Search Results - "Xia, Cindy Q"

Drug efflux transporters and multidrug resistance in acute leukemia: therapeutic impact and novel approaches to mediation by Xia, Cindy Q, Smith, Peter G

“…Multidrug resistance (MDR), which is mediated by multiple drug efflux ATP-binding cassette (ABC) transporters, is a critical issue in the treatment of acute…”
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Quantification of Four Efflux Drug Transporters in Liver and Kidney Across Species Using Targeted Quantitative Proteomics by Isotope Dilution NanoLC-MS/MS by Fallon, John K., Smith, Philip C., Xia, Cindy Q., Kim, Mi-Sook

“…ABSTRACT Purpose The expression levels of several efflux drug transporters in the liver and kidney were evaluated across species to address potential roles of…”
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Recent advances in the translation of drug metabolism and pharmacokinetics science for drug discovery and development by Lai, Yurong, Chu, Xiaoyan, Di, Li, Gao, Wei, Guo, Yingying, Liu, Xingrong, Lu, Chuang, Mao, Jialin, Shen, Hong, Tang, Huaping, Xia, Cindy Q., Zhang, Lei, Ding, Xinxin

“…Drug metabolism and pharmacokinetics (DMPK) is an important branch of pharmaceutical sciences. The nature of ADME (absorption, distribution, metabolism,…”
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In Vitro Drug-Induced Liver Injury Prediction: Criteria Optimization of Efflux Transporter IC50 and Physicochemical Properties by Yucha, Robert W, He, Kan, Shi, Qin, Cai, Lining, Nakashita, Yukie, Xia, Cindy Q, Liao, Mingxiang

“…Drug-induced liver injury (DILI) is a severe drug adverse response, which cannot always be reliably predicted in preclinical or clinical studies. Lack of…”
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Predicting Approximate Clinically Effective Doses in Oncology Using Preclinical Efficacy and Body Surface Area Conversion: A Retrospective Analysis by Griffin, Robert J, Avery, Ethan, Xia, Cindy Q

“…The correlation between efficacious doses in human tumor-xenograft mouse models and the human clinical doses of approved oncology agents was assessed using…”
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Comparison of uptake transporter functions in hepatocytes in different species to determine the optimal model for evaluating drug transporter activities in humans by Liao, Mingxiang, Zhu, Qing, Zhu, Andy, Gemski, Christopher, Ma, Bingli, Guan, Emily, Li, Albert P., Xiao, Guangqing, Xia, Cindy Q.

“…A thorough understanding of species-dependent differences in hepatic uptake transporters is critical for predicting human pharmacokinetics (PKs) from…”
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Preclinical absorption, distribution, metabolism, excretion and pharmacokinetics of a novel selective inhibitor of breast cancer resistance protein (BCRP) by Liao, Mingxiang, Chuang, Bei-Ching, Zhu, Qing, Li, Yuexian, Guan, Emily, Yu, Shaoxia, Yang, Johnny, Prakash, Shimoga, Xia, Cindy Q.

“…1. Breast cancer resistance protein (BCRP) plays an important role in drug absorption, distribution and excretion. It is challenging to evaluate BCRP functions…”
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Comparison of Intrinsic Clearance in Liver Microsomes and Hepatocytes from Rats and Humans: Evaluation of Free Fraction and Uptake in Hepatocytes by CHUANG LU, PING LI, GALLEGOS, Richard, UTTAMSINGH, Vinita, XIA, Cindy Q, MIWA, Gerald T, BALANI, Suresh K, GAN, Liang-Shang

“…Apparent intrinsic clearance (CL int,app ) of 7-ethoxycoumarin, phenacetin, propranolol, and midazolam was measured using rat and human liver microsomes and…”
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EXPRESSION, LOCALIZATION, AND FUNCTIONAL CHARACTERISTICS OF BREAST CANCER RESISTANCE PROTEIN IN CACO-2 CELLS by XIA, Cindy Q, NING LIU, YANG, David, MIWA, Gerald, GAN, Liang-Shang

“…The function of breast cancer resistance protein (BCRP) and its role in drug absorption, distribution, and elimination has recently been evaluated. The…”
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Interactions of Cyclosporin A with Breast Cancer Resistance Protein by XIA, Cindy Q, NING LIU, MIWA, Gerald T, GAN, Liang-Shang

“…The objective of this study was to investigate whether cyclosporin A (CsA) is a modulator for breast cancer resistance protein (BCRP). The interactions between…”
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The Perspective of DMPK on Recombinant Adeno-Associated Virus-Based Gene Therapy: Past Learning, Current Support, and Future Contribution by Chen, Nancy, Sun, Kefeng, Chemuturi, Nagendra Venkata, Cho, Hyelim, Xia, Cindy Q.

“…Given the recent success of gene therapy modalities and the growing number of cell and gene-based therapies in clinical development across many different…”
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Development of minimal physiologically-based pharmacokinetic-pharmacodynamic models for characterizing cellular kinetics of CAR T cells following local deliveries in mice by Tsai, Chia-Hung, Singh, Aman P., Xia, Cindy Q., Wang, Haiqing

“…Chimeric antigen receptor (CAR) T cell therapies have revolutionized the treatment of hematologic malignancies and have potentials for solid tumor treatment…”
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A Reduction in B, T, and Natural Killer Cells Expressing CD38 by TAK-079 Inhibits the Induction and Progression of Collagen-Induced Arthritis in Cynomolgus Monkeys by Korver, Wouter, Carsillo, Mary, Yuan, Josh, Idamakanti, Neeraja, Wagoner, Matthew, Shi, Pu, Xia, Cindy Q, Smithson, Glennda, McLean, Lachy, Zalevsky, Jonathan, Fedyk, Eric R

