Search Results - "Xanthopoulos, Kleanthis G."

Marked enhancement of antitumor immune responses in mouse brain tumor models by genetically modified dendritic cells producing Semliki Forest virus-mediated interleukin-12 by YAMANAKA, Ryuya, ZULLO, Susan A, RAMSEY, Jay, YAJIMA, Naoki, TSUCHIYA, Naoto, TANAKA, Ryuichi, BLAESE, Michael, XANTHOPOULOS, Kleanthis G

“…The authors evaluated dendritic cell (DC)-based immunotherapy for malignant brain tumor to improve its therapeutic efficacy. Dendritic cells were isolated from…”
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Biological Role of the CCAAT/Enhancer-binding Protein Family of Transcription Factors by Lekstrom-Himes, Julie, Xanthopoulos, Kleanthis G.

“…CCAAT/enhancer-binding proteins (C/EBPs) comprise a family of transcription factors that are critical for normal cellular differentiation and function in a…”
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The art of the alliance by Menzel, Garry E, Xanthopoulos, Kleanthis G

“…Securing a partner is only the beginning—you then have to put substantial effort and resources into keeping the collaboration functioning and productive…”
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Suppression of C/EBPα expression in periportal hepatoblasts may stimulate biliary cell differentiation through increased Hnf6 and Hnf1b expression by Yamasaki, Harufumi, Sada, Aiko, Iwata, Takeyuki, Niwa, Tohru, Tomizawa, Minoru, Xanthopoulos, Kleanthis G., Koike, Toru, Shiojiri, Nobuyoshi

“…The expression of C/EBPα, which may govern transcription of mature hepatocyte marker genes, was suppressed in periportal hepatoblasts in mouse liver…”
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Induction of antigen-specific immune responses against malignant brain tumors by intramuscular injection of sindbis DNA encoding gp100 and IL-18 by Yamanaka, Ryuya, Xanthopoulos, Kleanthis G

“…We constructed pSin-SV40-HDV-SV40pA, an improved Sindbis DNA expression vector, and evaluated the potential of this vector system for brain tumor therapy. We…”
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Induction of an antitumor immunological response by an intratumoral injection of dendritic cells pulsed with genetically engineered Semliki Forest virus to produce interleukin-18 combined with the systemic administration of interleukin-12 by YAMANAKA, Ryuya, TSUCHIYA, Naoto, YAJIMA, Naoki, HONMA, Junpei, HASEGAWA, Hitoshi, TANAKA, Ryuichi, RAMSEY, Jay, BLAESE, R. Michael, XANTHOPOULOS, Kleanthis G

“…The aim of this study was to investigate further immunogene treatment of malignant brain tumor to improve its therapeutic efficacy. Intratumoral dendritic…”
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Enhancement of antitumor immune response in glioma models in mice by genetically modified dendritic cells pulsed with Semliki Forest virus-mediated complementary DNA by YAMANAKA, Ryuya, ZULLO, Susan A, TANAKA, Ryuichi, BLAESE, Michael, XANTHOPOULOS, Kleanthis G

“…The aim of this study was to further investigate dendritic cell (DC)-based immunotherapy for malignant glioma to improve its therapeutic efficacy. Dendritic…”
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Administration of interleukin-12 and -18 enhancing the antitumor immunity of genetically modified dendritic cells that had been pulsed with Semliki Forest virus-mediated tumor complementary DNA by YAMANAKA, Ryuya, YAJIMA, Naoki, TSUCHIYA, Naoto, HONMA, Junpei, TANAKA, Ryuichi, RAMSEY, Jay, BLAESE, Michael, XANTHOPOULOS, Kleanthis G

“…Immunogene therapy for malignant gliomas was further investigated in this study to improve its therapeutic efficacy. Dendritic cells (DCs) were isolated from…”
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Development of improved Sindbis virus-based DNA expression vector by Yamanaka, Ryuya, Xanthopoulos, Kleanthis G

“…We have constructed an improved DNA expression vector based on the Sindbis virus. Several DNA-based Sindbis virus vectors were constructed to investigate the…”
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Induction of therapeutic antitumor antiangiogenesis by intratumoral injection of genetically engineered endostatin-producing Semliki Forest virus by Yamanaka, R, Zullo, S A, Ramsey, J, Onodera, M, Tanaka, R, Blaese, M, Xanthopoulos, K G

“…Antiangiogenic therapy using Semliki Forest virus (SFV) carrying Endostatin gene for malignant brain tumor was investigated to improve the therapeutic…”
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The Different Tissue Transcription Patterns of Genes for HNF-1, C/EBP, HNF-3, and HNF-4, Protein Factors that Govern Liver-Specific Transcription by XANTHOPOULOS, K. G, PRESIOSO, V. R, CHEN, W. S, SLADEK, F. M, CORTESE, R, DARNELL, J. E

“…The transcription factors that act in hepatocyte-specific gene expression include proteins that are present mainly in liver cells (HNF-1/LFB1, C/EBP, HNF-3,…”
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CCAAT/Enhancer Binding Protein ɛ Is Critical for Effective Neutrophil-Mediated Response to Inflammatory Challenge by Lekstrom-Himes, Julie, Xanthopoulos, Kleanthis G.

