Search Results - "Wyss, Matthias T."

In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons by Mächler, Philipp, Wyss, Matthias T., Elsayed, Maha, Stobart, Jillian, Gutierrez, Robin, von Faber-Castell, Alexandra, Kaelin, Vincens, Zuend, Marc, San Martín, Alejandro, Romero-Gómez, Ignacio, Baeza-Lehnert, Felipe, Lengacher, Sylvain, Schneider, Bernard L., Aebischer, Patrick, Magistretti, Pierre J., Barros, L. Felipe, Weber, Bruno

“…Investigating lactate dynamics in brain tissue is challenging, partly because in vivo data at cellular resolution are not available. We monitored lactate in…”
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A Probable Dual Mode of Action for Both L- and D-Lactate Neuroprotection in Cerebral Ischemia by Castillo, Ximena, Rosafio, Katia, Wyss, Matthias T, Drandarov, Konstantin, Buck, Alfred, Pellerin, Luc, Weber, Bruno, Hirt, Lorenz

“…Lactate has been shown to offer neuroprotection in several pathologic conditions. This beneficial effect has been attributed to its use as an alternative…”
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Simultaneous dynamic glucose-enhanced (DGE) MRI and fiber photometry measurements of glucose in the healthy mouse brain by Eleftheriou, Afroditi, Ravotto, Luca, Wyss, Matthias T., Warnock, Geoffrey, Siebert, Anita, Zaiss, Moritz, Weber, Bruno

“…•Fiber photometry with FRET biosensors complements MRI with cell-specific data.•Data from FRET fiber photometry are consistent with two-photon microscopy…”
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Channel-mediated lactate release by K⁺-stimulated astrocytes by Sotelo-Hitschfeld, Tamara, Niemeyer, María I, Mächler, Philipp, Ruminot, Iván, Lerchundi, Rodrigo, Wyss, Matthias T, Stobart, Jillian, Fernández-Moncada, Ignacio, Valdebenito, Rocío, Garrido-Gerter, Pamela, Contreras-Baeza, Yasna, Schneider, Bernard L, Aebischer, Patrick, Lengacher, Sylvain, San Martín, Alejandro, Le Douce, Juliette, Bonvento, Gilles, Magistretti, Pierre J, Sepúlveda, Francisco V, Weber, Bruno, Barros, L Felipe

“…Excitatory synaptic transmission is accompanied by a local surge in interstitial lactate that occurs despite adequate oxygen availability, a puzzling…”
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A complete pupillometry toolbox for real-time monitoring of locus coeruleus activity in rodents by Privitera, Mattia, Ferrari, Kim David, von Ziegler, Lukas M., Sturman, Oliver, Duss, Sian N., Floriou-Servou, Amalia, Germain, Pierre-Luc, Vermeiren, Yannick, Wyss, Matthias T., De Deyn, Peter P., Weber, Bruno, Bohacek, Johannes

“…The locus coeruleus (LC) is a region in the brainstem that produces noradrenaline and is involved in both normal and pathological brain function. Pupillometry,…”
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Cerebral glucose and lactate consumption during cerebral activation by physical activity in humans by Rasmussen, Peter, Wyss, Matthias T., Lundby, Carsten

“…ABSTRACT At rest, the brain takes up oxygen and carbohydrate at an ~6:1 ratio. Exercise increases systemic lactate availability reducing this to as little as…”
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NH4+ triggers the release of astrocytic lactate via mitochondrial pyruvate shunting by Rodrigo Lerchundi, Ignacio Fernández-Moncada, Yasna Contreras-Baeza, Tamara Sotelo-Hitschfeld, Philipp Mächler, Matthias T. Wyss, Jillian Stobart, Felipe Baeza-Lehnert, Karin Alegría, Bruno Weber, L. Felipe Barros

“…Neural activity is accompanied by a transient mismatch between local glucose and oxygen metabolism, a phenomenon of physiological and pathophysiological…”
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The bumpy road of purinergic inhibitors to clinical application in immune-mediated diseases by Wyss, Matthias T, Heuer, Christine, Herwerth, Marina

“…Purinergic signaling plays important roles throughout the body in the regulation of organ functions during and following the disruption of homeostasis. This is…”
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Axon degeneration: new actor in an old play by Herwerth, Marina, Wyss, Matthias

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Rewiring of hindlimb corticospinal neurons after spinal cord injury by Ghosh, Arko, Haiss, Florent, Sydekum, Esther, Schneider, Regula, Gullo, Miriam, Wyss, Matthias T, Mueggler, Thomas, Baltes, Christof, Rudin, Markus, Weber, Bruno, Schwab, Martin E

“…In rodents, descending corticospinal tracts can be rerouted to innervate new targets after a spinal cord injury. Here, Ghosh et al . show that such anatomical…”
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Labeled acetate as a marker of astrocytic metabolism by Wyss, Matthias T, Magistretti, Pierre J, Buck, Alfred, Weber, Bruno

