Search Results - "XUDONG GENG"

Fully Synthetic Carbohydrate HIV Antigens Designed on the Logic of the 2G12 Antibody by Krauss, Isaac J, Joyce, Joseph G, Finnefrock, Adam C, Song, Hong C, Dudkin, Vadim Y, Geng, Xudong, Warren, J. David, Chastain, Michael, Shiver, John W, Danishefsky, Samuel J

“…Di- and trivalent glycopeptide mimics of the HIV 2G12 epitope have been synthesized and evaluated for their comparative 2G12 binding characteristics. The…”
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New Efficient Synthesis of Resorcinylic Macrolides via Ynolides:  Establishment of Cycloproparadicicol as Synthetically Feasible Preclinical Anticancer Agent Based on Hsp90 as the Target by Yang, Zhi-Qiang, Geng, Xudong, Solit, David, Pratilas, Christine A, Rosen, Neal, Danishefsky, Samuel J

“…A program currently ongoing in our laboratory envisions natural macrolide radicicol-based inhibitors targeting the molecular chaperone Hsp90. Such inhibitors…”
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Design, Synthesis, and Biological Evaluation of New-Generation Taxoids by Ojima, Iwao, Chen, Jin, Sun, Liang, Borella, Christopher P, Wang, Tao, Miller, Michael L, Lin, Songnian, Geng, Xudong, Kuznetsova, Larisa, Qu, Chuanxing, Gallager, David, Zhao, Xianrui, Zanardi, Ilaria, Xia, Shujun, Horwitz, Susan B, Mallen-St. Clair, Jon, Guerriero, Jennifer L, Bar-Sagi, Dafna, Veith, Jean M, Pera, Paula, Bernacki, Ralph J

“…Novel second-generation taxoids with systematic modifications at the C2, C10, and C3′N positions were synthesized and their structure−activity relationships…”
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In Pursuit of Carbohydrate-Based HIV Vaccines, Part 2: The Total Synthesis of High-Mannose-Type gp120 Fragments-Evaluation of Strategies Directed to Maximal Convergence by Geng, Xudong, Dudkin, Vadim Y., Mandal, Mihirbaran, Danishefsky, Samuel J.

“…A “layered approach” and a “block approach” were used to assemble the high‐mannose glycan of gp120 glycopeptide fragments (e.g. high‐mannose‐type conjugates…”
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In Pursuit of Carbohydrate-Based HIV Vaccines, Part 1: The Total Synthesis of Hybrid-Type gp120 Fragments by Mandal, Mihirbaran, Dudkin, Vadim Y., Geng, Xudong, Danishefsky, Samuel J.

“…Key features in the successful synthesis of hybrid‐type gp‐120 fragments (see picture) include β‐mannosylations to construct the core trisaccharide and a…”
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Toward Fully Synthetic Carbohydrate-Based HIV Antigen Design:  On the Critical Role of Bivalency by Dudkin, Vadim Y, Orlova, Marianna, Geng, Xudong, Mandal, Mihirbaran, Olson, William C, Danishefsky, Samuel J

“…Synthetic gp120331-335 glycopeptide fragments carrying hybrid and high-mannose type N-linked glycans were evaluated for binding to broadly neutralizing…”
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Synthesis of Novel C2−C3‘N-Linked Macrocyclic Taxoids by Means of Highly Regioselective Heck Macrocyclization by Geng, Xudong, Miller, Michael L, Lin, Songnian, Ojima, Iwao

“…Novel C2−C3‘N-linked macrocyclic taxoids are synthesized using intramolecular Heck reaction in the key step. Macrocyclization proceeds with high…”
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Tumor-Specific Novel Taxoid−Monoclonal Antibody Conjugates by Ojima, Iwao, Geng, Xudong, Wu, Xinyuan, Qu, Chuanxing, Borella, Christopher P, Xie, Hongsheng, Wilhelm, Sharon D, Leece, Barbara A, Bartle, Laura M, Goldmacher, Victor S, Chari, Ravi V. J

“…Taxoids bearing methyldisulfanyl(alkanoyl) groups for taxoid−antibody immunoconjugates were designed, synthesized and their activities evaluated. A highly…”
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Impact of pipelines on cooling demand in the gaseous hydrogen refueling station by Wu, Yimei, Geng, Xudong, Chen, Jianye, Shao, Shuangquan

“…Hydrogen precooling is an effective method to realize safe, adequate, and fast filling for fuel cell vehicles. Estimating cooling demand is essential for the…”
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Performance analysis of a R134a/CO2 cascade heat pump in severe cold regions of China by Zhang, Hongwei, Geng, Xudong, Shao, Shuangquan, Si, Chunqiang, Wang, Zhichao

