Search Results - "XIANJUN QU"

Exosomal miR-146a-5p and miR-155-5p promote CXCL12/CXCR7-induced metastasis of colorectal cancer by crosstalk with cancer-associated fibroblasts by Wang, Dong, Wang, Xiaohui, Song, Yujia, Si, Mahan, Sun, Yuqi, Liu, Xiaohui, Cui, Shuxiang, Qu, Xianjun, Yu, Xinfeng

“…C-X-C motif chemokine receptor 7 (CXCR7) is a newly discovered atypical chemokine receptor that binds to C-X-C motif chemokine ligand 12 (CXCL12) with higher…”
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CXCL12/CXCR4 promotes inflammation-driven colorectal cancer progression through activation of RhoA signaling by sponging miR-133a-3p by Yu, Xinfeng, Wang, Dong, Wang, Xiaohui, Sun, Shiyue, Zhang, Yuhang, Wang, Shuqing, Miao, Rongrong, Xu, Xiaoxue, Qu, Xianjun

“…Activation of CXCL12/CXCR4 axis has been found to be associated with invasion and metastasis in many cancers. However, the underlying mechanism remains…”
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CXCL12/CXCR4 axis induced miR-125b promotes invasion and confers 5-fluorouracil resistance through enhancing autophagy in colorectal cancer by Yu, Xinfeng, Shi, Wenna, Zhang, Yuhang, Wang, Xiaohui, Sun, Shiyue, Song, Zhiyu, Liu, Man, Zeng, Qiao, Cui, Shuxiang, Qu, Xianjun

“…The activation of CXCL12/CXCR4 axis is associated with potential progression of cancer, such as invasion, metastasis and chemoresistance. However, the…”
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Silencing of MicroRNA-21 confers the sensitivity to tamoxifen and fulvestrant by enhancing autophagic cell death through inhibition of the PI3K-AKT-mTOR pathway in breast cancer cells by Yu, Xinfeng, Li, Ruilian, Shi, Wenna, Jiang, Tao, Wang, Yufei, Li, Cong, Qu, Xianjun

“…Abstract Tamoxifen (TAM) and fulvestrant (FUL) represent the major adjuvant therapy to estrogen receptor-alpha positive (ER+ ) breast cancer patients. However,…”
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Deficiency of interferon-gamma or its receptor promotes colorectal cancer development by Wang, Lu, Wang, Yan, Song, Zhiyu, Chu, Jiahui, Qu, Xianjun

“…Genetic variations in interferon-gamma (IFN-γ) and its receptor (IFNγR) subunits are closely associated with the risk of colorectal cancer (CRC) and survival…”
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ZnO nanoparticles promote the malignant transformation of colorectal epithelial cells in APCmin/+ mice by Meng, Jian, Yang, Juan, Pan, Ting, Qu, Xianjun, Cui, Shuxiang

“…[Display omitted] •ZnO NPs induce chronic inflammation in colorectal mucosal epithelia.•ZnO NPs promote malignant transformation of colonic cells in APCmin/+…”
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PLCG2 and IFNAR1: The Potential Biomarkers Mediated by Immune Infiltration and Osteoclast Differentiation of Ankylosing Spondylitis in the Peripheral Blood by Han, Bo, Xie, Qiaobo, Liang, Weishi, Yin, Peng, Qu, Xianjun, Hai, Yong

“…Objectives. Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease characterized by chronic spinal inflammation, arthritis, gut inflammation,…”
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LAIR1 drives glioma progression by nuclear focal adhesion kinase dependent expressions of cyclin D1 and immunosuppressive chemokines/cytokines by Wei, Xiaoqian, Pan, Shushan, Wang, Zirui, Chen, Jieru, Lu, Li, Cao, Qizhi, Song, Shuling, Zhang, Huachang, Liu, Xiaohui, Qu, Xianjun, Lin, Xiukun, Xu, Huanli

“…Leukocyte-associated immunoglobulin-like receptor-1 (LAIR1), an immune receptor containing immunoreceptor tyrosine-based inhibiory motifs (ITIMs), has emerged…”
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Resveratrol Inhibits the Invasion of Glioblastoma-Initiating Cells via Down-Regulation of the PI3K/Akt/NF-κB Signaling Pathway by Jiao, Yuming, Li, Hao, Liu, Yaodong, Guo, Anchen, Xu, Xiaoxue, Qu, Xianjun, Wang, Shuo, Zhao, Jizong, Li, Ye, Cao, Yong

“…Invasion and metastasis of glioblastoma-initiating cells (GICs) are thought to be responsible for the progression and recurrence of glioblastoma multiforme…”
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CXCL12/CXCR7/β-arrestin1 biased signal promotes epithelial-to-mesenchymal transition of colorectal cancer by repressing miRNAs through YAP1 nuclear translocation by Si, Mahan, Song, Yujia, Wang, Xiaohui, Wang, Dong, Liu, Xiaohui, Qu, Xianjun, Song, Zhiyu, Yu, Xinfeng