“…Astrocytes have various important roles in brain physiology. To further elucidate the details of astrocytic functions under normal and pathological states,…”
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SAFIR-I: Design and Performance of a High-Rate Preclinical PET Insert for MRI by Bebié, Pascal, Becker, Robert, Commichau, Volker, Debus, Jan, Dissertori, Günther, Djambazov, Lubomir, Eleftheriou, Afroditi, Fischer, Jannis, Fischer, Peter, Ito, Mikiko, Khateri, Parisa, Lustermann, Werner, Ritzer, Christian, Ritzert, Michael, Röser, Ulf, Tsoumpas, Charalampos, Warnock, Geoffrey, Weber, Bruno, Wyss, Matthias T, Zagozdzinska-Bochenek, Agnieszka

“…(1) Background: Small Animal Fast Insert for MRI detector I (SAFIR-I) is a preclinical Positron Emission Tomography (PET) insert for the Bruker BioSpec 70/30…”
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Measurement of cerebral oxygen pressure in living mice by two-photon phosphorescence lifetime microscopy by Erlebach, Eva, Ravotto, Luca, Wyss, Matthias T., Condrau, Jacqueline, Troxler, Thomas, Vinogradov, Sergei A., Weber, Bruno

“…The ability to quantify partial pressure of oxygen (pO2) is of primary importance for studies of metabolic processes in health and disease. Here, we present a…”
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DCC Is Required for the Development of Nociceptive Topognosis in Mice and Humans by da Silva, Ronan V., Johannssen, Helge C., Wyss, Matthias T., Roome, R. Brian, Bourojeni, Farin B., Stifani, Nicolas, Marsh, Ashley P.L., Ryan, Monique M., Lockhart, Paul J., Leventer, Richard J., Richards, Linda J., Rosenblatt, Bernard, Srour, Myriam, Weber, Bruno, Zeilhofer, Hanns Ulrich, Kania, Artur

“…Avoidance of environmental dangers depends on nociceptive topognosis, or the ability to localize painful stimuli. This is proposed to rely on somatotopic maps…”
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A Two-Compartment Mathematical Model of Neuroglial Metabolism Using [1-11C] Acetate by Lanz, Bernard, Uffmann, Kai, T Wyss, Matthias, Weber, Bruno, Buck, Alfred, Gruetter, Rolf

“…The purpose of this study was to develop a two-compartment metabolic model of brain metabolism to assess oxidative metabolism from [1-11C] acetate radiotracer…”
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In vivo evidence for lactate as a neuronal energy source by Wyss, Matthias T, Jolivet, Renaud, Buck, Alfred, Magistretti, Pierre J, Weber, Bruno

“…Cerebral energy metabolism is a highly compartmentalized and complex process in which transcellular trafficking of metabolites plays a pivotal role. Over the…”
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Arousal-induced cortical activity triggers lactate release from astrocytes by Zuend, Marc, Saab, Aiman S., Wyss, Matthias T., Ferrari, Kim David, Hösli, Ladina, Looser, Zoe J., Stobart, Jillian L., Duran, Jordi, Guinovart, Joan J., Barros, L. Felipe, Weber, Bruno

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Assessment of serotonin release capacity in the human brain using dexfenfluramine challenge and [18F]altanserin positron emission tomography by Quednow, Boris B., Treyer, Valerie, Hasler, Felix, Dörig, Nadja, Wyss, Matthias T., Burger, Cyrill, Rentsch, Katharina M., Westera, Gerrit, Schubiger, Pius August, Buck, Alfred, Vollenweider, Franz X.

“…Although alterations of serotonin (5-HT) system functioning have been proposed for a variety of psychiatric disorders, a direct method quantitatively assessing…”
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Neutrophils Obstructing Brain Capillaries Are a Major Cause of No-Reflow in Ischemic Stroke by El Amki, Mohamad, Glück, Chaim, Binder, Nadine, Middleham, William, Wyss, Matthias T., Weiss, Tobias, Meister, Hanna, Luft, Andreas, Weller, Michael, Weber, Bruno, Wegener, Susanne

“…Despite successful clot retrieval in large vessel occlusion stroke, ∼50% of patients have an unfavorable clinical outcome. The mechanisms underlying this…”
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Amino acid positron emission tomography to monitor chemotherapy response and predict seizure control and progression-free survival in WHO grade II gliomas by Roelcke, Ulrich, Wyss, Matthias T, Nowosielski, Martha, Rudà, Roberta, Roth, Patrick, Hofer, Silvia, Galldiks, Norbert, Crippa, Flavio, Weller, Michael, Soffietti, Riccardo

“…Patients with WHO grade II glioma may respond to chemotherapy that is currently not standardized regarding timing and treatment duration. Metabolic changes…”
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