Search Results - "XUEI, X"

Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence by Wang, J C, Grucza, R, Cruchaga, C, Hinrichs, A L, Bertelsen, S, Budde, J P, Fox, L, Goldstein, E, Reyes, O, Saccone, N, Saccone, S, Xuei, X, Bucholz, K, Kuperman, S, Nurnberger, J, Rice, J P, Schuckit, M, Tischfield, J, Hesselbrock, V, Porjesz, B, Edenberg, H J, Bierut, L J, Goate, A M

“…Alcohol dependence frequently co-occurs with cigarette smoking, another common addictive behavior. Evidence from genetic studies demonstrates that alcohol…”
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Association of the κ-opioid system with alcohol dependence by XUEI, X, DICK, D, TISCHFIELD, J, KUPERMAN, S, PORJESZ, B, BEGLEITER, H, FOROUD, T, EDENBERG, H. J, FLURY-WETHERILL, L, TIAN, H.-J, AGRAWAL, A, BIERUT, L, GOATE, A, BUCHOLZ, K, SCHUCKIT, M, NURNBERGER, J

“…Opioid receptors and their endogenous peptide ligands play important roles in the reward and reinforcement of drugs such as heroin, cocaine, and alcohol. The…”
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Genome-wide association data suggest ABCB1 and immune-related gene sets may be involved in adult antisocial behavior by Salvatore, J E, Edwards, A C, McClintick, J N, Bigdeli, T B, Adkins, A, Aliev, F, Edenberg, H J, Foroud, T, Hesselbrock, V, Kramer, J, Nurnberger, J I, Schuckit, M, Tischfield, J A, Xuei, X, Dick, D M

“…Adult antisocial behavior (AAB) is moderately heritable, relatively common and has adverse consequences for individuals and society. We examined the molecular…”
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323 Transcriptomic analysis indicates that loss of epidermal Pparg promotes TLR4 signaling and significant overlap with the NMSC transcriptome by Konger, R.L., Xuei, X., Gao, H.

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Association studies of ALOX5 and bone mineral density in healthy adults by Foroud, T., Ichikawa, S., Koller, D., Lai, D., Curry, L., Xuei, X., Edenberg, H. J., Hui, S., Peacock, M., Econs, M. J.

“…Summary Animal studies suggest that arachidonate 5-lipoxygenase (encoded by ALOX5) may be a genetic determinant of bone mineral density. We tested this…”
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Human ALOX12, but Not ALOX15, Is Associated With BMD in White Men and Women by Ichikawa, Shoji, Koller, Daniel L, Johnson, Michelle L, Lai, Dongbing, Xuei, Xiaoling, Edenberg, Howard J, Klein, Robert F, Orwoll, Eric S, Hui, Siu L, Foroud, Tatiana M, Peacock, Munro, Econs, Michael J

“…The Alox15 gene was recently identified as a negative regulator of peak BMD in mice. Polymorphisms in human ALOX12, but not ALOX15, were significantly…”
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Contribution of the LRP5 Gene to Normal Variation in Peak BMD in Women by Koller, Daniel L, Ichikawa, Shoji, Johnson, Michelle L, Lai, Dongbing, Xuei, Xiaoling, Edenberg, Howard J, Conneally, P Michael, Hui, Siu L, Johnston, C Conrad, Peacock, Munro, Foroud, Tatiana, Econs, Michael J

“…The role of the LRP5 gene in rare BMD‐related traits has recently been shown. We tested whether variation in this gene might play a role in normal variation in…”
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Polymorphisms in the bone morphogenetic protein 2 (BMP2) gene do not affect bone mineral density in white men or women by ICHIKAWA, S, JOHNSON, M. L, KOLLER, D. L, LAI, D, XUEI, X, EDENBERG, H. J, HUI, S. L, FOROUD, T. M, PEACOCK, M, ECONS, M. J

