Search Results - "Xi, Hualin S."

Using an atlas of gene regulation across 44 human tissues to inform complex disease- and trait-associated variation by Gamazon, Eric R., Segrè, Ayellet V., van de Bunt, Martijn, Wen, Xiaoquan, Xi, Hualin S., Hormozdiari, Farhad, Ongen, Halit, Konkashbaev, Anuar, Derks, Eske M., Aguet, François, Quan, Jie, Nicolae, Dan L., Eskin, Eleazar, Kellis, Manolis, Getz, Gad, McCarthy, Mark I., Dermitzakis, Emmanouil T., Cox, Nancy J., Ardlie, Kristin G.

“…We apply integrative approaches to expression quantitative loci (eQTLs) from 44 tissues from the Genotype-Tissue Expression project and genome-wide association…”
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Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis by Jaffe, Andrew E., Straub, Richard E., Shin, Joo Heon, Tao, Ran, Gao, Yuan, Collado-Torres, Leonardo, Kam-Thong, Tony, Xi, Hualin S., Quan, Jie, Chen, Qiang, Colantuoni, Carlo, Ulrich, William S., Maher, Brady J., Deep-Soboslay, Amy, Cross, Alan J., Brandon, Nicholas J., Leek, Jeffrey T., Hyde, Thomas M., Kleinman, Joel E., Weinberger, Daniel R.

“…Genome-wide association studies have identified 108 schizophrenia risk loci, but biological mechanisms for individual loci are largely unknown. Using…”
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3'Pool-seq: an optimized cost-efficient and scalable method of whole-transcriptome gene expression profiling by Sholder, Gabriel, Lanz, Thomas A, Moccia, Robert, Quan, Jie, Aparicio-Prat, Estel, Stanton, Robert, Xi, Hualin S

“…The advent of Next Generation Sequencing has allowed transcriptomes to be profiled with unprecedented accuracy, but the high costs of full-length mRNA…”
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Roadmap for the use of base editors to decipher drug mechanism of action by Aparicio-Prat, Estel, Yan, Dong, Mariotti, Marco, Bassik, Michael, Hess, Gaelen, Fortin, Jean-Philippe, Weston, Andrea, Xi, Hualin S, Stanton, Robert

“…CRISPR base editors are powerful tools for large-scale mutagenesis studies. This kind of approach can elucidate the mechanism of action of compounds, a key…”
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Transcriptomic RNAseq drug screen in cerebrocortical cultures: toward novel neurogenetic disease therapies by Hadwen, Jeremiah, Schock, Sarah, Mears, Alan, Yang, Robert, Charron, Philippe, Zhang, Liying, Xi, Hualin S, MacKenzie, Alex

“…Abstract Rare monogenic diseases affect millions worldwide; although over 4500 rare disease genotypes are known, disease-modifying drugs are available for only…”
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Activated microglia cause metabolic disruptions in developmental cortical interneurons that persist in interneurons from individuals with schizophrenia by Park, Gun-Hoo, Noh, Haneul, Shao, Zhicheng, Ni, Peiyan, Qin, Yiren, Liu, Dongxin, Beaudreault, Cameron P., Park, Joy S., Abani, Chiderah P., Park, James M., Le, Derek T., Gonzalez, Sasha Z., Guan, Youxin, Cohen, Bruce M., McPhie, Donna L., Coyle, Joseph T., Lanz, Thomas A., Xi, Hualin S., Yin, Changhong, Huang, Weihua, Kim, Hae-Young, Chung, Sangmi

“…The mechanisms by which prenatal immune activation increase the risk for neuropsychiatric disorders are unclear. Here, we generated developmental cortical…”
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Genetics of CD33 in Alzheimer's disease and acute myeloid leukemia by Malik, Manasi, Chiles, 3rd, Joe, Xi, Hualin S, Medway, Christopher, Simpson, James, Potluri, Shobha, Howard, Dianna, Liang, Ying, Paumi, Christian M, Mukherjee, Shubhabrata, Crane, Paul, Younkin, Steven, Fardo, David W, Estus, Steven

