Search Results - "XINGHUA LU"

Unsupervised deep learning reveals prognostically relevant subtypes of glioblastoma by Young, Jonathan D, Cai, Chunhui, Lu, Xinghua

“…One approach to improving the personalized treatment of cancer is to understand the cellular signaling transduction pathways that cause cancer at the level of…”
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Purely Coherent Nonlinear Optical Response in Solution Dispersions of Graphene Sheets by Wu, Rui, Zhang, Yingli, Yan, Shichao, Bian, Fei, Wang, Wenlong, Bai, Xuedong, Lu, Xinghua, Zhao, Jimin, Wang, Enge

“…We have developed an efficient chemical exfoliation approach for the high-throughput synthesis of solution-processable, high-quality graphene sheets that are…”
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MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma by Huang, Tianzhi, Kim, Chung Kwon, Alvarez, Angel A., Pangeni, Rajendra P., Wan, Xuechao, Song, Xiao, Shi, Taiping, Yang, Yongyong, Sastry, Namratha, Horbinski, Craig M., Lu, Songjian, Stupp, Roger, Kessler, John A., Nishikawa, Ryo, Nakano, Ichiro, Sulman, Erik P., Lu, Xinghua, James, Charles David, Yin, Xiao-Ming, Hu, Bo, Cheng, Shi-Yuan

“…ATG4B stimulates autophagy by promoting autophagosome formation through reversible modification of ATG8. We identify ATG4B as a substrate of mammalian…”
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Investigating immune and non-immune cell interactions in head and neck tumors by single-cell RNA sequencing by Kürten, Cornelius H. L., Kulkarni, Aditi, Cillo, Anthony R., Santos, Patricia M., Roble, Anna K., Onkar, Sayali, Reeder, Carly, Lang, Stephan, Chen, Xueer, Duvvuri, Umamaheswar, Kim, Seungwon, Liu, Angen, Tabib, Tracy, Lafyatis, Robert, Feng, Jian, Gao, Shou-Jiang, Bruno, Tullia C., Vignali, Dario A. A., Lu, Xinghua, Bao, Riyue, Vujanovic, Lazar, Ferris, Robert L.

“…Head and neck squamous cell carcinoma (HNSCC) is characterized by complex relations between stromal, epithelial, and immune cells within the tumor…”
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Activation of the Receptor Tyrosine Kinase AXL Regulates the Immune Microenvironment in Glioblastoma by Sadahiro, Hirokazu, Kang, Kyung-Don, Gibson, Justin T, Minata, Mutsuko, Yu, Hai, Shi, Junfeng, Chhipa, Rishi, Chen, Zhihong, Lu, Songjian, Simoni, Yannick, Furuta, Takuya, Sabit, Hemragul, Zhang, Suojun, Bastola, Soniya, Yamaguchi, Shinobu, Alsheikh, Hebaallah, Komarova, Svetlana, Wang, Jun, Kim, Sung-Hak, Hambardzumyan, Dolores, Lu, Xinghua, Newell, Evan W, DasGupta, Biplab, Nakada, Mitsutoshi, Lee, L James, Nabors, Burt, Norian, Lyse A, Nakano, Ichiro

“…Glioblastoma (GBM) is a lethal disease with no effective therapies available. We previously observed upregulation of the TAM (Tyro-3, Axl, and Mer) receptor…”
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Phenotypic Plasticity of Invasive Edge Glioma Stem-like Cells in Response to Ionizing Radiation by Minata, Mutsuko, Audia, Alessandra, Shi, Junfeng, Lu, Songjian, Bernstock, Joshua, Pavlyukov, Marat S., Das, Arvid, Kim, Sung-Hak, Shin, Yong Jae, Lee, Yeri, Koo, Harim, Snigdha, Kirti, Waghmare, Indrayani, Guo, Xing, Mohyeldin, Ahmed, Gallego-Perez, Daniel, Wang, Jia, Chen, Dongquan, Cheng, Peng, Mukheef, Farah, Contreras, Minerva, Reyes, Joel F., Vaillant, Brian, Sulman, Erik P., Cheng, Shi-Yuan, Markert, James M., Tannous, Bakhos A., Lu, Xinghua, Kango-Singh, Madhuri, Lee, L. James, Nam, Do-Hyun, Nakano, Ichiro, Bhat, Krishna P.

“…Unresectable glioblastoma (GBM) cells in the invading tumor edge can act as seeds for recurrence. The molecular and phenotypic properties of these cells remain…”
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A novel method of using Deep Belief Networks and genetic perturbation data to search for yeast signaling pathways by Lu, Songjian, Fan, Xiaonan, Chen, Lujia, Lu, Xinghua

“…Perturbing a signaling system with a serial of single gene deletions and then observing corresponding expression changes in model organisms, such as yeast, is…”
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DNA Translocation through Hydrophilic Nanopore in Hexagonal Boron Nitride by Zhou, Zhi, Hu, Ying, Wang, Hao, Xu, Zhi, Wang, Wenlong, Bai, Xuedong, Shan, Xinyan, Lu, Xinghua

“…Ultra-thin solid-state nanopore with good wetting property is strongly desired to achieve high spatial resolution for DNA sequencing applications. Atomic thick…”
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Explicit representation of protein activity states significantly improves causal discovery of protein phosphorylation networks by Liu, Jinling, Ma, Xiaojun, Cooper, Gregory F, Lu, Xinghua

