Search Results - "Xia, Guoqin"

Reversing conventional site-selectivity in C(sp3)–H bond activation by Xia, Guoqin, Weng, Jiang, Liu, Luoyan, Verma, Pritha, Li, Ziqi, Yu, Jin-Quan

“…One of the core barriers to developing C–H activation reactions is the ability to distinguish between multiple C–H bonds that are nearly identical in terms of…”
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Pd(II)-Catalyzed One-Step Construction of Cycloalkane-Fused Indoles and Its Application in Formal Synthesis of (±)-Aspidospermidine by Xia, Guoqin, Han, Xiuling, Lu, Xiyan

“…A highly efficient, redox-free Pd(II)-catalyzed tandem cyclization reaction initiated by intramolecular aminopalladation of alkynes followed by nucleophilic…”
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Ligand-accelerated non-directed C–H functionalization of arenes by Wang, Peng, Verma, Pritha, Xia, Guoqin, Shi, Jun, Qiao, Jennifer X., Tao, Shiwei, Cheng, Peter T. W., Poss, Michael A., Farmer, Marcus E., Yeung, Kap-Sun, Yu, Jin-Quan

“…Using a ligand as a promoter enhances the reactivity of the palladium catalyst in non-directed C–H functionalization of arenes, enabling the arene to be used…”
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Deoxygenative radical cross-coupling of C(sp3)−O/C(sp3)−H bonds promoted by hydrogen-bond interaction by Wang, Yue, Zhang, Suping, Zeng, Ke, Zhang, Pengli, Song, Xiaorong, Chen, Tie-Gen, Xia, Guoqin

“…Building C(sp 3 )-rich architectures using simple and readily available starting materials will greatly advance modern drug discovery. C(sp 3 )−H and C(sp 3…”
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Unmanned Surface Vehicle Collision Avoidance Trajectory Planning in an Uncertain Environment by Xia, Guoqin, Han, Zhiwei, Zhao, Bo, Wang, Xinwei

“…Unmanned surface vehicles (USVs) can encounter undetected moving obstacles while sailing along a planned global path. USVs need to plan collision avoidance…”
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Palladium(II)-Catalyzed Cyclization Reaction of 2-(Alk-2′-ynyl- oxy)benzonitriles or 2-(Alk-2′-ynylamino)benzonitriles: A Facile Way to 2H-Chromene and 1,2-Dihydroquinoline Derivatives by Xia, Guoqin, Han, Xiuling, Lu, Xiyan

“…An efficient synthesis of 2H‐chromenes and 1,2‐dihydroquinolines from palladium(II)‐catalyzed tandem reactions of 2‐(alk‐2′‐ynyloxy)benzonitriles or…”
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Diversity-oriented synthesis encoded by deoxyoligonucleotides by Hudson, Liam, Mason, Jeremy W., Westphal, Matthias V., Richter, Matthieu J. R., Thielman, Jonathan R., Hua, Bruce K., Gerry, Christopher J., Xia, Guoqin, Osswald, Heather L., Knapp, John M., Tan, Zher Yin, Kokkonda, Praveen, Tresco, Ben I. C., Liu, Shuang, Reidenbach, Andrew G., Lim, Katherine S., Poirier, Jennifer, Capece, John, Bonazzi, Simone, Gampe, Christian M., Smith, Nichola J., Bradner, James E., Coley, Connor W., Clemons, Paul A., Melillo, Bruno, Hon, C. Suk-Yee, Ottl, Johannes, Dumelin, Christoph E., Schaefer, Jonas V., Faust, Ann Marie E., Berst, Frédéric, Schreiber, Stuart L., Zécri, Frédéric J., Briner, Karin

“…Diversity-oriented synthesis (DOS) is a powerful strategy to prepare molecules with underrepresented features in commercial screening collections, resulting in…”
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Author Correction: Diversity-oriented synthesis encoded by deoxyoligonucleotides by Hudson, Liam, Mason, Jeremy W., Westphal, Matthias V., Richter, Matthieu J. R., Thielman, Jonathan R., Hua, Bruce K., Gerry, Christopher J., Xia, Guoqin, Osswald, Heather L., Knapp, John M., Tan, Zher Yin, Kokkonda, Praveen, Tresco, Ben I. C., Liu, Shuang, Reidenbach, Andrew G., Lim, Katherine S., Poirier, Jennifer, Capece, John, Bonazzi, Simone, Gampe, Christian M., Smith, Nichola J., Bradner, James E., Coley, Connor W., Clemons, Paul A., Melillo, Bruno, Hon, C. Suk-Yee, Ottl, Johannes, Dumelin, Christoph E., Schaefer, Jonas V., Faust, Ann Marie E., Berst, Frédéric, Schreiber, Stuart L., Zécri, Frédéric J., Briner, Karin

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Influencing factors of hospital-acquired COVID-19 prevention and control status among emergency support frontline healthcare workers under closed-loop management: a cross-sectional study by Luo, Man, Xia, Guoqin, Gan, Tieer, Zhao, Zhifang, Wu, Jiannong, Hu, Ting, Wang, Lucong, Zhang, Yiyin

