Search Results - "XIAONING SI"

Autophagosome Supports Coxsackievirus B3 Replication in Host Cells by WONG, Jerry, JINGCHUN ZHANG, XIAONING SI, GUANG GAO, MAO, Ivy, MCMANUS, Bruce M, HONGLIN LUO

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Toll-Like Receptor 4-Mediated Activation of p38 Mitogen-Activated Protein Kinase Is a Determinant of Respiratory Virus Entry and Tropism by MARCHANT, David, SINGHERA, Gurpreet K, UTOKAPARCH, Soraya, HACKETT, Tillie L, BOYD, John H, ZONGSHU LUO, XIAONING SI, DORSCHEID, Delbert R, MCMANUS, Bruce M, HEGELE, Richard G

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Ubiquitination is required for effective replication of coxsackievirus B3 by Si, Xiaoning, Gao, Guang, Wong, Jerry, Wang, Yahong, Zhang, Jingchun, Luo, Honglin

“…Protein ubiquitination and/or degradation by the ubiquitin/proteasome system (UPS) have been recognized as critical mechanisms in the regulation of numerous…”
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Dysregulation of the Ubiquitin-Proteasome System by Curcumin Suppresses Coxsackievirus B3 Replication by Si, Xiaoning, Wang, Yahong, Wong, Jerry, Zhang, Jingchun, McManus, Bruce M, Luo, Honglin

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Curcumin inhibits the replication of enterovirus 71 in vitro by Qin, Ying, Lin, Lexun, Chen, Yang, Wu, Shuo, Si, Xiaoning, Wu, Heng, Zhai, Xia, Wang, Yan, Tong, Lei, Pan, Bo, Zhong, Xiaoyan, Wang, Tianying, Zhao, Wenran, Zhong, Zhaohua

“…Human enterovirus 71 (EV71) is the main causative pathogen of hand, foot, and mouth disease (HFMD) in children. The epidemic of HFMD has been a public health…”
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Pyrrolidine Dithiocarbamate Reduces Coxsackievirus B3 Replication through Inhibition of the Ubiquitin-Proteasome Pathway by XIAONING SI, MCMANUS, Bruce M, JINGCHUN ZHANG, JI YUAN, CHEUNG, Caroline, ESFANDIAREI, Mitra, SUAREZ, Agripina, MORGAN, Andrew, HONGLIN LUO

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Stress-Activated Protein Kinases Are Involved in Coxsackievirus B3 Viral Progeny Release by XIAONING SI, HONGLIN LUO, MORGAN, Andrew, JINGCHUN ZHANG, WONG, Jerry, JI YUAN, ESFANDIAREI, Mitra, GUANG GAO, CHEUNG, Caroline, MCMANUS, Bruce M

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Pairwise network mechanisms in the host signaling response to coxsackievirus B3 infection by Garmaroudi, Farshid S., Marchant, David, Si, Xiaoning, Khalili, Abbas, Bashashati, Ali, Wong, Brian W., Tabet, Aline, Ng, Raymond T., Murphy, Kevin, Luo, Honglin, Janes, Kevin A., McManus, Bruce M.

“…Signal transduction networks can be perturbed biochemically, genetically, and pharmacologically to unravel their functions. But at the systems level, it is not…”
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Novel Role for Integrin-Linked Kinase in Modulation of Coxsackievirus B3 Replication and Virus-Induced Cardiomyocyte Injury by Esfandiarei, Mitra, Suarez, Agripina, Amaral, Ansel, Si, Xiaoning, Rahmani, Maziar, Dedhar, Shoukat, McManus, Bruce M

“…Viral myocarditis is a major cause of sudden cardiac death in children and young adults. Among viruses, coxsackievirus B3 (CVB3) is the most common agent for…”
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ERK MAP kinase-activated Arf6 trafficking directs coxsackievirus type B3 into an unproductive compartment during virus host-cell entry by Marchant, David, Sall, Alhousseynou, Si, Xiaoning, Abraham, Thomas, Wu, Winnie, Luo, Zongshu, Petersen, Tamar, Hegele, Richard G, McManus, Bruce M

“…The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Departments of Pathology and Laboratory Medicine, The University of British Columbia,…”
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Prenylation-dependent Association of Protein-tyrosine Phosphatases PRL-1, -2, and -3 with the Plasma Membrane and the Early Endosome by Zeng, Qi, Si, Xiaoning, Horstmann, Heinrich, Xu, Yue, Hong, Wanjin, Pallen, Catherine J.

