Search Results - "XIONGBIN LU"

Carbon nano-onion-mediated dual targeting of P-selectin and P-glycoprotein to overcome cancer drug resistance by Wang, Hai, Liang, Yutong, Yin, Yue, Zhang, Jie, Su, Wen, White, Alisa M., Bin Jiang, Xu, Jiangsheng, Zhang, Yuntian, Stewart, Samantha, Lu, Xiongbin, He, Xiaoming

“…The transmembrane P-glycoprotein (P-gp) pumps that efflux drugs are a major mechanism of cancer drug resistance. They are also important in protecting normal…”
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Harnessing tumorous flaws for immune supremacy: is miRNA-155 the weak link in breast cancer progression? by Sharma, Samantha, Opyrchal, Mateusz, Lu, Xiongbin

“…With the advent of immune checkpoint blockade (ICB) therapy, treatment strategies for late-stage cancers have seen a radical advancement. In this issue of…”
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Precise targeting of POLR2A as a therapeutic strategy for human triple negative breast cancer by Xu, Jiangsheng, Liu, Yunhua, Li, Yujing, Wang, Hai, Stewart, Samantha, Van der Jeught, Kevin, Agarwal, Pranay, Zhang, Yuntian, Liu, Sheng, Zhao, Gang, Wan, Jun, Lu, Xiongbin, He, Xiaoming

“…TP53 is the most frequently mutated or deleted gene in triple negative breast cancer (TNBC). Both the loss of TP53 and the lack of targeted therapy are…”
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Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance by Wang, Hai, Gao, Zan, Liu, Xuanyou, Agarwal, Pranay, Zhao, Shuting, Conroy, Daniel W., Ji, Guang, Yu, Jianhua, Jaroniec, Christopher P., Liu, Zhenguo, Lu, Xiongbin, Li, Xiaodong, He, Xiaoming

“…Multidrug resistance is a major challenge to cancer chemotherapy. The multidrug resistance phenotype is associated with the overexpression of the adenosine…”
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Hyaluronic acid-decorated dual responsive nanoparticles of Pluronic F127, PLGA, and chitosan for targeted co-delivery of doxorubicin and irinotecan to eliminate cancer stem-like cells by Wang, Hai, Agarwal, Pranay, Zhao, Shuting, Xu, Ronald X, Yu, Jianhua, Lu, Xiongbin, He, Xiaoming

“…Abstract Dual responsive nanoparticles are developed for co-delivery of multiple anticancer drugs to target the drug resistance mechanisms of cancer stem-like…”
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High-throughput acoustofluidic fabrication of tumor spheroids by Chen, Bin, Wu, Yue, Ao, Zheng, Cai, Hongwei, Nunez, Asael, Liu, Yunhua, Foley, John, Nephew, Kenneth, Lu, Xiongbin, Guo, Feng

“…Three-dimensional (3D) culture of multicellular spheroids, offering a desirable biomimetic microenvironment, is appropriate for recapitulating tissue cellular…”
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Chitosan-Decorated Doxorubicin-Encapsulated Nanoparticle Targets and Eliminates Tumor Reinitiating Cancer Stem-like Cells by Rao, Wei, Wang, Hai, Han, Jianfeng, Zhao, Shuting, Dumbleton, Jenna, Agarwal, Pranay, Zhang, Wujie, Zhao, Gang, Yu, Jianhua, Zynger, Debra L, Lu, Xiongbin, He, Xiaoming

“…Tumor reinitiating cancer stem-like cells are responsible for cancer recurrence associated with conventional chemotherapy. We developed a…”
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MicroRNA and signal transduction pathways in tumor radiation response by Zhao, Luqing, Lu, Xiongbin, Cao, Ya

“…Tumor radiation response is an essential issue in radiotherapy and a core determining factor of tumor radioresistance or radiosensitivity. Multiple factors can…”
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The ATM Kinase Induces MicroRNA Biogenesis in the DNA Damage Response by Zhang, Xinna, Wan, Guohui, Berger, Franklin G., He, Xiaoming, Lu, Xiongbin

“…The DNA damage response involves a complex network of processes that detect and repair DNA damage. Here we show that miRNA biogenesis is globally induced upon…”
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Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth by Yang, Lifeng, Achreja, Abhinav, Yeung, Tsz-Lun, Mangala, Lingegowda S., Jiang, Dahai, Han, Cecil, Baddour, Joelle, Marini, Juan C., Ni, Joseph, Nakahara, Ryuichi, Wahlig, Stephen, Chiba, Lisa, Kim, Sun Hye, Morse, Joshua, Pradeep, Sunila, Nagaraja, Archana Sidalaghatta, Haemmerle, Monika, Kyunghee, Noh, Derichsweiler, Mathew, Plackemeier, Thomas, Mercado-Uribe, Imelda, Lopez-Berestein, Gabriel, Moss, Tyler, Ram, Prahlad T., Liu, Jinsong, Lu, Xiongbin, Mok, Samuel C., Sood, Anil K., Nagrath, Deepak