“…Ectoenzyme CD38 is increased on lymphocytes in response to an antigenic challenge and it is hypothesized that targeting these activated lymphocytes could…”
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INVESTIGATION OF DRUG-DRUG INTERACTION POTENTIAL OF BORTEZOMIB IN VIVO IN FEMALE SPRAGUE-DAWLEY RATS AND IN VITRO IN HUMAN LIVER MICROSOMES by CHUANG LU, GALLEGOS, Richard, PING LI, XIA, Cindy Q, PUSALKAR, Sandeepraj, UTTAMSINGH, Vinita, NIX, Darrell, MIWA, Gerald T, GAN, Liang-Shang

“…Bortezomib (Velcade, PS-341), a dipeptidyl boronic acid, is a first-in-class proteasome inhibitor approved in 2003 for the treatment of multiple myeloma. In a…”
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Variability in P-glycoprotein inhibitory potency (IC₅₀) using various in vitro experimental systems: implications for universal digoxin drug-drug interaction risk assessment decision criteria by Bentz, Joe, O'Connor, Michael P, Bednarczyk, Dallas, Coleman, Joann, Lee, Caroline, Palm, Johan, Pak, Y Anne, Perloff, Elke S, Reyner, Eric, Balimane, Praveen, Brännström, Marie, Chu, Xiaoyan, Funk, Christoph, Guo, Ailan, Hanna, Imad, Herédi-Szabó, Krisztina, Hillgren, Kate, Li, Libin, Hollnack-Pusch, Evelyn, Jamei, Masoud, Lin, Xuena, Mason, Andrew K, Neuhoff, Sibylle, Patel, Aarti, Podila, Lalitha, Plise, Emile, Rajaraman, Ganesh, Salphati, Laurent, Sands, Eric, Taub, Mitchell E, Taur, Jan-Shiang, Weitz, Dietmar, Wortelboer, Heleen M, Xia, Cindy Q, Xiao, Guangqing, Yabut, Jocelyn, Yamagata, Tetsuo, Zhang, Lei, Ellens, Harma

“…A P-glycoprotein (P-gp) IC₅₀ working group was established with 23 participating pharmaceutical and contract research laboratories and one academic institution…”
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Comparison of Species Differences of P-Glycoproteins in Beagle Dog, Rhesus Monkey, and Human Using ATPase Activity Assays by Xia, Cindy Q, Xiao, Guangqing, Liu, Ning, Pimprale, Satish, Fox, Lisa, Patten, Chris J, Crespi, Charles L, Miwa, Gerald, Gan, Liang-Shang

“…P-glycoprotein (P-gp) is a transmembrane efflux transporter which possesses many important functions in drug absorption, disposition, metabolism, and toxicity…”
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PK/PD and Bioanalytical Considerations of AAV-Based Gene Therapies: an IQ Consortium Industry Position Paper by Kavita, Uma, Sun, Kefeng, Braun, Manuela, Lembke, Wibke, Mody, Hardik, Kamerud, John, Yang, Tong-Yuan, Braun, Inka V., Fang, Xiaodong, Gao, Wei, Gupta, Swati, Hofer, Magdalena, Liao, Michael Z., Loo, LiNa, McBlane, Fraser, Menochet, Karelle, Stubenrauch, Kay-Gunnar, Upreti, Vijay V., Vigil, Adam, Wiethoff, Christopher M., Xia, Cindy Q., Zhu, Xu, Jawa, Vibha, Chemuturi, Nagendra

“…Interest and efforts to use recombinant adeno-associated viruses (AAV) as gene therapy delivery tools to treat disease have grown exponentially. However, gaps…”
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Sinusoidal Organic Anion-Transporting Polypeptide 1B1/1B3 and Bile Canalicular Multidrug Resistance-Associated Protein 2 Play an Essential Role in the Hepatobiliary Disposition of a Synthetic Cyclic Dinucleotide (STING Agonist) by Sandoval, Philip, Chuang, Bei-Ching, Fallon, John K., Smith, Philip C., Chowdhury, Swapan K., Griffin, Robert J., Xia, Cindy Q., Iwasaki, Shinji, Chothe, Paresh P.

“…The liver is central to the elimination of many drugs from the body involving multiple processes and understanding of these processes is important to…”
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Preclinical Antitumor Activity and Biodistribution of a Novel Anti-GCC Antibody–Drug Conjugate in Patient-derived Xenografts by Abu-Yousif, Adnan O., Cvet, Donna, Gallery, Melissa, Bannerman, Bret M., Ganno, Michelle L., Smith, Michael D., Lai, Katharine C., Keating, Thomas A., Stringer, Bradley, Kamali, Afrand, Eng, Kurt, Koseoglu, Secil, Zhu, Andy, Xia, Cindy Q., Landen, Melissa Saylor, Borland, Maria, Robertson, Robbie, Bolleddula, Jayaprakasam, Qian, Mark G., Fretland, Jennifer, Veiby, O. Petter

“…Abstract Guanylyl cyclase C (GCC) is a unique therapeutic target with expression restricted to the apical side of epithelial cell tight junctions thought to be…”
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Utilizing In Vitro Dissolution-Permeation Chamber for the Quantitative Prediction of pH-Dependent Drug-Drug Interactions with Acid-Reducing Agents: a Comparison with Physiologically Based Pharmacokinetic Modeling by Zhu, Andy Z. X., Ho, Ming-Chih David, Gemski, Christopher K., Chuang, Bei-Ching, Liao, Mingxiang, Xia, Cindy Q.

“…For many orally administered basic drugs with pH-dependent solubility, concurrent administration with acid-reducing agents (ARAs) can significantly impair…”
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