“…Peak bone mineral density (BMD) achieved during adulthood is a major determinant of osteoporotic fracture in later life. Although environmental factors affect…”
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Changes over time in endorsement of 11 DSM‐IV alcohol use disorder (AUD) criteria in young adults with persistent or recurrent AUD in The Collaborative Study on the Genetics of Alcoholism by Schuckit, Marc A., Smith, Tom L., Danko, George, Tear, Jake, Hennies, Jessica, Mendoza, Lee Anne, Hesselbrock, Victor, Edenberg, Howard J., Hesselbrock, Michie, Bucholz, Kathleen, Chan, Grace, Kuperman, Samuel, Francis, Meredith W., Plawecki, Martin H., Porjesz, B., Hesselbrock, V., Foroud, T., Agrawal, A., Dick, D., Edenberg, H. J., Liu, Y., Plawecki, M., Kuperman, S., Kramer, J., Meyers, J., Kamarajan, C., Pandey, A., Bierut, L., Rice, J., Bucholz, K., Schuckit, M., Tischfield, J., Hart, R., Salvatore, J., Almasy, L., Goate, A., Slesinger, P., Scott, D., Nurnberger, J., Wetherill, L., Xuei, X., Lai, D., O’Connor, S., Chan, G., Chorlian, D. B., Zhang, J., Barr, P., Kinreich, S., Pandey, G., Mullins, N., Anokhin, A., Hartz, S., Johnson, E., McCutcheon, V., Saccone, S., Moore, J., Aliev, F., Pang, Z., Kuo, S., Merikangas, A., Chin, H., Parsian, A.

“…Background Endorsement of specific Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM‐IV) alcohol use disorder (AUD) criteria have been…”
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Integrating mRNA and miRNA Weighted Gene Co-Expression Networks with eQTLs in the Nucleus Accumbens of Subjects with Alcohol Dependence by Mamdani, Mohammed, Williamson, Vernell, McMichael, Gowon O, Blevins, Tana, Aliev, Fazil, Adkins, Amy, Hack, Laura, Bigdeli, Tim, van der Vaart, Andrew D, Web, Bradley Todd, Bacanu, Silviu-Alin, Kalsi, Gursharan, Kendler, Kenneth S, Miles, Michael F, Dick, Danielle, Riley, Brien P, Dumur, Catherine, Vladimirov, Vladimir I

“…Alcohol consumption is known to lead to gene expression changes in the brain. After performing weighted gene co-expression network analyses (WGCNA) on…”
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The collaborative study on the genetics of alcoholism: Sample and clinical data by Dick, Danielle M, Balcke, Emily, McCutcheon, Vivia, Francis, Meredith, Kuo, Sally, Salvatore, Jessica, Meyers, Jacquelyn, Bierut, Laura J, Schuckit, Marc, Hesselbrock, Victor, Edenberg, Howard J, Porjesz, Bernice, Kuperman, Samuel, Kramer, John, Bucholz, Kathleen

“…The collaborative study on the genetics of alcoholism (COGA) is a multi-site, multidisciplinary project with the goal of identifying how genes are involved in…”
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The Collaborative Study on the Genetics of Alcoholism: Overview by Agrawal, Arpana, Brislin, Sarah J, Bucholz, Kathleen K, Dick, Danielle, Hart, Ronald P, Johnson, Emma C, Meyers, Jacquelyn, Salvatore, Jessica, Slesinger, Paul, Almasy, Laura, Foroud, Tatiana, Goate, Alison, Hesselbrock, Victor, Kramer, John, Kuperman, Samuel, Merikangas, Alison K, Nurnberger, John I, Tischfield, Jay, Edenberg, Howard J, Porjesz, Bernice

