Search Results - "Xia, Anjie"

Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes by Xiao, Peng, Yan, Wei, Gou, Lu, Zhong, Ya-Ni, Kong, Liangliang, Wu, Chao, Wen, Xin, Yuan, Yuan, Cao, Sheng, Qu, Changxiu, Yang, Xin, Yang, Chuan-Cheng, Xia, Anjie, Hu, Zhenquan, Zhang, Qianqian, He, Yong-Hao, Zhang, Dao-Lai, Zhang, Chao, Hou, Gui-Hua, Liu, Huanxiang, Zhu, Lizhe, Fu, Ping, Yang, Shengyong, Rosenbaum, Daniel M., Sun, Jin-Peng, Du, Yang, Zhang, Lei, Yu, Xiao, Shao, Zhenhua

“…Dopamine receptors, including D1- and D2-like receptors, are important therapeutic targets in a variety of neurological syndromes, as well as cardiovascular…”
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A new generation Mpro inhibitor with potent activity against SARS-CoV-2 Omicron variants by Huang, Chong, Shuai, Huiping, Qiao, Jingxin, Hou, Yuxin, Zeng, Rui, Xia, Anjie, Xie, Lingwan, Fang, Zhen, Li, Yueyue, Yoon, Chaemin, Huang, Qiao, Hu, Bingjie, You, Jing, Quan, Baoxue, Zhao, Xiu, Guo, Nihong, Zhang, Shiyu, Ma, Ronggang, Zhang, Jiahao, Wang, Yifei, Yang, Ruicheng, Zhang, Shanshan, Nan, Jinshan, Xu, Haixing, Wang, Falu, Lei, Jian, Chu, Hin, Yang, Shengyong

“…Emerging SARS-CoV-2 variants, particularly the Omicron variant and its sublineages, continually threaten the global public health. Small molecule antivirals…”
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Discovery of 5-((1H-indazol-3-yl) methylene)-2-thioxoimidazolidin-4-one derivatives as a new class of AHR agonists with anti-psoriasis activity in a mouse model by Zhang, Guo, Xia, Ziyi, Tian, Chenyu, Xia, Anjie, You, Jing, Liu, Jie, Yang, Shengyong, Li, Linli

“…[Display omitted] Aryl hydrocarbon receptor (AHR) is a ligand dependent transcription factor and participates in the regulation of the immune balance of…”
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Structure‐Guided Discovery of a Potent and Selective Cell‐Active Inhibitor of SETDB1 Tudor Domain by Guo, Yinping, Mao, Xin, Xiong, Liang, Xia, Anjie, You, Jing, Lin, Guifeng, Wu, Chengyong, Huang, Luyi, Wang, Yiwei, Yang, Shengyong

“…SET domain bifurcated protein 1 (SETDB1) is a histone lysine methyltransferase that promotes the silencing of some tumour suppressor genes and is overexpressed…”
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C3 ester side chain plays a pivotal role in the antitumor activity of Maytansinoids by Li, Wenting, Huang, Minhao, Li, Yuyan, Xia, Anjie, Tan, Lun, Zhang, Zhixiong, Wang, Yuxi, Yang, Jinliang

“…Maytansinoids, the chemical derivatives of Maytansine, are commonly used as potent cytotoxic payloads in antibody-drug conjugates (ADC)…”
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Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1 by Yang, Xin, Wang, Xuehui, Xu, Zheng, Wu, Chao, Zhou, Yangli, Wang, Yifei, Lin, Guifeng, Li, Kan, Wu, Ming, Xia, Anjie, Liu, Jingming, Cheng, Lin, Zou, Jun, Yan, Wei, Shao, Zhenhua, Yang, Shengyong