“…To achieve efficient and reliable heating in severe cold regions below −20 °C, this paper investigates a R134a/CO2 cascade air source heat pump (ASHP) system…”
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Design, Synthesis, and Biological Evaluation of Novel C14-C3'BzN-Linked Macrocyclic Taxoids by LIANG SUN, XUDONG GENG, PERA, Paula, BEMACKI, Ralph J, OJIMA, Iwao, GENEY, Raphaël, YUAN LI, SIMMERLING, Carlos, ZHONG LI, LAUHER, Joseph W, SHUJUN XIA, HORWITZ, Susan B, VEITH, Jean M

“…Novel macrocyclic paclitaxel congeners were designed to mimic the bioactive conformation of paclitaxel. Computational analysis of the "REDOR-Taxol" structure…”
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Tubulins in the primate retina: evidence that xanthophylls may be endogenous ligands for the paclitaxel-binding site by Crabtree, Donald V, Ojima, Iwao, Geng, Xudong, Adler, Alice J

“…The xanthophylls—lutein, zeaxanthin, and meso-zeaxanthin (L&Z)—are found in the central region of the primate retina, which is called the macula lutea (yellow…”
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Synthesis and structure-activity relationships of new second-generation taxoids by Ojima, Iwao, Wang, Tao, Miller, Michael L., Lin, Songnian, Borella, Christopher P., Geng, Xudong, Pera, Paula, Bernacki, Rapph J.

“…A series of second-generation taxoids bearing a substitutent on the C-2-benzoyl group and modifications at C-3′/C-10 positions was synthesized. These taxoids…”
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A data-driven evaluating method on the defrosting effect of the air source heat pump system in Beijing by Guo, Yanhua, Shao, Shuangquan, Geng, Xudong, Li, Hao, Wang, Zhichao, Akkurt, Nevzat

“…•A data-driven model-based defrosting control method is proposed to save energy.•Long-term field measurement and manually labeling improve actual defrosting…”
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Design, synthesis and biological activity of novel C2-C3′ N-Linked macrocyclic taxoids by Ojima, Iwao, Geng, Xudong, Lin, Songnian, Pera, Paula, Bernacki, Ralph J

“…A series of novel macrocyclic taxoids was designed and synthesized by connecting the C-2 and C-3′ N positions of the taxoid framework with various tethers…”
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Investigation on the two-phase loop cooling system composed of maglev compressor and liquid pump for data centers by Wang, Bo, Wang, Fei, Yang, Minghong, Bao, Yunhao, Geng, Xudong, Shao, Shuangquan

“…•The cooling system composed of maglev compressor and liquid pump is proposed.•The two-phase loop cooling system is oil free and structurally reliable.•As…”
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Confined Cascade Metabolic Reprogramming Nanoreactor for Targeted Alcohol Detoxification and Alcoholic Liver Injury Management by Geng, Xudong, Du, Xuancheng, Wang, Weijie, Zhang, Chengmei, Liu, Xiangdong, Qu, Yuanyuan, Zhao, Mingwen, Li, Weifeng, Zhang, Mingzhen, Tu, Kangsheng, Li, Yong-Qiang

“…Alcoholic liver injury (ALI) is the leading cause of serious liver disease, whereas current treatments are mostly supportive and unable to metabolize alcohol…”
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Performance analysis of a heat pump dryer with separate heat recovery using an energy, exergy, and economic methodology by Jin, Jianlong, Geng, Xudong, Huang, Qunxing, Yuan, Ya, Dong, Jian, Lin, Chengqian, Li, Bo, Yang, Luwei

“…Heat pump drying system is prospect technology with high efficiency and energy saving. Stable and efficient operation of heat pump drying systems in cold…”
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Graphene Quantum Dots Nanoantibiotic-Sensitized TiO 2- x Heterojunctions for Sonodynamic-Nanocatalytic Therapy of Multidrug-Resistant Bacterial Infections by Qian, Ying, Wang, Jingming, Geng, Xudong, Jia, Bingqing, Wang, Lei, Li, Yong-Qiang, Geng, Bijiang, Huang, Weimin

“…The exploration of sonodynamic therapy (SDT) as a possible replacement for antibiotics by creating reactive oxygen species (ROS) is suggested as a…”
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Graphene Quantum Dots Nanoantibiotic‐Sensitized TiO2−x Heterojunctions for Sonodynamic‐Nanocatalytic Therapy of Multidrug‐Resistant Bacterial Infections by Qian, Ying, Wang, Jingming, Geng, Xudong, Jia, Bingqing, Wang, Lei, Li, Yong‐Qiang, Geng, Bijiang, Huang, Weimin

“…The exploration of sonodynamic therapy (SDT) as a possible replacement for antibiotics by creating reactive oxygen species (ROS) is suggested as a…”
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