“…Targeted mutation of CCAAT/enhancer binding protein (C/EBP) ɛ in mice results in early death, primarily due to spontaneous infection with Pseudomonas…”
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Differential patterns of expression of three C/EBP isoforms, HNF-1, and HNF-4 after partial hepatectomy in rats by Flodby, P, Antonson, P, Barlow, C, Blanck, A, Porsch-Hällström, I, Xanthopoulos, K G

“…Regenerating liver provides a system for studying the mechanisms controlling regulated proliferation of differentiated hepatocytes. A set of transcription…”
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Synergistic Activation of the Human Btk Promoter by Transcription Factors Sp1/3 and PU.1 by Müller, Susanne, Maas, Alex, Islam, Tahmina Choudhuri, Sideras, Paschalis, Suske, Guntram, Philipsen, Sjaak, Xanthopoulos, Kleanthis G., Hendriks, Rudolf W., Smith, C.I.Edvard

“…Analysis of the human Bruton's agammaglobulinemia tyrosine kinase (Btk) gene promoter revealed that 280 bp upstream of the transcriptional start site is…”
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Induction of a therapeutic antitumor immunological response by intratumoral injection of genetically engineered Semliki Forest virus to produce interleukin-12 by Yamanaka, R, Zullo, S A, Tanaka, R, Ramsey, J, Blaese, M, Xanthopoulos, K G

“…The authors investigated immunogene therapy for malignant glioma to determine whether its therapeutic efficacy could be improved. Four groups of…”
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The art of the alliance: securing a partner is only the beginning--you then have to put substantial effort and resources into keeping the collaboration functioning and productive by Menzel, Garry E, Xanthopoulos, Kleanthis G

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One factor recognizes the liver-specific enhancers in alpha 1-antitrypsin and transthyretin genes by Grayson, D R, Costa, R H, Xanthopoulos, K G, Darnell, J E

“…Four different regulatory sites required for transcriptional stimulation by the enhancers of two unrelated liver-specific genes alpha 1-antitrypsin and…”
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Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein ɛ-deficient mice by Yamanaka, Ryuya, Barlow, Carrolee, Lekstrom-Himes, Julie, Castilla, Lucio H., Liu, Pu P., Eckhaus, Michael, Decker, Thomas, Wynshaw-Boris, Anthony, Xanthopoulos, Kleanthis G.

“…Polymorphonuclear leukocytes are essential for host defense to infectious diseases. CCAAT/enhancer binding protein ɛ (C/EBPɛ) is preferentially expressed in…”
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CCAAT/enhancer binding protein ɛ is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing by Yamanaka, Ryuya, Kim, Gun-Do, Radomska, Hanna S., Lekstrom-Himes, Julie, Smith, Laura T., Antonson, Per, Tenen, Daniel G., Xanthopoulos, Kleanthis G.

“…CCAAT/enhancer binding protein (C/EBP) ɛ is a recently cloned member of the C/EBP family of transcription factors and is expressed exclusively in cells of…”
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US immigration order strikes against biotech by Maraganore, John, Hastings, Paul J, Cohen, Ron, Adams, Julian, Adams, Chris, Aspinall, Mara G, Babler, Martin, Barry, Zoe, Bolno, Paul B, Booth, Bruce, Bradbury, Daniel M, Brauer, Steven K, Cali, Brian M, Ciechanover, Isaac, Clark, Chip, Clayman, Michael D, Cobb, Paula, Cooper, Ron, Currie, Mark G, Dobmeier, Eric L, Doerfler, Doug, Dunsire, Deborah, Flesher, Gregory J, Formela, Jean-Francois, Forrester, Robert, Freeman, Mason W, Furst, Howard, Gage, Leonard Patrick, Gallagher, Brian M, Geraghty, James A, Gill, Simba, Gowen, Maxine, Grayzel, David, Greene, Barry, Grint, Paul, Haney, Bill, Ha-Ngoc, Tuan, Harris, Tim, Hasnain, Faheem, Heyman, Rich, Hoppenot, Herve, Hughes, Thomas E, Hutton, Wende S, Isaacs, Stephen T, Jenkins, Annalisa, Jonker, Jeff, Karsen, Perry, Kindler, Jeff, King, Rachel, Koenig, Scott, Kolchinsky, Peter, Laikind, Paul, Lee, John J, Leicher, Bruce A, Levin, Andrew, Levine, Arnold J, Lopatin, Uri, Maderis, Gail J, Mahadevia, Ankit, McArthur, James G, McCarthy, Sean A, Miralles, Diego, Moch, Kenneth I, More, Bob, Myers, Andrew G, Newell, William J, Olle, Bernat, Osborn, John E, Owens, Julia C, Pande, Atul, Papadopoulos, Stelios, Parmar, Kush M, Patterson, Matthew R, Perez, Rob, Pfeffer, Cary G, Ramamoorthi, Kartik, Rawcliffe, Adrian (Ad), Reid, Laurence E, Renaud, Ron C, Rieflin, William J, Robins, Chad, Rosin, Jonathan G, Rutter, William J, Saha, Saurabh, Samuels, Camille, Sato, Vicki L, Scangos, George, Schreiber, Stuart L, Schwab, Andrew, Simon, Nick J, Taglietti, Marco, Tandon, Nina, Termeer, Henri, Ulevitch, Richard, Vaishnaw, Akshay K, Varsavsky, Martin, Vlasuk, George P, Williams, Doug E, Zohar, Daphne, Zweifach, Sandford (Sandy)

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