“…Given the promising clinical value of allosteric modulators of G protein-coupled-receptors (GPCRs), mechanistic understanding of how these modulators alter…”
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Discovery of (S)-3-(4-(benzyloxy)phenyl)-2-(2-phenoxyacetamido)propanoic acid derivatives as a new class of GPR34 antagonists by Zhou, Pei, Zhao, Jinlong, Hu, Qian, Lin, Guifeng, Zhang, Jiahao, Xia, Anjie, Zhang, Shiyu, Nan, Jinshan, Li, Linli

“…[Display omitted] GPR34 is a rhodopsin-like class G protein-coupled receptor (GPCR) that is involved in the development and progression of several diseases…”
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Discovery of 2-vinyl-10H-phenothiazine derivatives as a class of ferroptosis inhibitors with minimal human Ether-a-go-go related gene (hERG) activity for the treatment of DOX-induced cardiomyopathy by You, Jing, Yang, Wei, Ma, Ronggang, Xia, Anjie, Zhang, Guo, Fang, Zhen, Guo, Nihong, Yang, Shengyong, Li, Linli

“…[Display omitted] Ferroptosis was an iron-dependent, nonapoptotic form of regulated cell death. In our previous study, we discovered a potent ferroptosis…”
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Metal-Free Aerobic Oxidative Selective C–C Bond Cleavage in Heteroaryl-Containing Primary and Secondary Alcohols by Xia, Anjie, Qi, Xueyu, Mao, Xin, Wu, Xiaoai, Yang, Xin, Zhang, Rong, Xiang, Zhiyu, Lian, Zhong, Chen, Yingchun, Yang, Shengyong

“…A transition-metal-free aerobic oxidative selective C–C bond-cleavage reaction in primary and secondary heteroaryl alcohols is reported. This reaction was…”
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Identification of a new class of activators of the Hippo pathway with antitumor activity in vitro and in vivo by Lin, Guifeng, Xia, Anjie, Qiao, Jingxin, Zhang, Hailin, Chen, Pei, Zhou, Pei, Hu, Qian, Xiang, Zhiyu, Zhang, Shiyu, Li, Linli, Yang, Shengyong

“…[Display omitted] The Hippo pathway is a key regulator of tissue growth, organ size, and tumorigenesis. Activating the Hippo pathway by gene editing or…”
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Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis by Jiao, Yan, Nan, Jinshan, Mu, Bo, Zhang, Yun, Zhou, Nenghua, Yang, Shunhua, Zhang, Shanshan, Lin, Wanting, Wang, Falu, Xia, Anjie, Cao, Zhixing, Chen, Pei, Pan, Zhiling, Lin, Guifeng, Pan, Shulei, Bin, Huachao, Li, Linli, Yang, Shengyong

“…The NLRP3 inflammasome, which regulated a proinflammatory programmed cell death form termed pyroptosis, is involved in the pathological process of various…”
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Discovery of Small Molecule Agonist of Gonadotropin-Releasing Hormone Receptor (GnRH1R) by Yang, Xin, Lin, Guifeng, Xia, Anjie, Liu, Jingming, Zhang, Shiyu, Zhou, Pei, Wang, Yiwei, Zhang, Jiahao, Zhou, Yangli, Chen, Pei, Wang, Yifei, Zheng, Tao, Li, Linli, Yang, Shengyong

“…The gonadotrophin-releasing hormone (GnRH) is a central regulator of the human reproductive system and exerts physiological effects by binding to GnRH1R. The…”
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Discovery of benzodiazepine derivatives as a new class of covalent inhibitors of SARS-CoV–2 main protease by Wang, Falu, Zeng, Rui, Qiao, Jingxin, Xia, Anjie, Li, Yueshan, Li, Feng, Wu, Yunjie, Liu, Yuanzhi, Zhao, Xiu, Lei, Jian, Yang, Shengyong

