Search Results - "XINARIANOS, George"

Quantitative High-Throughput Analysis of DNA Methylation Patterns by Base-Specific Cleavage and Mass Spectrometry by Mathias Ehrich, Nelson, Matthew R., Stanssens, Patrick, Zabeau, Marc, Triantafillos Liloglou, George Xinarianos, Cantor, Charles R., John K. Field, van den Boom, Dirk

“…Methylation is one of the major epigenetic processes pivotal to our understanding of carcinogenesis. It is now widely accepted that there is a relationship…”
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Cytoglobin: biochemical, functional and clinical perspective of the newest member of the globin family by Oleksiewicz, Urszula, Liloglou, Triantafillos, Field, John K., Xinarianos, George

“…Since the discovery of cytoglobin (Cygb) a decade ago, growing amounts of data have been gathered to characterise Cygb biochemistry, functioning and…”
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UHRF1‐mediated tumor suppressor gene inactivation in nonsmall cell lung cancer by Daskalos, Alexandros, Oleksiewicz, Urszula, Filia, Anastasia, Nikolaidis, George, Xinarianos, George, Gosney, John R., Malliri, Angeliki, Field, John K., Liloglou, Triantafillos

“…BACKGROUND: The UHRF1 gene possesses an essential role in DNA methylation maintenance, but its contribution to tumor suppressor gene hypermethylation in…”
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Neuroglobin and myoglobin in non-small cell lung cancer: Expression, regulation and prognosis by Oleksiewicz, Urszula, Daskoulidou, Nikoleta, Liloglou, Triantafillos, Tasopoulou, Kelly, Bryan, Julie, Gosney, John R, Field, John K, Xinarianos, George

“…Abstract Globins are respiratory proteins involved in oxygen metabolism, which is a critical factor in tumor growth and progression. The status of neuroglobin…”
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Cytoglobin, the Newest Member of the Globin Family, Functions as a Tumor Suppressor Gene by SHIVAPURKAR, Narayan, STASTNY, Victor, ROTH, Jack A, LILOGLOU, Triantafillos, XINARIANOS, George, FIELD, John K, MINNA, John D, GAZDAR, Adi F, OKUMURA, Naoki, GIRARD, Luc, YANG XIE, PRINSEN, Clemens, THUNNISSEN, Frederik B, WISTUBA, Ignacio I, CZERNIAK, Bogdan, FRENKEL, Eugene

“…Cytoglobin (CYGB) is a recently discovered vertebrate globin distantly related to myoglobin with unknown function. CYGB is assigned to chromosomal region…”
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Association of mutant TP53 with alternative lengthening of telomeres and favorable prognosis in glioma by Chen, Yu-Jen, Hakin-Smith, Vicky, Teo, Mario, Xinarianos, George E, Jellinek, David A, Carroll, Thomas, McDowell, David, MacFarlane, Martin R, Boet, Ronald, Baguley, Bruce C, Braithwaite, Antony W, Reddel, Roger R, Royds, Janice A

“…The molecular basis for alternative lengthening of telomeres (ALT), a prognostic marker for glioma patients, remains unknown. We examined TP53 status in…”
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COL1A1, PRPF40A, and UCP2 correlate with hypoxia markers in non-small cell lung cancer by Oleksiewicz, Urszula, Liloglou, Triantafillos, Tasopoulou, Kalliopi-Maria, Daskoulidou, Nikoleta, Gosney, John R., Field, John K., Xinarianos, George

“…Purpose Collagen 1A1 (COL1A1), RNA-binding and pre-mRNA Processing Factor (PRPF40A), and Uncoupling Protein 2 (UCP2) were identified as downstream effectors of…”
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Hypomethylation of retrotransposable elements correlates with genomic instability in non‐small cell lung cancer by Daskalos, Alexandros, Nikolaidis, Georgios, Xinarianos, George, Savvari, Paraskevi, Cassidy, Adrian, Zakopoulou, Roubini, Kotsinas, Athanasios, Gorgoulis, Vassilis, Field, John K., Liloglou, Triantafillos

