Search Results - "XUE-ZHI QIN"

γ-Secretase binding sites in aged and Alzheimer's disease human cerebrum: the choroid plexus as a putative origin of CSF Aβ by Liu, Fei, Xue, Zhi-Qin, Deng, Si-Hao, Kun, Xiong, Luo, Xue-Gang, Patrylo, Peter R., Rose, Gregory M., Cai, Huaibin, Struble, Robert G., Cai, Yan, Yan, Xiao-Xin

“…Deposition of β ‐amyloid (Aβ) peptides, cleavage products of β‐amyloid precursor protein (APP) by β‐secretase‐1 (BACE1) and γ‐secretase, is a neuropathological…”
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Experimental epidural hematoma causes cerebral infarction and activates neocortical glial and neuronal genesis in adult guinea pigs by Pan, Aihua, Li, Ming, Gao, Jun-Yan, Xue, Zhi-Qin, Li, Zhiyuan, Yuan, Xian-Yui, Luo, Duan-Wu, Luo, Xue-Gang, Yan, Xiao-Xin

“…Epidural hematoma (EDH) is a type of life‐threatening traumatic brain injury. Little is known about the extent to which EDH may cause neural damage and…”
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Tensile Properties and Deformation Behavior of Several Cast Ni-Based Superalloys Fabricated by Different Solidification Ways by Li, Hai-Tao, Liang, Yong-Chun, Zhong, Wan-Li, Qin, Xue-Zhi, Guo, Jian-Ting, Zhou, Lan-Zhang, Ren, Wei-Li

“…The tensile properties and deformation behavior of several cast Ni-based superalloys, respectively, in the equiaxed, columnar-crystal and single-crystal styles…”
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Tandem mass spectrum of a farnesyl transferase inhibitor- gas-phase rearrangements involving imidazole by Qin, Xue-Zhi

“…Compound 1 (1‐(3‐chlorophenyl)‐4‐[1‐(4‐cyanobenzyl)imidazolylmethyl]‐2‐piperazinone hydrochloride) is a farnesyl transferase inhibitor intended for treatment…”
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Collision-induced dissociation of the negative ions of simvastatin hydroxy acid and related species by Qin, Xue-Zhi

“…Simvastatin hydroxy acid (1) is a well‐known, potent HMG‐CoA reductase inhibitor for the treatment of hypercholesterolemia. Its lactone, simvastatin…”
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Novel rearrangements of an N-oxide degradate formed from oxidation of a morpholine acetal substance P antagonist by Zhao, Zhongxi Zack, Qin, Xue-Zhi, Wu, Allen, Yuan, Yang

“…Compound 1 [5-[2(R)-[1(R)-(3,5-bistrifluoromethylphenyl) ethoxy]-3(s)-(4-fluorophenyl)morpholin-4-ylmethyl]-3h-[1,2,3] triazol-4-ylmethyl]dimethylamine…”
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Age-related intraneuronal accumulation of αII-spectrin breakdown product SBDP120 in the human cerebrum is enhanced in Alzheimer's disease by Zhu, Hai-Xia, Xue, Zhi-Qin, Qiu, Wen-Ying, Zeng, Zhao-Jun, Dai, Jia-Pei, Ma, Chao, Luo, Xue-Gang, Yan, Xiao-Xin

“…Spectrins are a part of cytoskeletal platform that lines the intracellular side of plasma membrane, which can be proteolyzed by calcium-sensitive enzymes…”
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Application of liquid chromatography/mass spectrometry and nuclear magnetic resonance to the identification of degradates of a novel insulin sensitizer in aqueous solutions by WANG, Michael H, YUNHUI WU, HWANG, Tsang-Lin, QIN, Xue-Zhi, KARKI, Shyam, TREEMANEEKARN, Varaporn

“…Degradation of a novel insulin sensitizer in aqueous solutions was studied using high pressure liquid chromatography/mass spectrometry (LC/MS). The insulin…”
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Non-neuronal and neuronal BACE1 elevation in association with angiopathic and leptomeningeal β-amyloid deposition in the human brain by Xue, Zhi-Qin, He, Zheng-Wen, Yu, Jian-Jun, Cai, Yan, Qiu, Wen-Ying, Pan, Aihua, Gai, Wei-Ping, Cai, Huaibin, Luo, Xue-Gang, Ma, Chao, Yan, Xiao-Xin

