Search Results - "Xavier H. Mascle"

Characterization of a C-Terminal SUMO-Interacting Motif Present in Select PIAS-Family Proteins by Lussier-Price, Mathieu, Mascle, Xavier H., Cappadocia, Laurent, Kamada, Rui, Sakaguchi, Kazuyasu, Wahba, Haytham M., Omichinski, James G.

“…The human PIAS proteins are small ubiquitin-like modifier (SUMO) E3 ligases that participate in important cellular functions. Several of these functions depend…”
Get full text

Structural and Functional Characterization of the Phosphorylation-Dependent Interaction between PML and SUMO1 by Cappadocia, Laurent, Mascle, Xavier H., Bourdeau, Véronique, Tremblay-Belzile, Samuel, Chaker-Margot, Malik, Lussier-Price, Mathieu, Wada, Junya, Sakaguchi, Kazuyasu, Aubry, Muriel, Ferbeyre, Gerardo, Omichinski, James G.

“…PML and several other proteins localizing in PML-nuclear bodies (PML-NB) contain phosphoSIMs (SUMO-interacting motifs), and phosphorylation of this motif plays…”
Get full text

Identification of a Non-covalent Ternary Complex Formed by PIAS1, SUMO1, and UBC9 Proteins Involved in Transcriptional Regulation by Mascle, Xavier H., Lussier-Price, Mathieu, Cappadocia, Laurent, Estephan, Patricia, Raiola, Luca, Omichinski, James G., Aubry, Muriel

“…Post-translational modifications with ubiquitin-like proteins require three sequentially acting enzymes (E1, E2, and E3) that must unambiguously recognize each…”
Get full text

Acetylation of SUMO1 Alters Interactions with the SIMs of PML and Daxx in a Protein-Specific Manner by Mascle, Xavier H., Gagnon, Christina, Wahba, Haytham M., Lussier-Price, Mathieu, Cappadocia, Laurent, Sakaguchi, Kazuyasu, Omichinski, James G.

“…The interactions between SUMO proteins and SUMO-interacting motif (SIM) in nuclear bodies formed by the promyelocytic leukemia (PML) protein (PML-NBs) have…”
Get full text

Zinc controls PML nuclear body formation through regulation of a paralog specific auto-inhibition in SUMO1 by Lussier-Price, Mathieu, Wahba, Haytham M, Mascle, Xavier H, Cappadocia, Laurent, Bourdeau, Veronique, Gagnon, Christina, Igelmann, Sebastian, Sakaguchi, Kazuyasu, Ferbeyre, Gerardo, Omichinski, James G

“…Abstract SUMO proteins are important regulators of many key cellular functions in part through their ability to form interactions with other proteins…”
Get full text

Differential Roles of PML Isoforms by Nisole, Sébastien, Maroui, Mohamed Ali, Mascle, Xavier H, Aubry, Muriel, Chelbi-Alix, Mounira K

“…The tumor suppressor promyelocytic leukemia (PML) protein is fused to the retinoic acid receptor alpha in patients suffering from acute promyelocytic leukemia…”
Get full text

Sumoylation of the Transcriptional Intermediary Factor 1β (TIF1β), the Co-repressor of the KRAB Multifinger Proteins, Is Required for Its Transcriptional Activity and Is Modulated by the KRAB Domain by Mascle, Xavier H., Germain-Desprez, Delphine, Huynh, Phuong, Estephan, Patricia, Aubry, Muriel

“…Small ubiquitin-related modifier (SUMO) has emerged as a key post-translational modulator of protein functions. Here we show that TIF1β, a developmental…”
Get full text

Role of SUMO in RNF4-mediated Promyelocytic Leukemia Protein (PML) Degradation: Sumoylation of pml and phospho-switch control of its sumo binding domain dissected in living cells{sbox} by Percherancier, Yann, Germain-Desprez, Delphine, Galisson, Frédéric, Mascle, Xavier H, Dianoux, Laurent, Estephan, Patricia, Chelbi-Alix, Mounira K, Aubry, Muriel

“…Promyelocytic leukemia protein (PML) is a tumor suppressor acting as the organizer of subnuclear structures called PML nuclear bodies (NBs). Both covalent…”
Get full text

Role of SUMO in RNF4-mediated Promyelocytic Leukemia Protein (PML) Degradation by Percherancier, Yann, Germain-Desprez, Delphine, Galisson, Frédéric, Mascle, Xavier H., Dianoux, Laurent, Estephan, Patricia, Chelbi-Alix, Mounira K., Aubry, Muriel

“…Promyelocytic leukemia protein (PML) is a tumor suppressor acting as the organizer of subnuclear structures called PML nuclear bodies (NBs). Both covalent…”
Get full text

Structural and Functional Characterization of the Phosphorylation-Dependent Interaction between PML and SUMO1 by Cappadocia, Laurent, Mascle, Xavier H., Bourdeau, Véronique, Tremblay-Belzile, Samuel, Chaker-Margot, Malik, Lussier-Price, Mathieu, Wada, Junya, Sakaguchi, Kazuyasu, Aubry, Muriel, Ferbeyre, Gerardo, Omichinski, James G.

Get full text

Sumoylation of the transcriptional intermediary factor 1beta (TIF1beta), the Co-repressor of the KRAB Multifinger proteins, is required for its transcriptional activity and is modulated by the KRAB domain by Mascle, Xavier H, Germain-Desprez, Delphine, Huynh, Phuong, Estephan, Patricia, Aubry, Muriel

“…Small ubiquitin-related modifier (SUMO) has emerged as a key post-translational modulator of protein functions. Here we show that TIF1beta, a developmental…”
Get full text

Sumoylation of the Transcriptional Intermediary Factor 1β (TIF1β), the Co-repressor of the KRAB Multifinger Proteins, Is Required for Its Transcriptional Activity and Is Modulated by the KRAB Domain by Xavier H. Mascle, Delphine Germain-Desprez, Phuong Huynh, Patricia Estephan, Muriel Aubry

“…Small ubiquitin-related modifier (SUMO) has emerged as a key post-translational modulator of protein functions. Here we show that TIF1β, a developmental…”
Get full text