Search Results - "Xen Ping Hoi"

Cell death-induced immunogenicity enhances chemoimmunotherapeutic response by converting immune-excluded into T-cell inflamed bladder tumors by Nikolos, Fotis, Hayashi, Kazukuni, Hoi, Xen Ping, Alonzo, Mark Ellie, Mo, Qianxing, Kasabyan, Armine, Furuya, Hideki, Trepel, Jane, Di Vizio, Dolores, Guarnerio, Jlenia, Theodorescu, Dan, Rosser, Charles, Apolo, Andrea, Galsky, Matthew, Chan, Keith Syson

“…Chemoimmunotherapy has recently failed to demonstrate significant clinical benefit in advanced bladder cancer patients; and the mechanism(s) underlying such…”
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Toll-Like Receptors Induce Signal-Specific Reprogramming of the Macrophage Lipidome by Hsieh, Wei-Yuan, Zhou, Quan D., York, Autumn G., Williams, Kevin J., Scumpia, Philip O., Kronenberger, Eliza B., Hoi, Xen Ping, Su, Baolong, Chi, Xun, Bui, Viet L., Khialeeva, Elvira, Kaplan, Amber, Son, Young Min, Divakaruni, Ajit S., Sun, Jie, Smale, Stephen T., Flavell, Richard A., Bensinger, Steven J.

“…Macrophages reprogram their lipid metabolism in response to activation signals. However, a systems-level understanding of how different pro-inflammatory…”
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Metabolic targeting of cancer associated fibroblasts overcomes T-cell exclusion and chemoresistance in soft-tissue sarcomas by Broz, Marina T., Ko, Emily Y., Ishaya, Kristin, Xiao, Jinfen, De Simone, Marco, Hoi, Xen Ping, Piras, Roberta, Gala, Basia, Tessaro, Fernando H. G., Karlstaedt, Anja, Orsulic, Sandra, Lund, Amanda W., Chan, Keith Syson, Guarnerio, Jlenia

“…T cell-based immunotherapies have exhibited promising outcomes in tumor control; however, their efficacy is limited in immune-excluded tumors…”
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DNA vaccines against GPRC5D synergize with PD-1 blockade to treat multiple myeloma by Neeli, Praveen, Maza, Perry Ayn Mayson A., Chai, Dafei, Zhao, Dan, Hoi, Xen Ping, Chan, Keith Syson, Young, Ken H., Li, Yong

“…Multiple myeloma (MM), a hematological malignancy of the bone marrow, remains largely incurable. The orphan G protein-coupled receptor, GPRC5D, which is…”
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Development and Application of FASA, a Model for Quantifying Fatty Acid Metabolism Using Stable Isotope Labeling by Argus, Joseph P., Wilks, Moses Q., Zhou, Quan D., Hsieh, Wei Yuan, Khialeeva, Elvira, Hoi, Xen Ping, Bui, Viet, Xu, Shili, Yu, Amy K., Wang, Eric S., Herschman, Harvey R., Williams, Kevin J., Bensinger, Steven J.

“…It is well understood that fatty acids can be synthesized, imported, and modified to meet requisite demands in cells. However, following the movement of fatty…”
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Discoidin Domain Receptor-Driven Gene Signatures as Markers of Patient Response to Anti-PD-L1 Immune Checkpoint Therapy by You, Sungyong, Kim, Minhyung, Hoi, Xen Ping, Lee, Yu Cheng, Wang, Li, Spetzler, David, Abraham, Jim, Magee, Dan, Jain, Prerna, Galsky, Matthew D, Chan, Keith Syson, Theodorescu, Dan

“…Anti-programmed cell death 1 (anti-PD-1) and PD ligand 1 (PD-L1) immune checkpoint therapies (ICTs) provided durable responses only in a subset of cancer…”
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The Hallmarks of Precancer by Stangis, Mary M, Chen, Zhengyi, Min, Jimin, Glass, Sarah E, Jackson, Jordan O, Radyk, Megan D, Hoi, Xen Ping, Brennen, W Nathaniel, Yu, Ming, Dinh, Huy Q, Coffey, Robert J, Shrubsole, Martha J, Chan, Keith S, Grady, William M, Yegnasubramanian, Srinivasan, Lyssiotis, Costas A, Maitra, Anirban, Halberg, Richard B, Dey, Neelendu, Lau, Ken S

“…Research on precancers, as defined as at-risk tissues and early lesions, is of high significance given the effectiveness of early intervention. We discuss the…”
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Abstract 1255: Glucose dependent CD73+ CAFs enforce a tumor metabolic barrier that promotes T cell exclusion by Broz, Marina, Ko, Emily, Xiao, Jinfen, DeSimone, Marco, Piras, Roberta, Ishaya, Kristin, Hoi, Xen Ping, Guarnerio, Jlenia

“…Abstract Trafficking of T lymphocytes from the lymph nodes to the tumor microenvironment is a critical process of the tumor immunity cycle to elicit cytotoxic…”
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1432 Cancer-associated fibroblasts metabolic targeting overcomes T-cell exclusion and chemoresistance by Broz, Marina, Ko, Emily, Ishaya, Kristin, Xiao, Jinfen, DeSimone, Marco, Xen Ping Hoi, Piras, Roberta, Gala, Basia, Fernando HG Tessaro, Orsulic, Sandra, Balzer, Bonnie, Chan, Keith Syson, Guarnerio, Jlenia

“…BackgroundRecent advances in T cell-based immunotherapies have shown promise in controlling tumor growth, but their effectiveness is limited in immune-excluded…”
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