“…Abstract Background Chemokine CXC motif receptor 7 (CXCR7) is an atypical G protein-coupled receptor (GPCR) that signals in a biased fashion. CXCL12/CXCR7…”
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Activation of insulin-like growth factor-1 receptor (IGF-1R) promotes growth of colorectal cancer through triggering the MEX3A-mediated degradation of RIG-I by Xie, Qiaobo, Chu, Yanyan, Yuan, Wenmin, Li, Yanan, Li, Keqin, Wu, Xinfeng, Liu, Xiaohui, Xu, Rui, Cui, Shuxiang, Qu, Xianjun

“…Insulin-like growth factor-1 receptor (IGF-1R) has been made an attractive anticancer target due to its overexpression in cancers. However, targeting it has…”
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Targeting c-Met as a promising strategy for the treatment of hepatocellular carcinoma by Gao, Jianjun, Inagaki, Yoshinori, Song, Peipei, Qu, Xianjun, Kokudo, Norihiro, Tang, Wei

“…Hepatocellular carcinoma (HCC) is a severe condition that is found worldwide. Liver transplantation, surgical resection, and local-regional therapy such as…”
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Anti-metastatic and anti-angiogenic activities of sulfated polysaccharide of Sepiella maindroni ink by Zong, Aizhen, Zhao, Ting, Zhang, Yan, Song, Xinlei, Shi, Yikang, Cao, Hongzhi, Liu, Chunhui, Cheng, Yanna, Qu, Xianjun, Cao, Jichao, Wang, Fengshan

“…► Previous study demonstrated that SIP-SII had antimetastatic activity in vitro. ► SIP-SII significantly inhibited melanoma metastasis in vivo. ► SIP-SII…”
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Inhibition of angiogenesis and invasion by DMBT is mediated by downregulation of VEGF and MMP-9 through Akt pathway in MDA-MB-231 breast cancer cells by Tang, Linlin, Ma, Xiaowen, Tian, Qi, Cheng, Yanna, Yao, Hong, Liu, Zhaopeng, Qu, Xianjun, Han, Xiuzhen

“…► DMBT, a novel trehalose derivative, is one of brartemicin analogs. ► DMBT had no obvious inhibitory or cytotoxic effect in MDA-MB-231 cells. ► DMBT could…”
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Translocation of IGF-1R in endoplasmic reticulum enhances SERCA2 activity to trigger Ca2+ER perturbation in hepatocellular carcinoma by Li, Yanan, Li, Keqin, Pan, Ting, Xie, Qiaobo, Cheng, Yuyao, Wu, Xinfeng, Xu, Rui, Liu, Xiaohui, Liu, Li, Gao, Jiangming, Yuan, Wenmin, Qu, Xianjun, Cui, Shuxiang

“…The well-known insulin-like growth factor 1 (IGF1)/IGF-1 receptor (IGF-1R) signaling pathway is overexpressed in many tumors, and is thus an attractive target…”
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Strategies to overcome or circumvent P-glycoprotein mediated multidrug resistance by Yuan, Hongyu, Li, Xun, Wu, Jifeng, Li, Jinpei, Qu, Xianjun, Xu, Wenfang, Tang, Wei

“…Cancer patients who receive chemotherapy often experience intrinsic or acquired resistance to a broad spectrum of chemotherapeutic agents. The phenomenon,…”
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Altered mRNA expressions of sialyltransferases in human gastric cancer tissues by Jun, Li, Yuanshu, Wang, Yanying, Xie, Zhongfa, Xu, Jian, Yang, Fengling, Wang, Xianjun, Qu, Kokudo, Norihiro, Wei, Tang, Weixia, Zhong, Shuxiang, Cui

“…Aberrant sialylation and altered sialyltransferase (ST) expressions are frequently found in many types of cancer. In this study, we examined the expressions of…”
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SL-01, an oral gemcitabine derivative, inhibited human cancer growth more potently than gemcitabine by Zhao, Cuirong, Yue, Bin, Liu, Huiping, Sun, Cuicui, Li, Wenbao, Qu, Xianjun

“…SL-01, an oral gemcitabine derivative, was synthesized by introducing the moiety of 3-(dodecyloxycarbonyl)pyrazine-2-carbonyl at the N4-position on the…”
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Reversal of the multidrug resistance of human ileocecal adenocarcinoma cells by acetyl-11-keto-β-boswellic acid via downregulation of P-glycoprotein signals by Xue, Xia, Chen, Fang, Liu, Anxin, Sun, Deqing, Wu, Jing, Kong, Feng, Luan, Yun, Qu, Xianjun, Wang, Rongmei

“…Multidrug resistance (MDR) represents a clinical obstacle to cancer chemotherapy since it causes cancer recurrence and metastasis. Acetyl-11-keto-β-boswellic…”
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Monoclonal antibody-related drugs for cancer therapy by Li, Guoning, Wang, Siping, Xue, Xia, Qu, Xianjun, Liu, Huiping

“…Much progress has been made during the last few decades in the treatment of malignancies. Many types of cancer cells comprising the tumor mass carry molecular…”
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