkn1a axis by Xia, Xiaohuan, Lu, Hongfang, Li, Chunhong, Huang, Yunlong, Wang, Yi, Yang, Xiaoyu, Zheng, Jialin C

“…Recent studies suggested that miR-17~106 family was involved in the regulation of neural stem/progenitor cells (NPCs). However, distinct function of each…”
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