Search Results - "Xi, Hanmi"

The Effect of Inorganic Salt on Disintegration of Tablets with High Loading of Amorphous Solid Dispersion Containing Copovidone by Xi, Hanmi, Ren, Jie, Novak, Julie M., Kemp, Eric, Johnson, Gregory, Klinzing, Gerard, Johnson, Mary Ann, Xu, Wei

“…Purpose While including amorphous solid dispersion (ASD) in tablet formulations is increasingly common, tablets containing high ASD loading are associated with…”
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Cross-Nucleation between ROY Polymorphs by Chen, Shuang, Xi, Hanmi, Yu, Lian

“…Cross-nucleation between polymorphs is a newly discovered phenomenon important for understanding and controlling crystal polymorphism. It contradicts Ostwald's…”
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In-situ biophysical characterization of high-concentration protein formulations using wNMR by Song, Jing, Taraban, Marc, Yu, Y Bruce, Lu, Lynn, Biswas, Pallavi Guha, Xu, Wei, Xi, Hanmi, Bhambhani, Akhilesh, Hu, Guangli, Su, Yongchao

“…High-concentration protein formulation is of paramount importance in patient-centric drug product development, but it also presents challenges due to the…”
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Diffusion-controlled and "diffusionless" crystal growth near the glass transition temperature: relation between liquid dynamics and growth kinetics of seven ROY polymorphs by Sun, Ye, Xi, Hanmi, Ediger, M D, Richert, Ranko, Yu, Lian

“…The liquid dynamics of 5-methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile, named ROY for its red, orange, and yellow crystal polymorphs, was…”
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Characterizing Silicone Oil-Induced Protein Aggregation with Stimulated Raman Scattering Imaging by Wong, Brian, Zhao, Xi, Su, Yongchao, Ouyang, Hanlin, Rhodes, Timothy, Xu, Wei, Xi, Hanmi, Fu, Dan

“…Particles in biopharmaceutical products present high risks due to their detrimental impacts on product quality and safety. Identification and quantification of…”
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The Impact of Syringe Age Prior to Filling on Migration of Subvisible Silicone-Oil Particles into Drug Product by Song, Jing, Hu, Guangli, Hamzaoui, Hassen, Krishnamachari, Yogita, Persak, Steven C, Xi, Hanmi, Su, Yongchao

“…Silicone oil is often applied to the inner surface of glass syringes and cartridges to reduce friction between the glass surface and elastomeric plunger…”
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Identification of Surfactant Impact on a Monoclonal Antibody Characterization via HPLC-Separation Based and Biophysical Methods by Guo, Kaizhu, Song, Jing, Bennington, Petra, Pavon, Alexander J., Bothe, Jameson R., Xi, Hanmi, Gunawan, Rico C.

“…Purpose or Objective Surfactants, including polysorbates and poloxamers, play a crucial role in the formulation of therapeutic proteins by acting as…”
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In-situ biophysical characterization of high-concentration protein formulations using w NMR by Song, Jing, Taraban, Marc, Yu, Y Bruce, Lu, Lynn, Biswas, Pallavi Guha, Xu, Wei, Xi, Hanmi, Bhambhani, Akhilesh, Hu, Guangli, Su, Yongchao

“…High-concentration protein formulation is of paramount importance in patient-centric drug product development, but it also presents challenges due to the…”
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Variables Impacting Silicone Oil Migration and Biologics in Prefilled Syringes by Gentile, Kayla, Huang, Chengbin, Liu, Xiaoyang, Whitty-Léveillé, Laurence, Hamzaoui, Hassen, Cristofolli, Eduardo, Rayfield, William, Afanador, Nelson Lee, Mittal, Sarita, Krishnamachari, Yogita, Xi, Hanmi, Zhao, Xi

“…Prefilled syringes (PFS) as a primary container for parenteral drug products offer significant advantages, such as fast delivery time, ease of…”
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Designing an ADME liquid formulation with matching exposures to an amorphous dosage form by Xi, Hanmi, Yang, Zhen, Tatavarti, Aditya, Xu, Wei, Fuerst, Joy, Ormes, James

“…[Display omitted] Amorphous Solid Dispersion (ASD) based formulations have been frequently used to improve the bioavailability of poorly water soluble drugs,…”
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Fast Crystal Growth in o‑Terphenyl Glasses: A Possible Role for Fracture and Surface Mobility by Powell, C. Travis, Xi, Hanmi, Sun, Ye, Gunn, Erica, Chen, Yinshan, Ediger, M. D, Yu, Lian

“…Molecular liquids can develop a fast mode of crystal growth (“GC growth”) near the glass transition temperature. This phenomenon remains imperfectly understood…”
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Diffusion-controlled and diffusionless crystal growth in liquid o-terphenyl near its glass transition temperature by Xi, Hanmi, Sun, Ye, Yu, Lian

“…o-terphenyl is one of the organic liquids in which a fast mode of crystal growth is activated near the glass transition temperature T(g) and continues deep in…”
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Understanding the process-product-performance interplay of spray dried drug-polymer systems through complete structural and chemical characterization of single spray dried particles by Poozesh, Sadegh, Setiawan, Nico, Arce, Freddy, Sundararajan, Pavithra, Rocca, Joseph Della, Rumondor, Alfred, Wei, Douglas, Wenslow, Robert, Xi, Hanmi, Zhang, Shawn, Stellabott, Joyce, Su, Yongchao, Moser, Justin, Marsac, Patrick Jules

“…A complete description of the particle formation process can only be realized with techniques that enable the measurement of the composition and structural…”
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A novel approach for measuring room temperature enthalpy of mixing and associated solubility estimation of a drug in a polymer matrix by Alin, Jonas, Setiawan, Nico, Defrese, Matthew, DiNunzio, James, Lau, Hang, Lupton, Lisa, Xi, Hanmi, Su, Yongchao, Nie, Haichen, Hesse, Nathan, Taylor, Lynne S., Marsac, Patrick Jules

“…The utility of amorphization of drug molecules, such as enhanced solubility, dissolution rate and oral bioavailability, has been well exemplified in the…”
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Development of a HPMC-based controlled release formulation with hot melt extrusion (HME) by Ma, Decheng, Djemai, Abdenour, Gendron, Colleen M., Xi, Hanmi, Smith, Michelle, Kogan, Jessica, Li, Li

“…The objective of this study was to develop hydroxypropyl methylcellulose (HPMC) based controlled release (CR) formulations via hot melt extrusion (HME) with a…”
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Diffusionless Crystal Growth from Glass Has Precursor in Equilibrium Liquid by Sun, Ye, Xi, Hanmi, Ediger, M. D, Yu, Lian

“…A remarkable property of certain glass-forming liquids is that a fast mode of crystal growth is suddenly activated near the glass transition temperature, T g,…”
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Diffusionless crystal growth in organic glasses by Xi, Hanmi

“…A glass is a liquid that has been frozen into a solid without crystallizing. For many applications, glasses are preferred over crystalline solids. Some organic…”
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Development, synthesis and characterization of novel multifunctional polymer-secured self-registering molecular array systems by Xi, Hanmi

“…The main objective of this dissertation is to develop novel multifunctional polymer-secured self-registering molecular array systems with potential…”
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Development, synthesis and characterization of novel multifunctional polymer-secured self-registering molecular array systems by Xi, Hanmi

“…The main objective of this dissertation is to develop novel multifunctional polymer-secured self-registering molecular array systems with potential…”
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Diffusionless crystal growth in organic glasses by Xi, Hanmi

“…A glass is a liquid that has been frozen into a solid without crystallizing. For many applications, glasses are preferred over crystalline solids. Some organic…”
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