Search Results - "Xavier, Cristina P.R."

Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells by Xavier, Cristina P.R, Lima, Cristovao F, Preto, Ana, Seruca, Raquel, Fernandes-Ferreira, Manuel, Pereira-Wilson, Cristina

“…Abstract KRAS and BRAF mutations are frequent in colorectal carcinoma (CRC) and have the potential to activate proliferation and survival through MAPK/ERK…”
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Understanding Cancer Drug Resistance by Developing and Studying Resistant Cell Line Models by Xavier, Cristina P R, Pesic, Milica, Vasconcelos, M Helena

“…Despite the enormous number of anticancer drugs presently available in the clinic, treatment failure due to drug resistance is very frequent. The…”
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The multi-factorial nature of clinical multidrug resistance in cancer by Assaraf, Yehuda G., Brozovic, Anamaria, Gonçalves, Ana Cristina, Jurkovicova, Dana, Linē, Aija, Machuqueiro, Miguel, Saponara, Simona, Sarmento-Ribeiro, Ana Bela, Xavier, Cristina P.R., Vasconcelos, M. Helena

“…Curative cancer therapy remains a major challenge particularly in cancers displaying multidrug resistance (MDR). The MDR phenotype is characterized by…”
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Chitinase 3-like-1 and fibronectin in the cargo of extracellular vesicles shed by human macrophages influence pancreatic cancer cellular response to gemcitabine by Xavier, Cristina P.R., Castro, Inês, Caires, Hugo R., Ferreira, Dylan, Cavadas, Bruno, Pereira, Luisa, Santos, Lúcio L., Oliveira, Maria J., Vasconcelos, M. Helena

“…Tumour-associated macrophages have been implicated in pancreatic ductal adenocarcinoma (PDAC) therapy response and Extracellular vesicles (EVs) shed by…”
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Ursolic acid induces cell death and modulates autophagy through JNK pathway in apoptosis-resistant colorectal cancer cells by Xavier, Cristina P.R, Lima, Cristovao F, Pedro, Dalila F.N, Wilson, Jonathan M, Kristiansen, Karsten, Pereira-Wilson, Cristina

“…Colorectal carcinomas (CRCs) with P53 mutations have been shown to be resistant to chemotherapy with 5-fluorouracil (5-FU), the most widely used…”
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Salvia Fruticosa, Salvia Officinalis, and Rosmarinic Acid Induce Apoptosis and Inhibit Proliferation of Human Colorectal Cell Lines: The Role in MAPK/ERK Pathway by Xavier, Cristina P.R, Lima, Cristovao F, Fernandes-Ferreira, Manuel, Pereira-Wilson, Cristina

“…Epidemiological studies have shown that nutrition is a key factor in modulating sporadic colorectal carcinoma (CRC) risk. Aromatic plants of the genus Salvia…”
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Extracellular vesicles as a novel source of biomarkers in liquid biopsies for monitoring cancer progression and drug resistance by Vasconcelos, M. Helena, Caires, Hugo R., Ābols, Artūrs, Xavier, Cristina P.R., Linē, Aija

“…Cancer-derived extracellular vesicles (EVs) have been detected in the bloodstream and other biofluids of cancer patients. They carry various tumor-derived…”
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Fibroblasts in pancreatic cancer: molecular and clinical perspectives by Rebelo, Rita, Xavier, Cristina P.R., Giovannetti, Elisa, Vasconcelos, M. Helena

“…CAFs have dual roles in cancer because they can exert both tumor-promoting and tumor-suppressing effects, likely owing to their heterogeneity and…”
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The role of Extracellular Vesicles in glycolytic and lipid metabolic reprogramming of cancer cells: Consequences for drug resistance by Polónia, Bárbara, Xavier, Cristina P.R., Kopecka, Joanna, Riganti, Chiara, Vasconcelos, M. Helena

“…In order to adapt to a higher proliferative rate and an increased demand for energy sources, cancer cells rewire their metabolic pathways, a process currently…”
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The role of extracellular vesicles in the transfer of drug resistance competences to cancer cells by Xavier, Cristina P.R., Belisario, Dimas Carolina, Rebelo, Rita, Assaraf, Yehuda G., Giovannetti, Elisa, Kopecka, Joanna, Vasconcelos, M. Helena

