Search Results - "Wypijewska Del Nogal, Anna"

Exploring the conformational dynamics of the SARS-CoV-2 SL4 hairpin by combining optical tweezers and base analogues by Sundar Rajan, Vinoth, Wypijewska Del Nogal, Anna, Levin, Sune, Wilhelmsson, L Marcus, Westerlund, Fredrik

“…The parasitic nature of the SARS-CoV-2 virus demands selective packaging of its RNA genome (gRNA) from the abundance of other nucleic acids present in infected…”
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Getting DNA and RNA out of the dark with 2CNqA: a bright adenine analogue and interbase FRET donor by Wypijewska del Nogal, Anna, Füchtbauer, Anders F, Bood, Mattias, Nilsson, Jesper R, Wranne, Moa S, Sarangamath, Sangamesh, Pfeiffer, Pauline, Rajan, Vinoth Sundar, El-Sagheer, Afaf H, Dahlén, Anders, Brown, Tom, Grøtli, Morten, Wilhelmsson, L Marcus

“…Abstract With the central role of nucleic acids there is a need for development of fluorophores that facilitate the visualization of processes involving…”
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Complex Conformational Dynamics of the Heart Failure-Associated Pre-miRNA-377 Hairpin Revealed by Single-Molecule Optical Tweezers by Wypijewska del Nogal, Anna, Sundar Rajan, Vinoth, Westerlund, Fredrik, Wilhelmsson, L. Marcus

“…Pre-miRNA-377 is a hairpin-shaped regulatory RNA associated with heart failure. Here, we use single-molecule optical tweezers to unzip pre-miRNA-377 and study…”
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Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes by Kowalska, Joanna, Wypijewska del Nogal, Anna, Darzynkiewicz, Zbigniew M, Buck, Janina, Nicola, Corina, Kuhn, Andreas N, Lukaszewicz, Maciej, Zuberek, Joanna, Strenkowska, Malwina, Ziemniak, Marcin, Maciejczyk, Maciej, Bojarska, Elzbieta, Rhoads, Robert E, Darzynkiewicz, Edward, Sahin, Ugur, Jemielity, Jacek

“…Modified mRNA cap analogs aid in the study of mRNA-related processes and may enable creation of novel therapeutic interventions. We report the synthesis and…”
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Interbase-FRET binding assay for pre-microRNAs by Bood, Mattias, del Nogal, Anna Wypijewska, Nilsson, Jesper R., Edfeldt, Fredrik, Dahlén, Anders, Lemurell, Malin, Wilhelmsson, L. Marcus, Grøtli, Morten

“…The aberrant expression of microRNAs (miRs) has been linked to several human diseases. A promising approach for targeting these anomalies is the use of…”
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Decapping Scavenger (DcpS) enzyme: Advances in its structure, activity and roles in the cap-dependent mRNA metabolism by Milac, Adina L., Bojarska, Elzbieta, Wypijewska del Nogal, Anna

“…Decapping Scavenger (DcpS) enzyme rids eukaryotic cells of short mRNA fragments containing the 5′ mRNA cap structure, which appear in the 3′→5′ mRNA decay…”
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Short talk Studying the stability and conformational dynamics of the SARS-CoV-2 SL4 RNA hairpin combining base analogues and optical tweezers by Sundar Rajan, Vinoth, Wypijewska Del Nogal, Anna Wiktoria, Levin, Sune, Wilhelmsson, Marcus, Westerlund, Fredrik

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Analysis of decapping scavenger cap complex using modified cap analogs reveals molecular determinants for efficient cap binding by Wypijewska del Nogal, Anna, Surleac, Marius D., Kowalska, Joanna, Lukaszewicz, Maciej, Jemielity, Jacek, Bisaillon, Martin, Darzynkiewicz, Edward, Milac, Adina L., Bojarska, Elzbieta

“…Decapping scavenger (DcpS) assists in precluding inhibition of cap‐binding proteins by hydrolyzing cap species remaining after mRNA 3′→5′ degradation. Its…”
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