Search Results - "Xavier, Joana M."

Identification of candidate causal variants and target genes at 41 breast cancer risk loci through differential allelic expression analysis by Xavier, Joana M., Magno, Ramiro, Russell, Roslin, de Almeida, Bernardo P., Jacinta-Fernandes, Ana, Besouro-Duarte, André, Dunning, Mark, Samarajiwa, Shamith, O’Reilly, Martin, Maia, António M., Rocha, Cátia L., Rosli, Nordiana, Ponder, Bruce A. J., Maia, Ana-Teresa

“…Understanding breast cancer genetic risk relies on identifying causal variants and candidate target genes in risk loci identified by genome-wide association…”
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Targeting the p53 pathway of apoptosis by Amaral, Joana D, Xavier, Joana M, Steer, Clifford J, Rodrigues, Cecília M P

“…The tumor suppressor protein, p53 is regarded as a key player in tumor suppression, as it promotes growth arrest, apoptosis and cellular senescence, while also…”
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Distinct regulatory functions of calpain 1 and 2 during neural stem cell self-renewal and differentiation by Santos, Daniela M, Xavier, Joana M, Morgado, Ana L, Solá, Susana, Rodrigues, Cecília M P

“…Calpains are calcium regulated cysteine proteases that have been described in a wide range of cellular processes, including apoptosis, migration and cell cycle…”
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Characterization of the major histocompatibility complex locus association with Behçet’s disease in Iran by M Xavier, Joana, Davatchi, Fereydoun, Abade, Olga, Shahram, Farhad, Francisco, Vânia, Abdollahi, Bahar Sadeghi, Trindade, Hélder, Nadji, Abdolhadi, Shafiee, Niloofar Mojarad, Ghaderibarmi, Fahmida, Ligeiro, Dário, Oliveira, Sofia A

“…© 2015 Xavier et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License…”
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p53 interaction with JMJD3 results in its nuclear distribution during mouse neural stem cell differentiation by Solá, Susana, Xavier, Joana M, Santos, Daniela M, Aranha, Márcia M, Morgado, Ana L, Jepsen, Kristen, Rodrigues, Cecília M P

“…Conserved elements of apoptosis are also integral components of cellular differentiation. In this regard, p53 is involved in neurogenesis, being required for…”
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Genetic Variants Underlying Risk of Intracranial Aneurysms: Insights from a GWAS in Portugal by Abrantes, Patrícia, Santos, Maria M, Sousa, Inês, Xavier, Joana M, Francisco, Vânia, Krug, Tiago, Sobral, João, Matos, Mafalda, Martins, Madalena, Jacinto, António, Coiteiro, Domingos, Oliveira, Sofia A

“…Subarachnoid hemorrhage (SAH) is a life-threatening event that most frequently leads to severe disability and death. Its most frequent cause is the rupture of…”
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Apoptosis-associated microRNAs are modulated in mouse, rat and human neural differentiation by Aranha, Márcia M, Santos, Daniela M, Xavier, Joana M, Low, Walter C, Steer, Clifford J, Solá, Susana, Rodrigues, Cecília M P

“…MicroRNAs (miRs or miRNAs) regulate several biological processes in the cell. However, evidence for miRNAs that control the differentiation program of specific…”
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Cell death targets and potential modulators in Alzheimer's disease by Castro, Rui E, Santos, Maria M M, Glória, Paulo M C, Ribeiro, Carlos J A, Ferreira, Duarte M S, Xavier, Joana M, Moreira, Rui, Rodrigues, Cecília M P

“…Apoptosis is now recognized as a normal feature in the development of the nervous system and may also play a role in neurodegenerative disorders, such as…”
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Allelic expression imbalance of PIK3CA mutations is frequent in breast cancer and prognostically significant by Correia, Lizelle, Magno, Ramiro, Xavier, Joana M., de Almeida, Bernardo P., Duarte, Isabel, Esteves, Filipa, Ghezzo, Marinella, Eldridge, Matthew, Sun, Chong, Bosma, Astrid, Mittempergher, Lorenza, Marreiros, Ana, Bernards, Rene, Caldas, Carlos, Chin, Suet-Feung, Maia, Ana-Teresa

“…PIK3CA mutations are the most common in breast cancer, particularly in the estrogen receptor-positive cohort, but the benefit of PI3K inhibitors has had…”
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Gene expression profiling and association studies implicate the neuregulin signaling pathway in Behçet's disease susceptibility by M Xavier, Joana, Krug, Tiago, Davatchi, Fereydoun, Shahram, Farhad, Fonseca, Benedita V., Jesus, Gorete, Barcelos, Filipe, Vedes, Joana, Salgado, Manuel, Abdollahi, Bahar Sadeghi, Nadji, Abdolhadi, Moraes-Fontes, Maria Francisca, Shafiee, Niloofar Mojarad, Ghaderibarmi, Fahmida, Vaz Patto, José, Crespo, Jorge, Oliveira, Sofia A.