“…Reactive stromal cells are an integral part of tumor microenvironment (TME) and interact with cancer cells to regulate their growth. Although targeting stromal…”
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PLUS: Predicting cancer metastasis potential based on positive and unlabeled learning by Zhou, Junyi, Lu, Xiaoyu, Chang, Wennan, Wan, Changlin, Lu, Xiongbin, Zhang, Chi, Cao, Sha

“…Metastatic cancer accounts for over 90% of all cancer deaths, and evaluations of metastasis potential are vital for minimizing the metastasis-associated…”
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Microfluidics guided by deep learning for cancer immunotherapy screening by Ao, Zheng, Cai, Hongwei, Wu, Zhuhao, Hu, Liya, Nunez, Asael, Zhou, Zhuolong, Liu, Hongcheng, Bondesson, Maria, Lu, Xiongbin, Lu, Xin, Dao, Ming, Guo, Feng

“…Immunocyte infiltration and cytotoxicity play critical roles in both inflammation and immunotherapy. However, current cancer immunotherapy screening methods…”
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In-situ cryo-immune engineering of tumor microenvironment with cold-responsive nanotechnology for cancer immunotherapy by Ou, Wenquan, Stewart, Samantha, White, Alisa, Kwizera, Elyahb A., Xu, Jiangsheng, Fang, Yuanzhang, Shamul, James G., Xie, Changqing, Nurudeen, Suliat, Tirada, Nikki P., Lu, Xiongbin, Tkaczuk, Katherine H. R., He, Xiaoming

“…Cancer immunotherapy that deploys the host’s immune system to recognize and attack tumors, is a promising strategy for cancer treatment. However, its efficacy…”
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USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1 by Zhang, Xinna, Berger, Franklin G, Yang, Jianhua, Lu, Xiongbin

“…Tumour suppressor p53 levels in the cell are tightly regulated by controlled degradation through ubiquitin ligases including Mdm2, COP1, Pirh2, and ARF‐BP1…”
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USP13 promotes development and metastasis of high-grade serous ovarian carcinoma in a novel mouse model by Kwon, Juntae, Choi, Hyeongjwa, Ware, Anna D., Morillo, Bernadette Cecilia, Wang, Haiyang, Bouker, Kerrie B., Lu, Xiongbin, Waldman, Todd, Han, Cecil

“…Epithelial ovarian cancer is the most lethal gynecologic malignancy and one of the most common causes of cancer mortality among women worldwide…”
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TP53 loss creates therapeutic vulnerability in colorectal cancer by Liu, Yunhua, Zhang, Xinna, Han, Cecil, Wan, Guohui, Huang, Xingxu, Ivan, Cristina, Jiang, Dahai, Rodriguez-Aguayo, Cristian, Lopez-Berestein, Gabriel, Rao, Pulivarthi H., Maru, Dipen M., Pahl, Andreas, He, Xiaoming, Sood, Anil K., Ellis, Lee M., Anderl, Jan, Lu, Xiongbin

“…Genomic deletion of the tumour suppressor TP53 frequently includes other neighbouring genes, such as the POLR2A housekeeping gene that encodes a crucial RNA…”
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A Near-Infrared Laser-Activated "Nanobomb" for Breaking the Barriers to MicroRNA Delivery by Wang, Hai, Agarwal, Pranay, Zhao, Shuting, Yu, Jianhua, Lu, Xiongbin, He, Xiaoming

“…A near‐infrared laser‐activated “nanobomb” is synthesized using lipid and multiple polymers to break the extra­cellular and intracellular barriers to cytosolic…”
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Amplification of USP13 drives ovarian cancer metabolism by Han, Cecil, Yang, Lifeng, Choi, Hyun Ho, Baddour, Joelle, Achreja, Abhinav, Liu, Yunhua, Li, Yujing, Li, Jiada, Wan, Guohui, Huang, Cheng, Ji, Guang, Zhang, Xinna, Nagrath, Deepak, Lu, Xiongbin

“…Dysregulated energetic metabolism has been recently identified as a hallmark of cancer. Although mutations in metabolic enzymes hardwire metabolism to…”
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Intron retention-induced neoantigen load correlates with unfavorable prognosis in multiple myeloma by Dong, Chuanpeng, Cesarano, Annamaria, Bombaci, Giuseppe, Reiter, Jill L., Yu, Christina Y., Wang, Yue, Jiang, Zhaoyang, Zaid, Mohammad Abu, Huang, Kun, Lu, Xiongbin, Walker, Brian A., Perna, Fabiana, Liu, Yunlong

“…Neoantigen peptides arising from genetic alterations may serve as targets for personalized cancer vaccines and as positive predictors of response to immune…”
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Adaptive phase I–II clinical trial designs identifying optimal biological doses for targeted agents and immunotherapies by Zang, Yong, Guo, Beibei, Qiu, Yingjie, Liu, Hao, Opyrchal, Mateusz, Lu, Xiongbin

“…Targeted agents and immunotherapies have revolutionized cancer treatment, offering promising options for various cancer types. Unlike traditional therapies the…”
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