“…LINE‐1 and Alu elements are non‐LTR retrotransposons, constituting together over 30% of the human genome and they are frequently hypomethylated in human…”
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A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25 by Brennan, Paul, Hung, Rayjean J, McKay, James D, Gaborieau, Valerie, Boffetta, Paolo, Hashibe, Mia, Zaridze, David, Mukeria, Anush, Szeszenia-Dabrowska, Neonilia, Lissowska, Jolanta, Rudnai, Peter, Fabianova, Eleonora, Mates, Dana, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Chen, Chu, Goodman, Gary, Field, John K, Liloglou, Triantafillos, Xinarianos, George, Cassidy, Adrian, McLaughlin, John, Liu, Geoffrey, Narod, Steven, Krokan, Hans E, Skorpen, Frank, Elvestad, Maiken Bratt, Hveem, Kristian, Vatten, Lars, Linseisen, Jakob, Clavel-Chapelon, Françoise, Vineis, Paolo, Bueno-de-Mesquita, H. Bas, Lund, Eiliv, Martinez, Carmen, Bingham, Sheila, Rasmuson, Torgny, Hainaut, Pierre, Riboli, Elio, Ahrens, Wolfgang, Benhamou, Simone, Lagiou, Pagona, Trichopoulos, Dimitrios, Holcátová, Ivana, Merletti, Franco, Kjaerheim, Kristina, Agudo, Antonio, Macfarlane, Gary, Talamini, Renato, Simonato, Lorenzo, Lowry, Ray, Conway, David I, Znaor, Ariana, Healy, Claire, Zelenika, Diana, Boland, Anne, Delepine, Marc, Foglio, Mario, Lechner, Doris, Matsuda, Fumihiko, Blanche, Helene, Gut, Ivo, Heath, Simon, Lathrop, Mark

“…Lung cancer is the most common cause of cancer death worldwide, with over one million cases annually. To identify genetic factors that modify disease risk, we…”
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Cytoglobin has bimodal: tumour suppressor and oncogene functions in lung cancer cell lines by Oleksiewicz, Urszula, Liloglou, Triantafillos, Tasopoulou, Kalliopi-Maria, Daskoulidou, Nikoleta, Bryan, Julie, Gosney, John R, Field, John K, Xinarianos, George

“…Cytoglobin (CYGB) is frequently downregulated in many types of human malignancies, and its exogenous overexpression reduces proliferation of cancer cells…”
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The hOCT1 SNPs M420del and M408V alter imatinib uptake and M420del modifies clinical outcome in imatinib-treated chronic myeloid leukemia by Giannoudis, Athina, Wang, Lihui, Jorgensen, Andrea L., Xinarianos, George, Davies, Andrea, Pushpakom, Sudeep, Liloglou, Triantafilos, Zhang, Jieying-Eunice, Austin, Gemma, Holyoake, Tessa L., Foroni, Letizia, Kottaridis, Panagiotis D., Müller, Martin C., Pirmohamed, Munir, Clark, Richard E.

“…Although the prognosis of chronic myeloid leukemia (CML) patients treated with imatinib is good, many fail to develop an optimal response or lose one. This…”
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Simultaneous Pharmacogenetics-Based Population Pharmacokinetic Analysis of Darunavir and Ritonavir in HIV-Infected Patients by Moltó, José, Xinarianos, George, Miranda, Cristina, Pushpakom, Sudeep, Cedeño, Samandhy, Clotet, Bonaventura, Owen, Andrew, Valle, Marta

“…Background Darunavir is a potent protease inhibitor of HIV. To enhance its pharmacokinetic profile, darunavir must be co-administered with ritonavir. There is…”
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Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals by Lips, Esther H, Gaborieau, Valerie, McKay, James D, Chabrier, Amelie, Hung, Rayjean J, Boffetta, Paolo, Hashibe, Mia, Zaridze, David, Szeszenia-Dabrowska, Neonilia, Lissowska, Jolanta, Rudnai, Peter, Fabianova, Eleonora, Mates, Dana, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Field, John K, Liloglou, Triantafillos, Xinarianos, George, McLaughlin, John, Liu, Geoffrey, Skorpen, Frank, Elvestad, Maiken Bratt, Hveem, Kristian, Vatten, Lars, Study, EPIC, Benhamou, Simone, Lagiou, Pagona, Holcátová, Ivana, Merletti, Franco, Kjaerheim, Kristina, Agudo, Antonio, Castellsagué, Xavier, Macfarlane, Tatiana V, Barzan, Luigi, Canova, Cristina, Lowry, Ray, Conway, David I, Znaor, Ariana, Healy, Claire, Curado, Maria Paula, Koifman, Sergio, Eluf-Neto, Jose, Matos, Elena, Menezes, Ana, Fernandez, Leticia, Metspalu, Andres, Heath, Simon, Lathrop, Mark, Brennan, Paul

