Search Results - "XIAOQUAN RAO"

An emerging role of dipeptidyl peptidase 4 (DPP4) beyond glucose control: Potential implications in cardiovascular disease by Zhong, Jixin, Rao, Xiaoquan, Rajagopalan, Sanjay

“…Abstract The introduction of dipeptidyl peptidase 4 (DPP4) inhibitors for the treatment of Type 2 diabetes acknowledges the fundamental importance of incretin…”
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S100 Proteins As an Important Regulator of Macrophage Inflammation by Xia, Chang, Braunstein, Zachary, Toomey, Amelia C, Zhong, Jixin, Rao, Xiaoquan

“…The S100 proteins, a family of calcium-binding cytosolic proteins, have a broad range of intracellular and extracellular functions through regulating calcium…”
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Role of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated Inflammation by Xia, Chang, Zhong, Jixin, Rao, Xiaoquan

“…Although a critical role of adaptive immune system has been confirmed in driving local and systemic inflammation in type 2 diabetes and promoting insulin…”
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Regulation of Inflammation in Autoimmune Disease by Duan, Lihua, Rao, Xiaoquan, Sigdel, Keshav Raj

“…Recently, increasing evidences have shown that the abnormal inflammatory response is closely associated with many chronic diseases, especially in autoimmune…”
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CD36-Dependent 7-Ketocholesterol Accumulation in Macrophages Mediates Progression of Atherosclerosis in Response to Chronic Air Pollution Exposure by Rao, Xiaoquan, Zhong, Jixin, Maiseyeu, Andrei, Gopalakrishnan, Bhavani, Villamena, Frederick A, Chen, Lung-Chi, Harkema, Jack R, Sun, Qinghua, Rajagopalan, Sanjay

“…RATIONALE:Air pollution exposure has been shown to potentiate plaque progression in humans and animals. Our previous studies have suggested a role for oxidized…”
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Emerging Role of Dipeptidyl Peptidase-4 in Autoimmune Disease by Huang, Jie, Liu, Xinxin, Wei, Yingying, Li, Xinlu, Gao, Shupei, Dong, Lingli, Rao, Xiaoquan, Zhong, Jixin

“…Dipeptidyl-peptidase IV (DPP4), originally identified as an aminopeptidase in 1960s, is an ubiquitously expressed protease presented as either a membrane-bound…”
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GLP-1 receptor agonist as a modulator of innate immunity by Chen, Jun, Mei, Aihua, Wei, Yingying, Li, Chunlei, Qian, Hang, Min, Xinwen, Yang, Handong, Dong, Lingli, Rao, Xiaoquan, Zhong, Jixin

“…Glucagon-like peptide-1 (GLP-1) is a 30-amino acid hormone secreted by L cells in the distal ileum, colon, and pancreatic α cells, which participates in blood…”
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A Potential Role for Dendritic Cell/Macrophage-Expressing DPP4 in Obesity-Induced Visceral Inflammation by JIXIN ZHONG, XIAOQUAN RAO, DEIULIIS, Jeffrey, BRAUNSTEIN, Zachary, NARULA, Vimal, HAZEY, Jeffrey, MIKAMI, Dean, NEEDLEMAN, Bradley, SATOSKAR, Abhay R, RAJAGOPALAN, Sanjay

“…Dipeptidyl peptidase-4 (DDP4) inhibitors target the enzymatic degradation of incretin peptides and represent a major advance in the treatment of type 2…”
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Pathological Cardiopulmonary Evaluation of Rats Chronically Exposed to Traffic-Related Air Pollution by Edwards, Sabrina, Zhao, Gang, Tran, Joanne, Patten, Kelley T, Valenzuela, Anthony, Wallis, Christopher, Bein, Keith J, Wexler, Anthony S, Lein, Pamela J, Rao, Xiaoquan

“…Traffic-related air pollution (TRAP) is made up of complex mixtures of particulate matter, gases and volatile compounds. However, the effects of TRAP on the…”
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Role of Incretin Axis in Inflammatory Bowel Disease by Duan, Lihua, Rao, Xiaoquan, Braunstein, Zachary, Toomey, Amelia C, Zhong, Jixin

“…The inflammatory bowel diseases (IBDs), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic inflammatory conditions of the gastrointestinal…”
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T-Cell Costimulation Protects Obesity-Induced Adipose Inflammation and Insulin Resistance by JIXIN ZHONG, XIAOQUAN RAO, DEIULIIS, Jeffrey A, SATOSKAR, Abhay R, RAJAGOPALAN, Sanjay, BRAUNSTEIN, Zachary, TAYLOR, Anne, NARULA, Vimal, HAZEY, Jeffrey, MIKAMI, Dean, NEEDLEMAN, Bradley, RUTSKY, Jessica, QINGHUA SUN