“…Cerebral amyloid angiopathy (CAA) refers to the deposition of β-amyloid (Aβ) peptides in the wall of brain vasculature, commonly involving capillaries and…”
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γ-Secretase binding sites in aged and Alzheimer's disease human cerebrum: the choroid plexus as a putative origin of CSF Aβ by Liu, Fei, Xue, Zhi-Qin, Deng, Si-Hao, Kun, Xiong, Luo, Xue-Gang, Patrylo, Peter R., Rose, Gregory M., Cai, Huaibin, Struble, Robert G., Cai, Yan, Yan, Xiao-Xin

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Atmospheric pressure ionization tandem mass spectra of protonated timolol by Qin, Xue-Zhi

“…Structural identification of drugs by tandem mass spectrometry (MS/MS) is interesting, important and challenging. In this study, atmospheric pressure…”
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Amyloid plaque pathogenesis in 5XFAD mouse spinal cord: retrograde transneuronal modulation after peripheral nerve injury by Li, Jian-Ming, Xue, Zhi-Qin, Deng, Si-Hao, Luo, Xue-Gang, Patrylo, Peter R., Rose, Gregory W., Cai, Huaibin, Cai, Yan, Yan, Xiao-Xin

“…The spinal cord is composed of distinct neuronal groups with well-defined anatomic connections. In some transgenic (Tg) models of Alzheimer’s disease (AD),…”
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Parenteral formulation and thermal degradation pathways of a potent rebeccamycin based indolocarbazole topoisomerase I inhibitor by Sato, Yuichi, Breslin, David, Kitada, Hideyuki, Minagawa, Wataru, Nomoto, Takashi, Qin, Xue-Zhi, Karki, Shyam B.

“…The development of a practical and pharmaceutically acceptable parenteral dosage form of 1 is described. A cosolvent formulation strategy was selected to…”
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Atmospheric pressure chemical ionization tandem mass spectra of α- and β-aspartame by Qin, Xue-Zhi

“…Atmospheric pressure chemical ionization tandem mass spectrometry was used to study the gas‐phase reactions of protonated α‐ and β‐aspartame. The results show…”
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Collision-induced dissociation of protonated MK-0991: novel ring opening of a cyclic hexapeptide in the gas phase by Qin, Xue-Zhi, Wu, Yunhui, Zhao, Zack, Chen, Xin

“…Electrospray ionization tandem mass spectrometry was applied to probe the collision‐induced dissociation (CID) of protonated MK‐0991…”
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Tandem mass spectrum of a growth hormone secretagogue: amide bond cleavage and resultant gas-phase rearrangement by Qin, Xue-Zhi

“…Compound 1 {N-[1(R) − [(1,2-dihydro-1-methylsulfonylspiro[3H-indole-3,4′-piperidin]-1′-yl)carbonyl]-2-(phenylmethyloxy)ethyl]-2-amino-2-methylpropanamide}(MW…”
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Electrospray ionization/collision-induced dissociation of protonated substance P ions—effect of charge on the fragmentation patterns by Qin, Xue-Zhi, Yuan, Yang

“…Low-energy collision-induced dissociation (CID) of singly charged [ M + H] + and doubly charged [ M + 2H] 2+ substance P (SP) ions generated by electrospray…”
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ESR studies on the radical cation mechanism of the ring opening of cyclopropylamines by Qin, Xue Zhi, Williams, Ffrancon

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Identification of losartan degradates in stressed tablets by LC-MS and LC-MS/MS by Zhao, Zhongxi (Zack), Wang, Qingxi, Tsai, Eric W, Qin, Xue-Zhi, Ip, Dominic

“…Three unknown peaks were observed in the severely stressed losartan tablets (at 40°C and 75% relative humidity for 3 years) analyzed by a stability indicating…”
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Radical Cations from Dicyclopropylidenemethane and Its Octamethyl Derivative by Bally, Thomas, Müller, Beat, Gerson, Fabian, Qin, Xue-Zhi, von Seebach, Malte, Kozhushkov, Sergei I, de Meijere, Armin, Borovkov, Vsevolod I, Potashov, Pavel A

“…The radical cations of dicyclopropylidenemethane (2) and its octamethyl derivative (2-Me8) are prone to rearrangements into those of…”
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