“…The CD33 single-nucleotide polymorphism (SNP) rs3865444 has been associated with the risk of Alzheimer's disease (AD). Rs3865444 is in linkage disequilibrium…”
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BrainSeq: Neurogenomics to Drive Novel Target Discovery for Neuropsychiatric Disorders by Schubert, Christian R., O’Donnell, Patricio, Quan, Jie, Wendland, Jens R., Xi, Hualin S., Winslow, Ashley R., Domenici, Enrico, Essioux, Laurent, Kam-Thong, Tony, Airey, David C., Calley, John N., Collier, David A., Wang, Hong, Eastwood, Brian, Ebert, Philip, Liu, Yushi, Nisenbaum, Laura, Ruble, Cara, Scherschel, James E., Smith, Ryan Matthew, Qian, Hui-Rong, Merchant, Kalpana, Didriksen, Michael, Matsumoto, Mitsuyuki, Saito, Takeshi, Brandon, Nicholas J., Cross, Alan J., Wang, Qi, Manji, Husseini, Kolb, Hartmuth, Furey, Maura, Drevets, Wayne C., Shin, Joo Heon, Jaffe, Andrew E., Jia, Yankai, Straub, Richard E., Deep-Soboslay, Amy, Hyde, Thomas M., Kleinman, Joel E., Weinberger, Daniel R.

“…We outline an ambitious project to characterize the genetic and epigenetic regulation of multiple facets of transcription in distinct brain regions across the…”
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Translating Human Genetics into Novel Treatment Targets for Schizophrenia by Schubert, Christian R., Xi, Hualin S., Wendland, Jens R., O’Donnell, Patricio

“…Human genetics is a rational starting point for target identification in drug discovery, yet this approach has found little application in neuroscience. Recent…”
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HIF1α is required for survival maintenance of chronic myeloid leukemia stem cells by Zhang, Haojian, Li, Huawei, Xi, Hualin S., Li, Shaoguang

“…Hypoxia-inducible factor-1α (HIF1α), a master transcriptional regulator of the cellular and systemic hypoxia response, is essential for the maintenance of…”
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Improving genetic diagnosis in Mendelian disease with transcriptome sequencing by Cummings, Beryl B, Marshall, Jamie L, Tukiainen, Taru, Lek, Monkol, Donkervoort, Sandra, Foley, A Reghan, Bolduc, Veronique, Waddell, Leigh B, Sandaradura, Sarah A, O'Grady, Gina L, Estrella, Elicia, Reddy, Hemakumar M, Zhao, Fengmei, Weisburd, Ben, Karczewski, Konrad J, O'Donnell-Luria, Anne H, Birnbaum, Daniel, Sarkozy, Anna, Hu, Ying, Gonorazky, Hernan, Claeys, Kristl, Joshi, Himanshu, Bournazos, Adam, Oates, Emily C, Ghaoui, Roula, Davis, Mark R, Laing, Nigel G, Topf, Ana, Kang, Peter B, Beggs, Alan H, North, Kathryn N, Straub, Volker, Dowling, James J, Muntoni, Francesco, Clarke, Nigel F, Cooper, Sandra T, Bönnemann, Carsten G, MacArthur, Daniel G

“…Exome and whole-genome sequencing are becoming increasingly routine approaches in Mendelian disease diagnosis. Despite their success, the current diagnostic…”
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Investigating the neuroimmunogenic architecture of schizophrenia by Birnbaum, R, Jaffe, A E, Chen, Q, Shin, J H, Kleinman, J E, Hyde, T M, Weinberger, D R

“…The role of the immune system in schizophrenia remains controversial despite numerous studies to date. Most studies have profiled expression of select genes or…”
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Activated microglia cause metabolic disruptions in developmental cortical interneuron that persist in schizophrenia-patient-derived interneurons by Park, Gun-Hoo, Noh, Haneul, Shao, Zhicheng, Ni, Peiyan, Qin, Yiren, Liu, Dongxin, Beaudreault, Cameron P., Park, Joy S., Abani, Chiderah P., Park, James M., Le, Derek T., Gonzalez, Sasha Z., Guan, Youxin, Cohen, Bruce M., McPhie, Donna L., Coyle, Joseph T., Lanz, Thomas A., Xi, Hualin S, Yin, Changhong, Huang, Weihua, Kim, Hae-Young, Chung, Sangmi

“…The mechanisms by which prenatal immune activation increase risk for neuropsychiatric disorders are unclear. Here, we generated developmental cortical…”
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Potassium channel gene associations with joint processing speed and white matter impairments in schizophrenia by Bruce, H. A., Kochunov, P., Paciga, S. A., Hyde, C. L., Chen, X., Xie, Z., Zhang, B., Xi, H. S., O'Donnell, P., Whelan, C., Schubert, C. R., Bellon, A., Ament, S. A., Shukla, D. K., Du, X., Rowland, L. M., O'Neill, H., Hong, L. E.

“…Patients with schizophrenia show decreased processing speed on neuropsychological testing and decreased white matter integrity as measured by diffusion tensor…”
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