“…PRL-1, -2, and -3 represent a novel class of protein-tyrosine phosphatase with a C-terminal prenylation motif. Although PRL-1 has been suggested to be…”
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Bosentan Enhances Viral Load via Endothelin-1 Receptor Type-A–Mediated p38 Mitogen-Activated Protein Kinase Activation While Improving Cardiac Function During Coxsackievirus-Induced Myocarditis by Marchant, David, Dou, Ying, Luo, Honglin, Garmaroudi, Farshid S, McDonough, John E, Si, Xiaoning, Walker, Elizabeth, Luo, Zongshu, Arner, Anders, Hegele, Richard G, Laher, Ismail, McManus, Bruce M

“…Reduced cardiac output is one of the consequences of myocarditis. Bosentan, an endothelin-1 receptor (ET1R) antagonist, could be useful to reduce cardiac…”
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A 3Cpro-dependent bioluminescence imaging assay for in vivo evaluation of anti-enterovirus 71 agents by Guo, Zhiwei, Zhong, Xiaoyan, Lin, Lexun, Wu, Shuo, Wang, Tianying, Chen, Yang, Zhai, Xia, Wang, Yan, Wu, Heng, Tong, Lei, Han, Yelu, Pan, Bo, Peng, Yihong, Si, Xiaoning, Zhang, Fengmin, Zhao, Wenran, Zhong, Zhaohua

“…•A 3Cpro-dependent split luciferase imaging assay was established for EV71 detection.•This real-time imaging assay can specifically and quantitatively monitor…”
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Liposome-mediated transient transfection reduces cholesterol-dependent coxsackievirus infectivity by Wong, Jerry, Zhang, Jingchun, Gao, Guang, Esfandiarei, Mitra, Si, Xiaoning, Wang, Yahong, Yanagawa, Bobby, Suarez, Agripina, McManus, Bruce, Luo, Honglin

“…Liposome-mediated gene delivery provides a powerful strategy for the study of gene function and for gene therapy. Coxsackievirus B3 is an important human…”
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Cytoplasmic redistribution and cleavage of AUF1 during coxsackievirus infection enhance the stability of its viral genome by Wong, Jerry, Si, Xiaoning, Angeles, Arkhjamil, Zhang, Jingchun, Shi, Junyan, Fung, Gabriel, Jagdeo, Julienne, Wang, Tianying, Zhong, Zhaohua, Jan, Eric, Luo, Honglin

“…Coxsackievirus B3 (CVB3) is a causative agent of viral myocarditis, hepatitis, pancreatitis, and meningitis in humans. The adenosine‐uridine (AU)‐rich element…”
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Protease 2A induces stress granule formation during coxsackievirus B3 and enterovirus 71 infections by Wu, Shuo, Wang, Yan, Lin, Lexun, Si, Xiaoning, Wang, Tianying, Zhong, Xiaoyan, Tong, Lei, Luan, Ying, Chen, Yang, Li, Xiaoyu, Zhang, Fengmin, Zhao, Wenran, Zhong, Zhaohua

“…BACKGROUND: Stress granules (SGs) are granular aggregates in the cytoplasm that are formed under a variety of stress situations including viral infection…”
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Proteasome inhibition attenuates coxsackievirus-induced myocardial damage in mice by Gao, Guang, Zhang, Jingchun, Si, Xiaoning, Wong, Jerry, Cheung, Caroline, McManus, Bruce, Luo, Honglin

“…Coxsackievirus B3 (CVB3) is one of the most prevalent pathogens of viral myocarditis, which may persist chronically and progress to dilated cardiomyopathy. We…”
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AUF1 is recruited to the stress granules induced by coxsackievirus B3 by Wu, Shuo, Lin, Lexun, Zhao, Wenran, Li, Xiaobo, Wang, Yan, Si, Xiaoning, Wang, Tianying, Wu, Heng, Zhai, Xia, Zhong, Xiaoyan, Gao, Shuoyang, Tong, Lei, Xu, Zhikai, Zhong, Zhaohua

“…•CVB3 infection can induce SG formation.•AUF1 is recruited to SGs in cells infected with high dose of CVB3.•EV71 infection also induces SG formation and AUF1…”
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Pyrrolidine dithiocarbamate inhibits enterovirus 71 replication by down-regulating ubiquitin–proteasome system by Lin, Lexun, Qin, Ying, Wu, Heng, Chen, Yang, Wu, Shuo, Si, Xiaoning, Wang, Hui, Wang, Tianying, Zhong, Xiaoyan, Zhai, Xia, Tong, Lei, Pan, Bo, Zhang, Fengmin, Zhong, Zhaohua, Wang, Yan, Zhao, Wenran

“…•Pyrrolidine dithiocarbamate (PDTC) could inhibit the replication of enterovirus 71 (EV71).•PDTC down-regulates ubiquitin–proteasome system (UPS), which is…”
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Coxsackievirus B3 activates nuclear factor kappa B transcription factor via a phosphatidylinositol-3 kinase/protein kinase B-dependent pathway to improve host cell viability by Esfandiarei, Mitra, Boroomand, Seti, Suarez, Agripina, Si, Xiaoning, Rahmani, Maziar, McManus, Bruce

“…Coxsackievirus B3 (CVB3) is the most common viral infectant of heart muscle. CVB3 directly injures cardiomyocytes. We have previously reported on a regulatory…”
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