“…This study aimed to understand the hospital-acquired COVID-19 infection rate and infection prevention and control status of emergency support frontline…”
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Enantioselective amine α-functionalization via palladium-catalysed C–H arylation of thioamides by Jain, Pankaj, Verma, Pritha, Xia, Guoqin, Yu, Jin-Quan

“…Saturated aza-heterocycles are highly privileged building blocks that are commonly encountered in bioactive compounds and approved therapeutic agents. These…”
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δ‑C–H Mono- and Dihalogenation of Alcohols by Herron, Alastair N, Liu, Dongxin, Xia, Guoqin, Yu, Jin-Quan

“…Alkoxy radicals have long been known to enable remote C–H functionalization via 1,5-hydrogen atom abstraction. However, methods for their generation…”
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Efficient Synthesis of Heterocyle-Fused β‑Naphthylamines via Intramolecular Addition to a Cyano Group Initiated by Nucleopalladation of Alkynes by Xia, Guoqin, Han, Xiuling, Lu, Xiyan

“…A palladium(II)-catalyzed efficient synthesis of heterocycle-fused β-naphthylamines was accomplished via nucleophilic addition of a carbon–palladium bond to…”
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Ligand-Controlled Enantioselective and Regiodivergent Construction of 1,2- and 1,3-Disubstituted Alicycles by Zeng, Ke, Li, Ludi, Luo, Xiaoyao, Wang, Yue, Song, Xiaorong, Zhang, Pengli, Xia, Guoqin

“…Three-dimensional alicyclic skeletons with multiple stereochemically defined chiral centers are highly valuable in modern drug discovery. Here, we reported a…”
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Nickel-Catalyzed, Enantioselective Hydrofluoromethylation of Olefins: Access to Chiral α‑Fluoromethylated Amides and Esters by Du, Yiming, Chen, Shuxin, Cao, Hexiang, Zhang, Yichen, Lei, Hongtao, Xia, Guoqin, Huang, Huicai, Li, Zhaodong

“…We herein report the nickel-catalyzed enantioselective hydrofluoromethylation of enamides and enol esters with CH2FI as the fluoromethyl source to enable the…”
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δ-C–H Mono- and Di-Halogenation of Alcohols by Herron, Alastair N., Liu, Dongxin, Xia, Guoqin, Yu, Jin-Quan

“…Alkoxy radicals have long been known to enable remote C-H functionalization via 1,5-hydrogen atom abstraction. However, methods for their generation…”
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Ligand‐Enabled β‐Methylene C(sp3)−H Arylation of Masked Aliphatic Alcohols by Xia, Guoqin, Zhuang, Zhe, Liu, Luo‐Yan, Schreiber, Stuart L., Melillo, Bruno, Yu, Jin‐Quan

“…Despite recent advances, reactivity and site‐selectivity remain significant obstacles for the practical application of C(sp3)−H bond functionalization methods…”
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Genetic crosses within and between species of Cryptosporidium by Shaw, Sebastian, Cohn, Ian S, Baptista, Rodrigo P, Xia, Guoqin, Melillo, Bruno, Agyabeng-Dadzie, Fiifi, Kissinger, Jessica C, Striepen, Boris

“…Parasites and their hosts are engaged in reciprocal coevolution that balances competing mechanisms of virulence, resistance, and evasion. This often leads to…”
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Proteomic Ligandability Maps of Spirocycle Acrylamide Stereoprobes Identify Covalent ERCC3 Degraders by Liu, Zhonglin, Remsberg, Jarrett R., Li, Haoxin, Njomen, Evert, DeMeester, Kristen E., Tao, Yongfeng, Xia, Guoqin, Hayward, Rachel E., Yoo, Minjin, Nguyen, Tracey, Simon, Gabriel M., Schreiber, Stuart L., Melillo, Bruno, Cravatt, Benjamin F.

“…Covalent chemistry coupled with activity-based protein profiling (ABPP) offers a versatile way to discover ligands for proteins in native biological systems…”
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Enantioselective amine [alpha]-functionalization via palladium-catalysed C-H arylation of thioamides by Jain, Pankaj, Verma, Pritha, Xia, Guoqin, Yu, Jin-quan

“…Saturated aza-heterocycles are highly privileged building blocks that are commonly encountered in bioactive compounds and approved therapeutic agents. These…”
Get full text

Palladium(II)‐Catalyzed Cyclization Reaction of 2‐(Alk‐2′‐ynyl‐ oxy)benzonitriles or 2‐(Alk‐2′‐ynylamino)benzonitriles: A Facile Way to 2 H ‐Chromene and 1,2‐Dihydroquinoline Derivatives by Xia, Guoqin, Han, Xiuling, Lu, Xiyan

“…An efficient synthesis of 2 H ‐chromenes and 1,2‐dihydroquinolines from palladium(II)‐catalyzed tandem reactions of 2‐(alk‐2′‐ynyloxy)benzonitriles or…”
Get full text