“…A key pathophysiologic role for activated T-cells in mediating adipose inflammation and insulin resistance (IR) has been recently postulated. However,…”
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Mid1 promotes synovitis in rheumatoid arthritis via ubiquitin-dependent post-translational modification by Lin, Liman, Huang, Zhiwen, Li, Wenjuan, Liu, Xinxin, Li, Xinlu, Gao, Shupei, Chen, Jun, Yang, Chenxi, Min, Xinwen, Yang, Handong, Gong, Quan, Wei, Yingying, Tu, Shenghao, Rao, Xiaoquan, Zhang, Ziyang, Dong, Lingli, Zhong, Jixin

“…Current anti-rheumatic drugs are primarily modulating immune cell activation, yet their effectiveness remained suboptimal. Therefore, novel therapeutics…”
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Glucagon-Like Peptide-1 Receptor Regulates Macrophage Migration in Monosodium Urate-Induced Peritoneal Inflammation by Chen, Jun, Mei, Aihua, Liu, Xinxin, Braunstein, Zachary, Wei, Yingying, Wang, Biao, Duan, Lihua, Rao, Xiaoquan, Rajagopalan, Sanjay, Dong, Lingli, Zhong, Jixin

“…Glucagon-like peptide-1 (GLP-1) is an insulinotropic peptide that signals through the GLP-1 receptor (GLP-1R). GLP-1R, therefore, plays a critical role in…”
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Loss of Methyl-CpG-Binding Domain Protein 2 Enhances Endothelial Angiogenesis and Protects Mice Against Hind-Limb Ischemic Injury by XIAOQUAN RAO, JIXIN ZHONG, DAOWEN WANG, WANG, Cong-Yi, SHU ZHANG, YUSHAN ZHANG, QILIN YU, PING YANG, WANG, Mong-Heng, FULTON, David J, HUIDONG SHI, ZHENG DONG

“…Despite intensive investigation, how DNA methylation influences endothelial function remains poorly understood. We used methyl-CpG-binding domain protein 2…”
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The regulatory role of DPP4 in atherosclerotic disease by Duan, Lihua, Rao, Xiaoquan, Xia, Chang, Rajagopalan, Sanjay, Zhong, Jixin

“…The increasing prevalence of atherosclerosis has become a worldwide health concern. Although significant progress has been made in the understanding of…”
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Cytochrome P450 2J2 is highly expressed in hematologic malignant diseases and promotes tumor cell growth by Chen, Chen, Wei, Xin, Rao, Xiaoquan, Wu, Jun, Yang, Shenglan, Chen, Fuqiong, Ma, Ding, Zhou, Jianfeng, Dackor, Ryan T, Zeldin, Darryl C, Wang, Dao Wen

“…Cytochrome P450 2J2 (CYP2J2) epoxygenase converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EETs) that exert multiple biological…”
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The Function and Therapeutic Implications of TNF Signaling in MDSCs by Yu, Kun, Yu, Chengxin, Jiao, Liping, Miao, Kun, Ni, Li, Rao, Xiaoquan, Zhou, Ling, Zhao, Chunxia

“…Myeloid-derived suppressor cells (MDSCs) are a group of immature and heterogeneous myeloid cells with immunosuppressive functions. MDSCs play important roles…”
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Corrigendum: Glucagon-Like Peptide-1 Receptor Regulates Macrophage Migration in Monosodium Urate-Induced Peritoneal Inflammation by Chen, Jun, Mei, Aihua, Liu, Xinxin, Braunstein, Zachary, Wei, Yingying, Wang, Biao, Duan, Lihua, Rao, Xiaoquan, Rajagopalan, Sanjay, Dong, Lingli, Zhong, Jixin

“…[This corrects the article DOI: 10.3389/fimmu.2022.772446.]…”
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Unleashing the Potential of Nrf2: A Novel Therapeutic Target for Pulmonary Vascular Remodeling by Fang, Qin, Bai, Yang, Hu, Shuiqing, Ding, Jie, Liu, Lei, Dai, Meiyan, Qiu, Jie, Wu, Lujin, Rao, Xiaoquan, Wang, Yan

“…Pulmonary vascular remodeling, characterized by the thickening of all three layers of the blood vessel wall, plays a central role in the pathogenesis of…”
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Alpha2B-Adrenergic Receptor Regulates Neutrophil Recruitment in MSU-Induced Peritoneal Inflammation by Duan, Lihua, Chen, Jie, Razavi, Michael, Wei, Yingying, Tao, Ying, Rao, Xiaoquan, Zhong, Jixin

“…Gout is one of the most common metabolic disorders in human. Previous studies have shown that the disease activity is closely associated with sympathetic…”
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