Heterogeneous methodology of racial/ethnic classification may be responsible for the different risk assessments for prostate cancer between Black and White men in Brazil

To evaluate if the different results of prostate cancer risk between black and white Brazilian men may be associated with the varying methodology used to define participants as either Blacks or Whites. We evaluated median PSA values, rate of PSA level ≥ 4.0 ng/ mL, indications for prostate biopsy, p...

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Bibliographic Details
Published in:	International Brazilian Journal of Urology Vol. 41; no. 2; pp. 360 - 366
Main Authors:	Romero, Frederico R, Xavier, Luiz Ricardo T P, Romero, Antonio W, Almeida, Rui Manuel S de, Matias, Jorge Eduardo F, Tambara Filho, Renato
Format:	Journal Article
Language:	English
Published:	Brazil Sociedade Brasileira de Urologia 01-04-2015
Subjects:	African Continental Ancestry Group - classification African Continental Ancestry Group - ethnology Biopsy Brazil - ethnology Epidemiology Ethnology - classification European Continental Ancestry Group - classification European Continental Ancestry Group - ethnology Humans Male Middle Aged Multivariate Analysis Original Prevalence Prostate - pathology Prostate-Specific Antigen - blood Prostatic Neoplasms Prostatic Neoplasms - ethnology Prostatic Neoplasms - pathology Race Relations Reference Values Risk Assessment - methods Risk Factors Brazil
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Summary:	To evaluate if the different results of prostate cancer risk between black and white Brazilian men may be associated with the varying methodology used to define participants as either Blacks or Whites. We evaluated median PSA values, rate of PSA level ≥ 4.0 ng/ mL, indications for prostate biopsy, prostate cancer detection rate, biopsy/cancer rate, cancer/biopsy rate, and the relative risk of cancer between blacks versus whites, blacks versus non-blacks (browns and whites), non-whites (browns and blacks) versus whites, African versus non-African descendants, and African descendants or blacks versus non-African descendants and non-blacks. From 1544 participants, there were 51.4% whites, 37.2% browns, 11.4% blacks, and 5.4% African descendants. Median PSA level was 0.9 ng/mL in whites, browns, and non-African descendants, compared to 1.2 ng/mL in blacks, and African descendants or blacks, and 1.3 ng/mL in African descendants. Indications for prostate biopsy were present in 16.9% for African descendants, 15.9% of black, 12.3% of white, 11.4% for non-African descendants, and 9.9% of brown participants. Prostate cancer was diagnosed in 30.3% of performed biopsies: 6.2% of African descendants, 5.1% of blacks, 3.3% of whites, 3.0% of non-African descendants, and 2.6% of browns. Median PSA values were higher for Blacks versus Whites in all classification systems, except for non-white versus white men. The rate of prostate biopsy, prostate cancer detection rate, and relative risk for cancer was increased in African descendants, and African descendants or blacks, compared to non-African descendants, and non-African descendants and non-blacks, respectively.
Bibliography:	in memorian CONFLICT OF INTEREST: None declared.
ISSN:	1677-5538 1677-6119 1677-6119 1677-5538
DOI:	10.1590/S1677-5538.IBJU.2015.02.25