“…© Springer-Verlag Berlin Heidelberg 2013 Behçet's disease (BD) is a complex disease with genetic and environmental risk factors implicated in its etiology;…”
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IL10 low-frequency variants in Behçet's disease patients by Ramos de Matos, Mafalda, M Xavier, Joana, Abrantes, Patrícia, Sousa, Inês, Henriques Rei, Nádia Raquel, Davatchi, Fereydoun, Shahram, Farhad, Jesus, Gorete, Barcelos, Filipe, Vedes, Joana, Salgado, Manuel, Abdollahi, Bahar Sadeghi, Nadji, Abdolhadi, Moraes-Fontes, Maria Francisca, Shafiee, Niloofar Mojarad, Ghaderibarmi, Fahmida, Vaz Patto, José, Crespo, Jorge, De Oliveira, Sofia

“…© 2014 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd. Aim: To explain the missing heritability after the genome-wide…”
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The role of p53 in apoptosis by Amaral, Joana D, Xavier, Joana M, Steer, Clifford J, Rodrigues, Cecília M

“…The dynamic and multiple functions of p53, together with its involvement in the most common non-infectious diseases, underscore the need to elucidate the…”
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FUT2: filling the gap between genes and environment in Behçet's disease? by Xavier, Joana M, Shahram, Farhad, Sousa, Inês, Davatchi, Fereydoun, Matos, Mafalda, Abdollahi, Bahar Sadeghi, Sobral, João, Nadji, Abdolhadi, Oliveira, Manuela, Ghaderibarim, Fahmida, Shafiee, Niloofar Mojarad, Oliveira, Sofia A

“…To identify new susceptibility loci for Behçet's disease (BD), we performed a genome-wide association study (GWAS) using DNA pooling. Two replicate pools of…”
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Colocalised Genetic Associations Reveal Alternative Splicing Variants as Candidate Causal Links for Breast Cancer Risk in 10 Loci by Besouro-Duarte, André, Carrasqueiro, Beatriz, Sousa, Sofia, Xavier, Joana M, Maia, Ana-Teresa

“…Genome-wide association studies (GWASs) have revealed numerous loci associated with breast cancer risk, yet the precise causal variants, their impact on…”
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Mitochondria: Major Regulators of Neural Development by Xavier, Joana M., Rodrigues, Cecília M. P., Solá, Susana

“…Mitochondria are organelles derived from primitive symbiosis between archeon ancestors and prokaryotic α-proteobacteria species, which lost the capacity of…”
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Germline allelic expression of genes at 17q22 locus associates with risk of breast cancer by Esteves, Filipa, Xavier, Joana M., Ford, Anthony M., Rocha, Cátia, Pharoah, Paul D.P., Caldas, Carlos, Chin, Suet-Feung, Maia, Ana-Teresa

“…Translation of genome-wide association study (GWAS) findings into preventive approaches is challenged by the identification of the causal risk variants and the…”
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MicroRNA-34a Modulates Neural Stem Cell Differentiation by Regulating Expression of Synaptic and Autophagic Proteins by Morgado, Ana L., Xavier, Joana M., Dionísio, Pedro A., Ribeiro, Maria F. C., Dias, Raquel B., Sebastião, Ana M., Solá, Susana, Rodrigues, Cecília M. P.

“…We have previously demonstrated the involvement of specific apoptosis-associated microRNAs (miRNAs), including miR-34a, in mouse neural stem cell (NSC)…”
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Mitochondrial translocation of p53 modulates neuronal fate by preventing differentiation-induced mitochondrial stress by Xavier, Joana M, Morgado, Ana L, Solá, Susana, Rodrigues, Cecília M P

“…Apoptosis regulatory proteins, such as p53, play a pivotal role in neural differentiation, through mechanisms independent of cell death. In addition, p53 has…”
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Association study of IL10 and IL23R-IL12RB2 in Iranian patients with Behçet's disease by Xavier, Joana M., Shahram, Farhad, Davatchi, Fereydoun, Rosa, Alexandra, Crespo, Jorge, Abdollahi, Bahar Sadeghi, Nadji, Abdolhadi, Jesus, Gorete, Barcelos, Filipe, Patto, José Vaz, Shafiee, Niloofar Mojarad, Ghaderibarim, Fahmida, Oliveira, Sofia A.

“…Objective Independent replication of the findings from genome‐wide association studies (GWAS) remains the gold standard for results validation. Our aim was to…”
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Tauroursodeoxycholic acid increases neural stem cell pool and neuronal conversion by regulating mitochondria-cell cycle retrograde signaling by Xavier, Joana M, Morgado, Ana L, Rodrigues, Cecília MP, Solá, Susana

“…The low survival and differentiation rates of stem cells after either transplantation or neural injury have been a major concern of stem cell-based therapy…”
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