“…Background Genetic variants in 15q25 have been identified as potential risk markers for lung cancer (LC), but controversy exists as to whether this is a direct…”
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Global DNA hypomethylation-induced ΔNp73 transcriptional activation in non-small cell lung cancer by Daskalos, Alexandros, Logotheti, Stella, Markopoulou, Soultana, Xinarianos, George, Gosney, John R, Kastania, Anastasia N, Zoumpourlis, Vassilis, Field, John K, Liloglou, Triantafillos

“…Abstract p73 possesses an extrinsic P1 promoter and an intrinsic P2 promoter controlling the expression of the pro-apoptotic TAp73 isoforms and the…”
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Associations between genes for killer immunoglobulin-like receptors and their ligands in patients with solid tumors by Al Omar, Suliman, Middleton, Derek, Marshall, Ernie, Porter, Dawn, Xinarianos, George, Raji, Olaide, Field, John K, Christmas, Stephen E

“…Abstract Killer immunoglobulin-like receptor (KIR) and human leukocyte antigen (HLA) genotypes were analyzed from panels of lung (non–small-cell lung cancer…”
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Misoprostol-induced fever and genetic polymorphisms in drug transporters SLCO1B1 and ABCC4 in women of Latin American and European ancestry by Alfirevic, Ana, Durocher, Jill, Elati, Anisa, León, Wilfrido, Dickens, David, Rädisch, Steffen, Box, Helen, Siccardi, Marco, Curley, Paul, Xinarianos, George, Ardeshana, Arjun, Owen, Andrew, Zhang, J Eunice, Pirmohamed, Munir, Alfirevic, Zarko, Weeks, Andrew, Winikoff, Beverly

“…Misoprostol, a prostaglandin analogue used for the treatment of postpartum hemorrhage and termination of pregnancy, can cause high fevers. Genetic…”
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Neurofilament accumulation at the motor endplate and lack of axonal sprouting in a spinal muscular atrophy mouse model by Cifuentes-Diaz, Carmen, Nicole, Sophie, Velasco, Maria E., Borra-Cebrian, Christophe, Panozzo, Cristina, Frugier, Tony, Millet, Gaelle, Roblot, Natacha, Joshi, Vandana, Melki, Judith

“…Mutations of survival of the motor neuron gene (SMN1) are responsible for spinal muscular atrophy (SMA), a common genetic cause of death in childhood. The…”
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Frequent genetic and epigenetic abnormalities contribute to the deregulation of cytoglobin in non-small cell lung cancer by Xinarianos, George, McRonald, Fiona E., Risk, Janet M., Bowers, Naomi L., Nikolaidis, Georgios, Field, John K., Liloglou, Triantafillos

“…Lung cancer demonstrates the highest mortality in the UK. Previous studies have implicated allelic loss at chromosome 17q in the development of non-small cell…”
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Cytosine methylation profiles as a molecular marker in non-small cell lung cancer by EHRICH, Mathias, FIELD, John K, LILOGLOU, Triantafillos, XINARIANOS, George, OETH, Paul, NELSON, Matthew R, CANTOR, Charles R, VAN DEN BOOM, Dirk

“…Aberrant promoter methylation is frequently observed in different types of lung cancer. Epigenetic modifications are believed to occur before the clinical…”
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Sample size determination in clinical proteomic profiling experiments using mass spectrometry for class comparison by Cairns, David A, Barrett, Jennifer H, Billingham, Lucinda J, Stanley, Anthea J, Xinarianos, George, Field, John K, Johnson, Phillip J, Selby, Peter J, Banks, Rosamonde E

“…Mass spectrometric profiling approaches such as MALDI-TOF and SELDI-TOF are increasingly being used in disease marker discovery, particularly in the lower…”
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