“…Alcohol use disorders (AUD) are commonly occurring, heritable and polygenic disorders with etiological origins in the brain and the environment. To outline the…”
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Characterization of an echinocandin B-producing strain blocked for sterigmatocystin biosynthesis reveals a translocation in the stcW gene of the aflatoxin biosynthetic pathway by HODGES, R. L, KELKAR, H. S, XUEI, X, SKATRUD, P. L, KELLER, N. P, ADAMS, T. H, KAISER, R. E, VINCI, V. A, MCGILVRAY, D

“…Echinocandin B (ECB), a lipopolypeptide used as a starting material for chemical manufacture of the anti-Candida agent LY303366, is produced by fermentation…”
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The Impact of Peer Substance Use and Polygenic Risk on Trajectories of Heavy Episodic Drinking Across Adolescence and Emerging Adulthood by Li, James J., Cho, Seung Bin, Salvatore, Jessica E., Edenberg, Howard J., Agrawal, Arpana, Chorlian, David B., Porjesz, Bernice, Hesselbrock, Victor, Dick, Danielle M., Edenberg, H., Bierut, L., Nurnberger, J., Foroud, T., Kuperman, S., Kramer, J., Goate, A., Rice, J., Bucholz, K., Schuckit, M., Tischfield, J., Almasy, L., Taylor, R., Dick, D., Bauer, L., Koller, D., O'Connor, S., Wetherill, L., Xuei, X., Chan, Grace, Kang, S., Manz, N., Wang, J‐C, Brooks, A., Aliev, F., Parsian, A., Reilly, M.

“…Background Heavy episodic drinking is developmentally normative among adolescents and young adults, but is linked to adverse consequences in later life, such…”
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Rare missense variants in CHRNB3 and CHRNA3 are associated with risk of alcohol and cocaine dependence by Haller, Gabe, Kapoor, Manav, Budde, John, Xuei, Xiaoling, Edenberg, Howard, Nurnberger, John, Kramer, John, Brooks, Andy, Tischfield, Jay, Almasy, Laura, Agrawal, Arpana, Bucholz, Kathleen, Rice, John, Saccone, Nancy, Bierut, Laura, Goate, Alison

“…Previous findings have demonstrated that variants in nicotinic receptor genes are associated with nicotine, alcohol and cocaine dependence. Because of the…”
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Polygenic Risk Score Prediction of Alcohol Dependence Symptoms Across Population‐Based and Clinically Ascertained Samples by Savage, Jeanne E., Salvatore, Jessica E., Aliev, Fazil, Edwards, Alexis C., Hickman, Matthew, Kendler, Kenneth S., Macleod, John, Latvala, Antti, Loukola, Anu, Kaprio, Jaakko, Rose, Richard J., Chan, Grace, Hesselbrock, Victor, Webb, Bradley T., Adkins, Amy, Bigdeli, Tim B., Riley, Brien P., Dick, Danielle M., Porjesz, B., Edenberg, H., Bierut, L., Nurnberger, J., Foroud, T., Kuperman, S., Kramer, J., Rice, J., Bucholz, K., Agrawal, A., Schuckit, M., Tischfield, J., Brooks, A., Almasy, L., Goate, A., Taylor, R., Bauer, L., McClintick, J., Wetherill, L., Xuei, X., Liu, Y., Lai, D., O'Connor, S., Plawecki, M., Lourens, S., Meyers, J., Chorlian, D., Kamarajan, C., Pandey, A., Zhang, J., Wang, J.‐C., Kapoor, M., Bertelsen, S., Anokhin, A., McCutcheon, V., Saccone, S., Cho, B., Parsian, A., Reilly, M.