“…Protein phosphorylation networks play an important role in cell signaling. In these networks, phosphorylation of a protein kinase usually leads to its…”
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Discovering functional impacts of miRNAs in cancers using a causal deep learning model by Chen, Lujia, Lu, Xinghua

“…Micro-RNAs (miRNAs) play a significant role in regulating gene expression under physiological and pathological conditions such as cancers. However, it remains…”
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Circulating miR-19a-3p and miR-483-5p as Novel Diagnostic Biomarkers for the Early Diagnosis of Gastric Cancer by Cheng, Jieyao, Yang, Aiming, Cheng, Shujun, Feng, Lin, Wu, Xi, Lu, Xinghua, Zu, Ming, Cui, Jianfang, Yu, Hang, Zou, Long

“…BACKGROUND MicroRNAs (miRNAs) are attracting substantial interest as promising noninvasive biomarkers for gastric cancer (GC). Our study aimed to identify…”
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Integrating data and knowledge to identify functional modules of genes: a multilayer approach by Liang, Lifan, Chen, Vicky, Zhu, Kunju, Fan, Xiaonan, Lu, Xinghua, Lu, Songjian

“…Characterizing the modular structure of cellular network is an important way to identify novel genes for targeted therapeutics. This is made possible by the…”
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An individualized Bayesian method for estimating genomic variants of hypertension by Rahman, Md Asad, Cai, Chunhui, Bo, Na, McNamara, Dennis M, Ding, Ying, Cooper, Gregory F, Lu, Xinghua, Liu, Jinling

“…Genomic variants of the disease are often discovered nowadays through population-based genome-wide association studies (GWAS). Identifying genomic variations…”
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A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways by Huang, Tianzhi, Alvarez, Angel A., Pangeni, Rajendra P., M. Horbinski, Craig, Lu, Songjian, Kim, Sung-Hak, James, C. David, J. Raizer, Jeffery, A. Kessler, John, Brenann, Cameron W., Sulman, Erik P., Finocchiaro, Gaetano, Tan, Ming, Nishikawa, Ryo, Lu, Xinghua, Nakano, Ichiro, Hu, Bo, Cheng, Shi-Yuan

“…Molecularly defined subclassification is associated with phenotypic malignancy of glioblastoma (GBM). However, current understanding of the molecular basis of…”
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An individualized causal framework for learning intercellular communication networks that define microenvironments of individual tumors by Chen, Xueer, Chen, Lujia, Kürten, Cornelius H L, Jabbari, Fattaneh, Vujanovic, Lazar, Ding, Ying, Lu, Binfeng, Lu, Kevin, Kulkarni, Aditi, Tabib, Tracy, Lafyatis, Robert, Cooper, Gregory F, Ferris, Robert, Lu, Xinghua

“…Cells within a tumor microenvironment (TME) dynamically communicate and influence each other's cellular states through an intercellular communication network…”
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Machine learning based algorithms to impute PaO2 from SpO2 values and development of an online calculator by Ren, Shuangxia, Zupetic, Jill A., Tabary, Mohammadreza, DeSensi, Rebecca, Nouraie, Mehdi, Lu, Xinghua, Boyce, Richard D., Lee, Janet S.

“…We created an online calculator using machine learning (ML) algorithms to impute the partial pressure of oxygen (PaO 2 )/fraction of delivered oxygen (FiO 2 )…”
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FAK loss reduces BRAFV600E-induced ERK phosphorylation to promote intestinal stemness and cecal tumor formation by Gao, Chenxi, Ge, Huaibin, Kuan, Shih-Fan, Cai, Chunhui, Lu, Xinghua, Esni, Farzad, Schoen, Robert E, Wang, Jing H, Chu, Edward, Hu, Jing

“…BRAF V600E mutation is a driver mutation in the serrated pathway to colorectal cancers. BRAF V600E drives tumorigenesis through constitutive downstream…”
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Tumour-specific Causal Inference Discovers Distinct Disease Mechanisms Underlying Cancer Subtypes by Xue, Yifan, Cooper, Gregory, Cai, Chunhui, Lu, Songjian, Hu, Baoli, Ma, Xiaojun, Lu, Xinghua

“…Cancer is a disease mainly caused by somatic genome alterations (SGAs) that perturb cellular signalling systems. Furthermore, the combination of pathway…”
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Systematic discovery of the functional impact of somatic genome alterations in individual tumors through tumor-specific causal inference by Cai, Chunhui, Cooper, Gregory F, Lu, Kevin N, Ma, Xiaojun, Xu, Shuping, Zhao, Zhenlong, Chen, Xueer, Xue, Yifan, Lee, Adrian V, Clark, Nathan, Chen, Vicky, Lu, Songjian, Chen, Lujia, Yu, Liyue, Hochheiser, Harry S, Jiang, Xia, Wang, Q Jane, Lu, Xinghua

“…Cancer is mainly caused by somatic genome alterations (SGAs). Precision oncology involves identifying and targeting tumor-specific aberrations resulting from…”
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Effect of Tea Tree Essential Oil on the Quality, Antioxidant Activity, and Microbiological Safety of Lightly Processed Lily ( Lilium brownii var. viridulum ) during Storage by Guan, Yuge, Lu, Sainan, Sun, Yan, Zhang, Rentao, Lu, Xinghua, Pang, Linjiang, Wang, Lei

“…The Lanzhou lily is a regionally distinctive vegetable; the emergence of lightly processed lilies has addressed the inconvenience of consuming fresh lilies…”
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