Search Results - "XIAOLIN ZI"

Comprehensive analysis of cuproptosis-related genes on bladder cancer prognosis, tumor microenvironment invasion, and drug sensitivity by Wang, Honglei, Li, Jinqiao, Zi, Xiaolin, Yuan, Xueli

“…Cuproptosis, a newly discovered form of programmed cell death, plays a vital role in the occurrence and development of tumors. However, the role of cuproptosis…”
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A phase II study of docetaxel plus lycopene in metastatic castrate resistant prostate cancer by Zhuang, Eric, Uchio, Edward, Lilly, Michael, Zi, Xiaolin, Fruehauf, John P.

“…We carried out a phase II study to investigate the activity of docetaxel plus lycopene in advanced castrate resistant adenocarcinoma of the prostate. Patients…”
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Triazole–Dithiocarbamate Based Selective Lysine Specific Demethylase 1 (LSD1) Inactivators Inhibit Gastric Cancer Cell Growth, Invasion, and Migration by Zheng, Yi-Chao, Duan, Ying-Chao, Ma, Jin-Lian, Xu, Rui-Min, Zi, Xiaolin, Lv, Wen-Lei, Wang, Meng-Meng, Ye, Xian-Wei, Zhu, Shun, Mobley, David, Zhu, Yan-Yan, Wang, Jun-Wei, Li, Jin-Feng, Wang, Zhi-Ru, Zhao, Wen, Liu, Hong-Min

“…Lysine specific demethylase 1 (LSD1), the first identified histone demethylase, plays an important role in epigenetic regulation of gene activation and…”
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Inhibition of LSD1 induces ferroptosis through the ATF4-xCT pathway and shows enhanced anti-tumor effects with ferroptosis inducers in NSCLC by Du, Linna, Yang, Han, Ren, Yufei, Ding, Yanli, Xu, Yichao, Zi, Xiaolin, Liu, Hongmin, He, Pengxing

“…Lysine-specific demethylase 1 (LSD1) has been identified as an important epigenetic target, and recent advances in lung cancer therapy have highlighted the…”
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Rhodiola rosea extracts and salidroside decrease the growth of bladder cancer cell lines via inhibition of the mTOR pathway and induction of autophagy by Liu, Zhongbo, Li, Xuesen, Simoneau, Anne R., Jafari, Mahtab, Zi, Xiaolin

“…The incidence of human urinary bladder cancer increases markedly with age, suggesting a mechanistic connection between aging and bladder carcinogenesis and a…”
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A Novel Ferroptosis Related Gene Signature for Prognosis Prediction in Patients With Colon Cancer by Nie, Jianhua, Shan, Dan, Li, Shun, Zhang, Shuyuan, Zi, Xiaolin, Xing, Fan, Shi, Jiaqi, Liu, Caiqi, Wang, Tianjiao, Sun, Xiaoyuan, Zhang, Qian, Zhou, Meng, Luo, Shengnan, Meng, Hongxue, Zhang, Yanqiao, Zheng, Tongsen

“…Colon cancer (CC) is a serious disease burden. The prognosis of patients with CC is different, so looking for effective biomarkers to predict prognosis is…”
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Molecular targeted approaches to cancer therapy and prevention using chalcones by Jandial, Danielle D, Blair, Christopher A, Zhang, Saiyang, Krill, Lauren S, Zhang, Yan-Bing, Zi, Xiaolin

“…There is an emerging paradigm shift in oncology that seeks to emphasize molecularly targeted approaches for cancer prevention and therapy. Chalcones…”
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Down-regulation of Skp2 expression inhibits invasion and lung metastasis in osteosarcoma by Zhang, Yidan, Zvi, Yoav S., Batko, Brian, Zaphiros, Nikolas, O’Donnell, Edmond F., Wang, Jichuan, Sato, Kenji, Yang, Rui, Geller, David S., Koirala, Pratistha, Zhang, Wendong, Du, Xiuquan, Piperdi, Sajida, Liu, Yang, Zheng, Deyou, Roth, Michael, Gill, Jonathan, Zhang, Jinghang, Ren, Tingting, Gorlick, Richard, Zi, Xiaolin, Hoang, Bang H.

