Search Results - "Xi, Jinxiang"
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Correlating exhaled aerosol images to small airway obstructive diseases: A study with dynamic mode decomposition and machine learning
Published in PloS one (31-01-2019)“…Exhaled aerosols from lungs have unique patterns, and their variation can be correlated to the underlying lung structure and associated abnormities. However,…”
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Computational analysis of a flapping uvula on aerodynamics and pharyngeal wall collapsibility in sleep apnea
Published in Journal of biomechanics (20-09-2019)“…Studying the airflows and the resultant aerodynamic pressure/force in the pharyngeal airway is critical for understanding the pathophysiology of snoring and…”
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Radiation Dosimetry of Inhaled Radioactive Aerosols: CFPD and MCNP Transport Simulations of Radionuclides in the Lung
Published in Scientific reports (25-11-2019)“…Despite extensive efforts in studying radioactive aerosols, including the transmission of radionuclides in different chemical matrices throughout the body, the…”
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Oropharyngeal swallowing hydrodynamics of thin and mildly thick liquids in an anatomically accurate throat-epiglottis model
Published in Scientific reports (25-05-2024)“…Understanding the mechanisms underlying dysphagia is crucial in devising effective, etiology-centered interventions. However, current clinical assessment and…”
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Effect of MDI Actuation Timing on Inhalation Dosimetry in a Human Respiratory Tract Model
Published in Pharmaceuticals (Basel, Switzerland) (04-01-2022)“…Accurate knowledge of the delivery of locally acting drug products, such as metered-dose inhaler (MDI) formulations, to large and small airways is essential to…”
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Numerical predictions of submicrometer aerosol deposition in the nasal cavity using a novel drift flux approach
Published in International journal of heat and mass transfer (01-11-2008)“…Evaluating the health effects of inhaled submicrometer aerosols, such as combustion particulate matter and bioaerosols, requires a thorough understanding of…”
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Visualization and Estimation of Nasal Spray Delivery to Olfactory Mucosa in an Image-Based Transparent Nasal Model
Published in Pharmaceutics (01-06-2023)“…Nose-to-brain (N2B) drug delivery offers unique advantages over intravenous methods; however, the delivery efficiency to the olfactory region using…”
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Assessing Nasal Epithelial Dynamics: Impact of the Natural Nasal Cycle on Intranasal Spray Deposition
Published in Pharmaceuticals (Basel, Switzerland) (01-01-2024)“…This study investigated the intricate dynamics of intranasal spray deposition within nasal models, considering variations in head orientation and stages of the…”
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Transport and deposition of micro-aerosols in realistic and simplified models of the oral airway
Published in Annals of biomedical engineering (01-04-2007)“…A number of in vivo, in vitro and numerical studies have considered flow field characteristics and micro-particle deposition in the oral airway extending from…”
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Effects of Nozzle Retraction Elimination on Spray Distribution in Middle-Posterior Turbinate Regions: A Comparative Study
Published in Pharmaceutics (01-05-2024)“…The standard multi-dose nasal spray pump features an integrated actuator and nozzle, which inevitably causes a retraction of the nozzle tip during application…”
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A next‐generation vaccine for broader and long‐lasting COVID‐19 protection
Published in MedComm (2020) (01-06-2022)“…[...]including the N and RdRp antigens besides S1 was expected to elicit a broader and long-lasting immunity. [...]how well can it improve clinical outcomes…”
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Liquid Film Translocation Significantly Enhances Nasal Spray Delivery to Olfactory Region: A Numerical Simulation Study
Published in Pharmaceutics (18-06-2021)“…Previous in vivo and ex vivo studies have tested nasal sprays with varying head positions to enhance the olfactory delivery; however, such studies often…”
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Delivery of Agarose-aided Sprays to the Posterior Nose for Mucosa Immunization and Short-term Protection against Infectious Respiratory Diseases
Published in Current pharmaceutical biotechnology (01-01-2024)“…The study aimed to deliver sprays to the posterior nose for mucosa immunization or short-term protection. Respiratory infectious diseases often enter the human…”
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Sensitivity Analysis and Uncertainty Quantification of Nanoparticle Deposition from Tongue Morphological Variations
Published in Life (Basel, Switzerland) (01-03-2024)“…The human tongue has highly variable morphology. Its role in regulating respiratory flows and deposition of inhaled aerosols remains unclear. The objective of…”
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Numerical study of dynamic glottis and tidal breathing on respiratory sounds in a human upper airway model
Published in Sleep & breathing (01-05-2018)“…Background Human snores are caused by vibrating anatomical structures in the upper airway. The glottis is a highly variable structure and a critical organ…”
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Pulmonary Oxygen Exchange in a Rhythmically Expanding–Contracting Alveolus–Capillary Model
Published in Journal of respiration (08-11-2022)“…Pulmonary gas exchanges are vital to human health, and disruptions to this process have been associated with many respiratory diseases. Previous gas exchange…”
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Lower Inspiratory Breathing Depth Enhances Pulmonary Delivery Efficiency of ProAir Sprays
Published in Pharmaceuticals (Basel, Switzerland) (03-06-2022)“…Effective pulmonary drug delivery using a metered-dose inhaler (MDI) requires a match between the MDI sprays, the patient’s breathing, and respiratory…”
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Multi-Level Training and Testing of CNN Models in Diagnosing Multi-Center COVID-19 and Pneumonia X-ray Images
Published in Applied sciences (01-09-2023)“…This study aimed to address three questions in AI-assisted COVID-19 diagnostic systems: (1) How does a CNN model trained on one dataset perform on test…”
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Nanoparticle Deposition in Rhythmically Moving Acinar Models with Interalveolar Septal Apertures
Published in Nanomaterials (Basel, Switzerland) (04-08-2019)“…Pulmonary delivery of nanomedicines has been extensively studied in recent years because of their enhanced biocompatibility, sustained-release properties, and…”
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Data-Driven Discovery of Anomaly-Sensitive Parameters from Uvula Wake Flows Using Wavelet Analyses and Poincaré Maps
Published in Acoustics (Basel, Switzerland) (01-12-2023)“…This study presents a data-driven approach to identifying anomaly-sensitive parameters through a multiscale, multifaceted analysis of simulated respiratory…”
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