Search Results - "Wysolmerski, John J."

Parathyroid Hormone-Related Protein: An Update by Wysolmerski, John J

“…PTHrP was identified as a cause of hypercalcemia in cancer patients 25 yr ago. In the intervening years, we have learned that PTHrP and PTH are encoded by…”
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Crosstalk within a brain-breast-bone axis regulates mineral and skeletal metabolism during lactation by Athonvarangkul, Diana, Wysolmerski, John J

“…To support the increased calcium demands for milk production during lactation, a dramatic and reversible physiological response occurs to alter bone and…”
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Interactions between breast, bone, and brain regulate mineral and skeletal metabolism during lactation by Wysolmerski, John J.

“…Mammalian reproduction requires that nursing mothers transfer large amounts of calcium to their offspring through milk. As a result, lactation is associated…”
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Calcium-Sensing Receptor in Breast Physiology and Cancer by Kim, Wonnam, Wysolmerski, John J

“…The calcium-sensing receptor (CaSR) is expressed in normal breast epithelial cells and in breast cancer cells. During lactation, activation of the CaSR in…”
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PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer by Jeong, Jaekwang, VanHouten, Joshua N., Dann, Pamela, Kim, Wonnam, Sullivan, Catherine, Yu, Herbert, Liotta, Lance, Espina, Virginia, Stern, David F., Friedman, Peter A., Wysolmerski, John J.

“…In the lactating mammary gland, the plasma membrane calcium ATPase2 (PMCA2) transports milk calcium. Its expression is activated in breast cancers,where high…”
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HER2 signaling regulates HER2 localization and membrane retention by Jeong, Jaekwang, Kim, Wonnam, Kim, Lark Kyun, VanHouten, Joshua, Wysolmerski, John J

“…ErbB2/HER2/Neu is a receptor tyrosine kinase that is overexpressed in 25-30% of human breast cancers, usually associated with amplification of the ERBB2 gene…”
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The calcium-sensing receptor in the breast by VanHouten, Joshua N., Ph.D, Wysolmerski, John J., M.D

“…Normal breast epithelial cells and breast cancer cells express the calcium-sensing receptor (CaSR), the master regulator of systemic calcium metabolism. During…”
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PTHrP induces STAT5 activation, secretory differentiation and accelerates mammary tumor development by Grinman, Diego Y, Boras-Granic, Kata, Takyar, Farzin M, Dann, Pamela, Hens, Julie R, Marmol, Christina, Lee, Jongwon, Choi, Jungmin, Chodosh, Lewis A, Sola, Martin E Garcia, Wysolmerski, John J

“…Parathyroid hormone-related protein (PTHrP) is required for embryonic breast development and has important functions during lactation, when it is produced by…”
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Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis by Chu, Emily Y, Hens, Julie, Andl, Thomas, Kairo, Alladin, Yamaguchi, Terry P, Brisken, Cathrin, Glick, Adam, Wysolmerski, John J, Millar, Sarah E

“…Mammary glands, like other skin appendages such as hair follicles and teeth, develop from the surface epithelium and underlying mesenchyme; however, the…”
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Osteocytes remove and replace perilacunar mineral during reproductive cycles by Wysolmerski, John J

“…Abstract Lactation is associated with an increased demand for calcium and is accompanied by a remarkable cycle of bone loss and recovery that helps to supply…”
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The calcium-sensing receptor regulates mammary gland parathyroid hormone-related protein production and calcium transport by VanHouten, Joshua, Dann, Pamela, McGeoch, Grace, Brown, Edward M, Krapcho, Karen, Neville, Margaret, Wysolmerski, John J

“…The transfer of calcium from mother to milk during lactation is poorly understood. In this report, we demonstrate that parathyroid hormone-related protein…”
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Cancer-Associated Hypercalcemia by Guise, Theresa A, Wysolmerski, John J

“…Cancer-associated hypercalcemia often occurs late in the course of solid-tumor development and is associated with a poor prognosis. Treatment includes…”
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The butyrophilin 1a1 knockout mouse revisited: Ablation of Btn1a1 leads to concurrent cell death and renewal in the mammary epithelium during lactation by Jeong, Jaekwang, Kadegowda, Anil K. G., Meyer, Thomas J., Jenkins, Lisa M., Dinan, Jerry C., Wysolmerski, John J., Weigert, Roberto, Mather, Ian H.

“…Butyrophilin 1A1 (BTN1A1) is implicated in the secretion of lipid droplets from mammary epithelial cells as a membrane receptor, which forms a secretion…”
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Low Estrogen and High Parathyroid Hormone-Related Peptide Levels Contribute to Accelerated Bone Resorption and Bone Loss in Lactating Mice by VanHouten, Joshua N, Wysolmerski, John J

“…Providing enough calcium for milk production stresses calcium homeostasis in lactating mammals. A universal response to these demands for calcium appears to be…”
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Wnt signaling in breast organogenesis by Boras-Granic, Kata, Wysolmerski, John J.

“…Wnt signals play a critical role in regulating the normal development of the mammary gland and dysregulation of Wnt signaling causes breast cancer. This…”
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Mammary-specific deletion of parathyroid hormone-related protein preserves bone mass during lactation by VanHouten, Joshua N, Dann, Pamela, Stewart, Andrew F, Watson, Christine J, Pollak, Michael, Karaplis, Andrew C, Wysolmerski, John J

“…Large amounts of calcium are transferred to offspring by milk. This demand results in negative calcium balance in lactating mothers and is associated with…”
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Cancer-Associated Hypercalcemia. Reply by Guise, Theresa A, Wysolmerski, John J

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A Case of Hypercalcemia from PTHrP-Producing Fibromyxoid Sarcoma Responsive to Glucocorticoid Therapy by Niu, Isabella, Hsiao, Edward C., Wustrack, Rosanna, Wysolmerski, John J., Dann, Pamela, Masharani, Umesh

“…The treatment of parathyroid hormone-related protein (PTHrP)-mediated hypercalcemia of malignancy includes treating the malignancy, intravenous fluids, and…”
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Inhibition of ezrin causes PKCα-mediated internalization of erbb2/HER2 tyrosine kinase in breast cancer cells by Jeong, Jaekwang, Choi, Jungmin, Kim, Wonnam, Dann, Pamela, Takyar, Farzin, Gefter, Julia V., Friedman, Peter A., Wysolmerski, John J.

“…Unlike other ErbB family members, HER2 levels are maintained on the cell surface when the receptor is activated, allowing prolonged signaling and contributing…”
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Embryonic cells contribute directly to the quiescent stem cell population in the adult mouse mammary gland by Boras-Granic, Kata, Dann, Pamela, Wysolmerski, John J

“…Studies have identified multi-potent stem cells in the adult mammary gland. More recent studies have suggested that the embryonic mammary gland may also…”
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