“…Osteosarcoma (OS), the most common primary cancer of bone, exhibits a high propensity for local invasion and distant metastasis. This study sought to elucidate…”
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Kavalactone Kawain Impedes Urothelial Tumorigenesis in UPII-Mutant Ha-Ras Mice via Inhibition of mTOR Signaling and Alteration of Cancer Metabolism by Liu, Zhongbo, Song, Liankun, Xie, Jun, Wu, Xue-Ru, Gin, Greg E, Wang, Beverly, Uchio, Edward, Zi, Xiaolin

“…UPII-mutant Ha-ras transgenic mice develop urothelial hyperplasia and low-grade papillary carcinoma, which mimics human non-muscle invasive bladder cancer…”
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Wnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma by Rubin, Elyssa M, Guo, Yi, Tu, Khoa, Xie, Jun, Zi, Xiaolin, Hoang, Bang H

“…It has been reported that the progression of osteosarcoma was closely associated with the aberrant activation of canonical Wnt signaling. Wnt inhibitory…”
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Flavokawain B, a kava chalcone, induces apoptosis via up‐regulation of death‐receptor 5 and Bim expression in androgen receptor negative, hormonal refractory prostate cancer cell lines and reduces tumor growth by Tang, Yaxiong, Li, Xuesen, Liu, Zhongbo, Simoneau, Anne R., Xie, Jun, Zi, Xiaolin

“…Limited success has been achieved in extending the survival of patients with metastatic and hormone‐refractory prostate cancer (HRPC). There is a strong need…”
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Induction of G2M Arrest by Flavokawain A, a Kava Chalcone, Increases the Responsiveness of HER2-Overexpressing Breast Cancer Cells to Herceptin by Jandial, Danielle D, Krill, Lauren S, Chen, Lixia, Wu, Chunli, Ke, Yu, Xie, Jun, Hoang, Bang H, Zi, Xiaolin

“…HER2/neu positive breast tumors predict a high mortality and comprise 25%-30% of breast cancer. We have shown that Flavokawain A (FKA) preferentially reduces…”
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Targeting the NFAT1-MDM2-MDMX Network Inhibits the Proliferation and Invasion of Prostate Cancer Cells, Independent of p53 and Androgen by Qin, Jiang-Jiang, Li, Xin, Wang, Wei, Zi, Xiaolin, Zhang, Ruiwen

“…The MDM2 and MDMX oncogenes are overexpressed in various types of human cancer and are highly associated with the initiation, progression, metastasis and…”
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Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice by XIAOLIN ZI, SIMONEAU, Anne R

“…Consumption of the traditional kava preparation was reported to correlate with low and uncustomary gender ratios (more cancer in women than men) of cancer…”
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Chemoprevention of Urothelial Cell Carcinoma Tumorigenesis by Dietary Flavokawain A in UPII-Mutant Ha-ras Transgenic Mice by Liu, Zhongbo, Song, Liankun, Xie, Jun, Simoneau, Anne R, Uchio, Edward, Zi, Xiaolin

“…Non-muscle-invasive bladder cancer (NMIBC) has one of the highest recurrence rates among all solid cancers and the highest lifetime treatment cost per patient…”
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Flavokawain A Reduces Tumor-Initiating Properties and Stemness of Prostate Cancer by Song, Liankun, Mino, Merci, Yamak, Jana, Nguyen, Vyvyan, Lopez, Derron, Pham, Victor, Fazelpour, Ali, Le, Vinh, Fu, Dongjun, Tippin, Matthew, Uchio, Edward, Zi, Xiaolin

“…We have previously demonstrated the in vivo chemopreventive efficacy of flavokawain A (FKA), a novel chalcone from the kava plant, in prostate carcinogenesis…”
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Insulin-Like Growth Factor-I Receptor Signaling and Resistance to Trastuzumab (Herceptin) by Lu, Yuhong, Zi, Xiaolin, Zhao, Yunhua, Mascarenhas, Desmond, Pollak, Michael

“…Background: Trastuzumab (Herceptin), an anti-HER2/neu receptor monoclonal antibody that inhibits growth of ErbB2-overexpressing breast cancer, is used to treat…”
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Lycopene Enhances Docetaxel's Effect in Castration-Resistant Prostate Cancer Associated with Insulin-like Growth Factor I Receptor Levels by Tang, Yaxiong, Parmakhtiar, Basmina, Simoneau, Anne R, Xie, Jun, Fruehauf, John, Lilly, Michael, Zi, Xiaolin

“…Docetaxel is currently the most effective drug for the treatment of castration-resistant prostate cancer (CRPC), but it only extends life by an average of 2…”
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Flavokawain B targets protein neddylation for enhancing the anti-prostate cancer effect of Bortezomib via Skp2 degradation by Li, Xuesen, Pham, Victor, Tippin, Matthew, Fu, Dongjun, Rendon, Raymond, Song, Liankun, Uchio, Edward, Hoang, Bang H, Zi, Xiaolin

“…Flavokawain B (FKB) has been identified from kava root extracts as a potent apoptosis inducer for inhibiting the growth of various cancer cell lines, including…”
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The Wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transition by Yee, David S, Tang, Yaxiong, Li, Xuesen, Liu, Zhongbo, Guo, Yi, Ghaffar, Samia, McQueen, Peter, Atreya, Dash, Xie, Jun, Simoneau, Anne R, Hoang, Bang H, Zi, Xiaolin

“…Aberrations in the Wnt pathway have been reported to be involved in the metastasis of prostate cancer (PCa) to bone. We investigated the effect and underlying…”
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