“…[Display omitted] The COVID-19 pandemic has caused people immense suffering all over the world. Although the World Health Organization (WHO) has announced the…”
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Structure-based identification of a G protein-biased allosteric modulator of cannabinoid receptor CB1 by Shen, Siyuan, Wu, Chao, Lin, Guifeng, Yang, Xin, Zhou, Yangli, Zhao, Chang, Miao, Zhuang, Tian, Xiaowen, Wang, Kexin, Yang, Zhiqian, Liu, Zhiyu, Guo, Nihong, Li, Yueshan, Xia, Anjie, Zhou, Pei, Liu, Jingming, Yan, Wei, Ke, Bowen, Yang, Shengyong, Shao, Zhenhua

“…is known for its therapeutic benefit in various diseases including pain relief by targeting cannabinoid receptors. The primary component of cannabis,…”
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Discovery of 3-phenyl-1,2,4-oxadiazole derivatives as a new class of SARS-CoV-2 main protease inhibitors by Guo, Nihong, Huang, Chong, Qiao, Jingxin, Li, Yueyue, Wang, Yifei, Xia, Anjie, Zhang, Guo, Fang, Zhen, You, Jing, Li, Linli

“…[Display omitted] The ongoing COVID-19 pandemic has led to massive infections and deaths and caused tremendous grief among the people. Although vaccines have…”
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Discovery of 1,8-disubstituted-[1,2,3]triazolo[4,5-c]quinoline derivatives as a new class of Hippo signaling pathway inhibitors by Qiao, Jingxin, Lin, Guifeng, Xia, Anjie, Xiang, Zhiyu, Chen, Pei, Zhang, Guo, Li, Linli, Yang, Shengyong

“…[Display omitted] Inhibitors of the Hippo signaling pathway have been demonstrated to have a potential clinical application in cases such as tissue repair and…”
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Discovery of a novel pyroptosis inhibitor acting though modulating glutathionylation to suppress NLRP3-related signal pathway by Zhou, Nenghua, Zhang, Yun, Jiao, Yan, Nan, Jinshan, Xia, Anjie, Mu, Bo, Lin, Guifeng, Li, Xun, Zhang, Shanshan, Yang, Shengyong, Li, Linli

“…Pyroptosis is a proinflammatory type of regulated cell death and has been involved in many pathological processes. Inhibition of pyroptosis is thought to be a…”
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Corrigendum to “Discovery of a potent, selective and cell active inhibitor of m6A demethylase ALKBH5” [Eur. J. Med. Chem. 238 (2022) 114446] by Fang, Zhen, Mu, Bo, Liu, Yang, Guo, Nihong, Xiong, Liang, Guo, Yinping, Xia, Anjie, Zhang, Rong, Zhang, Hailin, Yao, Rui, Fan, Yan, Li, Linli, Yang, Shengyong, Xiang, Rong

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Discovery of 6,7-dihydro-5H-pyrrolo[3,4-d] pyrimidine derivatives as a new class of ATR inhibitors by Chen, Pei, Bin, Huachao, Jiao, Yan, Lin, Guifeng, Zhang, Yun, Xia, Anjie, Pan, Zhilin, Qiao, Jingxin, Guo, Yinping, Liu, Jingming, Zhou, Yangli, Li, Linli

“…[Display omitted] Ataxia telangiectasia and Rad3-related (ATR) kinase is a key regulating protein within the DNA damage response (DDR), responsible for sensing…”
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Discovery of 4‑(1,2,4-Oxadiazol-5-yl)azepan-2-one Derivatives as a New Class of Cannabinoid Type 2 Receptor Agonists for the Treatment of Inflammatory Pain by Nan, Jinshan, Liu, Jingming, Lin, Guifeng, Zhang, Shanshan, Xia, Anjie, Zhou, Pei, Zhou, Yangli, Zhang, Jiahao, Zhao, Jinlong, Zhang, Shiyu, Huang, Chong, Wang, Yifei, Hu, Qian, Chen, Junxian, Xiang, Mingli, Yang, Xin, Yang, Shengyong

“…Selectively targeting the cannabinoid receptor CB2 is an attractive therapeutic strategy for the treatment of inflammatory pain without psychiatric side…”
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