“…Background Despite consistent evidence of the heritability of alcohol use disorders (AUDs), few specific genes with an etiological role have been identified…”
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Variation in SWI/SNF Chromatin Remodeling Complex Proteins is Associated with Alcohol Dependence and Antisocial Behavior in Human Populations by Mathies, Laura D., Aliev, Fazil, Davies, Andrew G., Dick, Danielle M., Bettinger, Jill C., Porjesz, B., Hesselbrock, V., Edenberg, H., Bierut, L., Nurnberger, J., Foroud, T., Kuperman, S., Kramer, J., Porjesz, B., Bierut, L., Rice, J., Bucholz, K., Agrawal, A., Schuckit, M., Tischfield, J., Brooks, A., Almasy, L., Goate, A., Taylor, R., Bauer, L., McClintick, J., Wetherill, L., Xuei, X., Liu, Y., Lai, D., O'Connor, S., Plawecki, M., Lourens, S., Chan, G., Meyers, J., Chorlian, D., Kamarajan, C., Pandey, A., Zhang, J., Wang, J.‐C., Kapoor, M., Bertelsen, S., Anokhin, A., McCutcheon, V., Saccone, S., Salvatore, J., Cho, B., Kos, M., Parsian, A., Reilly, M.

“…Background Testing for direct gene or single nucleotide polymorphism replication of association across studies may not capture the true importance of a…”
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A strategy for discovery of novel broad-spectrum antibacterials using a high-throughput Streptococcus pneumoniae transcription/translation screen by Pratt, Steven D, David, Caroline A, Black-Schaefer, Candace, Dandliker, Peter J, Xuei, Xiaoling, Warrior, Usha, Burns, David J, Zhong, Ping, Cao, Zhensheng, Saiki, Anne Y C, Lerner, Claude G, Chovan, Linda E, Soni, Niru B, Nilius, Angela M, Wagenaar, Frank L, Merta, Philip J, Traphagen, Linda M, Beutel, Bruce A

“…The authors report the development of a high-throughput screen for inhibitors of Streptococcus pneumoniae transcription and translation (TT) using a luciferase…”
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Molecular karyotype alterations induced by transformation in Aspergillus nidulans are mitotically stable by Xuei, X. (Eli Lilly and Company, Indianapolis, (USA). Infectious Disease Research), Skatrud, P.L

“…Clamped homogeneous electric field (CHEF)gel electrophoresis was used to define the electrophoretic molecular karyotype of Aspergillus nidulans strain OC-1…”
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High Polygenic Risk Scores Are Associated With Early Age of Onset of Alcohol Use Disorder in Adolescents and Young Adults at Risk by Nurnberger, John I., Wang, Yumin, Zang, Yong, Lai, Dongbing, Wetherill, Leah, Edenberg, Howard J., Aliev, Fazil, Plawecki, Martin H., Chorlian, David, Chan, Grace, Bucholz, Kathleen, Bauer, Lance, Kamarajan, Chella, Salvatore, Jessica E., Kapoor, Manav, Hesselbrock, Victor, Dick, Danielle, Bierut, Laura, McCutcheon, Vivia, Meyers, Jacquelyn L., Porjesz, Bernice, Kramer, John, Kuperman, Samuel, Kinreich, Sivan, Anokhin, Andrey P., Porjesz, B., Hesselbrock, V., Foroud, T., Agrawal, A., Dick, D., Edenberg, H.J., Nurnberger, J., Liu, Y., Kuperman, S., Kramer, J., Meyers, J., Kamarajan, C., Pandey, A., Bierut, L., Rice, J., Bucholz, K., Schuckit, M., Tischfield, J., Brooks, A., Hart, R., Almasy, L., Salvatore, J., Goate, A., Kapoor, M., Slesinger, P., Scott, D., Bauer, L., Wetherill, L., Xuei, X., Lai, D., O’Connor, S., Plawecki, M., Zang, Y., Acion, L., Chan, G., Chorlian, D.B., Zhang, J., Kinreich, S., Pandey, G., Chao, M., Anokhin, A., McCutcheon, V., Saccone, S., Aliev, F., Barr, P., Chin, H., Parsian, A.

“…Genome-wide association studies have been conducted in alcohol use disorder (AUD), and they permit the use of polygenic risk scores (PRSs), in combination with…”
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