“…Drug resistance remains a major hurdle to successful cancer treatment, being accountable for approximately 90% of cancer-related deaths. In the past years,…”
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3D Cell Culture Models as Recapitulators of the Tumor Microenvironment for the Screening of Anti-Cancer Drugs by Barbosa, Mélanie A G, Xavier, Cristina P R, Pereira, Rúben F, Petrikaitė, Vilma, Vasconcelos, M Helena

“…Today, innovative three-dimensional (3D) cell culture models have been proposed as viable and biomimetic alternatives for initial drug screening, allowing the…”
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Impact of cancer metabolism on therapy resistance – Clinical implications by Gonçalves, Ana Cristina, Richiardone, Elena, Jorge, Joana, Polónia, Bárbara, Xavier, Cristina P.R., Salaroglio, Iris Chiara, Riganti, Chiara, Vasconcelos, M. Helena, Corbet, Cyril, Sarmento-Ribeiro, Ana Bela

“…Despite an increasing arsenal of anticancer therapies, many patients continue to have poor outcomes due to the therapeutic failures and tumor relapses. Indeed,…”
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Special Issue: "Drug Repurposing for Cancer Therapies" by Xavier, Cristina P R, Palmeira, Andreia

“…Cancer is one of the primary global causes of death, thus addressing cancer therapy remains a significant challenge, especially in cases where cancers exhibit…”
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Unravelling the complexities of resistance mechanism in pancreatic cancer: Insights from in vitro and ex-vivo model systems by Lencioni, Giulia, Gregori, Alessandro, Toledo, Belén, Rebelo, Rita, Immordino, Benoît, Amrutkar, Manoj, Xavier, Cristina P.R., Kocijančič, Anja, Pandey, Deo Prakash, Perán, Macarena, Castaño, Justo P., Walsh, Naomi, Giovannetti, Elisa

“…Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor prognosis and rising global deaths. Late diagnosis, due to absent early symptoms and…”
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The Role of Extracellular Vesicles in the Hallmarks of Cancer and Drug Resistance by Xavier, Cristina P R, Caires, Hugo R, Barbosa, Mélanie A G, Bergantim, Rui, Guimarães, José E, Vasconcelos, M Helena

“…Extracellular vesicles (EVs) mediate intercellular signaling and communication, allowing the intercellular exchange of proteins, lipids, and genetic material…”
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Novel family of [RuCp(N,N)(P)]+ compounds with simultaneous anticancer and antibacterial activity: Biological evaluation and solution chemistry studies by Teixeira, Ricardo G., Mészáros, János P., Matos, Beatriz, Côrte-Real, Leonor, Xavier, Cristina P.R., Fontrodona, Xavier, Garcia, M. Helena, Romero, Isabel, Spengler, Gabriella, Vasconcelos, M. Helena, Tomaz, Ana Isabel, Enyedy, Éva A., Valente, Andreia

“…A family of ten novel ruthenium(II)-cyclopentadienyl organometallics of general formula [Ru(η5-C5H5)(N,N)(PPh2(C6H4COOR)][CF3SO3] (1-10) in which (N,N) =…”
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Quercetin enhances 5-fluorouracil-induced apoptosis in MSI colorectal cancer cells through p53 modulation by Xavier, Cristina P. R., Lima, Cristovao F., Rohde, Mikkel, Pereira-Wilson, Cristina

“…Purpose Colorectal tumors (CRC) with microsatellite instability (MSI) show resistance to chemotherapy with 5-fluorouracil (5-FU), the most widely used…”
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Establishing and characterizing a novel doxorubicin-resistant acute myeloid leukaemia cell line by Castro, Inês, Lopes-Rodrigues, Vanessa, Branco, Helena, Vasconcelos, M. Helena, Xavier, Cristina P. R.

“…Drug resistance is a major setback in cancer treatment, thus models to study its mechanisms are needed. Our work aimed to establish and characterize a…”
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P-326 - Eucalyptus globulus Labill. decoction extract inhibits the growth of human tumor cell lines by Teixeira, Alexandra, DaCunha, Deborah C., Caires, Hugo R., Xavier, Cristina P.R., Barros, Lillian, Ferreira, Isabel C.F.R., Vasconcelos, Maria Helena

“…Eucalyptus globulus Labill. is a widespread evergreen plant with a plethora of medicinal properties, most notably antitumoral activity. The aims of this work…”
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Eucalyptus globulus Labill. decoction extract inhibits the growth of human tumor cell lines by Teixeira, Alexandra, DaCunha, Deborah C., Caires, Hugo R., Xavier, Cristina P.R., Barros, Lillian, Ferreira, Isabel C.F.R., Vasconcelos, Maria Helena

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