Search Results - "Xi, Jianzhong"
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MAVS activates TBK1 and IKKε through TRAFs in NEMO dependent and independent manner
Published in PLoS pathogens (01-11-2017)“…Mitochondrial antiviral-signaling protein (MAVS) transmits signals from RIG-I-like receptors after RNA virus infections. However, the mechanism by which MAVS…”
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Recurrently deregulated lncRNAs in hepatocellular carcinoma
Published in Nature communications (13-02-2017)“…Hepatocellular carcinoma (HCC) cells often invade the portal venous system and subsequently develop into portal vein tumour thrombosis (PVTT). Long noncoding…”
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Integrated analysis of lncRNA, miRNA and mRNA reveals novel insights into the fertility regulation of large white sows
Published in BMC genomics (14-09-2020)“…Improving sow fertility is extremely important as it can lead to increased reproductive efficiency and thus profitability for swine producers. There are…”
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FAM3D is essential for colon homeostasis and host defense against inflammation associated carcinogenesis
Published in Nature communications (20-11-2020)“…The physiological homeostasis of gut mucosal barrier is maintained by both genetic and environmental factors and its impairment leads to pathogenesis such as…”
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Efficient generation of mice carrying homozygous double-floxp alleles using the Cas9-Avidin/Biotin-donor DNA system
Published in Cell research (01-04-2017)“…The clustered, regularly interspaced, short palin- dromic repeats (CRISPR)/CRISPR-associated protein 9 (Casg) system is a versatile tool for genomic…”
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Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9
Published in Proceedings of the National Academy of Sciences - PNAS (19-11-2013)“…The ability to engineer genomes in a specific, systematic, and cost-effective way is critical for functional genomic studies. Recent advances using the…”
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Clathrin and phosphatidylinositol-4,5-bisphosphate regulate autophagic lysosome reformation
Published in Nature cell biology (01-09-2012)“…Autophagy is a lysosome-based degradation pathway. During autophagy, lysosomes fuse with autophagosomes to form autolysosomes. Following starvation-induced…”
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Biocompatibility Assessment of Detonation Nanodiamond in Non-Human Primates and Rats Using Histological, Hematologic, and Urine Analysis
Published in ACS nano (23-08-2016)“…Detonation nanodiamonds (DNDs) have been widely explored for biomedical applications ranging from cancer therapy to magnetic resonance imaging due to several…”
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High-Throughput Profiling of Cas12a Orthologues and Engineered Variants for Enhanced Genome Editing Activity
Published in International journal of molecular sciences (10-12-2021)“…CRISPR/Cas12a (formerly Cpf1), an RNA-guided endonuclease of the Class II Type V-A CRISPR system, provides a promising tool for genome engineering. Over 10…”
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MicroRNA-181a promotes tumor growth and liver metastasis in colorectal cancer by targeting the tumor suppressor WIF-1
Published in Molecular cancer (23-04-2014)“…Given the emerging role of microRNA in tumor disease progression, we investigated the association between microRNA expression, liver metastasis and prognosis…”
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Overexpression of LAMC2 predicts poor prognosis in colorectal cancer patients and promotes cancer cell proliferation, migration, and invasion
Published in Tumor biology (01-06-2017)“…Laminin γ2 (LAMC2) has been reported to be involved in the development and progression of a variety of tumors. However, its function in human colorectal cancer…”
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Real-Time Polymerase Chain Reaction MicroRNA Detection Based on Enzymatic Stem-Loop Probes Ligation
Published in Analytical chemistry (Washington) (01-07-2009)“…MiRNAs (microRNAs) are a group of endogenous, small noncoding RNA with the length of 18−25 nucleotides, which have recently been demonstrated to play important…”
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MicroRNA-19a mediates the suppressive effect of laminar flow on cyclin D1 expression in human umbilical vein endothelial cells
Published in Proceedings of the National Academy of Sciences - PNAS (16-02-2010)“…Endothelial cells (ECs) respond to changes in mechanical forces, leading to the modulation of signaling networks and cell function; an example is the…”
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Whole blood gas and biochemical reference intervals for Lohmann Silver layers
Published in Poultry science (01-09-2021)“…The blood gas and biochemical reference range established with i-STAT clinical analyzer in avian has become common, however, the reference value for various…”
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Effect of housing system and age on products and bone properties of Taihang chickens
Published in Poultry science (01-03-2020)“…The aim of this study was to compare egg quality, carcass, meat characteristics, and bone properties of Taihang chickens in 2 different housing systems at…”
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TALEN-based generation of a cynomolgus monkey disease model for human microcephaly
Published in Cell research (01-09-2016)“…Gene editing in non-human primates may lead to valuable models for exploring the etiologies and therapeutic strategies of genetically based neurological…”
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Genome editing with RNA-guided Cas9 nuclease in Zebrafish embryos
Published in Cell research (01-04-2013)“…Recent advances with the type II clustered regularly interspaced short palindromic repeats (CRISPR) system promise an improved approach to genome editing…”
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NADPH oxidase 2-derived reactive oxygen species mediate FFAs-induced dysfunction and apoptosis of β-cells via JNK, p38 MAPK and p53 pathways
Published in PloS one (29-12-2010)“…Dysfunction of β-cell is one of major characteristics in the pathogenesis of type 2 diabetes. The combination of obesity and type 2 diabetes, characterized as…”
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Targeted genome modification of crop plants using a CRISPR-Cas system
Published in Nature biotechnology (01-08-2013)Get full text
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